Esmolol (hydrochloride)_HEC-1-A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Esmolol (hydrochloride) perturbation in HEC-1-A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Esmolol (hydrochloride)_HEC-1-A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MYH9 myosin, heavy chain 9, non-muscle 0.0626186
PRELID2 PRELI domain containing 2 0.0568003
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0541819
ITGB8 integrin, beta 8 0.0522958
APP amyloid beta (A4) precursor protein 0.051012
PAX8 paired box 8 0.0497308
SMAD3 SMAD family member 3 0.0494398
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0445865
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0421404
FLNA filamin A, alpha 0.0385783
FNDC3B fibronectin type III domain containing 3B 0.0378699
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0368626
LPP LIM domain containing preferred translocation partner in lipoma 0.0361312
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0356842
HELZ helicase with zinc finger 0.0310651
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0299964
MBD5 methyl-CpG binding domain protein 5 0.0299642
SRRM2 serine/arginine repetitive matrix 2 0.029788
OSBPL10 oxysterol binding protein-like 10 0.0287029
SLTM SAFB-like, transcription modulator 0.0282255
MACROD2 MACRO domain containing 2 0.0259975
ANKRD36 ankyrin repeat domain 36 0.0256272
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0255237
RAD51B RAD51 paralog B 0.0252157
LIMCH1 LIM and calponin homology domains 1 0.0248663
ZNF638 zinc finger protein 638 0.0242705
TTC3 tetratricopeptide repeat domain 3 0.0238299
NRIP1 nuclear receptor interacting protein 1 0.0232946
SVIL supervillin 0.0229812
PTPN3 protein tyrosine phosphatase, non-receptor type 3 0.0227833
PCSK5 proprotein convertase subtilisin/kexin type 5 0.0221496
APLP2 amyloid beta (A4) precursor-like protein 2 0.0221088
AFDN afadin, adherens junction formation factor 0.0220504
ARHGAP29 Rho GTPase activating protein 29 0.0217953
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0217326
SETD5 SET domain containing 5 0.0216487
MACF1 microtubule-actin crosslinking factor 1 0.0210838
FTH1 ferritin, heavy polypeptide 1 0.0210458
MIDEAS mitotic deacetylase associated SANT domain protein 0.0207177
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0206202
EGFR epidermal growth factor receptor 0.0204759
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0204254
NF1 neurofibromin 1 0.0201689
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0200904
PSD3 pleckstrin and Sec7 domain containing 3 0.0199296
SEPTIN9 septin 9 0.0195918
TGFA transforming growth factor, alpha 0.0194231
FNIP1 folliculin interacting protein 1 0.0193724
KAZN kazrin, periplakin interacting protein 0.0188526
KMT2C lysine (K)-specific methyltransferase 2C 0.0185867
SEC14L1 SEC14-like 1 (S. cerevisiae) 0.018295
TBC1D5 TBC1 domain family, member 5 0.0182312
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0180467
GSK3B glycogen synthase kinase 3 beta 0.0179996
SBF2 SET binding factor 2 0.0176624
SMYD3 SET and MYND domain containing 3 0.0176623
CREB5 cAMP responsive element binding protein 5 0.0176178
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0176105
ZBTB20 zinc finger and BTB domain containing 20 0.0175557
UTRN utrophin 0.01741
WWC1 WW and C2 domain containing 1 0.0172299
BICC1 BicC family RNA binding protein 1 0.0171841
TRIO trio Rho guanine nucleotide exchange factor 0.0170936
ANKRD10 ankyrin repeat domain 10 0.0170275
RNF213 ring finger protein 213 0.0169617
MYEOV myeloma overexpressed 0.0165382
DIAPH1 diaphanous-related formin 1 0.0165001
KDM6A lysine (K)-specific demethylase 6A 0.0164637
ATXN7 ataxin 7 0.0163261
ANKRD17 ankyrin repeat domain 17 0.0161753
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0156288
GOLGB1 golgin B1 0.0154936
LAMA5 laminin, alpha 5 0.0153927
PICALM phosphatidylinositol binding clathrin assembly protein 0.0153841
PRRC2A proline-rich coiled-coil 2A 0.0153273
RUNX1 runt-related transcription factor 1 0.0152579
KIRREL1 kirre like nephrin family adhesion molecule 1 0.0152413
MPRIP myosin phosphatase Rho interacting protein 0.0150761
CTBP2 C-terminal binding protein 2 0.0150311
PATJ PATJ crumbs cell polarity complex component 0.014834
AGRN agrin 0.0148066
GOLGA4 golgin A4 0.0147622
SHB Src homology 2 domain containing adaptor protein B 0.0146819
BBS9 Bardet-Biedl syndrome 9 0.0146228
PHF3 PHD finger protein 3 0.0146125
SORL1 sortilin-related receptor, L(DLR class) A repeats containing 0.0145143
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0144381
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0144283
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0143966
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae) 0.0142249
NFIB nuclear factor I/B 0.0141808
JMJD1C jumonji domain containing 1C 0.0141269
PDGFC platelet derived growth factor C 0.0139518
CDK5RAP2 CDK5 regulatory subunit associated protein 2 0.0139288
AFF1 AF4/FMR2 family, member 1 0.0138774
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0138541
HSPA8 heat shock 70kDa protein 8 0.0138485
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0136937
ZNF292 zinc finger protein 292 0.0136374
ARID1A AT rich interactive domain 1A (SWI-like) 0.0136366

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.238262
MT2A metallothionein 2A -0.14629
FTL ferritin, light polypeptide -0.118467
RPL35A ribosomal protein L35a -0.115821
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.109005
PTMA prothymosin, alpha -0.108881
TPT1 tumor protein, translationally-controlled 1 -0.106668
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0670338
RPL23 ribosomal protein L23 -0.0605438
RPLP1 ribosomal protein, large, P1 -0.0595649
KRT7 keratin 7, type II -0.0592854
RPS8 ribosomal protein S8 -0.0579401
RPL31 ribosomal protein L31 -0.0579034
RPL34 ribosomal protein L34 -0.0566596
RPS24 ribosomal protein S24 -0.0561635
RPS19 ribosomal protein S19 -0.0546524
RPL12 ribosomal protein L12 -0.0540139
S100A10 S100 calcium binding protein A10 -0.0523836
RPS6 ribosomal protein S6 -0.0495886
LAMB3 laminin, beta 3 -0.0488154
CCND1 cyclin D1 -0.0485182
RPL32 ribosomal protein L32 -0.0478504
PKM pyruvate kinase, muscle -0.0465561
ACTG1 actin gamma 1 -0.0464657
RPL19 ribosomal protein L19 -0.0462261
TMSB4X thymosin beta 4, X-linked -0.0454705
TPM4 tropomyosin 4 -0.0447699
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0438248
B2M beta-2-microglobulin -0.0435515
RPLP0 ribosomal protein, large, P0 -0.0431175
S100A6 S100 calcium binding protein A6 -0.0413488
RPS27A ribosomal protein S27a -0.0402523
RPL9 ribosomal protein L9 -0.0402422
RPL11 ribosomal protein L11 -0.0375922
NDRG1 N-myc downstream regulated 1 -0.0370862
EIF1 eukaryotic translation initiation factor 1 -0.036635
RPLP2 ribosomal protein, large, P2 -0.0354555
HMGA1 high mobility group AT-hook 1 -0.0354347
RPS5 ribosomal protein S5 -0.0339484
HMGB1 high mobility group box 1 -0.0335072
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0333863
RPS21 ribosomal protein S21 -0.0333439
RPL5 ribosomal protein L5 -0.0330386
AHNAK AHNAK nucleoprotein -0.0328541
LMNA lamin A/C -0.0322786
RPS14 ribosomal protein S14 -0.0314732
RPL26 ribosomal protein L26 -0.0307726
RPS17 ribosomal protein S17 -0.0306251
TPI1 triosephosphate isomerase 1 -0.0306038
RPL37A ribosomal protein L37a -0.0303885
RPL7A ribosomal protein L7a -0.0295992
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0289599
RPS3 ribosomal protein S3 -0.0283951
RPL38 ribosomal protein L38 -0.0279237
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0279102
RACK1 receptor for activated C kinase 1 -0.0276553
RPS16 ribosomal protein S16 -0.0276436
RPL35 ribosomal protein L35 -0.0274982
RPS13 ribosomal protein S13 -0.0274533
RPS25 ribosomal protein S25 -0.0272169
RPS29 ribosomal protein S29 -0.0265008
GNAS GNAS complex locus -0.0261661
RPL15 ribosomal protein L15 -0.0261556
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0256007
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0255522
SEPTIN7 septin 7 -0.0253831
RPS15 ribosomal protein S15 -0.0250069
DSG2 desmoglein 2 -0.0249619
RPS4X ribosomal protein S4, X-linked -0.0249219
ENO1 enolase 1, (alpha) -0.024811
VDAC1 voltage-dependent anion channel 1 -0.0243357
RPS23 ribosomal protein S23 -0.0242334
CBX3 chromobox homolog 3 -0.0242277
DEK DEK proto-oncogene -0.0240959
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0239671
S100A9 S100 calcium binding protein A9 -0.0237454
RPS11 ribosomal protein S11 -0.0235876
KRT19 keratin 19, type I -0.0227524
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0226475
RPL7 ribosomal protein L7 -0.0225069
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0224107
EMP1 epithelial membrane protein 1 -0.0222326
RPL8 ribosomal protein L8 -0.0221452
SH3KBP1 SH3-domain kinase binding protein 1 -0.0215244
TUBA1B tubulin, alpha 1b -0.0213266
RSL1D1 ribosomal L1 domain containing 1 -0.0209616
RPL36A ribosomal protein L36a -0.0209377
S100A4 S100 calcium binding protein A4 -0.0209001
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0208524
TUBB4B tubulin, beta 4B class IVb -0.0207639
RPS10 ribosomal protein S10 -0.0205345
CD44 CD44 molecule (Indian blood group) -0.0203547
LAMA4 laminin, alpha 4 -0.0203532
CD63 CD63 molecule -0.0202835
PGK1 phosphoglycerate kinase 1 -0.0202553
FAM162A family with sequence similarity 162, member A -0.0201156
KLF6 Kruppel-like factor 6 -0.0200503
MYL12B myosin, light chain 12B, regulatory -0.0198238
PFN1 profilin 1 -0.0197355
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0197249