Erythromycin_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Erythromycin perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Erythromycin_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TXNRD1 thioredoxin reductase 1 0.0530981
MT2A metallothionein 2A 0.0504824
FTL ferritin, light polypeptide 0.0411083
EIF1 eukaryotic translation initiation factor 1 0.040817
FTH1 ferritin, heavy polypeptide 1 0.0344877
ERRFI1 ERBB receptor feedback inhibitor 1 0.0342686
AKAP12 A kinase (PRKA) anchor protein 12 0.0327185
RTN4 reticulon 4 0.0316614
TM4SF1 transmembrane 4 L six family member 1 0.0315684
RPL4 ribosomal protein L4 0.0285446
RPS12 ribosomal protein S12 0.0280875
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0267251
WDR43 WD repeat domain 43 0.0261554
EEF2 eukaryotic translation elongation factor 2 0.0239432
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0225839
HSPA8 heat shock 70kDa protein 8 0.0223859
PFDN2 prefoldin subunit 2 0.0212611
HDAC9 histone deacetylase 9 0.0192972
RPS17 ribosomal protein S17 0.0183917
RPS2 ribosomal protein S2 0.018012
RPS27A ribosomal protein S27a 0.0172497
TMSB10 thymosin beta 10 0.0167985
RPS6 ribosomal protein S6 0.016724
RPS27 ribosomal protein S27 0.0163205
SLC38A2 solute carrier family 38, member 2 0.0159761
BHLHE40 basic helix-loop-helix family, member e40 0.0154878
BIRC2 baculoviral IAP repeat containing 2 0.0150505
RPL32 ribosomal protein L32 0.0148795
YBX3 Y box binding protein 3 0.01416
PTMA prothymosin, alpha 0.0141265
RPL5 ribosomal protein L5 0.0141141
RPL37A ribosomal protein L37a 0.0140419
PSMC6 proteasome (prosome, macropain) 26S subunit, ATPase, 6 0.0135799
DDAH1 dimethylarginine dimethylaminohydrolase 1 0.0133839
KLF6 Kruppel-like factor 6 0.0123568
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0121942
RPL34 ribosomal protein L34 0.0121306
PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3 0.0121259
NR4A2 nuclear receptor subfamily 4, group A, member 2 0.0120783
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0118832
NOLC1 nucleolar and coiled-body phosphoprotein 1 0.0118517
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0118056
FAM168A family with sequence similarity 168, member A 0.0117224
RPS19 ribosomal protein S19 0.0117156
RPL36 ribosomal protein L36 0.0116873
PNISR PNN-interacting serine/arginine-rich protein 0.0116562
NOL10 nucleolar protein 10 0.0116495
S100A9 S100 calcium binding protein A9 0.0116288
SRP14 signal recognition particle 14kDa (homologous Alu RNA binding protein) 0.0116208
BCLAF1 BCL2-associated transcription factor 1 0.0115937
RPL26 ribosomal protein L26 0.0115105
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0114401
NACA nascent polypeptide-associated complex alpha subunit 0.0113247
LAPTM4A lysosomal protein transmembrane 4 alpha 0.011217
MKI67 marker of proliferation Ki-67 0.0111973
HBS1L HBS1-like translational GTPase 0.0111807
NTN4 netrin 4 0.0111719
TPX2 TPX2, microtubule-associated 0.0111651
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.011154
STARD4 StAR-related lipid transfer (START) domain containing 4 0.0109939
UBE2C ubiquitin-conjugating enzyme E2C 0.0108569
EEF1G eukaryotic translation elongation factor 1 gamma 0.0107163
SERF2 small EDRK-rich factor 2 0.0106078
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 0.010561
VMP1 vacuole membrane protein 1 0.0105441
AREG amphiregulin 0.0105105
PA2G4 proliferation-associated 2G4, 38kDa 0.0104536
RPL18 ribosomal protein L18 0.0104449
NAMPT nicotinamide phosphoribosyltransferase 0.010429
BRD2 bromodomain containing 2 0.0104156
RPS5 ribosomal protein S5 0.0103381
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0103341
CCNL1 cyclin L1 0.0101159
RPL37 ribosomal protein L37 0.0100626
PNN pinin, desmosome associated protein 0.00993997
EIF5B eukaryotic translation initiation factor 5B 0.00989302
RPS21 ribosomal protein S21 0.00986862
RPL12 ribosomal protein L12 0.00981294
PGAM4 phosphoglycerate mutase family member 4 0.00970535
MARCHF6 membrane associated ring-CH-type finger 6 0.00956956
SRRM1 serine/arginine repetitive matrix 1 0.00948142
NUDT21 nudix (nucleoside diphosphate linked moiety X)-type motif 21 0.00945089
TUBA1B tubulin, alpha 1b 0.00940576
FOXJ3 forkhead box J3 0.00939934
RPL11 ribosomal protein L11 0.00929924
RPLP2 ribosomal protein, large, P2 0.00928888
MIS18BP1 MIS18 binding protein 1 0.00921784
RPS10 ribosomal protein S10 0.00911384
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.00901484
EIF4H eukaryotic translation initiation factor 4H 0.00897256
PRPF4B pre-mRNA processing factor 4B 0.00893971
RPS16 ribosomal protein S16 0.00885828
ARPP19 cAMP-regulated phosphoprotein, 19kDa 0.00872753
RFWD3 ring finger and WD repeat domain 3 0.00851036
NUP93 nucleoporin 93kDa 0.0085036
SNU13 small nuclear ribonucleoprotein 13 0.0084217
NCAPD2 non-SMC condensin I complex, subunit D2 0.00836528
MDN1 MDN1, midasin homolog (yeast) 0.00830755
RSL1D1 ribosomal L1 domain containing 1 0.00828476
ATP5F1B ATP synthase F1 subunit beta 0.00821196

decreased expression

Symbol Name Standardized Value
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.148529
PDE4D phosphodiesterase 4D, cAMP-specific -0.144536
THSD4 thrombospondin, type I, domain containing 4 -0.0870376
DOCK4 dedicator of cytokinesis 4 -0.0668809
FNDC3B fibronectin type III domain containing 3B -0.0640164
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0609565
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0603713
SAMD4A sterile alpha motif domain containing 4A -0.0551361
IGFBP3 insulin-like growth factor binding protein 3 -0.0493333
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0446408
PM20D1 peptidase M20 domain containing 1 -0.0429356
FMNL2 formin-like 2 -0.0424207
SMOC1 SPARC related modular calcium binding 1 -0.0415594
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0395521
POTEF POTE ankyrin domain family, member F -0.0389539
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0376274
ARHGAP26 Rho GTPase activating protein 26 -0.0369385
MCL1 myeloid cell leukemia 1 -0.035663
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0347148
CMIP c-Maf inducing protein -0.0344249
TRIO trio Rho guanine nucleotide exchange factor -0.0336599
FLNB filamin B, beta -0.0332723
LDHA lactate dehydrogenase A -0.0331573
EGFR epidermal growth factor receptor -0.0311441
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0310849
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0310424
DST dystonin -0.030934
PTPRM protein tyrosine phosphatase, receptor type, M -0.0306612
EFNA5 ephrin-A5 -0.0304881
BICC1 BicC family RNA binding protein 1 -0.030322
MAML3 mastermind-like 3 (Drosophila) -0.0301073
RAD51B RAD51 paralog B -0.0299524
UTRN utrophin -0.0297704
GLIS3 GLIS family zinc finger 3 -0.0293513
SVIL supervillin -0.0292889
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0291752
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.029004
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.028694
NEBL nebulette -0.0286618
PKM pyruvate kinase, muscle -0.0285781
PYGL phosphorylase, glycogen, liver -0.0285363
ATXN1 ataxin 1 -0.027844
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0269236
AKAP13 A kinase (PRKA) anchor protein 13 -0.0269002
LPP LIM domain containing preferred translocation partner in lipoma -0.026654
WWOX WW domain containing oxidoreductase -0.0262229
USP34 ubiquitin specific peptidase 34 -0.0259069
PARD3 par-3 family cell polarity regulator -0.0257077
PTPRJ protein tyrosine phosphatase, receptor type, J -0.0246646
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0235432
GRAMD1B GRAM domain containing 1B -0.0234497
AHNAK AHNAK nucleoprotein -0.0233264
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0232164
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0230123
GLS2 glutaminase 2 (liver, mitochondrial) -0.0230093
PDE8A phosphodiesterase 8A -0.0224116
NDRG1 N-myc downstream regulated 1 -0.0219718
MYOF myoferlin -0.0219044
EXT1 exostosin glycosyltransferase 1 -0.0217234
NRG1 neuregulin 1 -0.0217033
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.021688
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0215459
BASP1 brain abundant, membrane attached signal protein 1 -0.0213093
NCOA2 nuclear receptor coactivator 2 -0.021232
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0211985
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0209915
DOCK5 dedicator of cytokinesis 5 -0.0209456
EHBP1 EH domain binding protein 1 -0.0205289
MACF1 microtubule-actin crosslinking factor 1 -0.0204985
PTPRG protein tyrosine phosphatase, receptor type, G -0.0204972
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 -0.0204857
NHSL1 NHS-like 1 -0.0204787
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0204476
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 -0.0202609
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0202043
PFKP phosphofructokinase, platelet -0.0201257
RAB7A RAB7A, member RAS oncogene family -0.0199067
CTBP2 C-terminal binding protein 2 -0.0196973
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0192457
ACTG1 actin gamma 1 -0.0192288
TPM1 tropomyosin 1 (alpha) -0.0189242
SOD2 superoxide dismutase 2, mitochondrial -0.0188085
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0187477
NEGR1 neuronal growth regulator 1 -0.0187194
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0185799
MYO1E myosin IE -0.0184894
UBASH3B ubiquitin associated and SH3 domain containing B -0.0183579
COPA coatomer protein complex, subunit alpha -0.018323
APP amyloid beta (A4) precursor protein -0.0182761
TTC28 tetratricopeptide repeat domain 28 -0.018159
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0177759
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0175497
PRR16 proline rich 16 -0.0175087
SPDYA speedy/RINGO cell cycle regulator family member A -0.017477
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0172938
ANXA2 annexin A2 -0.0171863
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0171846
PDIA3 protein disulfide isomerase family A, member 3 -0.0171283
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0169364
ZBTB20 zinc finger and BTB domain containing 20 -0.0169039