Erythromycin_NCI-H661 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Erythromycin perturbation in NCI-H661 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Erythromycin_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VIM vimentin 0.182117
PABPC1 poly(A) binding protein, cytoplasmic 1 0.161671
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.144804
RPS6 ribosomal protein S6 0.0990577
TMSB10 thymosin beta 10 0.0888186
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0880774
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0788769
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0689912
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0672159
ATP5F1B ATP synthase F1 subunit beta 0.0672114
PTMA prothymosin, alpha 0.0653232
CENPF centromere protein F, 350/400kDa 0.062007
RPS16 ribosomal protein S16 0.0607249
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0602793
RPS12 ribosomal protein S12 0.0575085
MKI67 marker of proliferation Ki-67 0.0539622
MDK midkine (neurite growth-promoting factor 2) 0.0515504
RPS2 ribosomal protein S2 0.0493511
TUBA1B tubulin, alpha 1b 0.0454994
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0435258
B2M beta-2-microglobulin 0.0430762
YES1 YES proto-oncogene 1, Src family tyrosine kinase 0.0429286
RPL11 ribosomal protein L11 0.0428513
BAZ2A bromodomain adjacent to zinc finger domain, 2A 0.0407319
CKAP2 cytoskeleton associated protein 2 0.0403001
RPL5 ribosomal protein L5 0.0398075
RPLP1 ribosomal protein, large, P1 0.0380716
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0379832
RPS8 ribosomal protein S8 0.0379434
RTN4 reticulon 4 0.0376554
RPL12 ribosomal protein L12 0.0375919
SMC4 structural maintenance of chromosomes 4 0.0374795
YBX1 Y box binding protein 1 0.0370766
RPS19 ribosomal protein S19 0.0370272
TMSB4X thymosin beta 4, X-linked 0.0369411
PFN1 profilin 1 0.0363295
RPL7 ribosomal protein L7 0.0362496
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 0.0356686
HMGB2 high mobility group box 2 0.0352744
EIF5B eukaryotic translation initiation factor 5B 0.0347504
RPL23 ribosomal protein L23 0.0345876
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0335702
SRSF11 serine/arginine-rich splicing factor 11 0.0326437
RAI1 retinoic acid induced 1 0.0325315
RPL35A ribosomal protein L35a 0.0324052
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa 0.0320478
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) 0.0318632
EEF2 eukaryotic translation elongation factor 2 0.0318617
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.0316122
NAP1L1 nucleosome assembly protein 1-like 1 0.0310669
CFL2 cofilin 2 (muscle) 0.0308232
RPS3 ribosomal protein S3 0.0304892
H1-4 H1.4 linker histone, cluster member 0.0304383
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0303944
CALR calreticulin 0.030055
EPRS1 glutamyl-prolyl-tRNA synthetase 1 0.0293752
TPX2 TPX2, microtubule-associated 0.0292789
NR2F1 nuclear receptor subfamily 2, group F, member 1 0.0292513
SERF2 small EDRK-rich factor 2 0.0288603
FBXO17 F-box protein 17 0.0287701
EIF1 eukaryotic translation initiation factor 1 0.0286573
RPL19 ribosomal protein L19 0.0281288
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0280102
RPL30 ribosomal protein L30 0.0279799
RPS14 ribosomal protein S14 0.0279643
ZNF292 zinc finger protein 292 0.027379
PDCD5 programmed cell death 5 0.0273283
THBS1 thrombospondin 1 0.0272003
HMGB1 high mobility group box 1 0.0271627
KPNB1 karyopherin (importin) beta 1 0.0270798
EEF1G eukaryotic translation elongation factor 1 gamma 0.0268621
ACTR2 ARP2 actin-related protein 2 homolog (yeast) 0.026621
PABPN1 poly(A) binding protein, nuclear 1 0.0264321
LYPLA1 lysophospholipase I 0.0261492
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0261013
SMC1A structural maintenance of chromosomes 1A 0.0260745
TPM3 tropomyosin 3 0.0259819
DIAPH3 diaphanous-related formin 3 0.0257852
GARS1 glycyl-tRNA synthetase 1 0.0255459
RPLP2 ribosomal protein, large, P2 0.0251963
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.02513
MTDH metadherin 0.0249802
DEK DEK proto-oncogene 0.0249787
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) 0.0246073
RPL26 ribosomal protein L26 0.0245085
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0243661
RPL27A ribosomal protein L27a 0.0243483
FBL fibrillarin 0.0243032
RPL36 ribosomal protein L36 0.0242402
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0241246
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 0.0240552
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0239996
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0239205
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0238833
RPL34 ribosomal protein L34 0.023663
ANXA1 annexin A1 0.0236435
RPS24 ribosomal protein S24 0.0236384
KIF5B kinesin family member 5B 0.0236056
TPT1 tumor protein, translationally-controlled 1 0.0235852
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.0232843

decreased expression

Symbol Name Standardized Value
COL11A1 collagen, type XI, alpha 1 -0.159616
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) -0.156981
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.139255
CTNNA2 catenin (cadherin-associated protein), alpha 2 -0.126094
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.11661
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.102782
FNDC3B fibronectin type III domain containing 3B -0.0909752
NTM neurotrimin -0.0753258
COL5A2 collagen, type V, alpha 2 -0.0724828
CDH10 cadherin 10, type 2 (T2-cadherin) -0.0719995
CADM2 cell adhesion molecule 2 -0.0678315
ADGRL2 adhesion G protein-coupled receptor L2 -0.0662593
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0650586
MED13L mediator complex subunit 13-like -0.0646465
HDAC9 histone deacetylase 9 -0.0634753
HS3ST5 heparan sulfate (glucosamine) 3-O-sulfotransferase 5 -0.0634246
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0625669
ADGRV1 adhesion G protein-coupled receptor V1 -0.0613063
MYO10 myosin X -0.0606707
PARD3B par-3 family cell polarity regulator beta -0.0599604
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 -0.0595535
TRPS1 trichorhinophalangeal syndrome I -0.0584618
NEBL nebulette -0.0561732
LRRC4C leucine rich repeat containing 4C -0.0556301
PCLO piccolo presynaptic cytomatrix protein -0.0547491
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 -0.0546968
PCDH9 protocadherin 9 -0.0537541
PGAP1 post-GPI attachment to proteins 1 -0.0523458
PRELID2 PRELI domain containing 2 -0.0514897
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0502632
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0501017
ANK2 ankyrin 2, neuronal -0.0496815
PLPP1 phospholipid phosphatase 1 -0.0494271
TRIO trio Rho guanine nucleotide exchange factor -0.0486788
ITGAV integrin, alpha V -0.0485167
PHIP pleckstrin homology domain interacting protein -0.048502
KCTD16 potassium channel tetramerization domain containing 16 -0.0484774
RBM20 RNA binding motif protein 20 -0.0471639
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase -0.0465393
DOCK5 dedicator of cytokinesis 5 -0.0458049
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 -0.0454151
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0448927
TENM3 teneurin transmembrane protein 3 -0.0445236
ZEB2 zinc finger E-box binding homeobox 2 -0.0443123
IGF1R insulin-like growth factor 1 receptor -0.0441958
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0436767
GPC3 glypican 3 -0.0431167
UTRN utrophin -0.0429707
SAMD4A sterile alpha motif domain containing 4A -0.0428074
KDM3A lysine (K)-specific demethylase 3A -0.042784
FOXP2 forkhead box P2 -0.0422765
CTNNA3 catenin (cadherin-associated protein), alpha 3 -0.0420963
TSC22D2 TSC22 domain family, member 2 -0.041923
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) -0.041522
STRN3 striatin, calmodulin binding protein 3 -0.0403209
NCAM2 neural cell adhesion molecule 2 -0.0402147
BMPR1A bone morphogenetic protein receptor, type IA -0.0397816
USP25 ubiquitin specific peptidase 25 -0.0388656
DSCAM Down syndrome cell adhesion molecule -0.03843
TENM2 teneurin transmembrane protein 2 -0.0382939
CHD1 chromodomain helicase DNA binding protein 1 -0.0377605
MAML2 mastermind-like 2 (Drosophila) -0.0377355
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0376731
ATXN2 ataxin 2 -0.0375511
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0375235
USP34 ubiquitin specific peptidase 34 -0.0374772
NCOA2 nuclear receptor coactivator 2 -0.0368171
CSMD3 CUB and Sushi multiple domains 3 -0.0367456
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0356312
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1 -0.0336621
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0336361
HS6ST2 heparan sulfate 6-O-sulfotransferase 2 -0.0335372
NF1 neurofibromin 1 -0.0330707
PICALM phosphatidylinositol binding clathrin assembly protein -0.0329648
TOX thymocyte selection-associated high mobility group box -0.0328833
CDH19 cadherin 19, type 2 -0.0321374
ANKRD33B ankyrin repeat domain 33B -0.0319775
RAB30 RAB30, member RAS oncogene family -0.0310448
HMCN1 hemicentin 1 -0.0308512
SLIT2 slit homolog 2 (Drosophila) -0.0304142
ZNF217 zinc finger protein 217 -0.0299181
NIPBL Nipped-B homolog (Drosophila) -0.029102
GALNTL6 polypeptide N-acetylgalactosaminyltransferase-like 6 -0.0288627
ARHGAP32 Rho GTPase activating protein 32 -0.0287779
DENND1A DENN/MADD domain containing 1A -0.0286282
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0285888
ARB2A ARB2 cotranscriptional regulator A -0.0285865
MRPS6 mitochondrial ribosomal protein S6 -0.0281588
KMT2E lysine (K)-specific methyltransferase 2E -0.0278992
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0278964
SREBF2 sterol regulatory element binding transcription factor 2 -0.027583
CUX1 cut-like homeobox 1 -0.0275068
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0270396
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0269689
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0266691
NHSL1 NHS-like 1 -0.0265345
NBAS neuroblastoma amplified sequence -0.0261881
WSB1 WD repeat and SOCS box containing 1 -0.0260936
PBX3 pre-B-cell leukemia homeobox 3 -0.0259021
PTPRJ protein tyrosine phosphatase, receptor type, J -0.0258426