| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Esmolol (hydrochloride) perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Esmolol (hydrochloride)_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NLGN1 | neuroligin 1 | 0.283526 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.271072 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.162726 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.158233 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.140001 |
| AREG | amphiregulin | 0.117727 |
| DST | dystonin | 0.0991529 |
| CELF2 | CUGBP, Elav-like family member 2 | 0.0922761 |
| ACTG1 | actin gamma 1 | 0.0760306 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0738761 |
| TENM3 | teneurin transmembrane protein 3 | 0.0721265 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0716693 |
| EGR1 | early growth response 1 | 0.0658413 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0654953 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0649911 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0640444 |
| H1-0 | H1.0 linker histone | 0.0608112 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0601943 |
| CMIP | c-Maf inducing protein | 0.0600566 |
| YAP1 | Yes-associated protein 1 | 0.0587415 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0576171 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | 0.0575109 |
| DTNA | dystrobrevin, alpha | 0.0536259 |
| EHBP1 | EH domain binding protein 1 | 0.0531785 |
| PFN1 | profilin 1 | 0.05245 |
| EDARADD | EDAR-associated death domain | 0.0520778 |
| MKI67 | marker of proliferation Ki-67 | 0.0520147 |
| CCN2 | cellular communication network factor 2 | 0.0519633 |
| ENO1 | enolase 1, (alpha) | 0.0516967 |
| TGM2 | transglutaminase 2 | 0.0512989 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.0510118 |
| PDGFC | platelet derived growth factor C | 0.0489241 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.0483604 |
| SNCA | synuclein, alpha (non A4 component of amyloid precursor) | 0.0444767 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0435066 |
| ADIPOR2 | adiponectin receptor 2 | 0.0431471 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0417172 |
| LOC112694756 | uncharaterized LOC112694756 | 0.04109 |
| MAP1B | microtubule-associated protein 1B | 0.0410084 |
| DPYD | dihydropyrimidine dehydrogenase | 0.0409107 |
| MYL12B | myosin, light chain 12B, regulatory | 0.0405085 |
| ERBIN | erbb2 interacting protein | 0.0404075 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0395176 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | 0.0393998 |
| RPL28 | ribosomal protein L28 | 0.0390815 |
| LARP1 | La ribonucleoprotein domain family, member 1 | 0.0382429 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0380096 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | 0.0379618 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0374939 |
| MTAP | methylthioadenosine phosphorylase | 0.0368129 |
| PA2G4 | proliferation-associated 2G4, 38kDa | 0.0361977 |
| ANXA1 | annexin A1 | 0.0359308 |
| ANKS1B | ankyrin repeat and sterile alpha motif domain containing 1B | 0.0355731 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | 0.0354483 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | 0.0352639 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0352339 |
| AXIN2 | axin 2 | 0.035028 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0346046 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0343925 |
| CCDC88A | coiled-coil domain containing 88A | 0.033867 |
| PRRC2A | proline-rich coiled-coil 2A | 0.0336719 |
| RAD51B | RAD51 paralog B | 0.0334455 |
| ARPC5 | actin related protein 2/3 complex, subunit 5, 16kDa | 0.0333458 |
| LDHA | lactate dehydrogenase A | 0.0330794 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0328579 |
| HLA-A | major histocompatibility complex, class I, A | 0.0324303 |
| TPI1 | triosephosphate isomerase 1 | 0.0319378 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0317801 |
| RPS8 | ribosomal protein S8 | 0.0316388 |
| TEAD4 | TEA domain family member 4 | 0.0315965 |
| HMGA2 | high mobility group AT-hook 2 | 0.031592 |
| NEBL | nebulette | 0.0315313 |
| ITGBL1 | integrin, beta-like 1 (with EGF-like repeat domains) | 0.0312401 |
| ZNF638 | zinc finger protein 638 | 0.0311403 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0307962 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0306724 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0306457 |
| RASAL2 | RAS protein activator like 2 | 0.0304201 |
| RPL13A | ribosomal protein L13a | 0.0302223 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0301107 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0298233 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0296377 |
| RNF213 | ring finger protein 213 | 0.0294817 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0293708 |
| VTI1A | vesicle transport through interaction with t-SNAREs 1A | 0.0289893 |
| POTEF | POTE ankyrin domain family, member F | 0.0289182 |
| CEP112 | centrosomal protein 112kDa | 0.0288917 |
| CENPF | centromere protein F, 350/400kDa | 0.0285548 |
| VCL | vinculin | 0.0281201 |
| NF1 | neurofibromin 1 | 0.0281014 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | 0.0280176 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0280091 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.027821 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | 0.0277363 |
| RPL27 | ribosomal protein L27 | 0.0277021 |
| CENPE | centromere protein E, 312kDa | 0.0276719 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | 0.0275389 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0273471 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0269083 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0264371 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.117726 |
| TMSB10 | thymosin beta 10 | -0.116044 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0834585 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0721976 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0658633 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0531717 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0412448 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | -0.0407709 |
| CLTC | clathrin, heavy chain (Hc) | -0.0403094 |
| TXNRD1 | thioredoxin reductase 1 | -0.0399906 |
| FTL | ferritin, light polypeptide | -0.0394646 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0387621 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | -0.0355171 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | -0.0340087 |
| CPOX | coproporphyrinogen oxidase | -0.0338532 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | -0.0300196 |
| MATR3 | matrin 3 | -0.0286117 |
| ASPH | aspartate beta-hydroxylase | -0.028545 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0277269 |
| RPS2 | ribosomal protein S2 | -0.0277191 |
| XPO1 | exportin 1 | -0.0270787 |
| HNRNPUL2 | heterogeneous nuclear ribonucleoprotein U-like 2 | -0.0261154 |
| IL6ST | interleukin 6 signal transducer | -0.0247752 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0247592 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0227728 |
| BIRC2 | baculoviral IAP repeat containing 2 | -0.0224746 |
| RPL38 | ribosomal protein L38 | -0.0224565 |
| NDUFV2 | NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa | -0.0215492 |
| FAR1 | fatty acyl CoA reductase 1 | -0.0202982 |
| OGA | O-GlcNAcase | -0.0200621 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0196324 |
| IPO7 | importin 7 | -0.019438 |
| ATP11A | ATPase, class VI, type 11A | -0.0192531 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | -0.0188245 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.0183724 |
| NKTR | natural killer cell triggering receptor | -0.0181378 |
| THOC1 | THO complex 1 | -0.018094 |
| RPL4 | ribosomal protein L4 | -0.0176453 |
| EIF2AK1 | eukaryotic translation initiation factor 2-alpha kinase 1 | -0.0175948 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0175393 |
| MGAT4C | MGAT4 family, member C | -0.0174031 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.0173498 |
| CCT4 | chaperonin containing TCP1, subunit 4 (delta) | -0.017286 |
| DSG2 | desmoglein 2 | -0.0171815 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | -0.0165161 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0164323 |
| SERINC3 | serine incorporator 3 | -0.0164185 |
| SKIC3 | SKI3 subunit of superkiller complex | -0.0163344 |
| GOLT1B | golgi transport 1B | -0.0162167 |
| PPP1CB | protein phosphatase 1, catalytic subunit, beta isozyme | -0.0160029 |
| ATP2C1 | ATPase, Ca++ transporting, type 2C, member 1 | -0.015695 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.015689 |
| MED13L | mediator complex subunit 13-like | -0.0155177 |
| CAPZA2 | capping protein (actin filament) muscle Z-line, alpha 2 | -0.0153911 |
| UQCRQ | ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa | -0.0150936 |
| TMEM123 | transmembrane protein 123 | -0.0150099 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0149976 |
| HNRNPA3 | heterogeneous nuclear ribonucleoprotein A3 | -0.0149954 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0149723 |
| RPLP1 | ribosomal protein, large, P1 | -0.0149051 |
| FGFR1OP2 | FGFR1 oncogene partner 2 | -0.0148144 |
| RPS18 | ribosomal protein S18 | -0.0147255 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | -0.0142639 |
| BTG3 | BTG family, member 3 | -0.014099 |
| FYTTD1 | forty-two-three domain containing 1 | -0.0140939 |
| ITGA6 | integrin, alpha 6 | -0.0140143 |
| ATP11B | ATPase, class VI, type 11B | -0.0138992 |
| YES1 | YES proto-oncogene 1, Src family tyrosine kinase | -0.0138957 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0137925 |
| DERA | deoxyribose-phosphate aldolase (putative) | -0.013718 |
| NCOA1 | nuclear receptor coactivator 1 | -0.0137051 |
| CDK19 | cyclin-dependent kinase 19 | -0.0136461 |
| CCT8 | chaperonin containing TCP1, subunit 8 (theta) | -0.0134973 |
| RPL41 | ribosomal protein L41 | -0.0133608 |
| CTTN | cortactin | -0.013071 |
| RNF168 | ring finger protein 168, E3 ubiquitin protein ligase | -0.0130402 |
| KIDINS220 | kinase D-interacting substrate, 220kDa | -0.0130135 |
| TGIF1 | TGFB-induced factor homeobox 1 | -0.0127454 |
| RPS23 | ribosomal protein S23 | -0.0127429 |
| PIK3CA | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha | -0.0126202 |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | -0.012609 |
| LANCL1 | LanC lantibiotic synthetase component C-like 1 (bacterial) | -0.0125797 |
| RPL32 | ribosomal protein L32 | -0.012521 |
| PDZD8 | PDZ domain containing 8 | -0.0124569 |
| PREPL | prolyl endopeptidase-like | -0.0124418 |
| TOP6BL | TOP6B like initiator of meiotic double strand breaks | -0.0124402 |
| RPL31 | ribosomal protein L31 | -0.0124164 |
| TOP2B | topoisomerase (DNA) II beta 180kDa | -0.012416 |
| TIPRL | TOR signaling pathway regulator | -0.0121844 |
| VIM | vimentin | -0.0121352 |
| COPB2 | coatomer protein complex, subunit beta 2 (beta prime) | -0.0120944 |
| KLHL24 | kelch-like family member 24 | -0.0120695 |
| PPM1L | protein phosphatase, Mg2+/Mn2+ dependent, 1L | -0.0120312 |
| ARRDC3 | arrestin domain containing 3 | -0.0119675 |
| AHR | aryl hydrocarbon receptor | -0.0119479 |
| CKAP5 | cytoskeleton associated protein 5 | -0.0118537 |
| PDIA5 | protein disulfide isomerase family A, member 5 | -0.0118096 |
| FUBP1 | far upstream element (FUSE) binding protein 1 | -0.0118011 |
| RPS20 | ribosomal protein S20 | -0.0116217 |
| PARD6B | par-6 family cell polarity regulator beta | -0.0116143 |
