| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Esmolol (hydrochloride) perturbation in A498 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Esmolol (hydrochloride)_A498 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CSF1 | colony stimulating factor 1 (macrophage) | 0.120746 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.101893 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0958645 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0837321 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0756579 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | 0.069116 |
| APP | amyloid beta (A4) precursor protein | 0.0668743 |
| MSN | moesin | 0.0576186 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.0538545 |
| POTEF | POTE ankyrin domain family, member F | 0.0534952 |
| NRP2 | neuropilin 2 | 0.0530761 |
| SMAD3 | SMAD family member 3 | 0.0510552 |
| ICAM1 | intercellular adhesion molecule 1 | 0.048767 |
| VCAM1 | vascular cell adhesion molecule 1 | 0.0486257 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.0483294 |
| ASPH | aspartate beta-hydroxylase | 0.0483136 |
| STOM | stomatin | 0.0434494 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0423704 |
| PTBP3 | polypyrimidine tract binding protein 3 | 0.0423031 |
| G0S2 | G0/G1 switch 2 | 0.0421758 |
| DENND2B | DENN domain containing 2B | 0.0421608 |
| FLNA | filamin A, alpha | 0.0404749 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.038312 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0376533 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0369443 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0368161 |
| SRPK2 | SRSF protein kinase 2 | 0.0359451 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0350763 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0350582 |
| GLIS3 | GLIS family zinc finger 3 | 0.0350266 |
| RPL3 | ribosomal protein L3 | 0.0346343 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0338308 |
| LRRFIP2 | leucine rich repeat (in FLII) interacting protein 2 | 0.0335409 |
| WDR43 | WD repeat domain 43 | 0.0333751 |
| RPS2 | ribosomal protein S2 | 0.032966 |
| DNAJB6 | DnaJ (Hsp40) homolog, subfamily B, member 6 | 0.0327479 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0318425 |
| PBX1 | pre-B-cell leukemia homeobox 1 | 0.0315188 |
| ANKRD33B | ankyrin repeat domain 33B | 0.0314091 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0308663 |
| CALU | calumenin | 0.0308557 |
| ACTN4 | actinin, alpha 4 | 0.0306813 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0306238 |
| TGFB2 | transforming growth factor, beta 2 | 0.0303915 |
| FAT1 | FAT atypical cadherin 1 | 0.0300567 |
| ANKRD11 | ankyrin repeat domain 11 | 0.029921 |
| PTK2 | protein tyrosine kinase 2 | 0.0292147 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0292038 |
| COL4A1 | collagen, type IV, alpha 1 | 0.0289746 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0286123 |
| BAZ1B | bromodomain adjacent to zinc finger domain, 1B | 0.0285233 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0282438 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0277911 |
| GOLPH3 | golgi phosphoprotein 3 (coat-protein) | 0.0276984 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0270141 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | 0.0268489 |
| KIRREL1 | kirre like nephrin family adhesion molecule 1 | 0.0265433 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0264489 |
| LENG8 | leukocyte receptor cluster (LRC) member 8 | 0.0264431 |
| ADAM10 | ADAM metallopeptidase domain 10 | 0.0261588 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0260069 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.025826 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0250935 |
| PFN1 | profilin 1 | 0.0250858 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0247854 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.0247494 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | 0.0244479 |
| UBE2G1 | ubiquitin-conjugating enzyme E2G 1 | 0.0242386 |
| QKI | QKI, KH domain containing, RNA binding | 0.024127 |
| EML4 | echinoderm microtubule associated protein like 4 | 0.0240838 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0239602 |
| KHDC4 | KH domain containing 4, pre-mRNA splicing factor | 0.0237943 |
| MSH6 | mutS homolog 6 | 0.0237044 |
| ITGAV | integrin, alpha V | 0.0236863 |
| DHX9 | DEAH (Asp-Glu-Ala-His) box helicase 9 | 0.0236266 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | 0.0232372 |
| BAZ2A | bromodomain adjacent to zinc finger domain, 2A | 0.0232322 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.02315 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0230075 |
| SKAP2 | src kinase associated phosphoprotein 2 | 0.0227116 |
| GDF15 | growth differentiation factor 15 | 0.0226545 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0225911 |
| DNM2 | dynamin 2 | 0.0225693 |
| LUC7L2 | LUC7-like 2 (S. cerevisiae) | 0.022484 |
| RBM39 | RNA binding motif protein 39 | 0.0224449 |
| ARRDC3 | arrestin domain containing 3 | 0.0223017 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0222665 |
| SP3 | Sp3 transcription factor | 0.0222428 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0222317 |
| USP3 | ubiquitin specific peptidase 3 | 0.0221215 |
| RTN4 | reticulon 4 | 0.0220959 |
| POLR2B | polymerase (RNA) II (DNA directed) polypeptide B, 140kDa | 0.021902 |
| IRS2 | insulin receptor substrate 2 | 0.0217759 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0216399 |
| DHX15 | DEAH (Asp-Glu-Ala-His) box helicase 15 | 0.0215347 |
| CCNL1 | cyclin L1 | 0.0214832 |
| HELZ | helicase with zinc finger | 0.0214398 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0214209 |
| NCKAP1 | NCK-associated protein 1 | 0.0212782 |
| RNF145 | ring finger protein 145 | 0.0212411 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.27347 |
| VIM | vimentin | -0.243661 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.230213 |
| FRMD4A | FERM domain containing 4A | -0.167596 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.151373 |
| TMSB10 | thymosin beta 10 | -0.129708 |
| FTL | ferritin, light polypeptide | -0.0937916 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0805194 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0747812 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0705658 |
| PLIN2 | perilipin 2 | -0.0681091 |
| RAI14 | retinoic acid induced 14 | -0.0648033 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0594976 |
| AHNAK | AHNAK nucleoprotein | -0.0572878 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0548535 |
| RND3 | Rho family GTPase 3 | -0.0532935 |
| RPL34 | ribosomal protein L34 | -0.0529533 |
| RPL35A | ribosomal protein L35a | -0.0519344 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0510912 |
| RPS24 | ribosomal protein S24 | -0.0490278 |
| SP100 | SP100 nuclear antigen | -0.0472983 |
| RPS8 | ribosomal protein S8 | -0.0467379 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0453307 |
| RPLP1 | ribosomal protein, large, P1 | -0.0431043 |
| CANX | calnexin | -0.0427373 |
| RIGI | RNA sensor RIG-I | -0.0425956 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0423649 |
| ARL4C | ADP-ribosylation factor-like 4C | -0.0423485 |
| NAV2 | neuron navigator 2 | -0.0408035 |
| CALR | calreticulin | -0.0406249 |
| RPL12 | ribosomal protein L12 | -0.0400828 |
| GOLGB1 | golgin B1 | -0.0389731 |
| VCL | vinculin | -0.0388473 |
| HM13 | histocompatibility (minor) 13 | -0.0384026 |
| HLA-E | major histocompatibility complex, class I, E | -0.0383231 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.0380971 |
| SDCBP | syndecan binding protein (syntenin) | -0.03782 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0378148 |
| RPL23 | ribosomal protein L23 | -0.0360983 |
| TKT | transketolase | -0.0349365 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | -0.0347701 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.034068 |
| FAM107B | family with sequence similarity 107, member B | -0.0339902 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0339895 |
| S100A10 | S100 calcium binding protein A10 | -0.0336502 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0334093 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0328614 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0324695 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0318678 |
| RPS19 | ribosomal protein S19 | -0.0316796 |
| RPL31 | ribosomal protein L31 | -0.0310695 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0308627 |
| CP | ceruloplasmin (ferroxidase) | -0.0306803 |
| PPIB | peptidylprolyl isomerase B (cyclophilin B) | -0.0306797 |
| RRBP1 | ribosome binding protein 1 | -0.0306414 |
| EGFR | epidermal growth factor receptor | -0.0305934 |
| MX1 | MX dynamin-like GTPase 1 | -0.0305534 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0304884 |
| MAP1B | microtubule-associated protein 1B | -0.0302821 |
| MMP7 | matrix metallopeptidase 7 | -0.0302621 |
| INTS6 | integrator complex subunit 6 | -0.0300723 |
| RPL7 | ribosomal protein L7 | -0.0298833 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0296651 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | -0.0295966 |
| MORF4L2 | mortality factor 4 like 2 | -0.0291968 |
| ANXA2 | annexin A2 | -0.0291584 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0287827 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0285759 |
| GPC6 | glypican 6 | -0.0284581 |
| RPL19 | ribosomal protein L19 | -0.0283469 |
| XAF1 | XIAP associated factor 1 | -0.0282034 |
| RPS27A | ribosomal protein S27a | -0.0275977 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0275744 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0275481 |
| S100A11 | S100 calcium binding protein A11 | -0.0274531 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0272844 |
| RPS20 | ribosomal protein S20 | -0.0271525 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0270969 |
| RPS6 | ribosomal protein S6 | -0.0268247 |
| UBC | ubiquitin C | -0.0266861 |
| AKR1B1 | aldo-keto reductase family 1, member B1 (aldose reductase) | -0.0266197 |
| TPM4 | tropomyosin 4 | -0.0261647 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0260016 |
| SETX | senataxin | -0.0258297 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.025783 |
| CAVIN1 | caveolae associated protein 1 | -0.0256605 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0256305 |
| RPL37A | ribosomal protein L37a | -0.0255897 |
| S100A6 | S100 calcium binding protein A6 | -0.0255781 |
| RPL38 | ribosomal protein L38 | -0.0254459 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.0254264 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0252157 |
| CUX1 | cut-like homeobox 1 | -0.0249195 |
| NDRG1 | N-myc downstream regulated 1 | -0.0248774 |
| RPL26 | ribosomal protein L26 | -0.0246457 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | -0.024624 |
| RAB2A | RAB2A, member RAS oncogene family | -0.0245706 |
| SSR3 | signal sequence receptor, gamma (translocon-associated protein gamma) | -0.0244774 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.024445 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0243887 |
