Erythromycin_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Erythromycin perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

158 genes differentially expressed following the Erythromycin_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.136598
NDRG1 N-myc downstream regulated 1 0.13424
NAMPT nicotinamide phosphoribosyltransferase 0.133289
NRG1 neuregulin 1 0.129172
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.121027
PTK2 protein tyrosine kinase 2 0.110957
PRELID2 PRELI domain containing 2 0.103534
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.101701
PDE10A phosphodiesterase 10A 0.0990646
EXT1 exostosin glycosyltransferase 1 0.0970729
PRRC2C proline-rich coiled-coil 2C 0.0962744
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0925876
CLTC clathrin, heavy chain (Hc) 0.0895432
AHR aryl hydrocarbon receptor 0.0885045
ALCAM activated leukocyte cell adhesion molecule 0.0871744
STC1 stanniocalcin 1 0.0800259
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0788744
ZMYND8 zinc finger, MYND-type containing 8 0.0777476
ZFC3H1 zinc finger, C3H1-type containing 0.0742775
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0737004
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0734547
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0725129
TRIO trio Rho guanine nucleotide exchange factor 0.0709963
ELL2 elongation factor, RNA polymerase II, 2 0.0709186
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0685897
EGR1 early growth response 1 0.0680257
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0676279
PARD3 par-3 family cell polarity regulator 0.0627547
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0614205
RNF145 ring finger protein 145 0.0607543
PUM2 pumilio RNA-binding family member 2 0.0601467
CXCL8 chemokine (C-X-C motif) ligand 8 0.0576281
ZNF638 zinc finger protein 638 0.0565777
CHD1 chromodomain helicase DNA binding protein 1 0.0535744
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0494748
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0483108
BIRC6 baculoviral IAP repeat containing 6 0.0475086
RTN4 reticulon 4 0.0467727
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0392626
SPAG9 sperm associated antigen 9 0.0366118
PSD3 pleckstrin and Sec7 domain containing 3 0.0364025
DSCAM Down syndrome cell adhesion molecule 0.034855
DLG1 discs, large homolog 1 (Drosophila) 0.0327786
AHNAK AHNAK nucleoprotein 0.0317682
MT2A metallothionein 2A 0.0315879
AKAP13 A kinase (PRKA) anchor protein 13 0.0295975
MAML3 mastermind-like 3 (Drosophila) 0.0288322
KMT2C lysine (K)-specific methyltransferase 2C 0.0284812
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.028382
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0254501
NAP1L1 nucleosome assembly protein 1-like 1 0.0249893
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0221143
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.021324
ZFAND3 zinc finger, AN1-type domain 3 0.0210717
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0188534
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0174592
TPR translocated promoter region, nuclear basket protein 0.0163377
MYO1E myosin IE 0.0162305
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0148789
FTL ferritin, light polypeptide 0.0120468
DST dystonin 0.0116559
ANKRD12 ankyrin repeat domain 12 0.0107961
ANXA2 annexin A2 0.0103031
PGK1 phosphoglycerate kinase 1 0.00760983
SENP5 SUMO1/sentrin specific peptidase 5 0.00558773
RPL12 ribosomal protein L12 0.00488607
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.00282124
GPHN gephyrin 0.00139945
SAMD4A sterile alpha motif domain containing 4A 0.00121982
WDFY3 WD repeat and FYVE domain containing 3 6.27205E-4
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 5.16442E-4

decreased expression

Symbol Name Standardized Value
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.226563
TMSB10 thymosin beta 10 -0.152464
LMO7 LIM domain 7 -0.143081
VIM vimentin -0.141474
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.140518
PTMA prothymosin, alpha -0.109941
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0893471
CD44 CD44 molecule (Indian blood group) -0.0834275
FNDC3B fibronectin type III domain containing 3B -0.0829257
SLTM SAFB-like, transcription modulator -0.081275
LPP LIM domain containing preferred translocation partner in lipoma -0.0803146
EGFR epidermal growth factor receptor -0.078908
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0712908
NALF1 NALCN channel auxiliary factor 1 -0.0698923
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0689371
ITGA6 integrin, alpha 6 -0.0677824
ASPH aspartate beta-hydroxylase -0.0667117
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0635134
PDE4D phosphodiesterase 4D, cAMP-specific -0.0632015
ZBTB20 zinc finger and BTB domain containing 20 -0.0631198
THSD4 thrombospondin, type I, domain containing 4 -0.0600369
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0594045
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0581416
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0555395
INHBA inhibin, beta A -0.0548848
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0545485
FN1 fibronectin 1 -0.0544019
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0534353
TPT1 tumor protein, translationally-controlled 1 -0.0532214
ENO1 enolase 1, (alpha) -0.0507655
TPM4 tropomyosin 4 -0.0492197
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0465868
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0464533
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0457451
RPL37A ribosomal protein L37a -0.044325
PRKCA protein kinase C, alpha -0.0435423
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0433888
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0426965
ARID1B AT rich interactive domain 1B (SWI1-like) -0.0422009
MYOF myoferlin -0.0408614
DPP10 dipeptidyl-peptidase 10 (non-functional) -0.0368154
RPL35A ribosomal protein L35a -0.0357463
COL6A3 collagen, type VI, alpha 3 -0.0349829
HMGA2 high mobility group AT-hook 2 -0.0349335
NKD1 naked cuticle homolog 1 (Drosophila) -0.0341964
PDLIM5 PDZ and LIM domain 5 -0.0341449
ACTG1 actin gamma 1 -0.0337561
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0332683
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0332099
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0324723
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0316619
MED13L mediator complex subunit 13-like -0.0313147
RPS6 ribosomal protein S6 -0.0296889
DOCK4 dedicator of cytokinesis 4 -0.0287666
CDH13 cadherin 13 -0.0268472
RPS12 ribosomal protein S12 -0.0260651
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0257035
USP34 ubiquitin specific peptidase 34 -0.0222257
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0216294
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0203515
RPS19 ribosomal protein S19 -0.0200872
MACF1 microtubule-actin crosslinking factor 1 -0.0192277
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0179055
GCC2 GRIP and coiled-coil domain containing 2 -0.0166391
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0164909
EEF2 eukaryotic translation elongation factor 2 -0.0162541
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0152033
NAV2 neuron navigator 2 -0.0147083
TNS3 tensin 3 -0.0139843
JMJD1C jumonji domain containing 1C -0.0137796
CUX1 cut-like homeobox 1 -0.0135768
ZNF292 zinc finger protein 292 -0.0131051
RPS8 ribosomal protein S8 -0.0128557
ESYT2 extended synaptotagmin-like protein 2 -0.0122742
AKAP12 A kinase (PRKA) anchor protein 12 -0.011886
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0102438
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.010027
RPS3 ribosomal protein S3 -0.00966262
DOCK5 dedicator of cytokinesis 5 -0.00880378
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.00729961
MED13 mediator complex subunit 13 -0.00706891
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 -0.00652391
WSB1 WD repeat and SOCS box containing 1 -0.00501479
GOLGA4 golgin A4 -0.00453741
PKM pyruvate kinase, muscle -0.00425223
EFNA5 ephrin-A5 -0.00203897
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -3.75164E-4