| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Esmolol (hydrochloride) perturbation in HCT15 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Esmolol (hydrochloride)_HCT15 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.349583 |
| EZR | ezrin | 0.117485 |
| DSCAM | Down syndrome cell adhesion molecule | 0.108655 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.101219 |
| FAT1 | FAT atypical cadherin 1 | 0.0997221 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0915316 |
| MCL1 | myeloid cell leukemia 1 | 0.0869972 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0832481 |
| EGR1 | early growth response 1 | 0.0815439 |
| VCL | vinculin | 0.0766549 |
| AHNAK | AHNAK nucleoprotein | 0.0754213 |
| TENM3 | teneurin transmembrane protein 3 | 0.0749728 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0740316 |
| PRELID2 | PRELI domain containing 2 | 0.0729279 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0726743 |
| TXNRD1 | thioredoxin reductase 1 | 0.06559 |
| KDM4C | lysine (K)-specific demethylase 4C | 0.061575 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0579718 |
| FHIT | fragile histidine triad | 0.0571034 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0562624 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | 0.0550272 |
| SMYD3 | SET and MYND domain containing 3 | 0.0540081 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0533869 |
| VMP1 | vacuole membrane protein 1 | 0.0514678 |
| RAD51B | RAD51 paralog B | 0.0504798 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0498176 |
| ANXA2 | annexin A2 | 0.0485519 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0480524 |
| NEBL | nebulette | 0.0474489 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0473069 |
| ACTN4 | actinin, alpha 4 | 0.0466035 |
| KRT8 | keratin 8, type II | 0.0463067 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0460709 |
| POTEF | POTE ankyrin domain family, member F | 0.0452166 |
| GPHN | gephyrin | 0.0449718 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0444954 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0432626 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | 0.0432147 |
| TJP1 | tight junction protein 1 | 0.043157 |
| PATJ | PATJ crumbs cell polarity complex component | 0.0429498 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0428658 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | 0.0426988 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.042563 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0415108 |
| SQSTM1 | sequestosome 1 | 0.0407997 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0404291 |
| EXOC6B | exocyst complex component 6B | 0.0402881 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.040112 |
| BBX | bobby sox homolog (Drosophila) | 0.0394273 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0391021 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0387503 |
| SPIDR | scaffolding protein involved in DNA repair | 0.0386075 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0379921 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0379008 |
| LSR | lipolysis stimulated lipoprotein receptor | 0.0378829 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0370226 |
| MED13L | mediator complex subunit 13-like | 0.037017 |
| WWC1 | WW and C2 domain containing 1 | 0.0367606 |
| JUN | jun proto-oncogene | 0.0366701 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0362744 |
| DOCK5 | dedicator of cytokinesis 5 | 0.036035 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0356784 |
| ANKRD17 | ankyrin repeat domain 17 | 0.035623 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | 0.035462 |
| SBF2 | SET binding factor 2 | 0.0354226 |
| ASPH | aspartate beta-hydroxylase | 0.0352742 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0351207 |
| WDFY3 | WD repeat and FYVE domain containing 3 | 0.0348777 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.034812 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.0346596 |
| ZNF292 | zinc finger protein 292 | 0.0342786 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0342353 |
| ZC3H12B | zinc finger CCCH-type containing 12B | 0.0340909 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | 0.0339628 |
| ATXN1 | ataxin 1 | 0.0336772 |
| KLF6 | Kruppel-like factor 6 | 0.0329035 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0328835 |
| RPS2 | ribosomal protein S2 | 0.0328658 |
| RCOR1 | REST corepressor 1 | 0.0321717 |
| NF1 | neurofibromin 1 | 0.0320874 |
| SHROOM3 | shroom family member 3 | 0.0315518 |
| PRRC2B | proline-rich coiled-coil 2B | 0.0315323 |
| APP | amyloid beta (A4) precursor protein | 0.0314387 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0314196 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0311811 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | 0.0307352 |
| RPL3 | ribosomal protein L3 | 0.030595 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0302154 |
| ARL5B | ADP-ribosylation factor-like 5B | 0.0301012 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.0298537 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0297214 |
| STK24 | serine/threonine kinase 24 | 0.0296515 |
| WWC2 | WW and C2 domain containing 2 | 0.0292194 |
| FER | fer (fps/fes related) tyrosine kinase | 0.0290243 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0289258 |
| DSPP | dentin sialophosphoprotein | 0.0287201 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.028714 |
| ACTG1 | actin gamma 1 | 0.0287016 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0284283 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | 0.0280453 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PTMA | prothymosin, alpha | -0.161771 |
| NDRG1 | N-myc downstream regulated 1 | -0.15181 |
| TMSB10 | thymosin beta 10 | -0.0904712 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0715329 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0543588 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0531584 |
| RPL35A | ribosomal protein L35a | -0.0384542 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0345074 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0333947 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0279115 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0277107 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.027481 |
| FTL | ferritin, light polypeptide | -0.0271097 |
| RPS24 | ribosomal protein S24 | -0.0268991 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0265859 |
| S100A6 | S100 calcium binding protein A6 | -0.0262336 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0253075 |
| FUT11 | fucosyltransferase 11 (alpha (1,3) fucosyltransferase) | -0.024882 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0246866 |
| RPS27A | ribosomal protein S27a | -0.0243668 |
| DDIT4 | DNA-damage-inducible transcript 4 | -0.0240387 |
| RPS13 | ribosomal protein S13 | -0.0219623 |
| SRP54 | signal recognition particle 54kDa | -0.0218488 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.021708 |
| MXI1 | MAX interactor 1, dimerization protein | -0.0207843 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0202743 |
| HOOK2 | hook microtubule-tethering protein 2 | -0.0200663 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0196828 |
| RSL1D1 | ribosomal L1 domain containing 1 | -0.0196451 |
| RPL34 | ribosomal protein L34 | -0.0191602 |
| FAM162A | family with sequence similarity 162, member A | -0.0190292 |
| WASF2 | WAS protein family, member 2 | -0.0190144 |
| CANX | calnexin | -0.0189511 |
| S100A9 | S100 calcium binding protein A9 | -0.0185281 |
| RNMT | RNA (guanine-7-) methyltransferase | -0.018389 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.018307 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0180849 |
| RPL8 | ribosomal protein L8 | -0.0171904 |
| CCNI | cyclin I | -0.0169777 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | -0.0165533 |
| CCT8 | chaperonin containing TCP1, subunit 8 (theta) | -0.0164266 |
| OSBP | oxysterol binding protein | -0.0160621 |
| RPS3 | ribosomal protein S3 | -0.0158812 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0158223 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0157176 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0156855 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0156294 |
| MTDH | metadherin | -0.0156146 |
| RPS25 | ribosomal protein S25 | -0.0155766 |
| COPB2 | coatomer protein complex, subunit beta 2 (beta prime) | -0.0155192 |
| DEK | DEK proto-oncogene | -0.015415 |
| ZNF395 | zinc finger protein 395 | -0.0154113 |
| EPCAM | epithelial cell adhesion molecule | -0.0153761 |
| TOMM20 | translocase of outer mitochondrial membrane 20 homolog (yeast) | -0.0153473 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | -0.0152337 |
| RPL32 | ribosomal protein L32 | -0.0152314 |
| LMNA | lamin A/C | -0.0151924 |
| RPS29 | ribosomal protein S29 | -0.0151747 |
| RPL31 | ribosomal protein L31 | -0.0151642 |
| TUBA1B | tubulin, alpha 1b | -0.0150345 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0149542 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0147985 |
| CCND1 | cyclin D1 | -0.0147641 |
| FN1 | fibronectin 1 | -0.01468 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0146059 |
| FBL | fibrillarin | -0.014567 |
| VEGFA | vascular endothelial growth factor A | -0.0145435 |
| RPLP1 | ribosomal protein, large, P1 | -0.0140087 |
| CDCP1 | CUB domain containing protein 1 | -0.0139454 |
| TMEM123 | transmembrane protein 123 | -0.0138727 |
| GOLPH3L | golgi phosphoprotein 3-like | -0.013792 |
| RPL38 | ribosomal protein L38 | -0.0137916 |
| WDR45B | WD repeat domain 45B | -0.0137216 |
| HLA-A | major histocompatibility complex, class I, A | -0.0136236 |
| FAM117B | family with sequence similarity 117, member B | -0.013453 |
| RPLP2 | ribosomal protein, large, P2 | -0.0133254 |
| IGFBP4 | insulin-like growth factor binding protein 4 | -0.0132717 |
| RPS15 | ribosomal protein S15 | -0.0131741 |
| S100A10 | S100 calcium binding protein A10 | -0.0131029 |
| DCAF7 | DDB1 and CUL4 associated factor 7 | -0.013066 |
| ACBD3 | acyl-CoA binding domain containing 3 | -0.0129597 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0128882 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0126728 |
| PDGFA | platelet-derived growth factor alpha polypeptide | -0.0125425 |
| CA9 | carbonic anhydrase IX | -0.0124607 |
| SEC61G | Sec61 gamma subunit | -0.0124342 |
| PERP | PERP, TP53 apoptosis effector | -0.0123906 |
| RPS8 | ribosomal protein S8 | -0.0121812 |
| RPS5 | ribosomal protein S5 | -0.0121221 |
| RIOK3 | RIO kinase 3 | -0.0121027 |
| IKBIP | IKBKB interacting protein | -0.0120758 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.011963 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0118992 |
| ERLEC1 | endoplasmic reticulum lectin 1 | -0.0117303 |
| HM13 | histocompatibility (minor) 13 | -0.0117033 |
| POLR3D | polymerase (RNA) III (DNA directed) polypeptide D, 44kDa | -0.0116919 |
| EIF3M | eukaryotic translation initiation factor 3, subunit M | -0.0116813 |
| ARF1 | ADP-ribosylation factor 1 | -0.0116688 |
| RPS10 | ribosomal protein S10 | -0.0116133 |
| MLLT6 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6 | -0.0115836 |
