| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Esmolol (hydrochloride) perturbation in HS-578T cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Esmolol (hydrochloride)_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | 0.516162 |
| COL6A3 | collagen, type VI, alpha 3 | 0.167636 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0830888 |
| CD44 | CD44 molecule (Indian blood group) | 0.0743654 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | 0.0728937 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0702196 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0572 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0571205 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0549015 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0524801 |
| MAP1B | microtubule-associated protein 1B | 0.0505597 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0494978 |
| VEGFA | vascular endothelial growth factor A | 0.0459335 |
| DPYSL3 | dihydropyrimidinase-like 3 | 0.0455811 |
| LDHA | lactate dehydrogenase A | 0.0441248 |
| ATP13A3 | ATPase type 13A3 | 0.0435768 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.042992 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | 0.0423054 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0401281 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.0385191 |
| LOX | lysyl oxidase | 0.0383675 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0374637 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0371105 |
| VCL | vinculin | 0.0334651 |
| HMGA2 | high mobility group AT-hook 2 | 0.0325531 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0322877 |
| CLIC4 | chloride intracellular channel 4 | 0.0316425 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0313247 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | 0.0307362 |
| EGR1 | early growth response 1 | 0.0299194 |
| FLNA | filamin A, alpha | 0.0297837 |
| PRELID2 | PRELI domain containing 2 | 0.02974 |
| SMAD3 | SMAD family member 3 | 0.0296714 |
| MSN | moesin | 0.0290318 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0285382 |
| PALLD | palladin, cytoskeletal associated protein | 0.0278404 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0277614 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0272533 |
| ECE1 | endothelin converting enzyme 1 | 0.0268081 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0257571 |
| COL6A1 | collagen, type VI, alpha 1 | 0.0256521 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0255595 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0252624 |
| VMP1 | vacuole membrane protein 1 | 0.0252621 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0248581 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0248171 |
| AXL | AXL receptor tyrosine kinase | 0.0245366 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0244911 |
| JAK2 | Janus kinase 2 | 0.0241255 |
| LTBP1 | latent transforming growth factor beta binding protein 1 | 0.0241188 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0236971 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0234951 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.023144 |
| NOTCH2 | notch 2 | 0.0230251 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0226964 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0222792 |
| SPAG9 | sperm associated antigen 9 | 0.0220917 |
| CYB5R3 | cytochrome b5 reductase 3 | 0.0220316 |
| SETD5 | SET domain containing 5 | 0.0219391 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0219098 |
| H1-0 | H1.0 linker histone | 0.0216041 |
| NAV1 | neuron navigator 1 | 0.021589 |
| ENO1 | enolase 1, (alpha) | 0.0213637 |
| NKAIN3 | Na+/K+ transporting ATPase interacting 3 | 0.0209652 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0209119 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0208992 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0207993 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0204412 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.020337 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | 0.0202865 |
| RASA2 | RAS p21 protein activator 2 | 0.0202203 |
| HP1BP3 | heterochromatin protein 1, binding protein 3 | 0.020196 |
| RIGI | RNA sensor RIG-I | 0.0201728 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0197184 |
| TAPBP | TAP binding protein (tapasin) | 0.0196815 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0196475 |
| SQLE | squalene epoxidase | 0.0194571 |
| PDE10A | phosphodiesterase 10A | 0.0192747 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0191355 |
| WASF2 | WAS protein family, member 2 | 0.0190099 |
| ARHGAP29 | Rho GTPase activating protein 29 | 0.0188596 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.0188447 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0188424 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0188013 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0187533 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0186914 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0186742 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0184581 |
| LENG8 | leukocyte receptor cluster (LRC) member 8 | 0.0184286 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0184175 |
| DSTN | destrin (actin depolymerizing factor) | 0.0180778 |
| ATXN1 | ataxin 1 | 0.018065 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.0173407 |
| RBFOX2 | RNA binding protein, fox-1 homolog (C. elegans) 2 | 0.0173404 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0173208 |
| APP | amyloid beta (A4) precursor protein | 0.0172193 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0171633 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0171352 |
| DST | dystonin | 0.0171296 |
| TFG | TRK-fused gene | 0.0170907 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.133615 |
| IER3 | immediate early response 3 | -0.115727 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.109471 |
| TMSB10 | thymosin beta 10 | -0.105679 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.100595 |
| MT2A | metallothionein 2A | -0.0785769 |
| NDRG1 | N-myc downstream regulated 1 | -0.0729937 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0727773 |
| CDH13 | cadherin 13 | -0.0685796 |
| RPL35A | ribosomal protein L35a | -0.0563616 |
| TPM4 | tropomyosin 4 | -0.0538455 |
| CADM1 | cell adhesion molecule 1 | -0.0504563 |
| COL1A2 | collagen, type I, alpha 2 | -0.0487422 |
| PTMA | prothymosin, alpha | -0.047528 |
| FTL | ferritin, light polypeptide | -0.0463331 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0434933 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0427166 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0422055 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0421925 |
| CAVIN1 | caveolae associated protein 1 | -0.0402771 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0378401 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0367732 |
| STC1 | stanniocalcin 1 | -0.0358554 |
| RPS8 | ribosomal protein S8 | -0.0351126 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0329061 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0320707 |
| RRBP1 | ribosome binding protein 1 | -0.0312572 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0301159 |
| MTDH | metadherin | -0.0295756 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0289429 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0270221 |
| CALR | calreticulin | -0.0266968 |
| TMSB4X | thymosin beta 4, X-linked | -0.0259382 |
| COL5A1 | collagen, type V, alpha 1 | -0.025708 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0248946 |
| RPLP1 | ribosomal protein, large, P1 | -0.0248202 |
| S100A9 | S100 calcium binding protein A9 | -0.0246565 |
| RPS24 | ribosomal protein S24 | -0.0238942 |
| GNAS | GNAS complex locus | -0.0235863 |
| HLA-B | major histocompatibility complex, class I, B | -0.0235188 |
| S100A6 | S100 calcium binding protein A6 | -0.0232907 |
| RPL23 | ribosomal protein L23 | -0.0226603 |
| CLMP | CXADR-like membrane protein | -0.0226159 |
| COL3A1 | collagen, type III, alpha 1 | -0.0222916 |
| ARL4C | ADP-ribosylation factor-like 4C | -0.0218969 |
| RPL34 | ribosomal protein L34 | -0.02183 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0210596 |
| S100A10 | S100 calcium binding protein A10 | -0.0203271 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.020154 |
| RPL31 | ribosomal protein L31 | -0.0201099 |
| RPS27A | ribosomal protein S27a | -0.0193676 |
| RPL38 | ribosomal protein L38 | -0.0189741 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0181678 |
| ADM | adrenomedullin | -0.0179769 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | -0.0179056 |
| SEC61G | Sec61 gamma subunit | -0.017732 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0176909 |
| LOXL2 | lysyl oxidase-like 2 | -0.0176322 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.017501 |
| EEF1D | eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) | -0.017419 |
| ACTG1 | actin gamma 1 | -0.01727 |
| RPS21 | ribosomal protein S21 | -0.0171906 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | -0.0169792 |
| JARID2 | jumonji, AT rich interactive domain 2 | -0.0166985 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0166347 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0163626 |
| COL1A1 | collagen, type I, alpha 1 | -0.0163082 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0161271 |
| AHNAK | AHNAK nucleoprotein | -0.0159632 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0159392 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0158698 |
| RPS19 | ribosomal protein S19 | -0.0158271 |
| RNF168 | ring finger protein 168, E3 ubiquitin protein ligase | -0.015723 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0156089 |
| RPL11 | ribosomal protein L11 | -0.0155792 |
| CD63 | CD63 molecule | -0.0154429 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0153684 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0150349 |
| SLC24A3 | solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 | -0.0150322 |
| LMNA | lamin A/C | -0.014949 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0148849 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0146912 |
| SORBS2 | sorbin and SH3 domain containing 2 | -0.0144531 |
| CCND1 | cyclin D1 | -0.014354 |
| LAMB3 | laminin, beta 3 | -0.0141908 |
| RPL12 | ribosomal protein L12 | -0.0141847 |
| RPL5 | ribosomal protein L5 | -0.0139978 |
| RPS15 | ribosomal protein S15 | -0.0137623 |
| RPL37A | ribosomal protein L37a | -0.0136847 |
| BNC2 | basonuclin 2 | -0.0136603 |
| INHBA | inhibin, beta A | -0.0136267 |
| RPS11 | ribosomal protein S11 | -0.0136217 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0135696 |
| RPLP2 | ribosomal protein, large, P2 | -0.0135679 |
| RPL9 | ribosomal protein L9 | -0.0135193 |
| IL6 | interleukin 6 | -0.0134455 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | -0.0134172 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0133736 |
| ST13 | suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) | -0.0133559 |
| RPL36 | ribosomal protein L36 | -0.0132041 |
