Esmolol (hydrochloride)_CFPAC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Esmolol (hydrochloride) perturbation in CFPAC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Esmolol (hydrochloride)_CFPAC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.21774
SYNE2 spectrin repeat containing, nuclear envelope 2 0.148615
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.130896
FTH1 ferritin, heavy polypeptide 1 0.124212
TGM2 transglutaminase 2 0.109378
LAMA4 laminin, alpha 4 0.0974486
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0932042
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0921894
EGR1 early growth response 1 0.0832286
APLP2 amyloid beta (A4) precursor-like protein 2 0.0813495
MCL1 myeloid cell leukemia 1 0.0810431
MYO1E myosin IE 0.0794883
IFI27 interferon, alpha-inducible protein 27 0.0784879
DST dystonin 0.0751252
B2M beta-2-microglobulin 0.0740058
IGFBP3 insulin-like growth factor binding protein 3 0.0734543
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0719616
FNDC3B fibronectin type III domain containing 3B 0.0687429
ENO1 enolase 1, (alpha) 0.0682877
MAML2 mastermind-like 2 (Drosophila) 0.0671669
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0670299
POTEF POTE ankyrin domain family, member F 0.0662376
KRT19 keratin 19, type I 0.0654551
SAMD4A sterile alpha motif domain containing 4A 0.0648199
MACF1 microtubule-actin crosslinking factor 1 0.0610471
LMO7 LIM domain 7 0.0596463
JUP junction plakoglobin 0.0593455
AKAP13 A kinase (PRKA) anchor protein 13 0.0580213
RNF213 ring finger protein 213 0.0577579
RCOR1 REST corepressor 1 0.0556251
BRD2 bromodomain containing 2 0.0556154
MT2A metallothionein 2A 0.0550471
HLA-A major histocompatibility complex, class I, A 0.0536557
RAD51B RAD51 paralog B 0.053524
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0531583
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.053042
BCL2L1 BCL2-like 1 0.0521237
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0513444
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0513258
ALCAM activated leukocyte cell adhesion molecule 0.0509819
ITGA6 integrin, alpha 6 0.0508149
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0502985
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0496955
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0480637
ACTN1 actinin, alpha 1 0.0469878
MEF2A myocyte enhancer factor 2A 0.0467062
BACE2 beta-site APP-cleaving enzyme 2 0.0466412
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.04587
RAB7A RAB7A, member RAS oncogene family 0.0451255
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0450038
PICALM phosphatidylinositol binding clathrin assembly protein 0.0442514
SGMS2 sphingomyelin synthase 2 0.0440302
H1-0 H1.0 linker histone 0.0436269
SVIL supervillin 0.0429545
LOC102724023 ES1 protein homolog, mitochondrial 0.0427999
AGRN agrin 0.0427111
HSPG2 heparan sulfate proteoglycan 2 0.0425815
OSMR oncostatin M receptor 0.0423179
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0421851
CLDN4 claudin 4 0.0420311
ZFP36L1 ZFP36 ring finger protein-like 1 0.0420307
SPAG9 sperm associated antigen 9 0.0413903
ZSWIM6 zinc finger, SWIM-type containing 6 0.0413129
VMP1 vacuole membrane protein 1 0.0412321
ARHGAP26 Rho GTPase activating protein 26 0.0409793
AREG amphiregulin 0.0406558
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.0406
TXNIP thioredoxin interacting protein 0.0405712
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0402557
RASAL2 RAS protein activator like 2 0.0402421
BICC1 BicC family RNA binding protein 1 0.0401926
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0396371
MAP1B microtubule-associated protein 1B 0.0393177
EZR ezrin 0.0389963
SEPTIN9 septin 9 0.0389713
DUSP5 dual specificity phosphatase 5 0.0389448
DIAPH1 diaphanous-related formin 1 0.0388203
C3 complement component 3 0.0384438
BLZF1 basic leucine zipper nuclear factor 1 0.0382674
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0376301
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0374093
STC1 stanniocalcin 1 0.0368661
ATXN1 ataxin 1 0.0363781
MX1 MX dynamin-like GTPase 1 0.0362856
NCOR2 nuclear receptor corepressor 2 0.0358597
JMJD1C jumonji domain containing 1C 0.0354247
PLS3 plastin 3 0.0353697
NPAS2 neuronal PAS domain protein 2 0.0353475
KTN1 kinectin 1 (kinesin receptor) 0.0353108
VEGFA vascular endothelial growth factor A 0.0351698
KMT2C lysine (K)-specific methyltransferase 2C 0.0351056
LAMA5 laminin, alpha 5 0.0350103
FTL ferritin, light polypeptide 0.0350009
SRRM2 serine/arginine repetitive matrix 2 0.0349771
PARD3 par-3 family cell polarity regulator 0.0349032
MYADM myeloid-associated differentiation marker 0.0347598
PRSS8 protease, serine, 8 0.0339225
SLC38A2 solute carrier family 38, member 2 0.033895
TJP1 tight junction protein 1 0.0337208
MUC4 mucin 4, cell surface associated 0.0334003

decreased expression

Symbol Name Standardized Value
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.13929
PTMA prothymosin, alpha -0.131095
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.12499
TMSB4X thymosin beta 4, X-linked -0.114798
TMSB10 thymosin beta 10 -0.112031
NAMPT nicotinamide phosphoribosyltransferase -0.0933428
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0825571
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0739469
TPT1 tumor protein, translationally-controlled 1 -0.0644136
RPS24 ribosomal protein S24 -0.0510846
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0500731
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0455687
KDM3A lysine (K)-specific demethylase 3A -0.0444132
IER3 immediate early response 3 -0.043334
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0406993
MATR3 matrin 3 -0.0406629
EIF1 eukaryotic translation initiation factor 1 -0.0402484
OGA O-GlcNAcase -0.0398088
RPL35A ribosomal protein L35a -0.0398027
RPLP1 ribosomal protein, large, P1 -0.0394903
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0394631
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0388295
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0385735
RBM39 RNA binding motif protein 39 -0.038184
RPL4 ribosomal protein L4 -0.0372021
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0348877
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0339231
MMP7 matrix metallopeptidase 7 -0.0324796
RPL34 ribosomal protein L34 -0.0320208
C15ORF48 chromosome 15 open reading frame 48 -0.0315477
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0307801
EPCAM epithelial cell adhesion molecule -0.0301983
RPLP0 ribosomal protein, large, P0 -0.0294176
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0285851
KLF6 Kruppel-like factor 6 -0.0281919
FAM162A family with sequence similarity 162, member A -0.0278952
RPS21 ribosomal protein S21 -0.0273438
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0272429
CANX calnexin -0.0264652
DENND4A DENN/MADD domain containing 4A -0.0263478
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0261946
HLA-C major histocompatibility complex, class I, C -0.0260917
RPS27A ribosomal protein S27a -0.0254451
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0252395
PGK1 phosphoglycerate kinase 1 -0.0248146
TXNRD1 thioredoxin reductase 1 -0.0247232
PPP1R15B protein phosphatase 1, regulatory subunit 15B -0.0243636
GARS1 glycyl-tRNA synthetase 1 -0.0242847
RPL23 ribosomal protein L23 -0.023876
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0237116
ANKRD10 ankyrin repeat domain 10 -0.022135
TMEM123 transmembrane protein 123 -0.0218032
ZNF217 zinc finger protein 217 -0.0215081
MARCHF6 membrane associated ring-CH-type finger 6 -0.0214305
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.0211488
HLA-E major histocompatibility complex, class I, E -0.0209843
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked -0.0208275
RPL5 ribosomal protein L5 -0.0208245
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa -0.0208
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0207601
MCTP1 multiple C2 domains, transmembrane 1 -0.0205923
ARF1 ADP-ribosylation factor 1 -0.0202352
AHNAK AHNAK nucleoprotein -0.0201599
PEG10 paternally expressed 10 -0.0200448
IRAK3 interleukin-1 receptor-associated kinase 3 -0.019948
KRT8 keratin 8, type II -0.0199006
DDX52 DEAD (Asp-Glu-Ala-Asp) box polypeptide 52 -0.0199
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0197945
EIF4A2 eukaryotic translation initiation factor 4A2 -0.0197532
RSRC2 arginine/serine-rich coiled-coil 2 -0.0197204
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0196593
KPNB1 karyopherin (importin) beta 1 -0.0195464
NAP1L1 nucleosome assembly protein 1-like 1 -0.01947
USP3 ubiquitin specific peptidase 3 -0.0193058
RPL31 ribosomal protein L31 -0.0189482
HPCAL1 hippocalcin-like 1 -0.0185973
TFPI2 tissue factor pathway inhibitor 2 -0.0184684
VPS37B vacuolar protein sorting 37 homolog B (S. cerevisiae) -0.0183872
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa -0.0182321
RPS8 ribosomal protein S8 -0.0182041
DHRS3 dehydrogenase/reductase (SDR family) member 3 -0.0180183
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme -0.0179823
EREG epiregulin -0.0179745
CCT8 chaperonin containing TCP1, subunit 8 (theta) -0.0176738
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0176044
TFRC transferrin receptor -0.0175333
TKT transketolase -0.0174413
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.0173411
PSMC6 proteasome (prosome, macropain) 26S subunit, ATPase, 6 -0.0172227
TNPO1 transportin 1 -0.0170673
TM9SF3 transmembrane 9 superfamily member 3 -0.0170345
FXR1 fragile X mental retardation, autosomal homolog 1 -0.0167361
RPL11 ribosomal protein L11 -0.0166346
HMGB2 high mobility group box 2 -0.0165314
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 -0.0165042
TPM1 tropomyosin 1 (alpha) -0.0164496
SEC11A SEC11 homolog A (S. cerevisiae) -0.016363
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) -0.016358
CDC73 cell division cycle 73 -0.0161153
RAD21 RAD21 homolog (S. pombe) -0.0159988