Esmolol (hydrochloride)_NCI-H2122 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Esmolol (hydrochloride) perturbation in NCI-H2122 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Esmolol (hydrochloride)_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.152118
SMAD3 SMAD family member 3 0.076573
EGFR epidermal growth factor receptor 0.0710167
EZR ezrin 0.0655445
COL6A3 collagen, type VI, alpha 3 0.0642196
ASPH aspartate beta-hydroxylase 0.0573106
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0565355
SDC4 syndecan 4 0.0525439
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0505385
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0498507
VIM vimentin 0.0489652
KYNU kynureninase 0.0489514
PLAUR plasminogen activator, urokinase receptor 0.0488064
B2M beta-2-microglobulin 0.0479125
TBC1D22A TBC1 domain family, member 22A 0.0460186
COL6A1 collagen, type VI, alpha 1 0.0447681
FTL ferritin, light polypeptide 0.044449
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0440205
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0438914
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0438462
HMGA2 high mobility group AT-hook 2 0.0437756
NAMPT nicotinamide phosphoribosyltransferase 0.0420826
PDLIM5 PDZ and LIM domain 5 0.0416687
EPAS1 endothelial PAS domain protein 1 0.0416647
MAST4 microtubule associated serine/threonine kinase family member 4 0.0407994
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0406951
MCL1 myeloid cell leukemia 1 0.0401838
MYH9 myosin, heavy chain 9, non-muscle 0.0399872
JUN jun proto-oncogene 0.0397346
CSNK1A1 casein kinase 1, alpha 1 0.0385381
CD44 CD44 molecule (Indian blood group) 0.0383232
TRIO trio Rho guanine nucleotide exchange factor 0.0379859
SPAG9 sperm associated antigen 9 0.037775
STC1 stanniocalcin 1 0.0376643
NF1 neurofibromin 1 0.0375761
CEMIP cell migration inducing protein, hyaluronan binding 0.0373969
H3-3B H3.3 histone B 0.0371079
SETD5 SET domain containing 5 0.03653
ATP13A3 ATPase type 13A3 0.0364237
KTN1 kinectin 1 (kinesin receptor) 0.0362421
VCL vinculin 0.0358965
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0353034
ANXA2 annexin A2 0.034819
COL1A2 collagen, type I, alpha 2 0.0336775
RTN4 reticulon 4 0.0333402
NDRG1 N-myc downstream regulated 1 0.0326166
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0325545
SEC24D SEC24 family member D 0.0321908
INHBA inhibin, beta A 0.0320264
ADGRB3 adhesion G protein-coupled receptor B3 0.0315848
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0314671
JUP junction plakoglobin 0.0314457
SEC31A SEC31 homolog A (S. cerevisiae) 0.0310492
EGR1 early growth response 1 0.0308256
AFF1 AF4/FMR2 family, member 1 0.0308037
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.03063
TXNIP thioredoxin interacting protein 0.0299812
MT2A metallothionein 2A 0.0299585
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0299486
BRD4 bromodomain containing 4 0.029714
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2 0.0296337
BHLHE40 basic helix-loop-helix family, member e40 0.029578
ELL2 elongation factor, RNA polymerase II, 2 0.0295698
IGF2 insulin-like growth factor 2 0.0295429
JMY junction mediating and regulatory protein, p53 cofactor 0.0291867
RPS12 ribosomal protein S12 0.0289694
PHF3 PHD finger protein 3 0.028757
WWTR1 WW domain containing transcription regulator 1 0.0283693
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0283629
KMT2C lysine (K)-specific methyltransferase 2C 0.0282182
BIRC6 baculoviral IAP repeat containing 6 0.0282165
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0275127
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0273982
SRPK2 SRSF protein kinase 2 0.0272646
RPL28 ribosomal protein L28 0.0272434
MYOF myoferlin 0.0272045
OGA O-GlcNAcase 0.0271755
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0266302
COL1A1 collagen, type I, alpha 1 0.0263754
SLTM SAFB-like, transcription modulator 0.0263196
ARID5B AT rich interactive domain 5B (MRF1-like) 0.0262414
COPA coatomer protein complex, subunit alpha 0.0261841
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 0.0260463
RPS11 ribosomal protein S11 0.0260401
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.02594
PTEN phosphatase and tensin homolog 0.0258334
H1-0 H1.0 linker histone 0.0257891
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0255556
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0254817
EXT1 exostosin glycosyltransferase 1 0.0252752
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0252349
ARHGAP32 Rho GTPase activating protein 32 0.0249819
LIMS1 LIM and senescent cell antigen-like domains 1 0.024922
SMG7 SMG7 nonsense mediated mRNA decay factor 0.0244528
VMP1 vacuole membrane protein 1 0.0243314
GLG1 golgi glycoprotein 1 0.024247
GRAMD1B GRAM domain containing 1B 0.0241784
SP3 Sp3 transcription factor 0.0241256
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0239523
USP3 ubiquitin specific peptidase 3 0.0238685

decreased expression

Symbol Name Standardized Value
FN1 fibronectin 1 -0.161307
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.128052
LMO7 LIM domain 7 -0.10109
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.09782
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0977587
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0655815
ABHD17C abhydrolase domain containing 17C -0.0622922
BACE2 beta-site APP-cleaving enzyme 2 -0.0595558
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0545343
LAMC2 laminin, gamma 2 -0.0539494
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0524677
SOX4 SRY (sex determining region Y)-box 4 -0.0468985
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 -0.0466472
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.0460721
FAM13A family with sequence similarity 13, member A -0.0452361
ATF6 activating transcription factor 6 -0.0442711
LIMCH1 LIM and calponin homology domains 1 -0.0435854
FMNL2 formin-like 2 -0.0432382
AHNAK AHNAK nucleoprotein -0.0430859
ATOSA atos homolog A -0.0397359
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0395914
MXD1 MAX dimerization protein 1 -0.0390142
MTUS1 microtubule associated tumor suppressor 1 -0.0386567
TXNRD1 thioredoxin reductase 1 -0.0380987
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 -0.0379587
RPL35A ribosomal protein L35a -0.0372797
RPL26 ribosomal protein L26 -0.0367892
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0365149
IGFBP3 insulin-like growth factor binding protein 3 -0.0362571
KDM5B lysine (K)-specific demethylase 5B -0.0357259
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0351074
KATNBL1 katanin p80 subunit B-like 1 -0.0348536
NHSL1 NHS-like 1 -0.0348057
ADAM9 ADAM metallopeptidase domain 9 -0.0343991
AK1 adenylate kinase 1 -0.0343358
GPC6 glypican 6 -0.0338805
BTG1 B-cell translocation gene 1, anti-proliferative -0.0330485
BASP1 brain abundant, membrane attached signal protein 1 -0.0328645
BRAF B-Raf proto-oncogene, serine/threonine kinase -0.0326704
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0323988
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0322655
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0322529
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0321429
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0318917
STAU2 staufen double-stranded RNA binding protein 2 -0.0316293
SMYD3 SET and MYND domain containing 3 -0.0315889
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0315014
ZMYND8 zinc finger, MYND-type containing 8 -0.0310022
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -0.0303552
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 -0.0301714
HECTD1 HECT domain containing E3 ubiquitin protein ligase 1 -0.0298737
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0295884
ELF2 E74-like factor 2 (ets domain transcription factor) -0.0293853
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0293362
ADM adrenomedullin -0.0291782
NLGN1 neuroligin 1 -0.0289776
RAB11FIP1 RAB11 family interacting protein 1 (class I) -0.0287433
RAI14 retinoic acid induced 14 -0.0286838
SAMD4A sterile alpha motif domain containing 4A -0.0284597
UGCG UDP-glucose ceramide glucosyltransferase -0.0283908
PLSCR1 phospholipid scramblase 1 -0.0281887
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0281232
IER3 immediate early response 3 -0.027875
ANTXR2 anthrax toxin receptor 2 -0.0278385
RUFY2 RUN and FYVE domain containing 2 -0.02752
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 -0.027483
VGF VGF nerve growth factor inducible -0.0273905
TTC19 tetratricopeptide repeat domain 19 -0.0273731
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0269239
TJP2 tight junction protein 2 -0.0267854
FOXO1 forkhead box O1 -0.0266613
ZNF706 zinc finger protein 706 -0.0266361
PRKCE protein kinase C, epsilon -0.0264907
CAMKMT calmodulin-lysine N-methyltransferase -0.0262951
KPNB1 karyopherin (importin) beta 1 -0.0262904
CALR calreticulin -0.0259805
TRPM7 transient receptor potential cation channel, subfamily M, member 7 -0.0258703
RABGAP1L RAB GTPase activating protein 1-like -0.0258496
SRP72 signal recognition particle 72kDa -0.0254488
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0254083
HIPK2 homeodomain interacting protein kinase 2 -0.0253852
TMSB10 thymosin beta 10 -0.02519
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0251855
MCTP2 multiple C2 domains, transmembrane 2 -0.0250532
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 -0.0249987
RPL38 ribosomal protein L38 -0.0249568
DUSP10 dual specificity phosphatase 10 -0.024932
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0248374
UBE2H ubiquitin-conjugating enzyme E2H -0.0246492
MRPS6 mitochondrial ribosomal protein S6 -0.0245789
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0245159
SERINC5 serine incorporator 5 -0.0244275
NAP1L4 nucleosome assembly protein 1-like 4 -0.0243331
SQSTM1 sequestosome 1 -0.024049
DENND1A DENN/MADD domain containing 1A -0.02388
ZNF217 zinc finger protein 217 -0.0238542
KCNK1 potassium channel, two pore domain subfamily K, member 1 -0.0238383
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0237101
STAU1 staufen double-stranded RNA binding protein 1 -0.0234573
SSBP2 single-stranded DNA binding protein 2 -0.023259