| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Esmolol (hydrochloride) perturbation in C32 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Esmolol (hydrochloride)_C32 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | 0.611169 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0945174 |
| TNNC1 | troponin C type 1 (slow) | 0.0719189 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0636376 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0615218 |
| GPC6 | glypican 6 | 0.0599404 |
| FMN1 | formin 1 | 0.05939 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0577177 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | 0.0543028 |
| LEF1 | lymphoid enhancer-binding factor 1 | 0.0536576 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0473785 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.0459128 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0456221 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0429302 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0407378 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0386454 |
| CD109 | CD109 molecule | 0.0386146 |
| ICAM1 | intercellular adhesion molecule 1 | 0.0371123 |
| NAV2 | neuron navigator 2 | 0.0357195 |
| APP | amyloid beta (A4) precursor protein | 0.0339939 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0336428 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.033544 |
| CDC73 | cell division cycle 73 | 0.0333912 |
| PHC2 | polyhomeotic homolog 2 (Drosophila) | 0.0333426 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.0328785 |
| AHR | aryl hydrocarbon receptor | 0.0327112 |
| A2M | alpha-2-macroglobulin | 0.0326598 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.0317269 |
| PI15 | peptidase inhibitor 15 | 0.0315925 |
| IFI16 | interferon, gamma-inducible protein 16 | 0.0309925 |
| NPC1 | Niemann-Pick disease, type C1 | 0.0301846 |
| SRPK2 | SRSF protein kinase 2 | 0.0300529 |
| ZNF292 | zinc finger protein 292 | 0.0300407 |
| PLA2G4A | phospholipase A2, group IVA (cytosolic, calcium-dependent) | 0.0296796 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0287724 |
| TMEM178B | transmembrane protein 178B | 0.0284114 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0282381 |
| VCL | vinculin | 0.0276463 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0276333 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0276302 |
| RTN4 | reticulon 4 | 0.0272641 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0265206 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0260407 |
| ENO1 | enolase 1, (alpha) | 0.0260328 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0259957 |
| PGK1 | phosphoglycerate kinase 1 | 0.0254697 |
| PRELID2 | PRELI domain containing 2 | 0.0248843 |
| RCAN1 | regulator of calcineurin 1 | 0.0243805 |
| SPRED1 | sprouty-related, EVH1 domain containing 1 | 0.023433 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.0227466 |
| SETBP1 | SET binding protein 1 | 0.0226698 |
| CD59 | CD59 molecule, complement regulatory protein | 0.0226639 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0223858 |
| TANC1 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 | 0.0223016 |
| MITF | microphthalmia-associated transcription factor | 0.0220388 |
| OXR1 | oxidation resistance 1 | 0.0219265 |
| LAMB1 | laminin, beta 1 | 0.0217969 |
| CHSY1 | chondroitin sulfate synthase 1 | 0.0217842 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | 0.0217009 |
| IL1RAP | interleukin 1 receptor accessory protein | 0.0216386 |
| CD74 | CD74 molecule, major histocompatibility complex, class II invariant chain | 0.0215497 |
| RNF145 | ring finger protein 145 | 0.0214133 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0212472 |
| COL19A1 | collagen, type XIX, alpha 1 | 0.0209665 |
| UHMK1 | U2AF homology motif (UHM) kinase 1 | 0.0207543 |
| CPEB2 | cytoplasmic polyadenylation element binding protein 2 | 0.0206928 |
| TPR | translocated promoter region, nuclear basket protein | 0.020669 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | 0.0206426 |
| VMP1 | vacuole membrane protein 1 | 0.0205075 |
| RBM33 | RNA binding motif protein 33 | 0.0204976 |
| ACTN1 | actinin, alpha 1 | 0.0202653 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0202099 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.020052 |
| OSMR | oncostatin M receptor | 0.0199304 |
| AFDN | afadin, adherens junction formation factor | 0.0198007 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | 0.0196998 |
| MT2A | metallothionein 2A | 0.0196447 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0196053 |
| LUC7L2 | LUC7-like 2 (S. cerevisiae) | 0.0195877 |
| EXOC4 | exocyst complex component 4 | 0.0194766 |
| INPP5F | inositol polyphosphate-5-phosphatase F | 0.0188715 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0188487 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.0185284 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0184997 |
| TAGLN2 | transgelin 2 | 0.0182313 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0182245 |
| DST | dystonin | 0.018127 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0181082 |
| NRP2 | neuropilin 2 | 0.0180549 |
| STOM | stomatin | 0.0179628 |
| HELZ | helicase with zinc finger | 0.0171901 |
| STRIP2 | striatin interacting protein 2 | 0.0170857 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0169777 |
| SFTPA2 | surfactant protein A2 | 0.0167908 |
| CAPZA2 | capping protein (actin filament) muscle Z-line, alpha 2 | 0.0165938 |
| CAMSAP2 | calmodulin regulated spectrin-associated protein family, member 2 | 0.0165919 |
| CDH19 | cadherin 19, type 2 | 0.0165678 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | 0.0165478 |
| DPYD | dihydropyrimidine dehydrogenase | 0.0164059 |
| PPP1R12B | protein phosphatase 1, regulatory subunit 12B | 0.0162515 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.080007 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.0440592 |
| TMSB10 | thymosin beta 10 | -0.0438608 |
| PTMA | prothymosin, alpha | -0.0421066 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0341946 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0330242 |
| HLA-B | major histocompatibility complex, class I, B | -0.0323059 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0284848 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0282946 |
| RPL35A | ribosomal protein L35a | -0.0261611 |
| RPLP1 | ribosomal protein, large, P1 | -0.0250509 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0232966 |
| TBC1D22A | TBC1 domain family, member 22A | -0.0230796 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0228516 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0223161 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0221719 |
| ZNF704 | zinc finger protein 704 | -0.0220224 |
| IER3 | immediate early response 3 | -0.021017 |
| LARGE1 | LARGE xylosyl- and glucuronyltransferase 1 | -0.0207326 |
| RPS8 | ribosomal protein S8 | -0.0202917 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0202424 |
| RPL37A | ribosomal protein L37a | -0.0199369 |
| RPL31 | ribosomal protein L31 | -0.0191535 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.0189456 |
| RPL34 | ribosomal protein L34 | -0.0189368 |
| VIM | vimentin | -0.0184474 |
| RPS24 | ribosomal protein S24 | -0.0183889 |
| PTK2 | protein tyrosine kinase 2 | -0.0183879 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | -0.0177339 |
| CALR | calreticulin | -0.0172699 |
| LMNA | lamin A/C | -0.0164451 |
| TRIM2 | tripartite motif containing 2 | -0.0162745 |
| MDGA2 | MAM domain containing glycosylphosphatidylinositol anchor 2 | -0.01607 |
| CPED1 | cadherin-like and PC-esterase domain containing 1 | -0.0155438 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0153354 |
| FTL | ferritin, light polypeptide | -0.0150257 |
| RPS29 | ribosomal protein S29 | -0.0149594 |
| LRRC23 | leucine rich repeat containing 23 | -0.014948 |
| CDK14 | cyclin-dependent kinase 14 | -0.0148583 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0147918 |
| CTBP2 | C-terminal binding protein 2 | -0.0147834 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0147743 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0145785 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0143086 |
| CADM1 | cell adhesion molecule 1 | -0.0141496 |
| GDF15 | growth differentiation factor 15 | -0.0139373 |
| SCFD2 | sec1 family domain containing 2 | -0.0138554 |
| RPS6 | ribosomal protein S6 | -0.0137058 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0136791 |
| RPS19 | ribosomal protein S19 | -0.0136477 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.013407 |
| INTS6 | integrator complex subunit 6 | -0.0134042 |
| FUS | FUS RNA binding protein | -0.0134041 |
| TLE4 | transducin-like enhancer of split 4 | -0.0133812 |
| CCND1 | cyclin D1 | -0.0132507 |
| RPL9 | ribosomal protein L9 | -0.0132017 |
| NPR2 | natriuretic peptide receptor 2 | -0.0131533 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0130579 |
| LINGO2 | leucine rich repeat and Ig domain containing 2 | -0.0128337 |
| RASA3 | RAS p21 protein activator 3 | -0.0127072 |
| RRBP1 | ribosome binding protein 1 | -0.012465 |
| SLC9A1 | solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 | -0.0123164 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.012178 |
| TRAF3 | TNF receptor-associated factor 3 | -0.0121763 |
| RPL38 | ribosomal protein L38 | -0.0117927 |
| RPLP2 | ribosomal protein, large, P2 | -0.011775 |
| PARVB | parvin, beta | -0.0117307 |
| RPL36 | ribosomal protein L36 | -0.0117248 |
| RPL23 | ribosomal protein L23 | -0.0117142 |
| CACNB4 | calcium channel, voltage-dependent, beta 4 subunit | -0.01166 |
| TBCA | tubulin folding cofactor A | -0.0115506 |
| RPL37 | ribosomal protein L37 | -0.0114907 |
| HMGA2 | high mobility group AT-hook 2 | -0.0114127 |
| HIP1 | huntingtin interacting protein 1 | -0.0112942 |
| RPS23 | ribosomal protein S23 | -0.0111888 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0111336 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0110642 |
| GTF2B | general transcription factor IIB | -0.0109841 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | -0.0109759 |
| CD63 | CD63 molecule | -0.0108064 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0105695 |
| RPS27A | ribosomal protein S27a | -0.0105387 |
| MYO1E | myosin IE | -0.0104691 |
| SCARB1 | scavenger receptor class B, member 1 | -0.010421 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0103678 |
| SLC25A4 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4 | -0.0102628 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0102066 |
| ORAI2 | ORAI calcium release-activated calcium modulator 2 | -0.0101628 |
| RPS12 | ribosomal protein S12 | -0.010116 |
| IGF2 | insulin-like growth factor 2 | -0.0100556 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | -0.00993241 |
| VDAC1 | voltage-dependent anion channel 1 | -0.00979611 |
| KIRREL1 | kirre like nephrin family adhesion molecule 1 | -0.00962832 |
| RPS13 | ribosomal protein S13 | -0.00945803 |
| ADORA1 | adenosine A1 receptor | -0.00940764 |
| NASP | nuclear autoantigenic sperm protein (histone-binding) | -0.00940128 |
| IFRD1 | interferon-related developmental regulator 1 | -0.00939386 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.00921289 |
| BZW2 | basic leucine zipper and W2 domains 2 | -0.00911795 |
| UBE2O | ubiquitin-conjugating enzyme E2O | -0.00901483 |
