| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Esmolol (hydrochloride) perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Esmolol (hydrochloride)_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.145935 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0847077 |
| CD44 | CD44 molecule (Indian blood group) | 0.0784903 |
| DST | dystonin | 0.0778348 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0759066 |
| POTEF | POTE ankyrin domain family, member F | 0.0705242 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.068431 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0662747 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0630227 |
| CAPRIN2 | caprin family member 2 | 0.0628657 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0597461 |
| RUNX1 | runt-related transcription factor 1 | 0.0558145 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0552163 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.0527458 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | 0.050157 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0484356 |
| PODXL | podocalyxin-like | 0.0480852 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0473289 |
| ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3 | 0.0462574 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0452514 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0443802 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0433919 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0421944 |
| ANKRD12 | ankyrin repeat domain 12 | 0.04166 |
| VIM | vimentin | 0.0409973 |
| RAD51B | RAD51 paralog B | 0.0405614 |
| APP | amyloid beta (A4) precursor protein | 0.0392273 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0385467 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0378414 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0368208 |
| TSC22D1 | TSC22 domain family, member 1 | 0.0367708 |
| ANGPTL4 | angiopoietin-like 4 | 0.0365372 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0361746 |
| CENPF | centromere protein F, 350/400kDa | 0.0360926 |
| RAB27B | RAB27B, member RAS oncogene family | 0.0349777 |
| ACTG1 | actin gamma 1 | 0.0341131 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0340005 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | 0.0328957 |
| EMP1 | epithelial membrane protein 1 | 0.0326574 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.032333 |
| FMNL2 | formin-like 2 | 0.0322586 |
| JMJD1C | jumonji domain containing 1C | 0.0322501 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0315145 |
| UBE2E3 | ubiquitin-conjugating enzyme E2E 3 | 0.0314402 |
| ENO1 | enolase 1, (alpha) | 0.0312366 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0312165 |
| MT2A | metallothionein 2A | 0.0307915 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0301513 |
| TOP1 | topoisomerase (DNA) I | 0.0299751 |
| EXOC4 | exocyst complex component 4 | 0.0297294 |
| VCL | vinculin | 0.0294958 |
| TRIP12 | thyroid hormone receptor interactor 12 | 0.029493 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.0291381 |
| MCL1 | myeloid cell leukemia 1 | 0.0283261 |
| PLEKHA4 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 | 0.0282081 |
| CMIP | c-Maf inducing protein | 0.0281881 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | 0.0281672 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0275536 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0273437 |
| TTC28 | tetratricopeptide repeat domain 28 | 0.0272132 |
| MYOF | myoferlin | 0.0271994 |
| PYGB | phosphorylase, glycogen; brain | 0.0268452 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0261104 |
| RNF213 | ring finger protein 213 | 0.0260901 |
| SDCCAG8 | serologically defined colon cancer antigen 8 | 0.0258209 |
| TGM2 | transglutaminase 2 | 0.0257209 |
| DOCK11 | dedicator of cytokinesis 11 | 0.0256829 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | 0.0253472 |
| EGR1 | early growth response 1 | 0.0250826 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | 0.0250326 |
| SHC1 | SHC (Src homology 2 domain containing) transforming protein 1 | 0.0250317 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0246467 |
| SMAD3 | SMAD family member 3 | 0.0246242 |
| GPAT3 | glycerol-3-phosphate acyltransferase 3 | 0.0246124 |
| SERPINB9 | serpin peptidase inhibitor, clade B (ovalbumin), member 9 | 0.0243269 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0237212 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0236847 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0235694 |
| LOXL2 | lysyl oxidase-like 2 | 0.0235106 |
| MYO10 | myosin X | 0.0234836 |
| EZR | ezrin | 0.0234731 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0234144 |
| SYAP1 | synapse associated protein 1 | 0.0231804 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0230804 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | 0.0228984 |
| ARHGAP5 | Rho GTPase activating protein 5 | 0.0227168 |
| DNER | delta/notch-like EGF repeat containing | 0.0226277 |
| ITGB4 | integrin, beta 4 | 0.0225954 |
| PRRC2A | proline-rich coiled-coil 2A | 0.022523 |
| RTTN | rotatin | 0.0224519 |
| SMYD3 | SET and MYND domain containing 3 | 0.022377 |
| CAPN2 | calpain 2, (m/II) large subunit | 0.0223131 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0222121 |
| BCAS3 | breast carcinoma amplified sequence 3 | 0.0221991 |
| SQSTM1 | sequestosome 1 | 0.02217 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0220577 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0220025 |
| FNIP1 | folliculin interacting protein 1 | 0.0218949 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.021711 |
| MEF2A | myocyte enhancer factor 2A | 0.0214813 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TMSB10 | thymosin beta 10 | -0.0986172 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0922124 |
| PTMA | prothymosin, alpha | -0.0714548 |
| TMSB4X | thymosin beta 4, X-linked | -0.047456 |
| RPL35A | ribosomal protein L35a | -0.0380834 |
| FTL | ferritin, light polypeptide | -0.031634 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0310063 |
| RPS24 | ribosomal protein S24 | -0.0280523 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0264567 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.025632 |
| CADM2 | cell adhesion molecule 2 | -0.0249006 |
| RPLP1 | ribosomal protein, large, P1 | -0.0237427 |
| RPL36A | ribosomal protein L36a | -0.0221865 |
| RPL31 | ribosomal protein L31 | -0.0220146 |
| RPS19 | ribosomal protein S19 | -0.021939 |
| RPL38 | ribosomal protein L38 | -0.0213856 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0205147 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0205123 |
| RPS23 | ribosomal protein S23 | -0.0203787 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0203389 |
| MATR3 | matrin 3 | -0.0183596 |
| RPL34 | ribosomal protein L34 | -0.0181526 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.018044 |
| RPS27A | ribosomal protein S27a | -0.0179576 |
| TMEM123 | transmembrane protein 123 | -0.0178695 |
| RPLP2 | ribosomal protein, large, P2 | -0.017591 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0175381 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0174953 |
| RPL12 | ribosomal protein L12 | -0.0174914 |
| RPS21 | ribosomal protein S21 | -0.0168537 |
| EFNA5 | ephrin-A5 | -0.0166195 |
| TP63 | tumor protein p63 | -0.0164904 |
| TOMM20 | translocase of outer mitochondrial membrane 20 homolog (yeast) | -0.0164608 |
| RPL36 | ribosomal protein L36 | -0.0164481 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0162453 |
| RPS29 | ribosomal protein S29 | -0.0159762 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | -0.0159626 |
| RPL26 | ribosomal protein L26 | -0.0155297 |
| ZNF217 | zinc finger protein 217 | -0.0153662 |
| NPR2 | natriuretic peptide receptor 2 | -0.015135 |
| WDR45B | WD repeat domain 45B | -0.0149013 |
| TNS3 | tensin 3 | -0.0147594 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0147007 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0144658 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.014198 |
| SRGN | serglycin | -0.0141856 |
| RPS5 | ribosomal protein S5 | -0.0140951 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0139655 |
| RPL37A | ribosomal protein L37a | -0.0139059 |
| EPHA4 | EPH receptor A4 | -0.013892 |
| CALR | calreticulin | -0.0138714 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0138012 |
| UBE3C | ubiquitin protein ligase E3C | -0.0132327 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.0132147 |
| FUS | FUS RNA binding protein | -0.0131224 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0130864 |
| RPL32 | ribosomal protein L32 | -0.0130615 |
| ARF1 | ADP-ribosylation factor 1 | -0.0127822 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | -0.0127791 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0126652 |
| RIOK3 | RIO kinase 3 | -0.0123542 |
| TFRC | transferrin receptor | -0.0123203 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0122309 |
| CAVIN1 | caveolae associated protein 1 | -0.0121428 |
| RPL37 | ribosomal protein L37 | -0.0118546 |
| RPS25 | ribosomal protein S25 | -0.011777 |
| KHSRP | KH-type splicing regulatory protein | -0.0117732 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0117071 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0115507 |
| MT1X | metallothionein 1X | -0.0114773 |
| HLA-B | major histocompatibility complex, class I, B | -0.011036 |
| RSL1D1 | ribosomal L1 domain containing 1 | -0.0109594 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.010895 |
| SMCHD1 | structural maintenance of chromosomes flexible hinge domain containing 1 | -0.010877 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0106502 |
| RPL19 | ribosomal protein L19 | -0.0102665 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | -0.010228 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0100305 |
| RPS8 | ribosomal protein S8 | -0.00995498 |
| OLA1 | Obg-like ATPase 1 | -0.00995295 |
| RBM39 | RNA binding motif protein 39 | -0.00992484 |
| RPS27 | ribosomal protein S27 | -0.00985984 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.00983271 |
| RFC3 | replication factor C (activator 1) 3, 38kDa | -0.00980149 |
| CCDC47 | coiled-coil domain containing 47 | -0.00973067 |
| SLC38A1 | solute carrier family 38, member 1 | -0.00968997 |
| NUP58 | nucleoporin 58 | -0.00964901 |
| RPL35 | ribosomal protein L35 | -0.00960895 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | -0.00960384 |
| HLA-E | major histocompatibility complex, class I, E | -0.00933383 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0092663 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | -0.00926426 |
| RPS28 | ribosomal protein S28 | -0.00925931 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.00922674 |
| RPL4 | ribosomal protein L4 | -0.00922373 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0092079 |
| RPL39 | ribosomal protein L39 | -0.00917329 |
| RAB7A | RAB7A, member RAS oncogene family | -0.00906531 |
| RPS13 | ribosomal protein S13 | -0.00900222 |
| RLF | rearranged L-myc fusion | -0.00880252 |
