| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Esmolol (hydrochloride) perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Esmolol (hydrochloride)_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | 0.389868 |
| FN1 | fibronectin 1 | 0.317306 |
| C3 | complement component 3 | 0.224436 |
| SLC38A2 | solute carrier family 38, member 2 | 0.127297 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.122027 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.114011 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.099283 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | 0.0964421 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0909461 |
| DSPP | dentin sialophosphoprotein | 0.0893702 |
| VCL | vinculin | 0.0878808 |
| EHBP1 | EH domain binding protein 1 | 0.0819008 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0807412 |
| GPAM | glycerol-3-phosphate acyltransferase, mitochondrial | 0.0804452 |
| GPC6 | glypican 6 | 0.0793568 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.0735473 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | 0.0714922 |
| ENO1 | enolase 1, (alpha) | 0.0661076 |
| DST | dystonin | 0.0650705 |
| SORL1 | sortilin-related receptor, L(DLR class) A repeats containing | 0.0639486 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | 0.0601991 |
| ITGAV | integrin, alpha V | 0.0555295 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0555279 |
| PEG3 | paternally expressed 3 | 0.0546 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.052969 |
| FRMD5 | FERM domain containing 5 | 0.0529612 |
| ATXN1 | ataxin 1 | 0.0524365 |
| DLC1 | DLC1 Rho GTPase activating protein | 0.0511777 |
| FAT1 | FAT atypical cadherin 1 | 0.049496 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0492009 |
| ASPH | aspartate beta-hydroxylase | 0.0469059 |
| LMCD1 | LIM and cysteine-rich domains 1 | 0.0447277 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | 0.043342 |
| ARHGAP9 | Rho GTPase activating protein 9 | 0.0419595 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.0416007 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0411831 |
| H1-0 | H1.0 linker histone | 0.0394325 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.0381656 |
| RUNX1 | runt-related transcription factor 1 | 0.0379558 |
| TNS1 | tensin 1 | 0.0376833 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0371823 |
| EGR1 | early growth response 1 | 0.0363599 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0363595 |
| DNAH17 | dynein, axonemal, heavy chain 17 | 0.0356447 |
| RNF213 | ring finger protein 213 | 0.0343941 |
| PAWR | PRKC, apoptosis, WT1, regulator | 0.0342529 |
| BCL2L1 | BCL2-like 1 | 0.0317153 |
| SMAD3 | SMAD family member 3 | 0.0316055 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0304635 |
| SOX5 | SRY (sex determining region Y)-box 5 | 0.0303734 |
| ACTN4 | actinin, alpha 4 | 0.0300532 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0295503 |
| ITGB5 | integrin, beta 5 | 0.0294301 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0291566 |
| ABTB3 | ankyrin repeat and BTB domain containing 3 | 0.0285265 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0283092 |
| OSBPL10 | oxysterol binding protein-like 10 | 0.0282069 |
| PTCHD4 | patched domain containing 4 | 0.0281263 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0277906 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0274184 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0273847 |
| KIZ | kizuna centrosomal protein | 0.0271503 |
| EPAS1 | endothelial PAS domain protein 1 | 0.0261732 |
| FAM107B | family with sequence similarity 107, member B | 0.0260673 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0259795 |
| SCN9A | sodium channel, voltage gated, type IX alpha subunit | 0.0254725 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0251384 |
| PLIN2 | perilipin 2 | 0.0251137 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.024888 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | 0.0248187 |
| HDAC4 | histone deacetylase 4 | 0.0245013 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0244191 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0243557 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0242135 |
| TPM1 | tropomyosin 1 (alpha) | 0.0241597 |
| TNS3 | tensin 3 | 0.0239891 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.0238872 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0238621 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | 0.0238146 |
| SEPTIN9 | septin 9 | 0.0237895 |
| FAM135A | family with sequence similarity 135, member A | 0.0236031 |
| ACTG1 | actin gamma 1 | 0.0234433 |
| CCN2 | cellular communication network factor 2 | 0.0228307 |
| PRAG1 | PEAK1 related, kinase-activating pseudokinase 1 | 0.0228284 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.02266 |
| ZHX2 | zinc fingers and homeoboxes 2 | 0.0225755 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0223905 |
| SPSB1 | splA/ryanodine receptor domain and SOCS box containing 1 | 0.0222603 |
| PRKCA | protein kinase C, alpha | 0.0219501 |
| ARHGEF18 | Rho/Rac guanine nucleotide exchange factor (GEF) 18 | 0.0218893 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0217931 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | 0.0217414 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0210631 |
| SLC20A2 | solute carrier family 20 (phosphate transporter), member 2 | 0.0210537 |
| ATP1A4 | ATPase, Na+/K+ transporting, alpha 4 polypeptide | 0.0208615 |
| EXT1 | exostosin glycosyltransferase 1 | 0.020856 |
| FHL2 | four and a half LIM domains 2 | 0.0207843 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0207653 |
| ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3 | 0.0205786 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0204239 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGF2 | insulin-like growth factor 2 | -0.136095 |
| IGFBP1 | insulin-like growth factor binding protein 1 | -0.0653602 |
| RPS24 | ribosomal protein S24 | -0.0618946 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0598446 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0586417 |
| GPC3 | glypican 3 | -0.0575646 |
| DDIT4 | DNA-damage-inducible transcript 4 | -0.048341 |
| APOB | apolipoprotein B | -0.0482938 |
| FTL | ferritin, light polypeptide | -0.0470801 |
| RPLP1 | ribosomal protein, large, P1 | -0.0451819 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0447055 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0428809 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0414535 |
| TRIM26 | tripartite motif containing 26 | -0.0400171 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0400072 |
| CCL20 | chemokine (C-C motif) ligand 20 | -0.0391323 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0377804 |
| APOE | apolipoprotein E | -0.0377314 |
| RPL11 | ribosomal protein L11 | -0.0370775 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0369013 |
| RBM39 | RNA binding motif protein 39 | -0.0360701 |
| RPL34 | ribosomal protein L34 | -0.0357341 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0354945 |
| MATR3 | matrin 3 | -0.0354123 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0353705 |
| RPS6 | ribosomal protein S6 | -0.0340967 |
| RPL5 | ribosomal protein L5 | -0.0340824 |
| RPL7 | ribosomal protein L7 | -0.033602 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0335984 |
| RPS8 | ribosomal protein S8 | -0.0332763 |
| RPL35A | ribosomal protein L35a | -0.03253 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0322464 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0320352 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0311934 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.0303717 |
| PTMA | prothymosin, alpha | -0.0300403 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | -0.0292722 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0289466 |
| SPAG9 | sperm associated antigen 9 | -0.0287885 |
| RPL31 | ribosomal protein L31 | -0.0286482 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.028066 |
| RPS19 | ribosomal protein S19 | -0.0279051 |
| RPLP0 | ribosomal protein, large, P0 | -0.0276503 |
| RPS27A | ribosomal protein S27a | -0.0262458 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.025908 |
| RPS3 | ribosomal protein S3 | -0.0252468 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | -0.0247904 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.024501 |
| RPL38 | ribosomal protein L38 | -0.0243912 |
| RRBP1 | ribosome binding protein 1 | -0.0239723 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | -0.0239021 |
| AHSG | alpha-2-HS-glycoprotein | -0.0235047 |
| OLA1 | Obg-like ATPase 1 | -0.0234678 |
| RPS23 | ribosomal protein S23 | -0.0232886 |
| SELENOP | selenoprotein P | -0.0230138 |
| B2M | beta-2-microglobulin | -0.0226709 |
| RPL32 | ribosomal protein L32 | -0.0224409 |
| RPL12 | ribosomal protein L12 | -0.0223938 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0221986 |
| RPL9 | ribosomal protein L9 | -0.0218588 |
| DNAJC1 | DnaJ (Hsp40) homolog, subfamily C, member 1 | -0.0216959 |
| RPS25 | ribosomal protein S25 | -0.0216376 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0216358 |
| RPL26 | ribosomal protein L26 | -0.0210763 |
| RPS12 | ribosomal protein S12 | -0.0210656 |
| MT2A | metallothionein 2A | -0.0207946 |
| RPL4 | ribosomal protein L4 | -0.0207854 |
| RPS5 | ribosomal protein S5 | -0.0201813 |
| RPL37A | ribosomal protein L37a | -0.0201699 |
| TMSB10 | thymosin beta 10 | -0.0200895 |
| CLTC | clathrin, heavy chain (Hc) | -0.0200409 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0197448 |
| RPL19 | ribosomal protein L19 | -0.0197254 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | -0.0197203 |
| RSL1D1 | ribosomal L1 domain containing 1 | -0.0196219 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0195265 |
| RPS13 | ribosomal protein S13 | -0.0193602 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | -0.0193451 |
| RACK1 | receptor for activated C kinase 1 | -0.0192339 |
| RPL23 | ribosomal protein L23 | -0.0190922 |
| RPS29 | ribosomal protein S29 | -0.019083 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | -0.0189346 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.01891 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0188419 |
| INSIG2 | insulin induced gene 2 | -0.018811 |
| RPS21 | ribosomal protein S21 | -0.0187321 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | -0.0186042 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0182245 |
| RLF | rearranged L-myc fusion | -0.0182111 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0181826 |
| MED13L | mediator complex subunit 13-like | -0.0181322 |
| GOLGA4 | golgin A4 | -0.0179148 |
| RPS17 | ribosomal protein S17 | -0.0176523 |
| FUS | FUS RNA binding protein | -0.0175552 |
| LCN2 | lipocalin 2 | -0.0174865 |
| ICAM1 | intercellular adhesion molecule 1 | -0.0173409 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.0173387 |
| ZFR | zinc finger RNA binding protein | -0.0171722 |
| RPLP2 | ribosomal protein, large, P2 | -0.0169265 |
| NAP1L4 | nucleosome assembly protein 1-like 4 | -0.0166468 |
