Erythromycin_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Erythromycin perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Erythromycin_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.231023
RPS6 ribosomal protein S6 0.132581
PTMA prothymosin, alpha 0.0736466
EIF1 eukaryotic translation initiation factor 1 0.0489851
RPS8 ribosomal protein S8 0.047707
RPS2 ribosomal protein S2 0.0439298
RPL12 ribosomal protein L12 0.0422163
GOLGA4 golgin A4 0.0386787
RPL13A ribosomal protein L13a 0.0384781
EEF1G eukaryotic translation elongation factor 1 gamma 0.0383112
RPS19 ribosomal protein S19 0.0378237
RPL26 ribosomal protein L26 0.0371327
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0361176
PLXNA1 plexin A1 0.0355197
RPS12 ribosomal protein S12 0.034467
RPL4 ribosomal protein L4 0.0344231
RPL36 ribosomal protein L36 0.0334617
WDR43 WD repeat domain 43 0.0309438
RPLP2 ribosomal protein, large, P2 0.0300024
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0290347
PFN1 profilin 1 0.0288243
RPL31 ribosomal protein L31 0.0279699
RPS17 ribosomal protein S17 0.0265126
TPT1 tumor protein, translationally-controlled 1 0.0262335
RPL9 ribosomal protein L9 0.0261625
RPL11 ribosomal protein L11 0.0261039
RPS23 ribosomal protein S23 0.0257156
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0252986
RPL18 ribosomal protein L18 0.0251386
AKAP12 A kinase (PRKA) anchor protein 12 0.0250935
DUSP4 dual specificity phosphatase 4 0.0247588
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0246778
ENOX1 ecto-NOX disulfide-thiol exchanger 1 0.0244634
RPL37A ribosomal protein L37a 0.0240114
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.0238386
RPS14 ribosomal protein S14 0.0236738
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0233526
RPS27A ribosomal protein S27a 0.0231946
PRRC2C proline-rich coiled-coil 2C 0.0230814
MT2A metallothionein 2A 0.0230185
FTL ferritin, light polypeptide 0.0229353
PGAM4 phosphoglycerate mutase family member 4 0.0226859
EBNA1BP2 EBNA1 binding protein 2 0.0225345
RPL32 ribosomal protein L32 0.0221335
PNN pinin, desmosome associated protein 0.0220852
ATF4 activating transcription factor 4 0.0214669
RPL10A ribosomal protein L10a 0.0214096
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0213074
PNISR PNN-interacting serine/arginine-rich protein 0.0212791
RPL28 ribosomal protein L28 0.0211991
RPS3 ribosomal protein S3 0.0204184
DHFR dihydrofolate reductase 0.019773
VMP1 vacuole membrane protein 1 0.0194664
RACK1 receptor for activated C kinase 1 0.0194228
RPS16 ribosomal protein S16 0.0187234
HMGA1 high mobility group AT-hook 1 0.018353
DAPK3 death-associated protein kinase 3 0.0183438
TMSB10 thymosin beta 10 0.0175603
DSTN destrin (actin depolymerizing factor) 0.0175208
RPL21 ribosomal protein L21 0.017515
VIM vimentin 0.0172475
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.0170116
FTH1 ferritin, heavy polypeptide 1 0.0168359
BAZ2A bromodomain adjacent to zinc finger domain, 2A 0.0167445
LENG8 leukocyte receptor cluster (LRC) member 8 0.0166376
PSAT1 phosphoserine aminotransferase 1 0.0165581
RPL34 ribosomal protein L34 0.0164643
TM4SF1 transmembrane 4 L six family member 1 0.0162501
CIRSR corepressor of RBPJ and splicing regulator 0.0150253
SERF2 small EDRK-rich factor 2 0.0149835
TPI1 triosephosphate isomerase 1 0.0149738
RPS27 ribosomal protein S27 0.0149585
CSF1 colony stimulating factor 1 (macrophage) 0.014924
BHLHE40 basic helix-loop-helix family, member e40 0.014915
RPL8 ribosomal protein L8 0.0147666
SMIM44 small integral membrane protein 44 0.0147002
GOLGA2 golgin A2 0.0146772
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0145721
EIF5B eukaryotic translation initiation factor 5B 0.014502
RTN4 reticulon 4 0.0143947
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0143823
TMEM158 transmembrane protein 158 (gene/pseudogene) 0.0141347
BCL2L1 BCL2-like 1 0.0141234
ZFAND3 zinc finger, AN1-type domain 3 0.0139363
CHD9 chromodomain helicase DNA binding protein 9 0.0138938
NFE2L1 nuclear factor, erythroid 2-like 1 0.013856
RRAS2 related RAS viral (r-ras) oncogene homolog 2 0.0135603
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A 0.0135521
RPL37 ribosomal protein L37 0.0134417
NACA nascent polypeptide-associated complex alpha subunit 0.0133978
RPL23 ribosomal protein L23 0.0132328
RPL7A ribosomal protein L7a 0.0130304
UQCRB ubiquinol-cytochrome c reductase binding protein 0.012918
RPL35 ribosomal protein L35 0.0128044
SESN2 sestrin 2 0.0127894
PMM2 phosphomannomutase 2 0.012788
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0127203
RPL5 ribosomal protein L5 0.0126804
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0124503
TTC17 tetratricopeptide repeat domain 17 0.0124491

decreased expression

Symbol Name Standardized Value
ADAM10 ADAM metallopeptidase domain 10 -0.144493
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.133605
AHNAK AHNAK nucleoprotein -0.108174
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.107633
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.105876
PKM pyruvate kinase, muscle -0.0903328
PDE4B phosphodiesterase 4B, cAMP-specific -0.085047
SOX6 SRY (sex determining region Y)-box 6 -0.0840124
TMSB4X thymosin beta 4, X-linked -0.0833719
PDE4D phosphodiesterase 4D, cAMP-specific -0.0741685
BMP10 bone morphogenetic protein 10 -0.0721634
VCL vinculin -0.0640016
TJP1 tight junction protein 1 -0.0626988
HDAC9 histone deacetylase 9 -0.0626093
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0614002
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0579803
PRELID2 PRELI domain containing 2 -0.0574402
EML4 echinoderm microtubule associated protein like 4 -0.0565358
NBEA neurobeachin -0.0558397
FOXP1 forkhead box P1 -0.0542094
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0536103
LDHA lactate dehydrogenase A -0.052837
DLG1 discs, large homolog 1 (Drosophila) -0.0519543
PGK1 phosphoglycerate kinase 1 -0.0513343
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0503895
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0479218
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0458788
CAMTA1 calmodulin binding transcription activator 1 -0.0453825
USP34 ubiquitin specific peptidase 34 -0.0448901
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0444346
EIF4A2 eukaryotic translation initiation factor 4A2 -0.0424936
TOP2A topoisomerase (DNA) II alpha 170kDa -0.04135
CENPF centromere protein F, 350/400kDa -0.0406861
CD47 CD47 molecule -0.0399209
ANXA1 annexin A1 -0.0398764
SMC4 structural maintenance of chromosomes 4 -0.0395407
FHIT fragile histidine triad -0.0393103
NF1 neurofibromin 1 -0.0393075
MYO5C myosin VC -0.0389343
MKI67 marker of proliferation Ki-67 -0.038912
ZNF638 zinc finger protein 638 -0.0388822
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0388084
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0382177
APP amyloid beta (A4) precursor protein -0.0380293
NAV2 neuron navigator 2 -0.0376966
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0376307
ECT2 epithelial cell transforming 2 -0.0370277
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.036013
TMEM65 transmembrane protein 65 -0.0358699
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.035537
PDGFC platelet derived growth factor C -0.0351323
IFI16 interferon, gamma-inducible protein 16 -0.0347148
NFIA nuclear factor I/A -0.0343153
PHIP pleckstrin homology domain interacting protein -0.0342183
GPHN gephyrin -0.0340694
ACTG1 actin gamma 1 -0.0338981
TGFBR3 transforming growth factor, beta receptor III -0.0338167
KDM4C lysine (K)-specific demethylase 4C -0.0336148
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 -0.0335984
KDM3A lysine (K)-specific demethylase 3A -0.0333622
DPYD dihydropyrimidine dehydrogenase -0.0329541
RLF rearranged L-myc fusion -0.0327773
POTEF POTE ankyrin domain family, member F -0.0327115
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0325035
HJURP Holliday junction recognition protein -0.0322454
RHOA ras homolog family member A -0.0321404
NAMPT nicotinamide phosphoribosyltransferase -0.0319901
NIPBL Nipped-B homolog (Drosophila) -0.0319147
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0318989
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0306971
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0303985
FXR1 fragile X mental retardation, autosomal homolog 1 -0.0301375
SSBP2 single-stranded DNA binding protein 2 -0.0298695
EZR ezrin -0.0297557
BMP2K BMP2 inducible kinase -0.0288853
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0288676
ZNF292 zinc finger protein 292 -0.0287944
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0286528
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0286046
CCND1 cyclin D1 -0.0284535
SPTAN1 spectrin, alpha, non-erythrocytic 1 -0.0281591
PDIA3 protein disulfide isomerase family A, member 3 -0.0278793
WDR45B WD repeat domain 45B -0.027784
TPM4 tropomyosin 4 -0.0275954
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 -0.0275749
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.027518
ENO1 enolase 1, (alpha) -0.0274426
EFNA5 ephrin-A5 -0.0271017
XPO1 exportin 1 -0.0270312
EVI5 ecotropic viral integration site 5 -0.0268826
USP9X ubiquitin specific peptidase 9, X-linked -0.0266771
MACROD2 MACRO domain containing 2 -0.0265539
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0265328
YEATS2 YEATS domain containing 2 -0.0264868
ZMYM2 zinc finger, MYM-type 2 -0.0264405
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0263573
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0261135
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0257902
HELZ helicase with zinc finger -0.025729
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0256488