Esmolol (hydrochloride)_BT-474 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Esmolol (hydrochloride) perturbation in BT-474 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Esmolol (hydrochloride)_BT-474 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ERBB2 erb-b2 receptor tyrosine kinase 2 0.172722
SRCIN1 SRC kinase signaling inhibitor 1 0.117381
VMP1 vacuole membrane protein 1 0.112002
CEP250 centrosomal protein 250kDa 0.107558
CATSPERB catsper channel auxiliary subunit beta 0.0902351
FTH1 ferritin, heavy polypeptide 1 0.0827424
NCOA3 nuclear receptor coactivator 3 0.0803326
THSD4 thrombospondin, type I, domain containing 4 0.0757077
ZMYND8 zinc finger, MYND-type containing 8 0.072167
LASP1 LIM and SH3 protein 1 0.0687515
LPP LIM domain containing preferred translocation partner in lipoma 0.0632968
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0626693
FBXL20 F-box and leucine-rich repeat protein 20 0.0597172
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0554176
ANKRD36C ankyrin repeat domain 36C 0.055115
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0549334
CEMIP cell migration inducing protein, hyaluronan binding 0.053329
TRIO trio Rho guanine nucleotide exchange factor 0.0525288
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta 0.0520282
ACTG1 actin gamma 1 0.0503981
HSPA8 heat shock 70kDa protein 8 0.0501468
PRRC2B proline-rich coiled-coil 2B 0.0488457
DTNA dystrobrevin, alpha 0.0486947
ACACA acetyl-CoA carboxylase alpha 0.0477709
MYH9 myosin, heavy chain 9, non-muscle 0.0476027
POTEF POTE ankyrin domain family, member F 0.046915
SHROOM3 shroom family member 3 0.046215
KIAA1217 KIAA1217 0.0458187
MCL1 myeloid cell leukemia 1 0.0452656
ACSS2 acyl-CoA synthetase short-chain family member 2 0.0445032
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0443778
PDLIM5 PDZ and LIM domain 5 0.0434296
CLTC clathrin, heavy chain (Hc) 0.0432344
SMYD3 SET and MYND domain containing 3 0.0432099
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 0.0423459
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0417679
KMT2C lysine (K)-specific methyltransferase 2C 0.0413966
KRT19 keratin 19, type I 0.0412816
TOM1L1 target of myb1 (chicken)-like 1 0.0412522
PLEC plectin 0.0396049
FNDC3A fibronectin type III domain containing 3A 0.0375299
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0365995
ENAH enabled homolog (Drosophila) 0.0363292
KIF1A kinesin family member 1A 0.0358932
UNC13B unc-13 homolog B (C. elegans) 0.0355205
SET SET nuclear proto-oncogene 0.0354982
LIMCH1 LIM and calponin homology domains 1 0.0352619
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0351601
RAB22A RAB22A, member RAS oncogene family 0.0339137
VEGFA vascular endothelial growth factor A 0.0331828
EHMT1 euchromatic histone-lysine N-methyltransferase 1 0.0324525
WAC WW domain containing adaptor with coiled-coil 0.0320982
MSI2 musashi RNA-binding protein 2 0.0318996
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0318282
VCP valosin containing protein 0.0318118
MYO1B myosin IB 0.031426
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0312983
PTPRK protein tyrosine phosphatase, receptor type, K 0.0312038
MLPH melanophilin 0.0311277
EGFR epidermal growth factor receptor 0.0308098
ACTN4 actinin, alpha 4 0.0307643
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.0305439
PBX1 pre-B-cell leukemia homeobox 1 0.0302071
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.0299796
SLC22A23 solute carrier family 22, member 23 0.0294942
LOC112694756 uncharaterized LOC112694756 0.0290625
NIBAN2 niban apoptosis regulator 2 0.0286955
APP amyloid beta (A4) precursor protein 0.0286268
STARD3 StAR-related lipid transfer (START) domain containing 3 0.0281622
YAP1 Yes-associated protein 1 0.0281331
KRT8 keratin 8, type II 0.028038
ANKRD12 ankyrin repeat domain 12 0.0278335
NCOR2 nuclear receptor corepressor 2 0.0277809
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0277441
RBM25 RNA binding motif protein 25 0.0276566
HLA-C major histocompatibility complex, class I, C 0.0275806
SAMD12 sterile alpha motif domain containing 12 0.0272586
KIF16B kinesin family member 16B 0.026452
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.026288
SYNRG synergin, gamma 0.0262855
MMP24OS MMP24 opposite strand 0.0261574
MUC6 mucin 6, oligomeric mucus/gel-forming 0.0261064
PRRC2A proline-rich coiled-coil 2A 0.0258443
SRRM2 serine/arginine repetitive matrix 2 0.0258285
AKAP9 A kinase (PRKA) anchor protein 9 0.0257893
FADS2 fatty acid desaturase 2 0.0256155
GOLGB1 golgin B1 0.025526
GSE1 Gse1 coiled-coil protein 0.0253191
CWC25 CWC25 spliceosome-associated protein homolog (S. cerevisiae) 0.0252588
UQCC1 ubiquinol-cytochrome c reductase complex assembly factor 1 0.0248677
NABP1 nucleic acid binding protein 1 0.0243652
SEC23A Sec23 homolog A (S. cerevisiae) 0.0239003
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0237304
TMEM45B transmembrane protein 45B 0.0234631
NCOA6 nuclear receptor coactivator 6 0.0232891
NEBL nebulette 0.0232104
TRAPPC9 trafficking protein particle complex 9 0.0231564
RPS2 ribosomal protein S2 0.023037
FASN fatty acid synthase 0.022954
FLNA filamin A, alpha 0.0229298

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.116639
RPL23 ribosomal protein L23 -0.0697882
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.061841
PTMA prothymosin, alpha -0.0570049
RPL35A ribosomal protein L35a -0.056658
TMSB10 thymosin beta 10 -0.051469
MT2A metallothionein 2A -0.0505747
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0486677
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0402335
TPT1 tumor protein, translationally-controlled 1 -0.0359141
AHNAK AHNAK nucleoprotein -0.0351948
MYO6 myosin VI -0.0343201
RPS24 ribosomal protein S24 -0.0326712
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family) -0.0316235
IER3 immediate early response 3 -0.0313128
TMEM123 transmembrane protein 123 -0.0308851
VIM vimentin -0.0296892
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.029036
CCNI cyclin I -0.028908
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0288418
PARP1 poly (ADP-ribose) polymerase 1 -0.0282541
ANLN anillin, actin binding protein -0.0280651
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 -0.0279879
RPLP1 ribosomal protein, large, P1 -0.0273847
ZNF217 zinc finger protein 217 -0.0266842
PDE4D phosphodiesterase 4D, cAMP-specific -0.0263482
RPS19 ribosomal protein S19 -0.0252724
LMAN1 lectin, mannose-binding, 1 -0.0249929
RPL19 ribosomal protein L19 -0.0248667
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0241992
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0230345
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0228554
ALCAM activated leukocyte cell adhesion molecule -0.0226448
TUBB tubulin, beta class I -0.0223067
YBX1 Y box binding protein 1 -0.0222358
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0220286
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0219283
UBE2K ubiquitin-conjugating enzyme E2K -0.021083
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0210769
NAMPT nicotinamide phosphoribosyltransferase -0.0204887
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0203006
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.019939
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0199289
ZCCHC2 zinc finger, CCHC domain containing 2 -0.0197095
PERP PERP, TP53 apoptosis effector -0.0196472
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0194768
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0192456
RPS8 ribosomal protein S8 -0.0190698
EXT1 exostosin glycosyltransferase 1 -0.0189268
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) -0.0187377
CENPF centromere protein F, 350/400kDa -0.0183967
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0181413
FN1 fibronectin 1 -0.0176027
STK17A serine/threonine kinase 17a -0.0175854
PRR11 proline rich 11 -0.0174651
RPLP0 ribosomal protein, large, P0 -0.0174137
RPL31 ribosomal protein L31 -0.0173989
MCTP1 multiple C2 domains, transmembrane 1 -0.0172095
ASPH aspartate beta-hydroxylase -0.0171141
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) -0.0169363
MAP4 microtubule-associated protein 4 -0.0169076
STC1 stanniocalcin 1 -0.0168945
CCT4 chaperonin containing TCP1, subunit 4 (delta) -0.0167813
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.0167101
HMGB1 high mobility group box 1 -0.0166866
RESF1 retroelement silencing factor 1 -0.0166543
STAU1 staufen double-stranded RNA binding protein 1 -0.0166255
TXNRD1 thioredoxin reductase 1 -0.0162886
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0162827
RPL34 ribosomal protein L34 -0.0162123
STK4 serine/threonine kinase 4 -0.0162032
AKAP12 A kinase (PRKA) anchor protein 12 -0.0161924
SLMAP sarcolemma associated protein -0.0161555
CRYBG1 crystallin beta-gamma domain containing 1 -0.0160009
TIPRL TOR signaling pathway regulator -0.0158804
DSG2 desmoglein 2 -0.0157722
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.0157321
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0157134
PFDN4 prefoldin subunit 4 -0.0156774
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0155826
SPDYA speedy/RINGO cell cycle regulator family member A -0.0155641
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0153954
EIF1 eukaryotic translation initiation factor 1 -0.0153203
SLFN5 schlafen family member 5 -0.0152149
EIF3E eukaryotic translation initiation factor 3, subunit E -0.0151205
TXNIP thioredoxin interacting protein -0.0150324
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0149242
RPS14 ribosomal protein S14 -0.0148503
CTDSPL2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2 -0.01481
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0148008
CCDC47 coiled-coil domain containing 47 -0.0147413
EMP1 epithelial membrane protein 1 -0.0146807
DPYD dihydropyrimidine dehydrogenase -0.0144869
NEK7 NIMA-related kinase 7 -0.0144188
ARL5B ADP-ribosylation factor-like 5B -0.014409
TM9SF3 transmembrane 9 superfamily member 3 -0.0143867
MAPK8 mitogen-activated protein kinase 8 -0.0142839
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 -0.0142396
GLG1 golgi glycoprotein 1 -0.0141783
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 -0.0141412