| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Esmolol (hydrochloride) perturbation in NCI-H2030 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Esmolol (hydrochloride)_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GRAMD1B | GRAM domain containing 1B | 0.184714 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0907397 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0746942 |
| POTEF | POTE ankyrin domain family, member F | 0.0662011 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0654271 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0646699 |
| ACTG1 | actin gamma 1 | 0.0616481 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0612067 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0568239 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0500185 |
| HSPA8 | heat shock 70kDa protein 8 | 0.049512 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0477052 |
| MCL1 | myeloid cell leukemia 1 | 0.0476521 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0464076 |
| BICC1 | BicC family RNA binding protein 1 | 0.0447791 |
| HDAC9 | histone deacetylase 9 | 0.043261 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.042655 |
| HDGF | hepatoma-derived growth factor | 0.0425633 |
| TPM3 | tropomyosin 3 | 0.042242 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0421397 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.041355 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0405821 |
| WDR43 | WD repeat domain 43 | 0.0381879 |
| SVIL | supervillin | 0.0380534 |
| RPS2 | ribosomal protein S2 | 0.0371431 |
| FAM168A | family with sequence similarity 168, member A | 0.0371096 |
| APP | amyloid beta (A4) precursor protein | 0.0368905 |
| DENND4A | DENN/MADD domain containing 4A | 0.036589 |
| EGR1 | early growth response 1 | 0.0365862 |
| RTN4 | reticulon 4 | 0.0359279 |
| RPL13A | ribosomal protein L13a | 0.0355254 |
| WWOX | WW domain containing oxidoreductase | 0.035478 |
| RPL3 | ribosomal protein L3 | 0.0349268 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0348607 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0341227 |
| IGF2 | insulin-like growth factor 2 | 0.0337765 |
| RPS12 | ribosomal protein S12 | 0.0331396 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.032976 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0328893 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0325773 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0322575 |
| OSMR | oncostatin M receptor | 0.032168 |
| SDC4 | syndecan 4 | 0.0321416 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0320241 |
| ASPH | aspartate beta-hydroxylase | 0.0317744 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0313088 |
| DGKD | diacylglycerol kinase, delta 130kDa | 0.0308886 |
| BRD2 | bromodomain containing 2 | 0.0308125 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | 0.0305139 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.030181 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | 0.0300927 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0292676 |
| SRGN | serglycin | 0.0286572 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0286115 |
| CMIP | c-Maf inducing protein | 0.0282283 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0279838 |
| RPS3 | ribosomal protein S3 | 0.0279635 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0277202 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.0276885 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0276527 |
| TTC28 | tetratricopeptide repeat domain 28 | 0.0275906 |
| GLIS3 | GLIS family zinc finger 3 | 0.0274821 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0274807 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.0271981 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.0269944 |
| IL6 | interleukin 6 | 0.026119 |
| NNMT | nicotinamide N-methyltransferase | 0.0259716 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.025951 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0258426 |
| MTHFD2L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like | 0.0250893 |
| LAMB1 | laminin, beta 1 | 0.0248127 |
| ZNF292 | zinc finger protein 292 | 0.0248027 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.0246134 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0245993 |
| PFKP | phosphofructokinase, platelet | 0.0242494 |
| USP34 | ubiquitin specific peptidase 34 | 0.0241812 |
| YBX3 | Y box binding protein 3 | 0.0241156 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0240089 |
| HLA-A | major histocompatibility complex, class I, A | 0.023888 |
| PDE8A | phosphodiesterase 8A | 0.0237407 |
| SLC25A6 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6 | 0.0236649 |
| RAD51B | RAD51 paralog B | 0.0236212 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0235572 |
| NTN4 | netrin 4 | 0.0235198 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | 0.0234932 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0234852 |
| PTP4A1 | protein tyrosine phosphatase type IVA, member 1 | 0.0233914 |
| ATP5F1B | ATP synthase F1 subunit beta | 0.0232456 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0231458 |
| PYGL | phosphorylase, glycogen, liver | 0.023143 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0231254 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0230943 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 0.0230255 |
| FLNA | filamin A, alpha | 0.022752 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.0226664 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | 0.0226483 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0226436 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.022592 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0224198 |
| RASAL2 | RAS protein activator like 2 | 0.0222085 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FTL | ferritin, light polypeptide | -0.205817 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.200777 |
| TMSB10 | thymosin beta 10 | -0.149197 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0760223 |
| S100A10 | S100 calcium binding protein A10 | -0.0541042 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0518106 |
| PTMA | prothymosin, alpha | -0.0481878 |
| LANCL1 | LanC lantibiotic synthetase component C-like 1 (bacterial) | -0.0476798 |
| RPL19 | ribosomal protein L19 | -0.0474649 |
| C15ORF48 | chromosome 15 open reading frame 48 | -0.0448556 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0441476 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0415225 |
| RPL23 | ribosomal protein L23 | -0.0404637 |
| RPL35A | ribosomal protein L35a | -0.0395288 |
| AHNAK | AHNAK nucleoprotein | -0.0371662 |
| RPLP1 | ribosomal protein, large, P1 | -0.0346777 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | -0.0331931 |
| RPL34 | ribosomal protein L34 | -0.0322959 |
| RPL31 | ribosomal protein L31 | -0.0311731 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0304728 |
| RPLP0 | ribosomal protein, large, P0 | -0.0294286 |
| RPS24 | ribosomal protein S24 | -0.0283496 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0274085 |
| VIM | vimentin | -0.0268696 |
| FNBP1L | formin binding protein 1-like | -0.0247391 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0246415 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0241497 |
| RPS15 | ribosomal protein S15 | -0.0238969 |
| RPS25 | ribosomal protein S25 | -0.023079 |
| RPS23 | ribosomal protein S23 | -0.0228744 |
| GSTP1 | glutathione S-transferase pi 1 | -0.0224262 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0223119 |
| MT2A | metallothionein 2A | -0.0215189 |
| ARPP19 | cAMP-regulated phosphoprotein, 19kDa | -0.0214902 |
| TKT | transketolase | -0.0212694 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | -0.0206309 |
| STC1 | stanniocalcin 1 | -0.0205047 |
| TNPO1 | transportin 1 | -0.0204364 |
| RPS5 | ribosomal protein S5 | -0.0189422 |
| NCOR1 | nuclear receptor corepressor 1 | -0.0189253 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0184319 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | -0.0184272 |
| TMEM123 | transmembrane protein 123 | -0.0182796 |
| ECT2 | epithelial cell transforming 2 | -0.017728 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0170819 |
| MATR3 | matrin 3 | -0.0168798 |
| HP1BP3 | heterochromatin protein 1, binding protein 3 | -0.0168525 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0166158 |
| NEK7 | NIMA-related kinase 7 | -0.0165276 |
| PPP3R1 | protein phosphatase 3, regulatory subunit B, alpha | -0.0163624 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.0159079 |
| CCT5 | chaperonin containing TCP1, subunit 5 (epsilon) | -0.0158192 |
| MAPK8 | mitogen-activated protein kinase 8 | -0.0154342 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.015337 |
| PARD3 | par-3 family cell polarity regulator | -0.0150585 |
| YTHDF3 | YTH N(6)-methyladenosine RNA binding protein 3 | -0.0149647 |
| FUS | FUS RNA binding protein | -0.0147977 |
| NPR2 | natriuretic peptide receptor 2 | -0.0147799 |
| USP3 | ubiquitin specific peptidase 3 | -0.0142907 |
| H1-0 | H1.0 linker histone | -0.0140331 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0137436 |
| SERF2 | small EDRK-rich factor 2 | -0.0136497 |
| UQCRQ | ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa | -0.0135505 |
| IER3 | immediate early response 3 | -0.0135135 |
| TMEM263 | transmembrane protein 263 | -0.0133784 |
| RPS8 | ribosomal protein S8 | -0.0132288 |
| VGLL4 | vestigial-like family member 4 | -0.0131924 |
| MRPL13 | mitochondrial ribosomal protein L13 | -0.013032 |
| PRRC1 | proline-rich coiled-coil 1 | -0.0126333 |
| HMGA1 | high mobility group AT-hook 1 | -0.012435 |
| RPS19 | ribosomal protein S19 | -0.0124247 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | -0.0124087 |
| RPL38 | ribosomal protein L38 | -0.0123289 |
| TOMM20 | translocase of outer mitochondrial membrane 20 homolog (yeast) | -0.0122674 |
| FMNL2 | formin-like 2 | -0.0122402 |
| ATP5MJ | ATP synthase membrane subunit j | -0.0121386 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0120751 |
| RPL32 | ribosomal protein L32 | -0.011977 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.011953 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0119423 |
| FRMD5 | FERM domain containing 5 | -0.0119351 |
| FHIP2A | FHF complex subunit HOOK interacting protein 2A | -0.0119073 |
| FAM222B | family with sequence similarity 222, member B | -0.0117517 |
| PPIB | peptidylprolyl isomerase B (cyclophilin B) | -0.0117213 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0115512 |
| FGD4 | FYVE, RhoGEF and PH domain containing 4 | -0.0115125 |
| CMTM4 | CKLF-like MARVEL transmembrane domain containing 4 | -0.0114769 |
| G2E3 | G2/M-phase specific E3 ubiquitin protein ligase | -0.0114308 |
| UBC | ubiquitin C | -0.0113773 |
| GNAS | GNAS complex locus | -0.0113602 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | -0.0113097 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | -0.011273 |
| CDK1 | cyclin-dependent kinase 1 | -0.0111998 |
| GOLGA4 | golgin A4 | -0.0111623 |
| RPS11 | ribosomal protein S11 | -0.0111131 |
| PHC3 | polyhomeotic homolog 3 (Drosophila) | -0.011112 |
| BTG3 | BTG family, member 3 | -0.0111115 |
| VEZT | vezatin, adherens junctions transmembrane protein | -0.0110996 |
| RPL41 | ribosomal protein L41 | -0.0110912 |
| COX7C | cytochrome c oxidase subunit VIIc | -0.0110878 |
