Esmolol (hydrochloride)_A-172 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Esmolol (hydrochloride) perturbation in A-172 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Esmolol (hydrochloride)_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.173007
PODXL podocalyxin-like 0.148038
NAV1 neuron navigator 1 0.121072
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.117397
POTEF POTE ankyrin domain family, member F 0.0752377
MAP1B microtubule-associated protein 1B 0.0699641
CD44 CD44 molecule (Indian blood group) 0.0665873
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.0624448
BHLHE40 basic helix-loop-helix family, member e40 0.0617553
FTH1 ferritin, heavy polypeptide 1 0.0616076
SEPTIN9 septin 9 0.051861
TRIO trio Rho guanine nucleotide exchange factor 0.0475544
SLC39A11 solute carrier family 39, member 11 0.0473841
C1D C1D nuclear receptor corepressor 0.04693
LENG8 leukocyte receptor cluster (LRC) member 8 0.0452099
L1CAM L1 cell adhesion molecule 0.0436069
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0425963
NCOR2 nuclear receptor corepressor 2 0.0403881
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0388235
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0380019
TIMP2 TIMP metallopeptidase inhibitor 2 0.0358194
HLA-B major histocompatibility complex, class I, B 0.0346236
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0345929
PLD3 phospholipase D family, member 3 0.0344293
PFN1 profilin 1 0.0342382
MYADM myeloid-associated differentiation marker 0.0332391
ZMIZ1 zinc finger, MIZ-type containing 1 0.0325805
LOC112694756 uncharaterized LOC112694756 0.0321434
RTN4 reticulon 4 0.0319589
FLNA filamin A, alpha 0.0309201
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0302041
SMC4 structural maintenance of chromosomes 4 0.0301299
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0291003
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0290221
SHB Src homology 2 domain containing adaptor protein B 0.0283586
SOX9 SRY (sex determining region Y)-box 9 0.0283575
AGRN agrin 0.0283249
MSN moesin 0.0281062
FOSL1 FOS-like antigen 1 0.0280121
RPL28 ribosomal protein L28 0.0277307
FSTL1 follistatin-like 1 0.0276487
MYOF myoferlin 0.0269932
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.026803
DCLK2 doublecortin-like kinase 2 0.0266811
RNF213 ring finger protein 213 0.0265611
RPS2 ribosomal protein S2 0.0258409
LAMA5 laminin, alpha 5 0.0256102
PIEZO1 piezo-type mechanosensitive ion channel component 1 0.0250331
HDAC9 histone deacetylase 9 0.0249559
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0249175
PPDPF pancreatic progenitor cell differentiation and proliferation factor 0.0248142
COL6A2 collagen, type VI, alpha 2 0.0247908
MIDEAS mitotic deacetylase associated SANT domain protein 0.0247341
SRRM2 serine/arginine repetitive matrix 2 0.02459
B2M beta-2-microglobulin 0.0241883
MKI67 marker of proliferation Ki-67 0.0238368
VEGFA vascular endothelial growth factor A 0.0230891
IFITM3 interferon induced transmembrane protein 3 0.0228527
ADAR adenosine deaminase, RNA-specific 0.0224143
NFE2L1 nuclear factor, erythroid 2-like 1 0.0221084
GSE1 Gse1 coiled-coil protein 0.0220852
CYB5R3 cytochrome b5 reductase 3 0.02192
CCDC88A coiled-coil domain containing 88A 0.0216993
SLC22A23 solute carrier family 22, member 23 0.021692
LHFPL6 LHFPL tetraspan subfamily member 6 0.0214919
RPS6 ribosomal protein S6 0.0213939
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0213043
RUNX1 runt-related transcription factor 1 0.0211969
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0209394
MNT MAX network transcriptional repressor 0.020906
ADNP activity-dependent neuroprotector homeobox 0.0208964
NOTCH2 notch 2 0.0205266
ADM adrenomedullin 0.0204278
FNDC3B fibronectin type III domain containing 3B 0.0202036
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein 0.0199476
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0199054
MB21D2 Mab-21 domain containing 2 0.019869
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0197354
ZNF292 zinc finger protein 292 0.0196233
ANKRD11 ankyrin repeat domain 11 0.0195838
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 0.0194772
NUPR1 nuclear protein, transcriptional regulator, 1 0.0193966
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.0193933
VCL vinculin 0.0192964
DIAPH3 diaphanous-related formin 3 0.0190245
GLIS3 GLIS family zinc finger 3 0.0189105
PLXNA3 plexin A3 0.0188971
NUCB2 nucleobindin 2 0.0184607
HLA-A major histocompatibility complex, class I, A 0.0184054
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0182982
TUBB4B tubulin, beta 4B class IVb 0.0179145
PML promyelocytic leukemia 0.0176853
HILPDA hypoxia inducible lipid droplet-associated 0.0175025
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0171633
PRRC2A proline-rich coiled-coil 2A 0.0171272
AXL AXL receptor tyrosine kinase 0.0169148
TAPBP TAP binding protein (tapasin) 0.0164554
FOSL2 FOS-like antigen 2 0.016367
HELZ2 helicase with zinc finger 2, transcriptional coactivator 0.016256
MYH9 myosin, heavy chain 9, non-muscle 0.0161934

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.272493
TMSB10 thymosin beta 10 -0.224166
VIM vimentin -0.180307
AHNAK AHNAK nucleoprotein -0.175657
COL3A1 collagen, type III, alpha 1 -0.151387
UBC ubiquitin C -0.13003
AKAP12 A kinase (PRKA) anchor protein 12 -0.124413
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.118862
PTMA prothymosin, alpha -0.0732429
FBN1 fibrillin 1 -0.0728634
CANX calnexin -0.0682188
SOD2 superoxide dismutase 2, mitochondrial -0.0674712
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0645338
CALR calreticulin -0.0641036
COL5A2 collagen, type V, alpha 2 -0.0630262
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0594087
LMNA lamin A/C -0.0503061
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0464468
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0443484
ZBTB20 zinc finger and BTB domain containing 20 -0.0440294
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0433072
COL1A2 collagen, type I, alpha 2 -0.0429956
IGFBP3 insulin-like growth factor binding protein 3 -0.0425595
RPS27A ribosomal protein S27a -0.0416839
LOXL2 lysyl oxidase-like 2 -0.040531
TMSB4X thymosin beta 4, X-linked -0.0399158
KDM3A lysine (K)-specific demethylase 3A -0.039392
TPM4 tropomyosin 4 -0.0393835
PKM pyruvate kinase, muscle -0.0353199
HLA-E major histocompatibility complex, class I, E -0.0352653
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.035169
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.034599
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0345987
ZEB1 zinc finger E-box binding homeobox 1 -0.0345847
COL8A1 collagen, type VIII, alpha 1 -0.0342545
S100A6 S100 calcium binding protein A6 -0.034249
NAP1L1 nucleosome assembly protein 1-like 1 -0.0342181
OGA O-GlcNAcase -0.0336367
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0333516
AUTS2 autism susceptibility candidate 2 -0.0330253
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0327164
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.032455
JAZF1 JAZF zinc finger 1 -0.0323215
EXT1 exostosin glycosyltransferase 1 -0.031691
FRMD5 FERM domain containing 5 -0.0309248
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase -0.0306755
CCND1 cyclin D1 -0.0304556
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0296754
RRBP1 ribosome binding protein 1 -0.0293449
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0288646
MARCHF6 membrane associated ring-CH-type finger 6 -0.0288193
GPC6 glypican 6 -0.0282026
HDLBP high density lipoprotein binding protein -0.0275863
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0271294
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0269437
CHD9 chromodomain helicase DNA binding protein 9 -0.0265991
TM4SF1 transmembrane 4 L six family member 1 -0.0262652
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0262403
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0260983
AHNAK2 AHNAK nucleoprotein 2 -0.0260055
DHRSX dehydrogenase/reductase (SDR family) X-linked -0.0257839
SH3KBP1 SH3-domain kinase binding protein 1 -0.0253822
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0252886
FRMD4A FERM domain containing 4A -0.0251777
ARL15 ADP-ribosylation factor-like 15 -0.025086
SUCNR1 succinate receptor 1 -0.0238938
PGK1 phosphoglycerate kinase 1 -0.023218
GLG1 golgi glycoprotein 1 -0.0226632
ACBD3 acyl-CoA binding domain containing 3 -0.0220763
DKK3 dickkopf WNT signaling pathway inhibitor 3 -0.0220646
SAMD9 sterile alpha motif domain containing 9 -0.0219515
SP100 SP100 nuclear antigen -0.0217193
DSG2 desmoglein 2 -0.0214694
SRPK2 SRSF protein kinase 2 -0.0212476
THBS2 thrombospondin 2 -0.021231
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0212305
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0212268
BIRC6 baculoviral IAP repeat containing 6 -0.0210512
ANKRD10 ankyrin repeat domain 10 -0.0208624
ABI3BP ABI family, member 3 (NESH) binding protein -0.0206067
PDIA4 protein disulfide isomerase family A, member 4 -0.0203353
ENO1 enolase 1, (alpha) -0.0202317
ZC3H11A zinc finger CCCH-type containing 11A -0.0201592
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0200207
USP34 ubiquitin specific peptidase 34 -0.0197073
SLFN5 schlafen family member 5 -0.019673
TPST1 tyrosylprotein sulfotransferase 1 -0.0195827
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.019522
GNS glucosamine (N-acetyl)-6-sulfatase -0.0194445
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 -0.0193958
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) -0.0193909
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -0.0192835
NAV2 neuron navigator 2 -0.0192214
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0191724
CLTC clathrin, heavy chain (Hc) -0.0191371
NCOA3 nuclear receptor coactivator 3 -0.019129
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.019106
CEP170 centrosomal protein 170kDa -0.0190902
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0190307
PARD3 par-3 family cell polarity regulator -0.018908