Erythromycin_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Erythromycin perturbation in LS 180 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Erythromycin_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.238655
RPS6 ribosomal protein S6 0.137484
FTH1 ferritin, heavy polypeptide 1 0.112441
RPS2 ribosomal protein S2 0.0830679
MUC6 mucin 6, oligomeric mucus/gel-forming 0.0778871
AREG amphiregulin 0.0654468
RPS12 ribosomal protein S12 0.0620983
EIF1 eukaryotic translation initiation factor 1 0.0540676
TXNIP thioredoxin interacting protein 0.04956
RPS19 ribosomal protein S19 0.0423036
FTL ferritin, light polypeptide 0.0412978
RPS8 ribosomal protein S8 0.0405563
PTMA prothymosin, alpha 0.0397419
RNF145 ring finger protein 145 0.0393756
MT2A metallothionein 2A 0.0368069
GOLGA4 golgin A4 0.0356805
RPS3 ribosomal protein S3 0.0355422
RPL36 ribosomal protein L36 0.0339118
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0339035
RPL37A ribosomal protein L37a 0.0332166
EEF2 eukaryotic translation elongation factor 2 0.0331277
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0315999
RPL26 ribosomal protein L26 0.0304083
FAM13A family with sequence similarity 13, member A 0.0296921
RBM39 RNA binding motif protein 39 0.0293841
EREG epiregulin 0.0290361
RPS27 ribosomal protein S27 0.0289028
NDRG1 N-myc downstream regulated 1 0.0284984
KMT2E lysine (K)-specific methyltransferase 2E 0.0279035
RPL12 ribosomal protein L12 0.0272183
GDF15 growth differentiation factor 15 0.0269511
ATF4 activating transcription factor 4 0.0263046
ERRFI1 ERBB receptor feedback inhibitor 1 0.0263025
RPL18 ribosomal protein L18 0.0262124
RPL34 ribosomal protein L34 0.0256262
RPLP2 ribosomal protein, large, P2 0.0256028
RPL21 ribosomal protein L21 0.0252322
RACK1 receptor for activated C kinase 1 0.0251741
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0251269
RPL4 ribosomal protein L4 0.0250271
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0250039
PCBP2 poly(rC) binding protein 2 0.0247751
S100P S100 calcium binding protein P 0.0247273
PRRC2C proline-rich coiled-coil 2C 0.0247232
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0240864
RPL9 ribosomal protein L9 0.0235392
BRD2 bromodomain containing 2 0.0234163
DDIT4 DNA-damage-inducible transcript 4 0.0232349
EEF1G eukaryotic translation elongation factor 1 gamma 0.0229068
BRD4 bromodomain containing 4 0.022611
PGAM4 phosphoglycerate mutase family member 4 0.0222897
RPS17 ribosomal protein S17 0.0222735
TRA2A transformer 2 alpha homolog (Drosophila) 0.0219377
MKNK2 MAP kinase interacting serine/threonine kinase 2 0.0217129
RPLP1 ribosomal protein, large, P1 0.0214519
PNN pinin, desmosome associated protein 0.0208469
RPL5 ribosomal protein L5 0.02062
ISG15 ISG15 ubiquitin-like modifier 0.020607
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0205722
BHLHE40 basic helix-loop-helix family, member e40 0.0205272
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0204428
RPS29 ribosomal protein S29 0.0201752
RPL11 ribosomal protein L11 0.020085
VIM vimentin 0.0197273
VEGFA vascular endothelial growth factor A 0.0193518
MUC5B mucin 5B, oligomeric mucus/gel-forming 0.0192378
TMF1 TATA element modulatory factor 1 0.019206
RPS16 ribosomal protein S16 0.0186763
WAC WW domain containing adaptor with coiled-coil 0.0185081
RPS23 ribosomal protein S23 0.0184965
PNISR PNN-interacting serine/arginine-rich protein 0.0182694
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0181202
RPL32 ribosomal protein L32 0.017942
RPL28 ribosomal protein L28 0.017899
RPL13A ribosomal protein L13a 0.0178667
ATF3 activating transcription factor 3 0.0178027
NUP58 nucleoporin 58 0.017628
LOC102724023 ES1 protein homolog, mitochondrial 0.0174994
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0173876
MT1X metallothionein 1X 0.0173202
SRRM1 serine/arginine repetitive matrix 1 0.0169346
PSAT1 phosphoserine aminotransferase 1 0.0166567
BAZ2A bromodomain adjacent to zinc finger domain, 2A 0.0166112
RPS14 ribosomal protein S14 0.0163268
RPL37 ribosomal protein L37 0.0163011
RSRC2 arginine/serine-rich coiled-coil 2 0.0159006
RPL10A ribosomal protein L10a 0.0158987
SRP54 signal recognition particle 54kDa 0.0157116
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.0156455
HSPA8 heat shock 70kDa protein 8 0.0156042
MUC13 mucin 13, cell surface associated 0.0155413
RPS25 ribosomal protein S25 0.0155202
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0154981
RPL31 ribosomal protein L31 0.0154807
EIF4H eukaryotic translation initiation factor 4H 0.015348
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 0.0153362
B2M beta-2-microglobulin 0.0151774
TMA7 translation machinery associated 7 homolog (S. cerevisiae) 0.0151074
UBE2B ubiquitin-conjugating enzyme E2B 0.0148304
UQCRB ubiquinol-cytochrome c reductase binding protein 0.014806

decreased expression

Symbol Name Standardized Value
NPSR1 neuropeptide S receptor 1 -0.234544
NALF1 NALCN channel auxiliary factor 1 -0.15787
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.13144
GMDS GDP-mannose 4,6-dehydratase -0.121334
CEMIP cell migration inducing protein, hyaluronan binding -0.115884
FAT1 FAT atypical cadherin 1 -0.113405
ALCAM activated leukocyte cell adhesion molecule -0.0991416
ITGA6 integrin, alpha 6 -0.0990761
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B -0.0972507
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0812241
PTPRK protein tyrosine phosphatase, receptor type, K -0.0811888
GPHN gephyrin -0.0808973
GREB1L growth regulation by estrogen in breast cancer-like -0.0778843
ANXA2 annexin A2 -0.0774094
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0771262
ANTXR2 anthrax toxin receptor 2 -0.0751091
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0707457
AHNAK AHNAK nucleoprotein -0.0704858
KRT18 keratin 18, type I -0.067967
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0632789
BCAT1 branched chain amino-acid transaminase 1, cytosolic -0.0601525
PDE4D phosphodiesterase 4D, cAMP-specific -0.05897
CADPS Ca++-dependent secretion activator -0.0567527
PPARG peroxisome proliferator-activated receptor gamma -0.0566965
FLNB filamin B, beta -0.0565221
TPM4 tropomyosin 4 -0.0562629
FHIT fragile histidine triad -0.055212
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0527389
SLC35F3 solute carrier family 35, member F3 -0.0515756
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0515512
RNF217 ring finger protein 217 -0.0514528
ACTN4 actinin, alpha 4 -0.0511896
SMYD3 SET and MYND domain containing 3 -0.0502579
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0488926
KRT8 keratin 8, type II -0.0485665
PATJ PATJ crumbs cell polarity complex component -0.0482838
PIGR polymeric immunoglobulin receptor -0.0457913
LPP LIM domain containing preferred translocation partner in lipoma -0.0453037
EHBP1 EH domain binding protein 1 -0.045093
SAMD5 sterile alpha motif domain containing 5 -0.04462
SLCO1B3 solute carrier organic anion transporter family, member 1B3 -0.0441757
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0440472
PSD3 pleckstrin and Sec7 domain containing 3 -0.0432756
NFIA nuclear factor I/A -0.0428384
MAML3 mastermind-like 3 (Drosophila) -0.042766
NRXN3 neurexin 3 -0.0424033
BIRC6 baculoviral IAP repeat containing 6 -0.0417188
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0415063
CCSER1 coiled-coil serine-rich protein 1 -0.0411017
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.040797
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0404657
RAD51B RAD51 paralog B -0.0403092
ARHGAP32 Rho GTPase activating protein 32 -0.0397205
MAML2 mastermind-like 2 (Drosophila) -0.0389829
FRMD5 FERM domain containing 5 -0.038517
MECOM MDS1 and EVI1 complex locus -0.0381219
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0379597
VCL vinculin -0.0376596
MSI2 musashi RNA-binding protein 2 -0.0372784
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0372222
CANX calnexin -0.0372166
PGK1 phosphoglycerate kinase 1 -0.037184
CCND1 cyclin D1 -0.0371365
PTPRR protein tyrosine phosphatase, receptor type, R -0.0371114
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0369666
CALB1 calbindin 1, 28kDa -0.0368099
CD46 CD46 molecule, complement regulatory protein -0.0367061
SH3D19 SH3 domain containing 19 -0.0364864
DLGAP1 discs, large (Drosophila) homolog-associated protein 1 -0.0363523
PRSS3 protease, serine, 3 -0.0357127
LDHA lactate dehydrogenase A -0.0356986
BAZ2B bromodomain adjacent to zinc finger domain, 2B -0.035512
PRELID2 PRELI domain containing 2 -0.0354835
DIAPH2 diaphanous-related formin 2 -0.0353425
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0351019
EPCAM epithelial cell adhesion molecule -0.034789
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0342793
FERMT1 fermitin family member 1 -0.0339451
DLG1 discs, large homolog 1 (Drosophila) -0.0336338
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide -0.0333226
POTEF POTE ankyrin domain family, member F -0.0328612
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) -0.0328472
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0328044
ZBTB20 zinc finger and BTB domain containing 20 -0.0324743
FOXP1 forkhead box P1 -0.0324516
ARHGAP5 Rho GTPase activating protein 5 -0.0324054
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 -0.0319542
TBC1D5 TBC1 domain family, member 5 -0.0315115
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0311526
ONECUT3 one cut homeobox 3 -0.0309999
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0309692
GCC2 GRIP and coiled-coil domain containing 2 -0.0308237
SERINC5 serine incorporator 5 -0.0307718
ARHGAP6 Rho GTPase activating protein 6 -0.0306542
ASPH aspartate beta-hydroxylase -0.0300656
DENND1A DENN/MADD domain containing 1A -0.0297705
EXOC4 exocyst complex component 4 -0.0295291
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -0.0294765
MYO1E myosin IE -0.0294465
MYOF myoferlin -0.029394