| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Esmolol (hydrochloride) perturbation in A549 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Esmolol (hydrochloride)_A549 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.116021 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.100567 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0862249 |
| SMAD3 | SMAD family member 3 | 0.0842562 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0711471 |
| PDE10A | phosphodiesterase 10A | 0.0636962 |
| MT2A | metallothionein 2A | 0.0627502 |
| OSMR | oncostatin M receptor | 0.0579445 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.0568238 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0552145 |
| FNDC3B | fibronectin type III domain containing 3B | 0.049905 |
| CMIP | c-Maf inducing protein | 0.0481035 |
| KYNU | kynureninase | 0.0411953 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0396355 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0392334 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0378587 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0378549 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0377343 |
| MT1X | metallothionein 1X | 0.0369575 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0364822 |
| TGM2 | transglutaminase 2 | 0.0353547 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0335454 |
| EFNA5 | ephrin-A5 | 0.0331335 |
| BMAL2 | basic helix-loop-helix ARNT like 2 | 0.0329572 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0312763 |
| NPC1 | Niemann-Pick disease, type C1 | 0.0311585 |
| MCL1 | myeloid cell leukemia 1 | 0.0301792 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0284692 |
| RNF213 | ring finger protein 213 | 0.027897 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0274969 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0269758 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0266198 |
| BCL2L1 | BCL2-like 1 | 0.0263089 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0258886 |
| EPAS1 | endothelial PAS domain protein 1 | 0.0257733 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0254229 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.025311 |
| DGKD | diacylglycerol kinase, delta 130kDa | 0.025175 |
| ANGPTL4 | angiopoietin-like 4 | 0.0251057 |
| SMYD3 | SET and MYND domain containing 3 | 0.0246884 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0244344 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.024366 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0243115 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0240378 |
| WWC1 | WW and C2 domain containing 1 | 0.0234087 |
| EXOC6B | exocyst complex component 6B | 0.0230332 |
| FGD6 | FYVE, RhoGEF and PH domain containing 6 | 0.0230256 |
| AXL | AXL receptor tyrosine kinase | 0.0227168 |
| ACTN4 | actinin, alpha 4 | 0.022205 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | 0.021651 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0213268 |
| ITGB5 | integrin, beta 5 | 0.0211539 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0207202 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | 0.020192 |
| KDM7A | lysine (K)-specific demethylase 7A | 0.0200485 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0200166 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0198661 |
| VMP1 | vacuole membrane protein 1 | 0.0198416 |
| MYO9A | myosin IXA | 0.01983 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0197218 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0194667 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | 0.0193317 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0186312 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0184476 |
| SEPTIN9 | septin 9 | 0.018439 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0183004 |
| KIRREL3 | kin of IRRE like 3 (Drosophila) | 0.0182059 |
| TCIM | transcriptional and immune response regulator | 0.0181372 |
| VCL | vinculin | 0.0180799 |
| OGA | O-GlcNAcase | 0.017993 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | 0.0178217 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 0.0176594 |
| DUSP5 | dual specificity phosphatase 5 | 0.0175352 |
| EGR1 | early growth response 1 | 0.0172804 |
| KIAA1217 | KIAA1217 | 0.017176 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0168327 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0168081 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0167033 |
| MYO1E | myosin IE | 0.0166881 |
| RIN2 | Ras and Rab interactor 2 | 0.0166048 |
| BTBD10 | BTB (POZ) domain containing 10 | 0.016581 |
| NAV2 | neuron navigator 2 | 0.0162291 |
| STC1 | stanniocalcin 1 | 0.0160576 |
| ARHGAP5 | Rho GTPase activating protein 5 | 0.0159968 |
| GRAMD1B | GRAM domain containing 1B | 0.0159575 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0158489 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0157421 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | 0.0157254 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0156339 |
| GPHN | gephyrin | 0.015599 |
| RTN4 | reticulon 4 | 0.015562 |
| ANXA2 | annexin A2 | 0.0152319 |
| NF1 | neurofibromin 1 | 0.0151449 |
| FAM107B | family with sequence similarity 107, member B | 0.0151325 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0147797 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0146962 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0144881 |
| NEDD4 | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase | 0.0143547 |
| IL1RAP | interleukin 1 receptor accessory protein | 0.0143456 |
| KDM4C | lysine (K)-specific demethylase 4C | 0.0142057 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0872446 |
| NDRG1 | N-myc downstream regulated 1 | -0.0622103 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0621818 |
| RPS6 | ribosomal protein S6 | -0.0597501 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.058812 |
| FTL | ferritin, light polypeptide | -0.0569975 |
| USP3 | ubiquitin specific peptidase 3 | -0.0515568 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0513132 |
| TMSB10 | thymosin beta 10 | -0.0493679 |
| VIM | vimentin | -0.0450109 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0438414 |
| PKM | pyruvate kinase, muscle | -0.0428704 |
| PTMA | prothymosin, alpha | -0.0397222 |
| AKR1C2 | aldo-keto reductase family 1, member C2 | -0.0378077 |
| PARD3 | par-3 family cell polarity regulator | -0.0328092 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0323131 |
| UBC | ubiquitin C | -0.0320185 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -0.0318223 |
| PFN1 | profilin 1 | -0.0317824 |
| RPS19 | ribosomal protein S19 | -0.0316457 |
| KRT81 | keratin 81, type II | -0.0314968 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | -0.0314282 |
| ACTG1 | actin gamma 1 | -0.0310945 |
| SPAG9 | sperm associated antigen 9 | -0.0298537 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.029678 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0294595 |
| GOLGA4 | golgin A4 | -0.0294027 |
| LDHA | lactate dehydrogenase A | -0.0288901 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0288336 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0280069 |
| RPS8 | ribosomal protein S8 | -0.0278133 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0273076 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0267266 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0265756 |
| HELZ | helicase with zinc finger | -0.026024 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0254969 |
| S100A10 | S100 calcium binding protein A10 | -0.0253379 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0247108 |
| RPS16 | ribosomal protein S16 | -0.0239329 |
| RPL37A | ribosomal protein L37a | -0.023343 |
| RPS3 | ribosomal protein S3 | -0.0226099 |
| TKT | transketolase | -0.0224366 |
| PCBP2 | poly(rC) binding protein 2 | -0.0221425 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.021394 |
| SQSTM1 | sequestosome 1 | -0.0212212 |
| KRT18 | keratin 18, type I | -0.0211892 |
| HMGA1 | high mobility group AT-hook 1 | -0.0210865 |
| RPL26 | ribosomal protein L26 | -0.0208551 |
| INTS6 | integrator complex subunit 6 | -0.020829 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0207182 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0204283 |
| RPS24 | ribosomal protein S24 | -0.0200777 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0199676 |
| AADAC | arylacetamide deacetylase | -0.0197032 |
| AKR1B1 | aldo-keto reductase family 1, member B1 (aldose reductase) | -0.0196096 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | -0.0191888 |
| POTEF | POTE ankyrin domain family, member F | -0.0190153 |
| SETD5 | SET domain containing 5 | -0.0190071 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0188162 |
| WAC | WW domain containing adaptor with coiled-coil | -0.0187714 |
| RPS27A | ribosomal protein S27a | -0.0186367 |
| S100A6 | S100 calcium binding protein A6 | -0.0184535 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0182798 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.018264 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.0181972 |
| HDGF | hepatoma-derived growth factor | -0.0181648 |
| KCTD9 | potassium channel tetramerization domain containing 9 | -0.0181527 |
| RPL12 | ribosomal protein L12 | -0.0180327 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0179981 |
| IER3 | immediate early response 3 | -0.0179362 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0175521 |
| MORF4L2 | mortality factor 4 like 2 | -0.0174235 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0173687 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | -0.0168399 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0167952 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0167426 |
| ENO1 | enolase 1, (alpha) | -0.0166964 |
| QKI | QKI, KH domain containing, RNA binding | -0.016436 |
| RPL9 | ribosomal protein L9 | -0.0164349 |
| DDIT4 | DNA-damage-inducible transcript 4 | -0.0163089 |
| BHLHE40 | basic helix-loop-helix family, member e40 | -0.0162739 |
| AUTS2 | autism susceptibility candidate 2 | -0.016216 |
| CLINT1 | clathrin interactor 1 | -0.0161579 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | -0.0159994 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0158862 |
| ST6GAL2 | ST6 beta-galactosamide alpha-2,6-sialyltranferase 2 | -0.0156794 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.0154982 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0154456 |
| NUP58 | nucleoporin 58 | -0.0153615 |
| RPS20 | ribosomal protein S20 | -0.0153454 |
| KRT7 | keratin 7, type II | -0.0152967 |
| RPS12 | ribosomal protein S12 | -0.0151461 |
| NRG1 | neuregulin 1 | -0.0147416 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0146541 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0146524 |
| RPS14 | ribosomal protein S14 | -0.0145881 |
| PALLD | palladin, cytoskeletal associated protein | -0.0144419 |
| TMSB4X | thymosin beta 4, X-linked | -0.014322 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0142251 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.014198 |
