Esmolol (hydrochloride)_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Esmolol (hydrochloride) perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Esmolol (hydrochloride)_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MT2A metallothionein 2A 0.108247
SMAD3 SMAD family member 3 0.104934
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0888657
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.066139
TGM2 transglutaminase 2 0.064269
EFNA5 ephrin-A5 0.063547
CD44 CD44 molecule (Indian blood group) 0.0590574
MYC v-myc avian myelocytomatosis viral oncogene homolog 0.0482186
DOCK5 dedicator of cytokinesis 5 0.0473524
NAV2 neuron navigator 2 0.0427539
EGFR epidermal growth factor receptor 0.0398645
OSMR oncostatin M receptor 0.0387127
DSCAM Down syndrome cell adhesion molecule 0.0370766
RPS12 ribosomal protein S12 0.0337177
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0322187
ZBTB20 zinc finger and BTB domain containing 20 0.0301589
KSR1 kinase suppressor of ras 1 0.0299033
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0293533
AKAP9 A kinase (PRKA) anchor protein 9 0.028858
NPC1 Niemann-Pick disease, type C1 0.0287969
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0284497
EEF2 eukaryotic translation elongation factor 2 0.0273803
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0273665
BACE2 beta-site APP-cleaving enzyme 2 0.0267345
RPS19 ribosomal protein S19 0.0265963
GFPT2 glutamine-fructose-6-phosphate transaminase 2 0.0264038
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0255769
MCL1 myeloid cell leukemia 1 0.0249253
FAM20C family with sequence similarity 20, member C 0.0249209
ZC3H12C zinc finger CCCH-type containing 12C 0.0235177
RAD51B RAD51 paralog B 0.0228082
ECE1 endothelin converting enzyme 1 0.0222926
SKAP2 src kinase associated phosphoprotein 2 0.0222238
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0218692
DUSP5 dual specificity phosphatase 5 0.0216741
MYO10 myosin X 0.0214395
BPTF bromodomain PHD finger transcription factor 0.0208715
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0205257
PTPRM protein tyrosine phosphatase, receptor type, M 0.0204516
ACTG1 actin gamma 1 0.0202907
VEGFA vascular endothelial growth factor A 0.0202282
BRD2 bromodomain containing 2 0.020075
MEIS1 Meis homeobox 1 0.0199104
RPL13A ribosomal protein L13a 0.0194892
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0194809
RPS6 ribosomal protein S6 0.0193387
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) 0.0192065
KLF6 Kruppel-like factor 6 0.0191754
SHB Src homology 2 domain containing adaptor protein B 0.0191251
SYAP1 synapse associated protein 1 0.0190449
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0186914
RPL36 ribosomal protein L36 0.0186801
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0185583
IL1R1 interleukin 1 receptor, type I 0.0184351
EPAS1 endothelial PAS domain protein 1 0.0181631
SAMD4A sterile alpha motif domain containing 4A 0.0181631
GDI2 GDP dissociation inhibitor 2 0.0180185
RPL37A ribosomal protein L37a 0.0178572
RPS2 ribosomal protein S2 0.0178165
FER fer (fps/fes related) tyrosine kinase 0.0177521
CD59 CD59 molecule, complement regulatory protein 0.0176902
NCOA7 nuclear receptor coactivator 7 0.0173579
RBM25 RNA binding motif protein 25 0.017321
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0172591
RPL27 ribosomal protein L27 0.0172542
RPL23 ribosomal protein L23 0.0171355
LUZP1 leucine zipper protein 1 0.0169506
ANGPTL4 angiopoietin-like 4 0.0168842
BASP1 brain abundant, membrane attached signal protein 1 0.0167809
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0166083
ZC3H6 zinc finger CCCH-type containing 6 0.01632
RPL5 ribosomal protein L5 0.0162912
KIAA1328 KIAA1328 0.0162645
NSUN6 NOP2/Sun domain family, member 6 0.0162097
BCAS3 breast carcinoma amplified sequence 3 0.0160434
SRRM2 serine/arginine repetitive matrix 2 0.0159022
ADAMTS14 ADAM metallopeptidase with thrombospondin type 1 motif, 14 0.0158067
MMP2 matrix metallopeptidase 2 0.0156188
RPL11 ribosomal protein L11 0.0155676
RPLP2 ribosomal protein, large, P2 0.0154995
TGFB2 transforming growth factor, beta 2 0.0154644
TUT7 terminal uridylyl transferase 7 0.0154364
MTERF1 mitochondrial transcription termination factor 1 0.0153561
RPL3 ribosomal protein L3 0.0152906
CEP250 centrosomal protein 250kDa 0.015181
RPL12 ribosomal protein L12 0.0151353
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0148207
HELZ2 helicase with zinc finger 2, transcriptional coactivator 0.0148152
YBX3 Y box binding protein 3 0.0146759
RPL30 ribosomal protein L30 0.0146639
MYH9 myosin, heavy chain 9, non-muscle 0.0145581
KIAA1217 KIAA1217 0.0145053
SDC4 syndecan 4 0.0144939
ATP5MC2 ATP synthase membrane subunit c locus 2 0.0144586
SPRED1 sprouty-related, EVH1 domain containing 1 0.014407
SCAPER S-phase cyclin A-associated protein in the ER 0.0143094
FHL2 four and a half LIM domains 2 0.0143093
ARHGAP26 Rho GTPase activating protein 26 0.0141411
HEG1 heart development protein with EGF-like domains 1 0.013988
RPS29 ribosomal protein S29 0.0137404

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.156467
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.127594
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.0988712
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0917387
FN1 fibronectin 1 -0.0858356
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0811786
PDE4D phosphodiesterase 4D, cAMP-specific -0.0802089
MEF2A myocyte enhancer factor 2A -0.0798196
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0785785
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0761825
TMSB10 thymosin beta 10 -0.0737608
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0713539
VIM vimentin -0.0675888
DLG1 discs, large homolog 1 (Drosophila) -0.0667579
FAM13A family with sequence similarity 13, member A -0.0613411
SDK1 sidekick cell adhesion molecule 1 -0.0581686
IGFBP3 insulin-like growth factor binding protein 3 -0.0555277
RAB1A RAB1A, member RAS oncogene family -0.0554203
KDM3A lysine (K)-specific demethylase 3A -0.0551818
FTL ferritin, light polypeptide -0.0549865
RIOK3 RIO kinase 3 -0.054542
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0536672
PTMA prothymosin, alpha -0.0530025
PARP8 poly (ADP-ribose) polymerase family, member 8 -0.0529427
GRB10 growth factor receptor-bound protein 10 -0.0516873
NPEPPS aminopeptidase puromycin sensitive -0.0515487
USP3 ubiquitin specific peptidase 3 -0.0515239
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0513032
RBM39 RNA binding motif protein 39 -0.0509615
PCBP2 poly(rC) binding protein 2 -0.0471793
WAC WW domain containing adaptor with coiled-coil -0.0463017
HMGA2 high mobility group AT-hook 2 -0.0455898
PDIA3 protein disulfide isomerase family A, member 3 -0.0453166
CAMK1D calcium/calmodulin-dependent protein kinase ID -0.044907
NAP1L1 nucleosome assembly protein 1-like 1 -0.0442382
S100A6 S100 calcium binding protein A6 -0.0440188
NDRG1 N-myc downstream regulated 1 -0.0438141
SOD2 superoxide dismutase 2, mitochondrial -0.0433756
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0428556
PIAS2 protein inhibitor of activated STAT, 2 -0.0416977
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0407166
KDM2A lysine (K)-specific demethylase 2A -0.040273
RAI14 retinoic acid induced 14 -0.0402115
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0398821
SETD5 SET domain containing 5 -0.0397812
DDIT3 DNA-damage-inducible transcript 3 -0.0394143
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0393688
ZFP36L1 ZFP36 ring finger protein-like 1 -0.039045
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.0389185
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0388496
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0387985
TFPI2 tissue factor pathway inhibitor 2 -0.0387092
STC1 stanniocalcin 1 -0.0385341
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0384959
MAP1B microtubule-associated protein 1B -0.0378901
HILPDA hypoxia inducible lipid droplet-associated -0.0376614
PDK3 pyruvate dehydrogenase kinase, isozyme 3 -0.0376568
CDH13 cadherin 13 -0.0375482
NAMPT nicotinamide phosphoribosyltransferase -0.0373047
AP3S1 adaptor-related protein complex 3, sigma 1 subunit -0.0371513
ITCH itchy E3 ubiquitin protein ligase -0.0367565
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0367204
PLIN2 perilipin 2 -0.036042
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0355951
NGLY1 N-glycanase 1 -0.0348897
BCAT1 branched chain amino-acid transaminase 1, cytosolic -0.03468
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 -0.034523
SNX9 sorting nexin 9 -0.0344531
ELL2 elongation factor, RNA polymerase II, 2 -0.034206
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0340269
KCMF1 potassium channel modulatory factor 1 -0.0338661
PDGFA platelet-derived growth factor alpha polypeptide -0.0337057
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0335123
SPAG9 sperm associated antigen 9 -0.0332969
RAB6A RAB6A, member RAS oncogene family -0.0332915
ESYT2 extended synaptotagmin-like protein 2 -0.0331692
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0331389
GPC6 glypican 6 -0.0331161
HELZ helicase with zinc finger -0.0325737
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0323137
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0320241
ASPH aspartate beta-hydroxylase -0.0320107
BTG1 B-cell translocation gene 1, anti-proliferative -0.031874
QKI QKI, KH domain containing, RNA binding -0.0318643
CDH2 cadherin 2, type 1, N-cadherin (neuronal) -0.031735
ATP13A3 ATPase type 13A3 -0.0313495
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0309241
MARCHF6 membrane associated ring-CH-type finger 6 -0.0308738
LDHA lactate dehydrogenase A -0.0308701
ZFAND3 zinc finger, AN1-type domain 3 -0.0307906
KMT2C lysine (K)-specific methyltransferase 2C -0.0307267
EDIL3 EGF-like repeats and discoidin I-like domains 3 -0.0307124
MTSS1 metastasis suppressor 1 -0.0296045
INSIG1 insulin induced gene 1 -0.0294756
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0293558
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0291895
BIRC6 baculoviral IAP repeat containing 6 -0.0285015
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0284029
OXSR1 oxidative stress responsive 1 -0.0278885
PTK2 protein tyrosine kinase 2 -0.027591