Esmolol (hydrochloride)_HT-29 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Esmolol (hydrochloride) perturbation in HT-29 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Esmolol (hydrochloride)_HT-29 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.139061
SMAD3 SMAD family member 3 0.115807
EXT1 exostosin glycosyltransferase 1 0.111301
LMO7 LIM domain 7 0.0945814
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.088025
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0839024
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 0.0800081
VCL vinculin 0.0795043
FTH1 ferritin, heavy polypeptide 1 0.0775097
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0692258
ZSWIM6 zinc finger, SWIM-type containing 6 0.0635708
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.063147
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0612709
ADARB1 adenosine deaminase, RNA-specific, B1 0.0597072
ERRFI1 ERBB receptor feedback inhibitor 1 0.0586453
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0574569
TJP1 tight junction protein 1 0.0562288
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.054886
BCL2L1 BCL2-like 1 0.0540675
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0485447
FOXO1 forkhead box O1 0.0477952
POTEF POTE ankyrin domain family, member F 0.0441845
SRRM2 serine/arginine repetitive matrix 2 0.0440213
RPL21 ribosomal protein L21 0.0434073
PDLIM5 PDZ and LIM domain 5 0.0431795
NTN4 netrin 4 0.0416643
MYO1E myosin IE 0.0415661
APLP2 amyloid beta (A4) precursor-like protein 2 0.0413866
PDIA3 protein disulfide isomerase family A, member 3 0.0409485
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0405391
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0392791
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0392339
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0381169
NCEH1 neutral cholesterol ester hydrolase 1 0.0372607
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0360051
VMP1 vacuole membrane protein 1 0.0356069
HYOU1 hypoxia up-regulated 1 0.035171
RPL23 ribosomal protein L23 0.0351145
SEPTIN9 septin 9 0.0349657
SGMS2 sphingomyelin synthase 2 0.0348745
MCL1 myeloid cell leukemia 1 0.0348383
SPRED2 sprouty-related, EVH1 domain containing 2 0.0341606
EGR1 early growth response 1 0.0331991
AGRN agrin 0.0331473
CCNYL1 cyclin Y-like 1 0.0331095
PPL periplakin 0.0323695
INTS6 integrator complex subunit 6 0.0322474
FLNB filamin B, beta 0.032107
ATXN1 ataxin 1 0.0317975
RPS6 ribosomal protein S6 0.0313307
MYH9 myosin, heavy chain 9, non-muscle 0.0305411
ACTG1 actin gamma 1 0.03024
ARHGAP29 Rho GTPase activating protein 29 0.0300918
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0300684
ARHGAP42 Rho GTPase activating protein 42 0.029515
MSN moesin 0.0289395
AKAP13 A kinase (PRKA) anchor protein 13 0.0286084
HKDC1 hexokinase domain containing 1 0.0282761
WWC1 WW and C2 domain containing 1 0.0274632
AREG amphiregulin 0.0269933
PDZD8 PDZ domain containing 8 0.0269716
TNS4 tensin 4 0.0260315
SUCO SUN domain containing ossification factor 0.0256758
ARHGAP23 Rho GTPase activating protein 23 0.0253401
HSPA8 heat shock 70kDa protein 8 0.0250126
SHB Src homology 2 domain containing adaptor protein B 0.0249946
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0247292
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 0.0246646
MYOF myoferlin 0.024472
EEF2 eukaryotic translation elongation factor 2 0.0243882
FNDC3B fibronectin type III domain containing 3B 0.0241861
SETX senataxin 0.0241449
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0240806
CEMIP2 cell migration inducing hyaluronidase 2 0.0238016
SAMD4A sterile alpha motif domain containing 4A 0.0237074
SEL1L sel-1 suppressor of lin-12-like (C. elegans) 0.023429
PRKN parkin RBR E3 ubiquitin protein ligase 0.0232567
ITPRID2 ITPR interacting domain containing 2 0.0231626
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 0.0228289
FLNA filamin A, alpha 0.0224068
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 0.0223472
CTBP2 C-terminal binding protein 2 0.0223242
ABHD2 abhydrolase domain containing 2 0.0223079
RBMS2 RNA binding motif, single stranded interacting protein 2 0.0222886
AKAP9 A kinase (PRKA) anchor protein 9 0.0222871
CYSTM1 cysteine-rich transmembrane module containing 1 0.0219627
SIK3 SIK family kinase 3 0.0218549
PDIA4 protein disulfide isomerase family A, member 4 0.0217783
PLK2 polo-like kinase 2 0.0215926
LENG8 leukocyte receptor cluster (LRC) member 8 0.0214438
ERN1 endoplasmic reticulum to nucleus signaling 1 0.020994
TGFA transforming growth factor, alpha 0.0209665
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0209232
FHL2 four and a half LIM domains 2 0.0209193
DST dystonin 0.0206184
FAT1 FAT atypical cadherin 1 0.0204777
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 0.0201626
LATS2 large tumor suppressor kinase 2 0.0201571
EGFR epidermal growth factor receptor 0.0201261
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0199566

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.126745
AHNAK AHNAK nucleoprotein -0.0996846
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0986643
TPT1 tumor protein, translationally-controlled 1 -0.0876791
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0873549
ITPKC inositol-trisphosphate 3-kinase C -0.0795376
TMSB10 thymosin beta 10 -0.0791887
LYZ lysozyme -0.0710517
GMDS GDP-mannose 4,6-dehydratase -0.0696553
NDRG1 N-myc downstream regulated 1 -0.0650097
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0626355
ZMYND8 zinc finger, MYND-type containing 8 -0.0550604
SLC45A4 solute carrier family 45, member 4 -0.0549306
PTK2 protein tyrosine kinase 2 -0.0518946
RAD21 RAD21 homolog (S. pombe) -0.0517468
ACACA acetyl-CoA carboxylase alpha -0.0493158
JUN jun proto-oncogene -0.0471714
DIAPH2 diaphanous-related formin 2 -0.0453426
PGK1 phosphoglycerate kinase 1 -0.0452542
SAMD12 sterile alpha motif domain containing 12 -0.0448401
RRBP1 ribosome binding protein 1 -0.0438549
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0408443
NECTIN2 nectin cell adhesion molecule 2 -0.0407458
MMP7 matrix metallopeptidase 7 -0.0406501
CD2AP CD2-associated protein -0.0404012
ST14 suppression of tumorigenicity 14 (colon carcinoma) -0.0375259
S100A6 S100 calcium binding protein A6 -0.0371862
GARS1 glycyl-tRNA synthetase 1 -0.0367239
NF1 neurofibromin 1 -0.0360691
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0359862
DGKH diacylglycerol kinase, eta -0.0357167
ITGA1 integrin, alpha 1 -0.0355172
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0354337
RPS24 ribosomal protein S24 -0.0348821
TMEM123 transmembrane protein 123 -0.0347952
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0339213
KRT8 keratin 8, type II -0.0336333
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.03294
MYH14 myosin, heavy chain 14, non-muscle -0.0323415
RPLP1 ribosomal protein, large, P1 -0.0323109
PRELID2 PRELI domain containing 2 -0.0322303
MECOM MDS1 and EVI1 complex locus -0.0322135
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.032196
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) -0.0316346
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -0.031538
ZBTB20 zinc finger and BTB domain containing 20 -0.0315352
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein -0.0314444
RPS21 ribosomal protein S21 -0.0312369
MKI67 marker of proliferation Ki-67 -0.0309354
LOC102724023 ES1 protein homolog, mitochondrial -0.0308779
KDM3A lysine (K)-specific demethylase 3A -0.0303622
EPCAM epithelial cell adhesion molecule -0.0301214
LMNA lamin A/C -0.029871
PATJ PATJ crumbs cell polarity complex component -0.0287028
USP3 ubiquitin specific peptidase 3 -0.0285416
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.028535
CAMK2D calcium/calmodulin-dependent protein kinase II delta -0.0283991
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0282763
GCC2 GRIP and coiled-coil domain containing 2 -0.0281907
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0280236
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0279702
NPEPPS aminopeptidase puromycin sensitive -0.0279252
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0277621
NAMPT nicotinamide phosphoribosyltransferase -0.0276669
UBE2K ubiquitin-conjugating enzyme E2K -0.0276625
NFIA nuclear factor I/A -0.0276179
KPNB1 karyopherin (importin) beta 1 -0.027232
TFRC transferrin receptor -0.0270865
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0263638
NPC1 Niemann-Pick disease, type C1 -0.0258562
PLAUR plasminogen activator, urokinase receptor -0.0258149
NIPBL Nipped-B homolog (Drosophila) -0.025814
ZMYM2 zinc finger, MYM-type 2 -0.0257488
PCED1B PC-esterase domain containing 1B -0.0255459
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0254431
MARCHF6 membrane associated ring-CH-type finger 6 -0.025366
TCF12 transcription factor 12 -0.0252337
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.025072
FRY furry homolog (Drosophila) -0.0250456
TRPS1 trichorhinophalangeal syndrome I -0.0249655
MAP3K8 mitogen-activated protein kinase kinase kinase 8 -0.0248009
HMGB1 high mobility group box 1 -0.0247322
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0244585
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0242037
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase -0.0237146
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0236335
ABHD12 abhydrolase domain containing 12 -0.0232448
ANXA2 annexin A2 -0.0230059
DLG1 discs, large homolog 1 (Drosophila) -0.0227669
TAS2R14 taste receptor, type 2, member 14 -0.0226885
SOX4 SRY (sex determining region Y)-box 4 -0.0226403
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) -0.0226128
TM9SF3 transmembrane 9 superfamily member 3 -0.0223483
STAU1 staufen double-stranded RNA binding protein 1 -0.0221801
ANXA4 annexin A4 -0.0220336
BIRC6 baculoviral IAP repeat containing 6 -0.0217535
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0216482
MAML3 mastermind-like 3 (Drosophila) -0.0213478
TRIM56 tripartite motif containing 56 -0.0213461
KRT18 keratin 18, type I -0.0213223