Erythromycin_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Erythromycin perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Erythromycin_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.202114
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0648155
PTMA prothymosin, alpha 0.0577322
RPS6 ribosomal protein S6 0.0473529
EGR1 early growth response 1 0.043988
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.037848
EIF1 eukaryotic translation initiation factor 1 0.0365961
PEAK1 pseudopodium-enriched atypical kinase 1 0.036088
FTL ferritin, light polypeptide 0.0360309
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0350873
EEF2 eukaryotic translation elongation factor 2 0.034515
GARS1 glycyl-tRNA synthetase 1 0.0336023
IPO11 importin 11 0.0333865
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 0.0329388
RPL4 ribosomal protein L4 0.0325958
GPR107 G protein-coupled receptor 107 0.0322103
ANKHD1 ankyrin repeat and KH domain containing 1 0.0320354
TPI1 triosephosphate isomerase 1 0.0314092
FTH1 ferritin, heavy polypeptide 1 0.0313397
NPAS2 neuronal PAS domain protein 2 0.0309218
RTN4 reticulon 4 0.0300665
GOLGA4 golgin A4 0.0298349
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.0297021
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0288807
RPS8 ribosomal protein S8 0.0286917
GIGYF2 GRB10 interacting GYF protein 2 0.0276227
DIAPH3 diaphanous-related formin 3 0.0276019
BAIAP2L1 BAI1-associated protein 2-like 1 0.0270591
BRD4 bromodomain containing 4 0.0264687
TUBA1B tubulin, alpha 1b 0.0262466
ANKZF1 ankyrin repeat and zinc finger domain containing 1 0.0255333
STAG3 stromal antigen 3 0.0254719
BAZ2A bromodomain adjacent to zinc finger domain, 2A 0.0250391
PARD3 par-3 family cell polarity regulator 0.0247779
PER1 period circadian clock 1 0.0247102
TM4SF1 transmembrane 4 L six family member 1 0.0246185
SNX3 sorting nexin 3 0.0245521
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0238407
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 0.0236454
HILPDA hypoxia inducible lipid droplet-associated 0.0235892
RPL26 ribosomal protein L26 0.0233216
DCAF7 DDB1 and CUL4 associated factor 7 0.0230488
RPL18 ribosomal protein L18 0.0228603
ZC3H15 zinc finger CCCH-type containing 15 0.0227059
UBC ubiquitin C 0.0226603
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3 0.0224472
HDLBP high density lipoprotein binding protein 0.0223236
SUCO SUN domain containing ossification factor 0.0223079
TIAL1 TIA1 cytotoxic granule-associated RNA binding protein-like 1 0.0220344
UBE4B ubiquitination factor E4B 0.0219767
ASTN2 astrotactin 2 0.0217019
RPL21 ribosomal protein L21 0.0215495
BSDC1 BSD domain containing 1 0.0215439
RPL34 ribosomal protein L34 0.0210882
SERF2 small EDRK-rich factor 2 0.0209443
KLHDC10 kelch domain containing 10 0.0206715
PPM1G protein phosphatase, Mg2+/Mn2+ dependent, 1G 0.0203883
RNF111 ring finger protein 111 0.0200306
FANCI Fanconi anemia, complementation group I 0.0199316
WAC WW domain containing adaptor with coiled-coil 0.0198046
RIMKLB ribosomal modification protein rimK-like family member B 0.0197259
RPS16 ribosomal protein S16 0.0194894
GRB10 growth factor receptor-bound protein 10 0.0191488
RBM27 RNA binding motif protein 27 0.0191157
DOT1L DOT1-like histone H3K79 methyltransferase 0.0191021
RPL35A ribosomal protein L35a 0.0189163
ZNF148 zinc finger protein 148 0.0188046
RPL32 ribosomal protein L32 0.0187124
BHLHE40 basic helix-loop-helix family, member e40 0.0186242
FOCAD focadhesin 0.0186207
CLIC4 chloride intracellular channel 4 0.0185484
YES1 YES proto-oncogene 1, Src family tyrosine kinase 0.0185469
TPBG trophoblast glycoprotein 0.018525
TPT1 tumor protein, translationally-controlled 1 0.0184782
MTCH1 mitochondrial carrier 1 0.0183842
MINK1 misshapen-like kinase 1 0.0183743
OSBPL2 oxysterol binding protein-like 2 0.0183291
CENPN centromere protein N 0.0181802
UQCRH ubiquinol-cytochrome c reductase hinge protein 0.018119
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0180941
SFTPA2 surfactant protein A2 0.0179289
TRA2A transformer 2 alpha homolog (Drosophila) 0.0178706
COX6A1 cytochrome c oxidase subunit VIa polypeptide 1 0.0178186
EXOC6 exocyst complex component 6 0.017771
SRRM1 serine/arginine repetitive matrix 1 0.0176947
DNMT1 DNA (cytosine-5-)-methyltransferase 1 0.0176763
TERF2IP telomeric repeat binding factor 2, interacting protein 0.0176506
RACK1 receptor for activated C kinase 1 0.0176481
CAPNS1 calpain, small subunit 1 0.0176094
TTC17 tetratricopeptide repeat domain 17 0.017494
ALG9 ALG9, alpha-1,2-mannosyltransferase 0.0174145
DDX52 DEAD (Asp-Glu-Ala-Asp) box polypeptide 52 0.0173844
VKORC1 vitamin K epoxide reductase complex, subunit 1 0.0173628
S100A9 S100 calcium binding protein A9 0.0173078
FAM193A family with sequence similarity 193, member A 0.0172369
CREBRF CREB3 regulatory factor 0.0172159
SETD2 SET domain containing 2 0.0172031
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 0.0170077
IFITM3 interferon induced transmembrane protein 3 0.0169686
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha 0.016929

decreased expression

Symbol Name Standardized Value
BIRC3 baculoviral IAP repeat containing 3 -0.113702
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0941058
LDHA lactate dehydrogenase A -0.0936448
FNDC3B fibronectin type III domain containing 3B -0.0928681
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0780275
TRIO trio Rho guanine nucleotide exchange factor -0.0756765
CD44 CD44 molecule (Indian blood group) -0.0715371
DST dystonin -0.0677715
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0672322
OSMR oncostatin M receptor -0.0663023
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.066108
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0645535
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0639114
ANKRD28 ankyrin repeat domain 28 -0.0634465
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.062549
PALM2AKAP2 PALM2 and AKAP2 fusion -0.061896
SPAG9 sperm associated antigen 9 -0.0602464
SMYD3 SET and MYND domain containing 3 -0.0596458
ELL2 elongation factor, RNA polymerase II, 2 -0.0590566
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0590007
ERBIN erbb2 interacting protein -0.0569631
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0562353
FMNL2 formin-like 2 -0.0552909
MACF1 microtubule-actin crosslinking factor 1 -0.0528424
USP34 ubiquitin specific peptidase 34 -0.052532
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.051657
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.051169
PDE4D phosphodiesterase 4D, cAMP-specific -0.0505768
NAV2 neuron navigator 2 -0.049436
TXNRD1 thioredoxin reductase 1 -0.0479967
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 -0.0478466
MBNL1 muscleblind-like splicing regulator 1 -0.047176
ATM ATM serine/threonine kinase -0.0470382
NCEH1 neutral cholesterol ester hydrolase 1 -0.045849
CENPF centromere protein F, 350/400kDa -0.0448588
VCL vinculin -0.0441971
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.043668
DSCAM Down syndrome cell adhesion molecule -0.0434813
AKAP13 A kinase (PRKA) anchor protein 13 -0.0426641
FBXL7 F-box and leucine-rich repeat protein 7 -0.0404061
DPYD dihydropyrimidine dehydrogenase -0.040288
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0394412
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase -0.0392589
MBD5 methyl-CpG binding domain protein 5 -0.039073
BCAS3 breast carcinoma amplified sequence 3 -0.0390667
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0387169
FER fer (fps/fes related) tyrosine kinase -0.0384405
TMEM123 transmembrane protein 123 -0.0380502
RIGI RNA sensor RIG-I -0.0379507
MBNL2 muscleblind-like splicing regulator 2 -0.0371802
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0369831
LMO7 LIM domain 7 -0.0367444
IRAK2 interleukin-1 receptor-associated kinase 2 -0.0367346
SOD2 superoxide dismutase 2, mitochondrial -0.0366626
NF1 neurofibromin 1 -0.0366215
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0365494
BIRC6 baculoviral IAP repeat containing 6 -0.0362817
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0352354
BABAM2 BRISC and BRCA1 A complex member 2 -0.0351341
SQSTM1 sequestosome 1 -0.0348501
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0347295
FBXL17 F-box and leucine-rich repeat protein 17 -0.0341713
ANKRD12 ankyrin repeat domain 12 -0.0338363
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.033741
DOCK4 dedicator of cytokinesis 4 -0.0336134
ADAM10 ADAM metallopeptidase domain 10 -0.0336108
ATXN1 ataxin 1 -0.0334401
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0334312
SMAD3 SMAD family member 3 -0.0331303
KMT2E lysine (K)-specific methyltransferase 2E -0.0330713
NT5E 5'-nucleotidase, ecto (CD73) -0.0328252
CCDC91 coiled-coil domain containing 91 -0.0327736
YAP1 Yes-associated protein 1 -0.0326755
EFNA5 ephrin-A5 -0.0325445
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0324784
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0319629
SVIL supervillin -0.0316816
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0316563
CCDC88A coiled-coil domain containing 88A -0.0315073
RAB7A RAB7A, member RAS oncogene family -0.0313953
SAMD4A sterile alpha motif domain containing 4A -0.0310051
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0309531
EXT1 exostosin glycosyltransferase 1 -0.0308951
MON2 MON2 homolog (S. cerevisiae) -0.030742
RUNX1 runt-related transcription factor 1 -0.0297856
ZMYND8 zinc finger, MYND-type containing 8 -0.0296347
ZNF292 zinc finger protein 292 -0.0294859
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0294375
SON SON DNA binding protein -0.0292454
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0289678
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0289078
DENND4A DENN/MADD domain containing 4A -0.0289017
MRE11 MRE11 homolog, double strand break repair nuclease -0.0288169
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0287173
NALCN sodium leak channel, non selective -0.0285986
ZNF652 zinc finger protein 652 -0.0285148
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0281948
EFL1 elongation factor like GTPase 1 -0.0281459
RALY RALY heterogeneous nuclear ribonucleoprotein -0.0279979
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0279379