Erythromycin_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Erythromycin perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Erythromycin_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.155735
MT2A metallothionein 2A 0.0537379
PTMA prothymosin, alpha 0.0526927
RPS6 ribosomal protein S6 0.0506486
FTH1 ferritin, heavy polypeptide 1 0.045767
RPS2 ribosomal protein S2 0.0372283
EIF1 eukaryotic translation initiation factor 1 0.0313025
RPS8 ribosomal protein S8 0.029275
FTL ferritin, light polypeptide 0.0224028
RPL12 ribosomal protein L12 0.0203075
UBE2C ubiquitin-conjugating enzyme E2C 0.0202599
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0202091
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 0.0201798
RACK1 receptor for activated C kinase 1 0.0201537
RPL36 ribosomal protein L36 0.0168788
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0163943
RPL18 ribosomal protein L18 0.0148997
EGR1 early growth response 1 0.0148456
PGAM4 phosphoglycerate mutase family member 4 0.0137142
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0131948
RPL4 ribosomal protein L4 0.0128727
RPS19 ribosomal protein S19 0.012384
RPS14 ribosomal protein S14 0.012305
EIF4H eukaryotic translation initiation factor 4H 0.012181
EIF5B eukaryotic translation initiation factor 5B 0.0120576
RPS12 ribosomal protein S12 0.0120321
GOLGA4 golgin A4 0.0120215
RPL21 ribosomal protein L21 0.0117651
PNN pinin, desmosome associated protein 0.0112282
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0106295
RPL5 ribosomal protein L5 0.0106243
RPS27 ribosomal protein S27 0.0105642
RPL9 ribosomal protein L9 0.0101144
MKI67 marker of proliferation Ki-67 0.00969327
RPL26 ribosomal protein L26 0.00959779
MT1X metallothionein 1X 0.00911542
CAMLG calcium modulating ligand 0.00905314
RPS17 ribosomal protein S17 0.00903206
RPS16 ribosomal protein S16 0.00896954
RPS23 ribosomal protein S23 0.00890297
GPX4 glutathione peroxidase 4 0.00867813
BHLHE40 basic helix-loop-helix family, member e40 0.00861836
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.00853803
RPL10A ribosomal protein L10a 0.00815717
RPL37A ribosomal protein L37a 0.00812183
RPS3 ribosomal protein S3 0.00800612
DHX40 DEAH (Asp-Glu-Ala-His) box polypeptide 40 0.00800561
RPL11 ribosomal protein L11 0.00791382
RPL27 ribosomal protein L27 0.00787825
RPL13A ribosomal protein L13a 0.00746489
RPS7 ribosomal protein S7 0.00740481
HSPA8 heat shock 70kDa protein 8 0.0073142
BRD4 bromodomain containing 4 0.00703602
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa 0.0067218
RPL36A ribosomal protein L36a 0.00666052
SRRM1 serine/arginine repetitive matrix 1 0.00665878
ATF4 activating transcription factor 4 0.00665804
PFDN2 prefoldin subunit 2 0.00656802
HDGF hepatoma-derived growth factor 0.00653834
BAZ2A bromodomain adjacent to zinc finger domain, 2A 0.00653717
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 0.00650568
NACA nascent polypeptide-associated complex alpha subunit 0.00646035
RPL34 ribosomal protein L34 0.00640775
SNX3 sorting nexin 3 0.00639961
TMA7 translation machinery associated 7 homolog (S. cerevisiae) 0.006347
DSTN destrin (actin depolymerizing factor) 0.00634628
MPHOSPH10 M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein) 0.00626668
RPL35 ribosomal protein L35 0.00616521
RPL28 ribosomal protein L28 0.00613931
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) 0.00611179
PPIG peptidylprolyl isomerase G (cyclophilin G) 0.00604124
RPL6 ribosomal protein L6 0.00600753
NUCB2 nucleobindin 2 0.0059841
ATP5F1E ATP synthase F1 subunit epsilon 0.005944
RPL32 ribosomal protein L32 0.00587278
CENPF centromere protein F, 350/400kDa 0.00583034
CSTB cystatin B (stefin B) 0.00572752
RPL8 ribosomal protein L8 0.00572124
EEF1G eukaryotic translation elongation factor 1 gamma 0.00572049
TUBA1B tubulin, alpha 1b 0.00557303
TPI1 triosephosphate isomerase 1 0.00554991
CD68 CD68 molecule 0.00549768
UQCRB ubiquinol-cytochrome c reductase binding protein 0.00538469
TMF1 TATA element modulatory factor 1 0.00528303
BSDC1 BSD domain containing 1 0.00526567
SORBS3 sorbin and SH3 domain containing 3 0.00522545
EIF3I eukaryotic translation initiation factor 3, subunit I 0.00520383
PER1 period circadian clock 1 0.00512934
DNAJC2 DnaJ (Hsp40) homolog, subfamily C, member 2 0.00511695
ITGB4 integrin, beta 4 0.00506134
SERF2 small EDRK-rich factor 2 0.00505368
WBP11 WW domain binding protein 11 0.00504621
ARHGAP29 Rho GTPase activating protein 29 0.00504126
PRR13 proline rich 13 0.00503053
DCAF7 DDB1 and CUL4 associated factor 7 0.00500572
NIFK nucleolar protein interacting with the FHA domain of MKI67 0.0050027
RPLP2 ribosomal protein, large, P2 0.00496109
NKAP NFKB activating protein 0.00489491
IGFBP6 insulin-like growth factor binding protein 6 0.00488192
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 0.0048477

decreased expression

Symbol Name Standardized Value
DST dystonin -0.116405
PSD3 pleckstrin and Sec7 domain containing 3 -0.110024
CD44 CD44 molecule (Indian blood group) -0.0994943
TP63 tumor protein p63 -0.0841151
VIM vimentin -0.0769561
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.076103
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0752811
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0703299
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0654447
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0558401
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0552086
TMSB4X thymosin beta 4, X-linked -0.053994
ENO1 enolase 1, (alpha) -0.0510901
CADM2 cell adhesion molecule 2 -0.0507257
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0487039
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0482735
UBC ubiquitin C -0.0470898
LDHA lactate dehydrogenase A -0.0463206
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.045692
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.045302
APP amyloid beta (A4) precursor protein -0.0448284
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0429192
WARS1 tryptophanyl-tRNA synthetase 1 -0.042418
PGK1 phosphoglycerate kinase 1 -0.0415796
HLA-B major histocompatibility complex, class I, B -0.0407367
AHNAK AHNAK nucleoprotein -0.0405742
FMNL2 formin-like 2 -0.0395053
DPYD dihydropyrimidine dehydrogenase -0.0375236
RNF213 ring finger protein 213 -0.037438
PDE10A phosphodiesterase 10A -0.0373254
SPAG9 sperm associated antigen 9 -0.037238
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0369137
ARHGAP5 Rho GTPase activating protein 5 -0.0365877
TXNRD1 thioredoxin reductase 1 -0.0360259
USP34 ubiquitin specific peptidase 34 -0.0356842
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0353083
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0350939
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0345871
ZDHHC14 zinc finger, DHHC-type containing 14 -0.0343148
PTK2 protein tyrosine kinase 2 -0.0326057
CANX calnexin -0.0325939
TSC22D1 TSC22 domain family, member 1 -0.0323203
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0318481
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.031624
ZMYND8 zinc finger, MYND-type containing 8 -0.0315838
EEF2 eukaryotic translation elongation factor 2 -0.0312035
DNER delta/notch-like EGF repeat containing -0.0307572
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0303836
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase -0.0303783
RIGI RNA sensor RIG-I -0.0303275
MYOF myoferlin -0.0300321
PRELID2 PRELI domain containing 2 -0.0297912
ZNF217 zinc finger protein 217 -0.0295017
ADAM10 ADAM metallopeptidase domain 10 -0.0292687
TNS3 tensin 3 -0.0291818
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0286631
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0282676
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0282163
SOD2 superoxide dismutase 2, mitochondrial -0.0279913
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0279442
BIRC3 baculoviral IAP repeat containing 3 -0.027479
POTEF POTE ankyrin domain family, member F -0.0272954
KMT2E lysine (K)-specific methyltransferase 2E -0.0269598
RAD51B RAD51 paralog B -0.0265504
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 -0.0264473
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 -0.0264312
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0262912
DLG1 discs, large homolog 1 (Drosophila) -0.025881
CSMD3 CUB and Sushi multiple domains 3 -0.0258564
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0257539
USP9X ubiquitin specific peptidase 9, X-linked -0.0256808
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0256553
EHBP1 EH domain binding protein 1 -0.0255945
PKM pyruvate kinase, muscle -0.0255375
JMJD1C jumonji domain containing 1C -0.0252528
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0251995
KDM4C lysine (K)-specific demethylase 4C -0.0250219
TRIP12 thyroid hormone receptor interactor 12 -0.0249744
HDAC9 histone deacetylase 9 -0.0245462
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0244759
TM4SF1 transmembrane 4 L six family member 1 -0.024348
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0240625
EXOC4 exocyst complex component 4 -0.0239742
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0238923
BIRC6 baculoviral IAP repeat containing 6 -0.0237384
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0236914
ADGRG6 adhesion G protein-coupled receptor G6 -0.0236232
NPAS2 neuronal PAS domain protein 2 -0.0235318
EZR ezrin -0.0228809
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0227691
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0227368
EFNA5 ephrin-A5 -0.0225813
JUN jun proto-oncogene -0.0218571
GCLM glutamate-cysteine ligase, modifier subunit -0.0218203
BCAR3 breast cancer anti-estrogen resistance 3 -0.0215663
EPHA4 EPH receptor A4 -0.021511
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0214444
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0213866
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.0213809
PIAS2 protein inhibitor of activated STAT, 2 -0.0213738