Erythromycin_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Erythromycin perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Erythromycin_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0947911
LAMB3 laminin, beta 3 0.0924147
ERRFI1 ERBB receptor feedback inhibitor 1 0.0785788
EGR1 early growth response 1 0.0660232
FTH1 ferritin, heavy polypeptide 1 0.0556137
SRRM2 serine/arginine repetitive matrix 2 0.0538065
EEF2 eukaryotic translation elongation factor 2 0.0527649
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0505509
CES1 carboxylesterase 1 0.0492306
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.0489358
ANO6 anoctamin 6 0.0463181
MKI67 marker of proliferation Ki-67 0.0462166
RPL4 ribosomal protein L4 0.0458903
H1-0 H1.0 linker histone 0.0448654
BAZ2A bromodomain adjacent to zinc finger domain, 2A 0.0419038
NSUN6 NOP2/Sun domain family, member 6 0.0405134
SPAG9 sperm associated antigen 9 0.0405079
DSCAM Down syndrome cell adhesion molecule 0.0389242
EIF1 eukaryotic translation initiation factor 1 0.037711
LAMC2 laminin, gamma 2 0.0375946
TMSB10 thymosin beta 10 0.0371364
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0368821
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.034584
ANKRD10 ankyrin repeat domain 10 0.0340301
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.0327563
PCBP2 poly(rC) binding protein 2 0.03226
ABLIM1 actin binding LIM protein 1 0.0318647
TPD52 tumor protein D52 0.0314584
RPS2 ribosomal protein S2 0.031457
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0299213
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) 0.0296178
MARF1 meiosis regulator and mRNA stability factor 1 0.0294126
YEATS2 YEATS domain containing 2 0.0292587
EIF4H eukaryotic translation initiation factor 4H 0.0290794
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.0284957
NDE1 nudE neurodevelopment protein 1 0.028492
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0283259
DLGAP4 discs, large (Drosophila) homolog-associated protein 4 0.028191
EYA2 EYA transcriptional coactivator and phosphatase 2 0.0278209
CYFIP1 cytoplasmic FMR1 interacting protein 1 0.0277523
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0273629
F11R F11 receptor 0.0269108
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0262757
CAMTA1 calmodulin binding transcription activator 1 0.0256733
ST14 suppression of tumorigenicity 14 (colon carcinoma) 0.0256474
BHLHE40 basic helix-loop-helix family, member e40 0.0253023
TNIP1 TNFAIP3 interacting protein 1 0.0252777
FNIP1 folliculin interacting protein 1 0.0251924
ZBTB1 zinc finger and BTB domain containing 1 0.0251654
FGD6 FYVE, RhoGEF and PH domain containing 6 0.0244762
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0244685
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 0.0237539
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0235801
GPC5 glypican 5 0.023108
NR4A2 nuclear receptor subfamily 4, group A, member 2 0.0229367
BRD2 bromodomain containing 2 0.0228885
EIF4B eukaryotic translation initiation factor 4B 0.0228493
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 0.022354
KDM3B lysine (K)-specific demethylase 3B 0.0218144
ANKLE2 ankyrin repeat and LEM domain containing 2 0.0218058
RPL5 ribosomal protein L5 0.0217611
HSPA8 heat shock 70kDa protein 8 0.0216727
MYO6 myosin VI 0.0213712
VIM vimentin 0.0212436
TAPBP TAP binding protein (tapasin) 0.0210211
ATXN2L ataxin 2-like 0.0209929
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0208804
FAM193A family with sequence similarity 193, member A 0.0208157
TTC3 tetratricopeptide repeat domain 3 0.0207941
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0206088
SDC4 syndecan 4 0.0205383
PER1 period circadian clock 1 0.0205119
RSL1D1 ribosomal L1 domain containing 1 0.0204937
ARF1 ADP-ribosylation factor 1 0.0204794
ATF3 activating transcription factor 3 0.0199384
KIAA1217 KIAA1217 0.0197152
RUNX1 runt-related transcription factor 1 0.0196655
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0196644
EMP1 epithelial membrane protein 1 0.0196258
MXI1 MAX interactor 1, dimerization protein 0.019394
JMY junction mediating and regulatory protein, p53 cofactor 0.0191732
ZC3H11A zinc finger CCCH-type containing 11A 0.0191707
SFTPA2 surfactant protein A2 0.0191305
KLRD1 killer cell lectin-like receptor subfamily D, member 1 0.019096
ARL5B ADP-ribosylation factor-like 5B 0.0189486
LAMA4 laminin, alpha 4 0.0189256
SQSTM1 sequestosome 1 0.0187891
KDM5C lysine (K)-specific demethylase 5C 0.0185856
TBL1X transducin (beta)-like 1X-linked 0.0185262
CTTN cortactin 0.0184419
PGAM4 phosphoglycerate mutase family member 4 0.018112
MAP3K4 mitogen-activated protein kinase kinase kinase 4 0.0178544
RNF169 ring finger protein 169 0.0178533
GOLGB1 golgin B1 0.0176539
NR6A1 nuclear receptor subfamily 6, group A, member 1 0.0174804
PRRC2C proline-rich coiled-coil 2C 0.017459
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa 0.0172148
BRD4 bromodomain containing 4 0.0171721
AGO2 argonaute RISC catalytic component 2 0.0170124
PGK1 phosphoglycerate kinase 1 0.016923

decreased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.243085
EGFR epidermal growth factor receptor -0.215916
THSD4 thrombospondin, type I, domain containing 4 -0.183868
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.172434
ASPH aspartate beta-hydroxylase -0.145574
FNDC3B fibronectin type III domain containing 3B -0.102288
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0900584
MT2A metallothionein 2A -0.0857105
PTPRM protein tyrosine phosphatase, receptor type, M -0.0823216
GRAMD1B GRAM domain containing 1B -0.0679821
PDE4D phosphodiesterase 4D, cAMP-specific -0.0646707
MYOF myoferlin -0.0622037
PDIA3 protein disulfide isomerase family A, member 3 -0.0609565
CAV1 caveolin 1, caveolae protein, 22kDa -0.0605423
ANKRD12 ankyrin repeat domain 12 -0.0598877
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0584901
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0550793
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0548746
SCEL sciellin -0.054303
LDHA lactate dehydrogenase A -0.0526325
NPAS2 neuronal PAS domain protein 2 -0.0524906
PDLIM5 PDZ and LIM domain 5 -0.051913
BIRC6 baculoviral IAP repeat containing 6 -0.0500874
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 -0.0499981
PM20D1 peptidase M20 domain containing 1 -0.0485793
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial) -0.0480602
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0475373
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0473567
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0470678
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0465186
GRB10 growth factor receptor-bound protein 10 -0.0460713
TXNRD1 thioredoxin reductase 1 -0.045985
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0459849
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0435432
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0421295
RNF213 ring finger protein 213 -0.0414993
POTEF POTE ankyrin domain family, member F -0.0414926
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 -0.0412192
OSMR oncostatin M receptor -0.03999
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0397379
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0393324
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0389797
RIMS2 regulating synaptic membrane exocytosis 2 -0.0389465
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0387041
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0379798
ANKRD11 ankyrin repeat domain 11 -0.0368289
SEC61G Sec61 gamma subunit -0.0368237
STC1 stanniocalcin 1 -0.0366373
SUMF1 sulfatase modifying factor 1 -0.0364638
CD163L1 CD163 molecule-like 1 -0.0364131
TOP1 topoisomerase (DNA) I -0.0357755
MT1X metallothionein 1X -0.0354573
LRP12 low density lipoprotein receptor-related protein 12 -0.0351221
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0346427
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0343222
CPE carboxypeptidase E -0.0341206
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0339578
CDCP1 CUB domain containing protein 1 -0.0339503
NF1 neurofibromin 1 -0.0330029
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.032185
SEL1L sel-1 suppressor of lin-12-like (C. elegans) -0.0316491
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -0.0315599
EFNA5 ephrin-A5 -0.0315488
NABP1 nucleic acid binding protein 1 -0.0313219
RAB7A RAB7A, member RAS oncogene family -0.0312943
RAB27B RAB27B, member RAS oncogene family -0.0312871
DLG1 discs, large homolog 1 (Drosophila) -0.0312658
SMYD3 SET and MYND domain containing 3 -0.0310783
PTK2 protein tyrosine kinase 2 -0.0309233
MAML3 mastermind-like 3 (Drosophila) -0.0305856
RAD51B RAD51 paralog B -0.0304548
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0303328
NAMPT nicotinamide phosphoribosyltransferase -0.0300045
GCLC glutamate-cysteine ligase, catalytic subunit -0.0299798
TJP1 tight junction protein 1 -0.0299716
LGALS12 lectin, galactoside-binding, soluble, 12 -0.0298407
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0296884
PDE8A phosphodiesterase 8A -0.0296376
PDIA6 protein disulfide isomerase family A, member 6 -0.0296154
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0294679
IGFBP5 insulin-like growth factor binding protein 5 -0.0292439
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0287611
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0286689
IGF1R insulin-like growth factor 1 receptor -0.0285984
MACF1 microtubule-actin crosslinking factor 1 -0.0281348
PTPRJ protein tyrosine phosphatase, receptor type, J -0.0280246
KMT2E lysine (K)-specific methyltransferase 2E -0.0279732
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0275772
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0273687
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) -0.0273279
ZMYM2 zinc finger, MYM-type 2 -0.0270972
TM9SF3 transmembrane 9 superfamily member 3 -0.0268136
BCAR3 breast cancer anti-estrogen resistance 3 -0.026768
VCL vinculin -0.0266713
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 -0.0265851
ANKRD37 ankyrin repeat domain 37 -0.0265806
DTNA dystrobrevin, alpha -0.0264125
RBM25 RNA binding motif protein 25 -0.026315
BBX bobby sox homolog (Drosophila) -0.0260477
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0259244