Esmolol (hydrochloride)_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Esmolol (hydrochloride) perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Esmolol (hydrochloride)_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
RAD51B RAD51 paralog B 0.0944014
GRAMD1B GRAM domain containing 1B 0.0659768
TRIO trio Rho guanine nucleotide exchange factor 0.0525922
ERRFI1 ERBB receptor feedback inhibitor 1 0.0455744
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0430053
PDE4D phosphodiesterase 4D, cAMP-specific 0.0427549
EXOC4 exocyst complex component 4 0.0408382
SMAD3 SMAD family member 3 0.040283
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0402795
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0369304
THSD4 thrombospondin, type I, domain containing 4 0.0332199
KTN1 kinectin 1 (kinesin receptor) 0.0317603
AKAP12 A kinase (PRKA) anchor protein 12 0.0304542
ANO6 anoctamin 6 0.0299696
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0294338
TPM3 tropomyosin 3 0.0276693
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0274306
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0268322
MYH9 myosin, heavy chain 9, non-muscle 0.0266093
PRKCE protein kinase C, epsilon 0.0260956
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0258829
PRRC2A proline-rich coiled-coil 2A 0.0256472
SHB Src homology 2 domain containing adaptor protein B 0.0254195
DOCK5 dedicator of cytokinesis 5 0.0253147
GOLGB1 golgin B1 0.0251586
ADAR adenosine deaminase, RNA-specific 0.0247828
EGFR epidermal growth factor receptor 0.0242058
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.024197
MCL1 myeloid cell leukemia 1 0.0240227
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.0239319
WWOX WW domain containing oxidoreductase 0.0232265
ZNF638 zinc finger protein 638 0.0231866
ATXN1 ataxin 1 0.0231061
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0228797
ZBTB20 zinc finger and BTB domain containing 20 0.0226911
AFF3 AF4/FMR2 family, member 3 0.0217248
KDM2A lysine (K)-specific demethylase 2A 0.0215832
RNF213 ring finger protein 213 0.0212679
PDE10A phosphodiesterase 10A 0.0204704
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0204145
TAS2R14 taste receptor, type 2, member 14 0.0203836
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0201611
ATP11A ATPase, class VI, type 11A 0.0199826
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0198725
HSPA8 heat shock 70kDa protein 8 0.0196446
ANKRD36 ankyrin repeat domain 36 0.0190354
CMIP c-Maf inducing protein 0.018939
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae) 0.0188025
R3HDM2 R3H domain containing 2 0.0186415
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0184587
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.018119
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0179139
EPAS1 endothelial PAS domain protein 1 0.0176937
TBC1D5 TBC1 domain family, member 5 0.0176666
PLEC plectin 0.0176227
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0174599
BABAM2 BRISC and BRCA1 A complex member 2 0.0172151
KMT2D lysine (K)-specific methyltransferase 2D 0.0171569
MARCHF4 membrane associated ring-CH-type finger 4 0.0171417
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0171186
KDM4B lysine (K)-specific demethylase 4B 0.0170674
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0170043
CAMKMT calmodulin-lysine N-methyltransferase 0.0169987
CCDC91 coiled-coil domain containing 91 0.016909
FAM168A family with sequence similarity 168, member A 0.0167884
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.0167191
ACTN1 actinin, alpha 1 0.0166716
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0165998
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0165959
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0164724
PRELID2 PRELI domain containing 2 0.0163223
NOTCH2 notch 2 0.0163158
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0162566
EIF4B eukaryotic translation initiation factor 4B 0.0160888
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0160328
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.0160062
AKAP9 A kinase (PRKA) anchor protein 9 0.0159908
MBD5 methyl-CpG binding domain protein 5 0.0159602
TCIM transcriptional and immune response regulator 0.0159141
PCLO piccolo presynaptic cytomatrix protein 0.015835
NCOR2 nuclear receptor corepressor 2 0.0157293
WDR70 WD repeat domain 70 0.0155443
DST dystonin 0.0153708
INTS1 integrator complex subunit 1 0.0153595
IGF1R insulin-like growth factor 1 receptor 0.0152572
CSNK1A1 casein kinase 1, alpha 1 0.0150842
PFKP phosphofructokinase, platelet 0.0149986
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0148738
SND1 staphylococcal nuclease and tudor domain containing 1 0.0147907
MMP12 matrix metallopeptidase 12 0.0147345
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.0147261
FCHSD2 FCH and double SH3 domains 2 0.0147152
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0147126
KIAA1328 KIAA1328 0.0146969
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) 0.0145867
PTK2 protein tyrosine kinase 2 0.0145831
SMYD3 SET and MYND domain containing 3 0.0144859
NBAS neuroblastoma amplified sequence 0.0144527
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0144368
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0144301

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.243521
TMSB10 thymosin beta 10 -0.156089
VIM vimentin -0.100811
PTMA prothymosin, alpha -0.1007
RPS21 ribosomal protein S21 -0.0585944
TPI1 triosephosphate isomerase 1 -0.0562007
RPL35A ribosomal protein L35a -0.0550034
RPLP1 ribosomal protein, large, P1 -0.0437533
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0417899
CCT4 chaperonin containing TCP1, subunit 4 (delta) -0.0405871
RPL23 ribosomal protein L23 -0.0383704
MYL12B myosin, light chain 12B, regulatory -0.037652
RPLP0 ribosomal protein, large, P0 -0.0371844
TPT1 tumor protein, translationally-controlled 1 -0.0359052
RPS24 ribosomal protein S24 -0.035783
TFPI2 tissue factor pathway inhibitor 2 -0.0348437
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0336561
HLA-B major histocompatibility complex, class I, B -0.0332878
RPL34 ribosomal protein L34 -0.0327401
IFI6 interferon, alpha-inducible protein 6 -0.0322339
NAP1L1 nucleosome assembly protein 1-like 1 -0.031104
RPL31 ribosomal protein L31 -0.0308784
RPS19 ribosomal protein S19 -0.0308451
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0302477
S100A10 S100 calcium binding protein A10 -0.029753
RPS15 ribosomal protein S15 -0.0295244
RPL12 ribosomal protein L12 -0.02895
RPS3 ribosomal protein S3 -0.0278078
RPS8 ribosomal protein S8 -0.0274289
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.0271173
RAB7A RAB7A, member RAS oncogene family -0.0267699
RPS27A ribosomal protein S27a -0.0259618
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0252805
TM4SF1 transmembrane 4 L six family member 1 -0.0250533
CBX3 chromobox homolog 3 -0.0248667
RPL19 ribosomal protein L19 -0.024857
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0245679
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0245065
RPL11 ribosomal protein L11 -0.0237977
FTL ferritin, light polypeptide -0.0235908
TUBA1B tubulin, alpha 1b -0.0225476
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0221443
RPLP2 ribosomal protein, large, P2 -0.0218793
GNAS GNAS complex locus -0.021768
RPS29 ribosomal protein S29 -0.0213426
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0211438
RPS27 ribosomal protein S27 -0.0208329
CAVIN1 caveolae associated protein 1 -0.0208245
MATR3 matrin 3 -0.0205743
RPS25 ribosomal protein S25 -0.0205126
RPL5 ribosomal protein L5 -0.0205094
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) -0.020378
RPL8 ribosomal protein L8 -0.0203101
EIF1 eukaryotic translation initiation factor 1 -0.0201027
RPL36A ribosomal protein L36a -0.0199536
ACTG1 actin gamma 1 -0.0199393
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0197796
MT2A metallothionein 2A -0.0197411
KDM3A lysine (K)-specific demethylase 3A -0.0197055
MT1X metallothionein 1X -0.019703
RPL37A ribosomal protein L37a -0.0193425
RPL38 ribosomal protein L38 -0.0193387
RPS13 ribosomal protein S13 -0.0191891
RACK1 receptor for activated C kinase 1 -0.0191564
RPL32 ribosomal protein L32 -0.019073
PKM pyruvate kinase, muscle -0.0188881
LDHA lactate dehydrogenase A -0.0187318
RPS4X ribosomal protein S4, X-linked -0.0186942
RPS10 ribosomal protein S10 -0.0184246
RPL9 ribosomal protein L9 -0.0181788
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0180575
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0179018
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0178671
C15ORF48 chromosome 15 open reading frame 48 -0.0177387
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.017717
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0176592
STAU1 staufen double-stranded RNA binding protein 1 -0.0175353
GSTP1 glutathione S-transferase pi 1 -0.0174218
IER3 immediate early response 3 -0.0173556
YBX1 Y box binding protein 1 -0.0171615
OAZ1 ornithine decarboxylase antizyme 1 -0.0170305
TAGLN2 transgelin 2 -0.0168307
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0167514
NIPBL Nipped-B homolog (Drosophila) -0.0166661
RPS14 ribosomal protein S14 -0.0165912
RPS23 ribosomal protein S23 -0.0164454
HMGA1 high mobility group AT-hook 1 -0.0163095
H3-3B H3.3 histone B -0.0162962
RPL26 ribosomal protein L26 -0.0161232
LOC102724023 ES1 protein homolog, mitochondrial -0.0161026
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.0158826
LDHB lactate dehydrogenase B -0.0158584
PFN1 profilin 1 -0.0158286
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0155019
RBM25 RNA binding motif protein 25 -0.0154595
DEK DEK proto-oncogene -0.0154186
KRT18 keratin 18, type I -0.0153861
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.015326
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0153057
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0152563