Erythromycin_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Erythromycin perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Erythromycin_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0805754
RPS6 ribosomal protein S6 0.0786735
FTH1 ferritin, heavy polypeptide 1 0.0666679
PTMA prothymosin, alpha 0.0609411
MT2A metallothionein 2A 0.059594
PODXL podocalyxin-like 0.0473958
RPS8 ribosomal protein S8 0.0432898
PGAM4 phosphoglycerate mutase family member 4 0.0428884
TMSB10 thymosin beta 10 0.0381201
BHLHE40 basic helix-loop-helix family, member e40 0.0354456
PRRC2C proline-rich coiled-coil 2C 0.0334714
RPS2 ribosomal protein S2 0.0328083
FLNA filamin A, alpha 0.0327796
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0318326
RPS12 ribosomal protein S12 0.0304908
RPLP2 ribosomal protein, large, P2 0.0301031
RPS3 ribosomal protein S3 0.0268531
RACK1 receptor for activated C kinase 1 0.0267212
SQLE squalene epoxidase 0.0259411
EIF1 eukaryotic translation initiation factor 1 0.0244942
LAMA5 laminin, alpha 5 0.0241255
RPL4 ribosomal protein L4 0.0240693
FTL ferritin, light polypeptide 0.0238967
RPS19 ribosomal protein S19 0.0227591
MT1X metallothionein 1X 0.0220135
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0219816
RPS14 ribosomal protein S14 0.0217929
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0216421
RPL5 ribosomal protein L5 0.0214057
VIM vimentin 0.0211793
NCOR2 nuclear receptor corepressor 2 0.0208641
RNF19B ring finger protein 19B 0.0208129
DLGAP4 discs, large (Drosophila) homolog-associated protein 4 0.0205375
BAZ2A bromodomain adjacent to zinc finger domain, 2A 0.0205236
RPL36 ribosomal protein L36 0.0204329
RPL36A ribosomal protein L36a 0.0196722
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.019422
CNRIP1 cannabinoid receptor interacting protein 1 0.0192279
RPL9 ribosomal protein L9 0.0188658
SRRM2 serine/arginine repetitive matrix 2 0.0182689
RPL37 ribosomal protein L37 0.0181991
RPL12 ribosomal protein L12 0.0180299
ADRM1 adhesion regulating molecule 1 0.0178174
RPL21 ribosomal protein L21 0.0176528
CD99 CD99 molecule 0.0176004
UBE2C ubiquitin-conjugating enzyme E2C 0.0173821
RPLP1 ribosomal protein, large, P1 0.0173232
YBX1 Y box binding protein 1 0.0171689
EEF1G eukaryotic translation elongation factor 1 gamma 0.0171605
RPS27A ribosomal protein S27a 0.0171312
RPS27 ribosomal protein S27 0.0171196
RPL31 ribosomal protein L31 0.0169863
SRRM1 serine/arginine repetitive matrix 1 0.0168428
ATP5F1E ATP synthase F1 subunit epsilon 0.0166403
AKAP12 A kinase (PRKA) anchor protein 12 0.0166028
GNAS GNAS complex locus 0.0165736
RPL35 ribosomal protein L35 0.0165259
RPS17 ribosomal protein S17 0.0165147
RPS4X ribosomal protein S4, X-linked 0.0164739
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 0.0164399
HSPG2 heparan sulfate proteoglycan 2 0.0162736
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 0.0160731
EIF4H eukaryotic translation initiation factor 4H 0.016042
TPT1 tumor protein, translationally-controlled 1 0.0160109
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0159933
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0159855
RPL37A ribosomal protein L37a 0.0159021
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0157734
S100A6 S100 calcium binding protein A6 0.0157049
RPL34 ribosomal protein L34 0.0156469
IFITM3 interferon induced transmembrane protein 3 0.0156373
UQCRB ubiquinol-cytochrome c reductase binding protein 0.0155713
TNIP1 TNFAIP3 interacting protein 1 0.0155149
SF3A1 splicing factor 3a, subunit 1, 120kDa 0.0152803
MKI67 marker of proliferation Ki-67 0.0151349
GOLGA4 golgin A4 0.0150629
HLA-B major histocompatibility complex, class I, B 0.0149458
RIPOR1 RHO family interacting cell polarization regulator 1 0.0149326
RPL11 ribosomal protein L11 0.0148109
RPL13A ribosomal protein L13a 0.0147155
EIF5B eukaryotic translation initiation factor 5B 0.0145885
RPS21 ribosomal protein S21 0.0144873
KRT6A keratin 6A, type II 0.0144023
FSCN1 fascin actin-bundling protein 1 0.0142758
DHFR dihydrofolate reductase 0.0142542
ITGB4 integrin, beta 4 0.0142098
RPL10A ribosomal protein L10a 0.0139636
RPL8 ribosomal protein L8 0.0139516
KRT17 keratin 17, type I 0.0138277
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0134779
RPS16 ribosomal protein S16 0.0133868
BCL9L B-cell CLL/lymphoma 9-like 0.013316
RPL26 ribosomal protein L26 0.0132395
PDGFB platelet-derived growth factor beta polypeptide 0.0132344
LMNA lamin A/C 0.0132028
RPL18 ribosomal protein L18 0.0130471
PFN1 profilin 1 0.0130392
OGFR opioid growth factor receptor 0.0130068
SRSF11 serine/arginine-rich splicing factor 11 0.0128996
RPL35A ribosomal protein L35a 0.0128921

decreased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.211074
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.171324
NDRG1 N-myc downstream regulated 1 -0.131355
DPYD dihydropyrimidine dehydrogenase -0.130306
MYOF myoferlin -0.121457
ITGA6 integrin, alpha 6 -0.0815075
FLNB filamin B, beta -0.0812231
FOXO1 forkhead box O1 -0.0808373
LMO7 LIM domain 7 -0.0771144
AHNAK AHNAK nucleoprotein -0.076194
CD44 CD44 molecule (Indian blood group) -0.0751143
SULF1 sulfatase 1 -0.0746062
MBNL1 muscleblind-like splicing regulator 1 -0.0682775
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0615859
PDLIM5 PDZ and LIM domain 5 -0.0602732
LDHA lactate dehydrogenase A -0.0560133
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0557707
PSD3 pleckstrin and Sec7 domain containing 3 -0.0550491
PDE4D phosphodiesterase 4D, cAMP-specific -0.0549505
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0548778
PTK2 protein tyrosine kinase 2 -0.053216
NAMPT nicotinamide phosphoribosyltransferase -0.0521226
NEK7 NIMA-related kinase 7 -0.0518296
PRELID2 PRELI domain containing 2 -0.0511493
PGK1 phosphoglycerate kinase 1 -0.0504681
RASAL2 RAS protein activator like 2 -0.0499804
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0499677
SLC35F3 solute carrier family 35, member F3 -0.0497044
TRIO trio Rho guanine nucleotide exchange factor -0.0495955
MECOM MDS1 and EVI1 complex locus -0.0484285
MACF1 microtubule-actin crosslinking factor 1 -0.0483885
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 -0.0482206
FN1 fibronectin 1 -0.0477275
CEMIP cell migration inducing protein, hyaluronan binding -0.0470413
GRB10 growth factor receptor-bound protein 10 -0.0456591
ASPH aspartate beta-hydroxylase -0.0451425
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0444621
OSMR oncostatin M receptor -0.0440285
PICALM phosphatidylinositol binding clathrin assembly protein -0.0440112
CUL4B cullin 4B -0.0438192
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0428156
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0427848
FOXP1 forkhead box P1 -0.0424705
CAV1 caveolin 1, caveolae protein, 22kDa -0.0424151
CANX calnexin -0.0423725
CDK6 cyclin-dependent kinase 6 -0.0419661
NRIP1 nuclear receptor interacting protein 1 -0.0412323
MEF2A myocyte enhancer factor 2A -0.0407411
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0407006
MTSS1 metastasis suppressor 1 -0.0402324
PALLD palladin, cytoskeletal associated protein -0.0401561
DOCK4 dedicator of cytokinesis 4 -0.0387966
EXT1 exostosin glycosyltransferase 1 -0.0387378
DOCK5 dedicator of cytokinesis 5 -0.0387346
CALU calumenin -0.0377433
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.0372862
ARHGAP29 Rho GTPase activating protein 29 -0.0371111
MSN moesin -0.0369841
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) -0.0369721
FNDC3B fibronectin type III domain containing 3B -0.0368059
MYH9 myosin, heavy chain 9, non-muscle -0.03647
RAI14 retinoic acid induced 14 -0.0362955
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.0359527
ZEB1 zinc finger E-box binding homeobox 1 -0.0356923
JMJD1C jumonji domain containing 1C -0.0356867
AMOTL1 angiomotin like 1 -0.0356274
ANXA2 annexin A2 -0.0354891
COPA coatomer protein complex, subunit alpha -0.0354567
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0351182
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0348581
SEC31A SEC31 homolog A (S. cerevisiae) -0.0346887
EMP1 epithelial membrane protein 1 -0.0342094
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) -0.0341994
TSC22D1 TSC22 domain family, member 1 -0.0338582
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0338492
LAMC1 laminin, gamma 1 (formerly LAMB2) -0.0337869
SAMD9 sterile alpha motif domain containing 9 -0.0336875
AKAP13 A kinase (PRKA) anchor protein 13 -0.0332136
EFNA5 ephrin-A5 -0.0326343
DOCK9 dedicator of cytokinesis 9 -0.0321454
SMYD3 SET and MYND domain containing 3 -0.0315706
CLIC4 chloride intracellular channel 4 -0.0314093
NRG1 neuregulin 1 -0.031255
DGKH diacylglycerol kinase, eta -0.0309898
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0308595
INTS6 integrator complex subunit 6 -0.030349
ITCH itchy E3 ubiquitin protein ligase -0.0297058
EGFR epidermal growth factor receptor -0.0296341
AOPEP aminopeptidase O (putative) -0.0296313
SULF2 sulfatase 2 -0.0295338
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase -0.0295322
RIN2 Ras and Rab interactor 2 -0.0293131
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0293099
NCOA3 nuclear receptor coactivator 3 -0.0291507
TMSB4X thymosin beta 4, X-linked -0.028946
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0288991
HMGA2 high mobility group AT-hook 2 -0.0288938
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0288542
ALCAM activated leukocyte cell adhesion molecule -0.0287463
MAML2 mastermind-like 2 (Drosophila) -0.0286687