| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Esmolol (hydrochloride) perturbation in HOP62 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Esmolol (hydrochloride)_HOP62 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.341906 |
| FAM13A | family with sequence similarity 13, member A | 0.0872498 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0679252 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0644219 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0592342 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.055953 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0546504 |
| COL6A2 | collagen, type VI, alpha 2 | 0.0529336 |
| SEPTIN9 | septin 9 | 0.0503489 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0450627 |
| SMAD3 | SMAD family member 3 | 0.0443541 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 0.0436156 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.042557 |
| FN1 | fibronectin 1 | 0.0405233 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0400913 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.0377358 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0339461 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0313726 |
| SPAG9 | sperm associated antigen 9 | 0.031151 |
| DUSP6 | dual specificity phosphatase 6 | 0.0310211 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0309615 |
| MCL1 | myeloid cell leukemia 1 | 0.0302825 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.0296006 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0292548 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0282595 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0272773 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0270385 |
| MT2A | metallothionein 2A | 0.0270235 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0270209 |
| ZNF292 | zinc finger protein 292 | 0.0267591 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | 0.0266772 |
| NGLY1 | N-glycanase 1 | 0.0261497 |
| HELZ | helicase with zinc finger | 0.0259023 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0253448 |
| EGR1 | early growth response 1 | 0.0252012 |
| FLNA | filamin A, alpha | 0.0251275 |
| ADM | adrenomedullin | 0.0247793 |
| RNF24 | ring finger protein 24 | 0.0246316 |
| RLF | rearranged L-myc fusion | 0.0244279 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0244225 |
| TXNIP | thioredoxin interacting protein | 0.0228133 |
| SETD5 | SET domain containing 5 | 0.0226572 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0225295 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0223091 |
| MIMS1 | mitochondrial inner membrane scaffold 1 | 0.0221857 |
| FLNB | filamin B, beta | 0.022077 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.021645 |
| MSN | moesin | 0.0214568 |
| COL6A1 | collagen, type VI, alpha 1 | 0.0213399 |
| RNMT | RNA (guanine-7-) methyltransferase | 0.0211066 |
| CD109 | CD109 molecule | 0.0208881 |
| USP3 | ubiquitin specific peptidase 3 | 0.0208877 |
| LOX | lysyl oxidase | 0.0208171 |
| GOLGA4 | golgin A4 | 0.020424 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.019944 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0198802 |
| RPL3 | ribosomal protein L3 | 0.0192669 |
| ATP13A3 | ATPase type 13A3 | 0.0192484 |
| DNMBP | dynamin binding protein | 0.0190217 |
| WDR45B | WD repeat domain 45B | 0.0189926 |
| MIS18BP1 | MIS18 binding protein 1 | 0.0187126 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0186004 |
| ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3 | 0.0185883 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0185545 |
| YBX3 | Y box binding protein 3 | 0.018519 |
| PLEC | plectin | 0.0182143 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0182088 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.018196 |
| TGFB1 | transforming growth factor, beta 1 | 0.0179139 |
| APP | amyloid beta (A4) precursor protein | 0.0178794 |
| CAPRIN2 | caprin family member 2 | 0.0177528 |
| RPS2 | ribosomal protein S2 | 0.0177031 |
| HP1BP3 | heterochromatin protein 1, binding protein 3 | 0.0175581 |
| SEC24A | SEC24 family member A | 0.0174782 |
| HPCAL1 | hippocalcin-like 1 | 0.0171065 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0170053 |
| NUP58 | nucleoporin 58 | 0.0169512 |
| DOT1L | DOT1-like histone H3K79 methyltransferase | 0.0168665 |
| OGA | O-GlcNAcase | 0.0167455 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0167421 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0166811 |
| DHX15 | DEAH (Asp-Glu-Ala-His) box helicase 15 | 0.01639 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0163306 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | 0.0163017 |
| PRRC2A | proline-rich coiled-coil 2A | 0.0162504 |
| VMP1 | vacuole membrane protein 1 | 0.0161903 |
| SRP54 | signal recognition particle 54kDa | 0.0158228 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0158034 |
| COPA | coatomer protein complex, subunit alpha | 0.0157912 |
| AXL | AXL receptor tyrosine kinase | 0.0156092 |
| AFDN | afadin, adherens junction formation factor | 0.0155583 |
| IRS2 | insulin receptor substrate 2 | 0.0155436 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0153172 |
| PDE10A | phosphodiesterase 10A | 0.0151468 |
| UBE2O | ubiquitin-conjugating enzyme E2O | 0.0151264 |
| SUPT6H | suppressor of Ty 6 homolog (S. cerevisiae) | 0.014951 |
| MIDEAS | mitotic deacetylase associated SANT domain protein | 0.014597 |
| RPL28 | ribosomal protein L28 | 0.0145745 |
| NECTIN2 | nectin cell adhesion molecule 2 | 0.0144189 |
| AGRN | agrin | 0.0144172 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.351043 |
| TMSB10 | thymosin beta 10 | -0.172314 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.1177 |
| IGF2 | insulin-like growth factor 2 | -0.115357 |
| CDH13 | cadherin 13 | -0.102664 |
| ASPH | aspartate beta-hydroxylase | -0.0993498 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0857805 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0770546 |
| AHNAK | AHNAK nucleoprotein | -0.0741366 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0681223 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0667456 |
| LAMB3 | laminin, beta 3 | -0.0613556 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0611116 |
| HMGA2 | high mobility group AT-hook 2 | -0.0609217 |
| COL5A1 | collagen, type V, alpha 1 | -0.0553155 |
| MYO10 | myosin X | -0.0545315 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0542659 |
| NAV1 | neuron navigator 1 | -0.0512869 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0499817 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0494567 |
| RAI14 | retinoic acid induced 14 | -0.045937 |
| CLMP | CXADR-like membrane protein | -0.0458357 |
| ENO1 | enolase 1, (alpha) | -0.0423708 |
| CCND1 | cyclin D1 | -0.0409269 |
| FRMD4A | FERM domain containing 4A | -0.040665 |
| DIAPH2 | diaphanous-related formin 2 | -0.0381152 |
| RPS24 | ribosomal protein S24 | -0.0379925 |
| RPL35A | ribosomal protein L35a | -0.0371074 |
| PRSS23 | protease, serine, 23 | -0.0368102 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0361815 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.035375 |
| TPM4 | tropomyosin 4 | -0.0349257 |
| RPLP1 | ribosomal protein, large, P1 | -0.0348158 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0343941 |
| AFF3 | AF4/FMR2 family, member 3 | -0.033464 |
| RRBP1 | ribosome binding protein 1 | -0.0327359 |
| INHBA | inhibin, beta A | -0.0326025 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0324396 |
| S100A10 | S100 calcium binding protein A10 | -0.0301585 |
| CALR | calreticulin | -0.0298252 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0297672 |
| TPM1 | tropomyosin 1 (alpha) | -0.0297254 |
| CDK6 | cyclin-dependent kinase 6 | -0.0295663 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0293658 |
| ANXA2 | annexin A2 | -0.0292211 |
| FMN1 | formin 1 | -0.0291485 |
| RPL34 | ribosomal protein L34 | -0.0289364 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0273913 |
| ARHGAP22 | Rho GTPase activating protein 22 | -0.0266846 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | -0.026381 |
| SLC16A3 | solute carrier family 16 (monocarboxylate transporter), member 3 | -0.0262519 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.0260497 |
| PGK1 | phosphoglycerate kinase 1 | -0.0254625 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0248673 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0248298 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0245189 |
| RPL31 | ribosomal protein L31 | -0.0244987 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0244368 |
| MMP14 | matrix metallopeptidase 14 (membrane-inserted) | -0.0242897 |
| ERGIC1 | endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 | -0.0242469 |
| ACTG1 | actin gamma 1 | -0.0242291 |
| ATXN1 | ataxin 1 | -0.0240653 |
| KIAA1549L | KIAA1549-like | -0.0237921 |
| ZBTB38 | zinc finger and BTB domain containing 38 | -0.0237703 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0236782 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0236615 |
| TUBB6 | tubulin, beta 6 class V | -0.0236402 |
| EGFR | epidermal growth factor receptor | -0.0230691 |
| DST | dystonin | -0.0227208 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.022564 |
| PRELID2 | PRELI domain containing 2 | -0.022537 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0225217 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0220535 |
| RPS8 | ribosomal protein S8 | -0.021731 |
| CAPN2 | calpain 2, (m/II) large subunit | -0.0217285 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0215282 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0213136 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0212703 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.0211281 |
| TPI1 | triosephosphate isomerase 1 | -0.0211153 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | -0.0210221 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0205359 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.020307 |
| CDCP1 | CUB domain containing protein 1 | -0.0201947 |
| GNAS | GNAS complex locus | -0.0201505 |
| CUX1 | cut-like homeobox 1 | -0.0200532 |
| CANX | calnexin | -0.0199321 |
| PRKCA | protein kinase C, alpha | -0.0197164 |
| PRH1 | proline-rich protein HaeIII subfamily 1 | -0.0197146 |
| NAV3 | neuron navigator 3 | -0.0196877 |
| MTDH | metadherin | -0.0196792 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0196436 |
| BCAT1 | branched chain amino-acid transaminase 1, cytosolic | -0.0195894 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0195813 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | -0.0194795 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0193351 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0193231 |
| RAD51B | RAD51 paralog B | -0.0192964 |
| PTMA | prothymosin, alpha | -0.019263 |
| TMSB4X | thymosin beta 4, X-linked | -0.0190126 |
