| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Esmolol (hydrochloride) perturbation in NCI-H1573 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Esmolol (hydrochloride)_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.104872 |
| CES1 | carboxylesterase 1 | 0.101338 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0929307 |
| LAMA4 | laminin, alpha 4 | 0.0896289 |
| FAM13A | family with sequence similarity 13, member A | 0.0886418 |
| MCL1 | myeloid cell leukemia 1 | 0.0801516 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0647573 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0616623 |
| NDRG1 | N-myc downstream regulated 1 | 0.0587429 |
| OSMR | oncostatin M receptor | 0.0568329 |
| SLTM | SAFB-like, transcription modulator | 0.0534284 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0511153 |
| SMAD3 | SMAD family member 3 | 0.0490167 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0486562 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0474767 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0471937 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0466432 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0459317 |
| SPAG9 | sperm associated antigen 9 | 0.0410894 |
| NGLY1 | N-glycanase 1 | 0.0399762 |
| SYAP1 | synapse associated protein 1 | 0.03981 |
| MT2A | metallothionein 2A | 0.0395816 |
| RUNX1 | runt-related transcription factor 1 | 0.0381139 |
| CCNL1 | cyclin L1 | 0.0369718 |
| TOP1 | topoisomerase (DNA) I | 0.035776 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0355916 |
| ZNF638 | zinc finger protein 638 | 0.0354448 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | 0.0352839 |
| AGO2 | argonaute RISC catalytic component 2 | 0.0351861 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0347223 |
| NABP1 | nucleic acid binding protein 1 | 0.0342256 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0336215 |
| LANCL2 | LanC lantibiotic synthetase component C-like 2 (bacterial) | 0.0332537 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0330863 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0327365 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0323569 |
| HELZ | helicase with zinc finger | 0.0316808 |
| JMJD1C | jumonji domain containing 1C | 0.0316404 |
| ATP11A | ATPase, class VI, type 11A | 0.0300695 |
| FRY | furry homolog (Drosophila) | 0.0299966 |
| ATP13A3 | ATPase type 13A3 | 0.029829 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.0296563 |
| EGR1 | early growth response 1 | 0.029536 |
| NPC1 | Niemann-Pick disease, type C1 | 0.0291911 |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 | 0.0288411 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0279557 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0277259 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0276201 |
| KMT2D | lysine (K)-specific methyltransferase 2D | 0.027045 |
| MKI67 | marker of proliferation Ki-67 | 0.0270222 |
| RTN4 | reticulon 4 | 0.0267664 |
| EPAS1 | endothelial PAS domain protein 1 | 0.0266229 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0266184 |
| ARGLU1 | arginine and glutamate rich 1 | 0.0264784 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0263101 |
| H1-0 | H1.0 linker histone | 0.0258503 |
| YTHDC1 | YTH domain containing 1 | 0.025794 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0257139 |
| ZNF292 | zinc finger protein 292 | 0.0254227 |
| RASA2 | RAS p21 protein activator 2 | 0.0252968 |
| PYGL | phosphorylase, glycogen, liver | 0.0247819 |
| BLZF1 | basic leucine zipper nuclear factor 1 | 0.0239703 |
| RAD51B | RAD51 paralog B | 0.0237768 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0237034 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0235834 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0231171 |
| DCUN1D3 | DCN1, defective in cullin neddylation 1, domain containing 3 | 0.0225291 |
| SMTN | smoothelin | 0.0222692 |
| LRP1B | low density lipoprotein receptor-related protein 1B | 0.0218425 |
| STRN3 | striatin, calmodulin binding protein 3 | 0.021642 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0216066 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | 0.0214972 |
| ZC3H12B | zinc finger CCCH-type containing 12B | 0.0212798 |
| ITGB5 | integrin, beta 5 | 0.0212772 |
| SUPT6H | suppressor of Ty 6 homolog (S. cerevisiae) | 0.0210724 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | 0.0209979 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0209636 |
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | 0.020905 |
| OFD1 | oral-facial-digital syndrome 1 | 0.0208661 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | 0.0208637 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0206557 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.020593 |
| DUSP5 | dual specificity phosphatase 5 | 0.020415 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0204068 |
| OGA | O-GlcNAcase | 0.0201167 |
| CSNK1E | casein kinase 1, epsilon | 0.0200702 |
| PDE8A | phosphodiesterase 8A | 0.0200118 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0196277 |
| WDR26 | WD repeat domain 26 | 0.0194359 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0191943 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | 0.0188294 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0187391 |
| KDM5B | lysine (K)-specific demethylase 5B | 0.0186998 |
| XDH | xanthine dehydrogenase | 0.0184648 |
| TMEM165 | transmembrane protein 165 | 0.0183997 |
| LPCAT2 | lysophosphatidylcholine acyltransferase 2 | 0.0183118 |
| TNFAIP8 | tumor necrosis factor, alpha-induced protein 8 | 0.0183108 |
| EP300 | E1A binding protein p300 | 0.0180519 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0180414 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0178033 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TMSB10 | thymosin beta 10 | -0.247344 |
| TXNRD1 | thioredoxin reductase 1 | -0.171747 |
| ASPH | aspartate beta-hydroxylase | -0.137812 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.127034 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.11603 |
| S100A10 | S100 calcium binding protein A10 | -0.0931926 |
| PTMA | prothymosin, alpha | -0.091524 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0879574 |
| KRT7 | keratin 7, type II | -0.0839143 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0811525 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0802776 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | -0.0786818 |
| CST3 | cystatin C | -0.0773565 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.0773267 |
| PKM | pyruvate kinase, muscle | -0.0772555 |
| ACTG1 | actin gamma 1 | -0.0748107 |
| KRT18 | keratin 18, type I | -0.074659 |
| CCND1 | cyclin D1 | -0.0657264 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0634864 |
| AHNAK | AHNAK nucleoprotein | -0.0627705 |
| B2M | beta-2-microglobulin | -0.0615683 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.0593704 |
| RPS24 | ribosomal protein S24 | -0.0587365 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0576345 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0552629 |
| FTL | ferritin, light polypeptide | -0.0535623 |
| RPL35A | ribosomal protein L35a | -0.053007 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0494946 |
| ENO1 | enolase 1, (alpha) | -0.0486111 |
| ANXA2 | annexin A2 | -0.0462206 |
| RPL34 | ribosomal protein L34 | -0.0450063 |
| LMO7 | LIM domain 7 | -0.0441998 |
| CAPZA2 | capping protein (actin filament) muscle Z-line, alpha 2 | -0.0429561 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0421533 |
| RPS25 | ribosomal protein S25 | -0.0416525 |
| LDHA | lactate dehydrogenase A | -0.0415958 |
| LAMC2 | laminin, gamma 2 | -0.040511 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0396664 |
| TPM4 | tropomyosin 4 | -0.0383397 |
| RPL31 | ribosomal protein L31 | -0.0382108 |
| RPLP1 | ribosomal protein, large, P1 | -0.0379714 |
| KRT8 | keratin 8, type II | -0.037439 |
| SEC61G | Sec61 gamma subunit | -0.037283 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0371931 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.036579 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.0346335 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0342741 |
| AGR2 | anterior gradient 2 | -0.0327597 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | -0.0327147 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0318613 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0317293 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0315867 |
| DSG2 | desmoglein 2 | -0.0315543 |
| SCEL | sciellin | -0.0313428 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0311716 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0307663 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0303115 |
| S100A11 | S100 calcium binding protein A11 | -0.0302827 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0300609 |
| CANX | calnexin | -0.029964 |
| S100A9 | S100 calcium binding protein A9 | -0.0296981 |
| KRT19 | keratin 19, type I | -0.029513 |
| RPL19 | ribosomal protein L19 | -0.029278 |
| UGDH | UDP-glucose 6-dehydrogenase | -0.0288418 |
| RPS27A | ribosomal protein S27a | -0.0282402 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0277409 |
| EGFR | epidermal growth factor receptor | -0.0270787 |
| C15ORF48 | chromosome 15 open reading frame 48 | -0.0270627 |
| RPS8 | ribosomal protein S8 | -0.0268716 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0266478 |
| RPL37A | ribosomal protein L37a | -0.0265734 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0264882 |
| HLA-B | major histocompatibility complex, class I, B | -0.0264388 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0264009 |
| CAV2 | caveolin 2 | -0.0261974 |
| DSPP | dentin sialophosphoprotein | -0.0258434 |
| S100A6 | S100 calcium binding protein A6 | -0.0256408 |
| SP100 | SP100 nuclear antigen | -0.0253233 |
| CUX1 | cut-like homeobox 1 | -0.0252228 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0252074 |
| PRDX1 | peroxiredoxin 1 | -0.0249166 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0248355 |
| CTSL | cathepsin L | -0.0248188 |
| RSL1D1 | ribosomal L1 domain containing 1 | -0.0247075 |
| AP1S3 | adaptor-related protein complex 1, sigma 3 subunit | -0.0246666 |
| FLNB | filamin B, beta | -0.0240397 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0237701 |
| ITGA6 | integrin, alpha 6 | -0.0237538 |
| IER3 | immediate early response 3 | -0.0237194 |
| PGK1 | phosphoglycerate kinase 1 | -0.0237045 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0235502 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0234179 |
| EHBP1 | EH domain binding protein 1 | -0.023315 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | -0.0233007 |
| ABCC3 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | -0.0228787 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0227682 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0223835 |
| MCU | mitochondrial calcium uniporter | -0.0223587 |
| AHNAK2 | AHNAK nucleoprotein 2 | -0.0223333 |
| GNAS | GNAS complex locus | -0.0222189 |
