Erythromycin_NCI-H2122 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Erythromycin perturbation in NCI-H2122 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Erythromycin_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.114246
VGF VGF nerve growth factor inducible 0.0905508
NAMPT nicotinamide phosphoribosyltransferase 0.0897244
WAC WW domain containing adaptor with coiled-coil 0.0877154
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0861208
LOC102724023 ES1 protein homolog, mitochondrial 0.0818914
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0805158
KIF5B kinesin family member 5B 0.0799379
GPC6 glypican 6 0.0785131
ECPAS Ecm29 proteasome adaptor and scaffold 0.0781122
GRB10 growth factor receptor-bound protein 10 0.0757278
PNISR PNN-interacting serine/arginine-rich protein 0.0736991
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0732
BHLHE40 basic helix-loop-helix family, member e40 0.0710824
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0687773
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0687468
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0680621
XPO1 exportin 1 0.0672341
SPAG9 sperm associated antigen 9 0.0663273
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0645294
AKAP12 A kinase (PRKA) anchor protein 12 0.0642454
CNOT4 CCR4-NOT transcription complex, subunit 4 0.063751
CADM1 cell adhesion molecule 1 0.0633313
RPL12 ribosomal protein L12 0.062046
NEK7 NIMA-related kinase 7 0.0613183
CCNL1 cyclin L1 0.0609252
MEF2A myocyte enhancer factor 2A 0.059676
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0594704
EEF2 eukaryotic translation elongation factor 2 0.0593986
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) 0.0583459
PAPOLA poly(A) polymerase alpha 0.0582489
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.05785
WDR45B WD repeat domain 45B 0.057824
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0577151
KDM6A lysine (K)-specific demethylase 6A 0.0572949
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0569795
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.0569607
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0567818
STT3B STT3B, subunit of the oligosaccharyltransferase complex (catalytic) 0.0561077
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0559875
AREG amphiregulin 0.0557214
CSNK1A1 casein kinase 1, alpha 1 0.0555582
PDPK1 3-phosphoinositide dependent protein kinase 1 0.0546084
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0538211
KMT2E lysine (K)-specific methyltransferase 2E 0.0535173
RPL37A ribosomal protein L37a 0.0529725
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0525828
NBAS neuroblastoma amplified sequence 0.0524134
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0523639
ANXA1 annexin A1 0.0522267
ACTN4 actinin, alpha 4 0.0520332
SEPTIN7 septin 7 0.051817
ITGA6 integrin, alpha 6 0.0509353
SEPTIN9 septin 9 0.0504548
FTH1 ferritin, heavy polypeptide 1 0.0502705
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0498158
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0490119
ELL2 elongation factor, RNA polymerase II, 2 0.048787
PCBP2 poly(rC) binding protein 2 0.0478906
COPA coatomer protein complex, subunit alpha 0.0478802
SETD5 SET domain containing 5 0.0476866
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.047539
ATP11A ATPase, class VI, type 11A 0.0473743
PICALM phosphatidylinositol binding clathrin assembly protein 0.0470021
PRRC2C proline-rich coiled-coil 2C 0.0466026
RPL4 ribosomal protein L4 0.0459941
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0453083
RAD23B RAD23 homolog B (S. cerevisiae) 0.0452727
ZNF292 zinc finger protein 292 0.044479
ZFHX3 zinc finger homeobox 3 0.0443695
EFNA5 ephrin-A5 0.0443464
DTNA dystrobrevin, alpha 0.0437453
ANKHD1 ankyrin repeat and KH domain containing 1 0.0436891
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0433303
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0428391
NUP58 nucleoporin 58 0.0427734
IRS2 insulin receptor substrate 2 0.0426398
USP3 ubiquitin specific peptidase 3 0.042461
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0423906
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.0420751
LMAN1 lectin, mannose-binding, 1 0.0417703
TNIP1 TNFAIP3 interacting protein 1 0.0415776
EMSY EMSY transcriptional repressor, BRCA2 interacting 0.0415442
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.0412646
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0408382
TAOK3 TAO kinase 3 0.0408285
VMP1 vacuole membrane protein 1 0.0408128
RLF rearranged L-myc fusion 0.0405021
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0403292
GOLGA4 golgin A4 0.03986
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0397531
NEMF nuclear export mediator factor 0.0394637
LCOR ligand dependent nuclear receptor corepressor 0.039388
RBM39 RNA binding motif protein 39 0.0393027
MAP1B microtubule-associated protein 1B 0.0392999
RPS6 ribosomal protein S6 0.0392378
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.038933
TES testin LIM domain protein 0.0386157
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0378665
IPO7 importin 7 0.0372366

decreased expression

Symbol Name Standardized Value
NDRG1 N-myc downstream regulated 1 -0.19069
FN1 fibronectin 1 -0.181667
LMO7 LIM domain 7 -0.179341
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.13234
PRKCA protein kinase C, alpha -0.116786
FNDC3B fibronectin type III domain containing 3B -0.115159
BACE2 beta-site APP-cleaving enzyme 2 -0.114446
TMEM165 transmembrane protein 165 -0.110767
TM4SF1 transmembrane 4 L six family member 1 -0.107821
ANXA2 annexin A2 -0.107737
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.107442
DSCAM Down syndrome cell adhesion molecule -0.103447
LAMB3 laminin, beta 3 -0.100913
PKM pyruvate kinase, muscle -0.0954621
VIM vimentin -0.0939273
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0938876
AK1 adenylate kinase 1 -0.0915997
MT2A metallothionein 2A -0.0883981
JMJD1C jumonji domain containing 1C -0.0868944
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0861565
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0859783
TMSB10 thymosin beta 10 -0.0850063
ESYT2 extended synaptotagmin-like protein 2 -0.0836329
ATOSA atos homolog A -0.0823711
LIMCH1 LIM and calponin homology domains 1 -0.0794104
ASPH aspartate beta-hydroxylase -0.0787021
ENO1 enolase 1, (alpha) -0.0762684
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0750501
ZNF638 zinc finger protein 638 -0.0748782
KRT17 keratin 17, type I -0.0742928
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 -0.072757
FTL ferritin, light polypeptide -0.0710216
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0708238
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0700261
RPS8 ribosomal protein S8 -0.0672685
CD44 CD44 molecule (Indian blood group) -0.0661365
NAP1L1 nucleosome assembly protein 1-like 1 -0.063099
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0622903
ZMYND8 zinc finger, MYND-type containing 8 -0.0593751
TXNRD1 thioredoxin reductase 1 -0.0589346
METTL15 methyltransferase like 15 -0.0561359
SMYD3 SET and MYND domain containing 3 -0.0555862
B2M beta-2-microglobulin -0.0553632
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 -0.0553237
MBNL2 muscleblind-like splicing regulator 2 -0.0541191
SEC31A SEC31 homolog A (S. cerevisiae) -0.053946
KRT19 keratin 19, type I -0.0526839
RERE arginine-glutamic acid dipeptide (RE) repeats -0.051782
NPEPPS aminopeptidase puromycin sensitive -0.0514459
EXT1 exostosin glycosyltransferase 1 -0.048964
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0480984
APP amyloid beta (A4) precursor protein -0.0480294
STAU1 staufen double-stranded RNA binding protein 1 -0.0478394
FNIP1 folliculin interacting protein 1 -0.047818
PDIA3 protein disulfide isomerase family A, member 3 -0.0461595
IGF1R insulin-like growth factor 1 receptor -0.0460073
USP34 ubiquitin specific peptidase 34 -0.0449437
RAB7A RAB7A, member RAS oncogene family -0.0440148
NAV2 neuron navigator 2 -0.0437393
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -0.0429429
ADAM17 ADAM metallopeptidase domain 17 -0.0424528
LOC112694756 uncharaterized LOC112694756 -0.0424284
TAS2R14 taste receptor, type 2, member 14 -0.0406019
HECTD1 HECT domain containing E3 ubiquitin protein ligase 1 -0.0398916
CALU calumenin -0.0398486
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0389717
ABHD17C abhydrolase domain containing 17C -0.0382646
RPL35A ribosomal protein L35a -0.0382466
ANKRD11 ankyrin repeat domain 11 -0.0368072
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0366998
SCFD1 sec1 family domain containing 1 -0.0365422
RPL11 ribosomal protein L11 -0.03609
HLA-B major histocompatibility complex, class I, B -0.0356811
CEMIP cell migration inducing protein, hyaluronan binding -0.0353198
ERBIN erbb2 interacting protein -0.0351041
RRBP1 ribosome binding protein 1 -0.0349673
RPS21 ribosomal protein S21 -0.034235
IGF2 insulin-like growth factor 2 -0.0340493
WDR7 WD repeat domain 7 -0.034002
EGFR epidermal growth factor receptor -0.0339525
EZR ezrin -0.0327773
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 -0.0325804
SAMD4A sterile alpha motif domain containing 4A -0.0325747
MAP2K1 mitogen-activated protein kinase kinase 1 -0.0325036
MSI2 musashi RNA-binding protein 2 -0.0324411
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0308014
SVIL supervillin -0.0303588
CMIP c-Maf inducing protein -0.0301743
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0299227
ARHGAP12 Rho GTPase activating protein 12 -0.0297418
TPI1 triosephosphate isomerase 1 -0.0291474
BMAL2 basic helix-loop-helix ARNT like 2 -0.0289642
MXD1 MAX dimerization protein 1 -0.028893
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.028761
SFTPA2 surfactant protein A2 -0.0286032
RPL23 ribosomal protein L23 -0.0285935
OGA O-GlcNAcase -0.0280792
RIGI RNA sensor RIG-I -0.0279211
TTC3 tetratricopeptide repeat domain 3 -0.0277411
NF1 neurofibromin 1 -0.0275962