Esmolol (hydrochloride)_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Esmolol (hydrochloride) perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Esmolol (hydrochloride)_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.210737
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.18835
PALM2AKAP2 PALM2 and AKAP2 fusion 0.144321
DPYD dihydropyrimidine dehydrogenase 0.13541
FLNB filamin B, beta 0.130838
FOXO1 forkhead box O1 0.106997
PDLIM5 PDZ and LIM domain 5 0.104106
MTSS1 metastasis suppressor 1 0.103301
MSN moesin 0.10103
MYOF myoferlin 0.0946262
PODXL podocalyxin-like 0.0855781
PDE4D phosphodiesterase 4D, cAMP-specific 0.0854491
SULF1 sulfatase 1 0.0843236
SLC35F3 solute carrier family 35, member F3 0.0839718
MACF1 microtubule-actin crosslinking factor 1 0.0801911
HSPG2 heparan sulfate proteoglycan 2 0.0798719
TGM2 transglutaminase 2 0.0789933
LMO7 LIM domain 7 0.075987
MBNL1 muscleblind-like splicing regulator 1 0.0756542
APLP2 amyloid beta (A4) precursor-like protein 2 0.0745019
POTEF POTE ankyrin domain family, member F 0.0742118
DOCK5 dedicator of cytokinesis 5 0.0706797
PLS3 plastin 3 0.0679371
GRB10 growth factor receptor-bound protein 10 0.0675753
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.0670954
CD44 CD44 molecule (Indian blood group) 0.0659704
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0657953
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0656901
LAMA5 laminin, alpha 5 0.0653662
ASPH aspartate beta-hydroxylase 0.0643713
BCAR3 breast cancer anti-estrogen resistance 3 0.06274
ITGA6 integrin, alpha 6 0.061757
AMOTL1 angiomotin like 1 0.0615404
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0596548
MYH9 myosin, heavy chain 9, non-muscle 0.0590388
AKAP13 A kinase (PRKA) anchor protein 13 0.0578968
RASAL2 RAS protein activator like 2 0.0574415
ANO1 anoctamin 1, calcium activated chloride channel 0.0573694
MYO10 myosin X 0.0568498
BCL2L1 BCL2-like 1 0.0563344
MEF2A myocyte enhancer factor 2A 0.0557821
TIMP3 TIMP metallopeptidase inhibitor 3 0.0551221
RIGI RNA sensor RIG-I 0.0549418
PTK2 protein tyrosine kinase 2 0.054703
RIN2 Ras and Rab interactor 2 0.0545952
PLEC plectin 0.0537671
PSD3 pleckstrin and Sec7 domain containing 3 0.0534685
CLU clusterin 0.0520134
PICALM phosphatidylinositol binding clathrin assembly protein 0.0518954
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.051609
NEK7 NIMA-related kinase 7 0.0515796
FOXP1 forkhead box P1 0.0513002
ACTN4 actinin, alpha 4 0.0510622
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 0.0501457
PALLD palladin, cytoskeletal associated protein 0.0500139
ENO1 enolase 1, (alpha) 0.0499397
TRIO trio Rho guanine nucleotide exchange factor 0.0498457
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0487502
ZEB1 zinc finger E-box binding homeobox 1 0.0483479
CDK6 cyclin-dependent kinase 6 0.0479407
H1-0 H1.0 linker histone 0.0479213
RABGAP1L RAB GTPase activating protein 1-like 0.0470935
OSMR oncostatin M receptor 0.0470229
EFNA5 ephrin-A5 0.0467573
MPRIP myosin phosphatase Rho interacting protein 0.0463905
TSC22D1 TSC22 domain family, member 1 0.0461558
MAML2 mastermind-like 2 (Drosophila) 0.0450614
HMGA2 high mobility group AT-hook 2 0.0446686
SULF2 sulfatase 2 0.0445498
MECOM MDS1 and EVI1 complex locus 0.0434576
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0433961
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0433811
RAD51B RAD51 paralog B 0.0433742
SRRM2 serine/arginine repetitive matrix 2 0.043204
EGFR epidermal growth factor receptor 0.042836
EXT1 exostosin glycosyltransferase 1 0.0427327
PLXNA2 plexin A2 0.0427184
ALCAM activated leukocyte cell adhesion molecule 0.0426783
SMYD3 SET and MYND domain containing 3 0.0423927
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 0.0421427
PLAT plasminogen activator, tissue 0.0420696
LUZP1 leucine zipper protein 1 0.0419147
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0418343
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.041277
CAV1 caveolin 1, caveolae protein, 22kDa 0.0412348
PRSS23 protease, serine, 23 0.0405162
VCL vinculin 0.0403459
CAPRIN2 caprin family member 2 0.0400863
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0395412
DST dystonin 0.0394442
SLCO4A1 solute carrier organic anion transporter family, member 4A1 0.0393801
AOPEP aminopeptidase O (putative) 0.0393482
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0392926
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0389982
PCDH1 protocadherin 1 0.0388348
CEMIP cell migration inducing protein, hyaluronan binding 0.0386452
LAMC2 laminin, gamma 2 0.0380591
SAMD9 sterile alpha motif domain containing 9 0.0377281
FTH1 ferritin, heavy polypeptide 1 0.0376447
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.037398

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.085914
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0696975
TMSB10 thymosin beta 10 -0.0692712
KDM3A lysine (K)-specific demethylase 3A -0.0525458
RPLP1 ribosomal protein, large, P1 -0.0475794
TPT1 tumor protein, translationally-controlled 1 -0.0409108
RPS24 ribosomal protein S24 -0.0401272
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.035442
OGA O-GlcNAcase -0.0346645
IGF2 insulin-like growth factor 2 -0.0342777
RPL35A ribosomal protein L35a -0.0341741
FTL ferritin, light polypeptide -0.03352
DLG1 discs, large homolog 1 (Drosophila) -0.0334095
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0313178
LMNA lamin A/C -0.0302098
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0297248
RLF rearranged L-myc fusion -0.0257809
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0256303
NAMPT nicotinamide phosphoribosyltransferase -0.0244964
RPL31 ribosomal protein L31 -0.0241135
SEC31A SEC31 homolog A (S. cerevisiae) -0.0229036
RPS21 ribosomal protein S21 -0.0228875
RPL34 ribosomal protein L34 -0.0219771
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0216532
MORF4L2 mortality factor 4 like 2 -0.021248
S100A10 S100 calcium binding protein A10 -0.0208133
RPL36A ribosomal protein L36a -0.0203379
GOLGA4 golgin A4 -0.0202528
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0198323
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.0196394
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.019531
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0193627
ARF1 ADP-ribosylation factor 1 -0.0193128
EIF1 eukaryotic translation initiation factor 1 -0.0192315
IER3 immediate early response 3 -0.0192307
GNAS GNAS complex locus -0.0190488
MATR3 matrin 3 -0.0187601
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.0185699
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.0181866
HLA-E major histocompatibility complex, class I, E -0.0179978
TMSB4X thymosin beta 4, X-linked -0.0178976
LMAN1 lectin, mannose-binding, 1 -0.0174197
TKT transketolase -0.017013
NAP1L1 nucleosome assembly protein 1-like 1 -0.0165018
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0163413
VDAC1 voltage-dependent anion channel 1 -0.0162691
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0160364
SUCO SUN domain containing ossification factor -0.0160306
PARK7 parkinson protein 7 -0.0159953
STAU1 staufen double-stranded RNA binding protein 1 -0.0159839
MARCHF6 membrane associated ring-CH-type finger 6 -0.0158736
ANLN anillin, actin binding protein -0.01583
RPL4 ribosomal protein L4 -0.0153413
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.015138
MXI1 MAX interactor 1, dimerization protein -0.0151332
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0149959
CANX calnexin -0.0149914
SERINC3 serine incorporator 3 -0.0147355
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0144275
ARRDC3 arrestin domain containing 3 -0.0142455
KPNB1 karyopherin (importin) beta 1 -0.0142421
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.0141879
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.01407
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -0.0135156
HLA-B major histocompatibility complex, class I, B -0.0135054
RBM39 RNA binding motif protein 39 -0.0134928
CAVIN1 caveolae associated protein 1 -0.0134089
NPEPPS aminopeptidase puromycin sensitive -0.0132945
SLC31A1 solute carrier family 31 (copper transporter), member 1 -0.0130733
RPS5 ribosomal protein S5 -0.0130433
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0129932
RPS27A ribosomal protein S27a -0.0129641
HYCC2 hyccin PI4KA lipid kinase complex subunit 2 -0.0129435
DPM1 dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit -0.0128848
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.0127162
SEPTIN2 septin 2 -0.0126893
RSL1D1 ribosomal L1 domain containing 1 -0.012496
PRRC1 proline-rich coiled-coil 1 -0.012421
COPB1 coatomer protein complex, subunit beta 1 -0.0123988
FOXO3 forkhead box O3 -0.01236
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0123161
UBC ubiquitin C -0.0122492
BIRC2 baculoviral IAP repeat containing 2 -0.0122251
CLINT1 clathrin interactor 1 -0.0121124
TRPM7 transient receptor potential cation channel, subfamily M, member 7 -0.0121015
DHRS3 dehydrogenase/reductase (SDR family) member 3 -0.0120812
RPL5 ribosomal protein L5 -0.012029
UQCRH ubiquinol-cytochrome c reductase hinge protein -0.0119714
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0117453
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0116685
GATA6 GATA binding protein 6 -0.0116127
RPL39 ribosomal protein L39 -0.0115806
RPS20 ribosomal protein S20 -0.0115059
CSE1L CSE1 chromosome segregation 1-like (yeast) -0.0114107
TMEM123 transmembrane protein 123 -0.0113491
KHSRP KH-type splicing regulatory protein -0.0113454
ANKRD10 ankyrin repeat domain 10 -0.0112819
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.011196
KIAA1217 KIAA1217 -0.0110208
GM2A GM2 ganglioside activator -0.0109909