| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Esmolol (hydrochloride) perturbation in NCI-H2347 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Esmolol (hydrochloride)_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.231434 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.224319 |
| ACTG1 | actin gamma 1 | 0.19247 |
| POTEF | POTE ankyrin domain family, member F | 0.136565 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.125755 |
| GRB10 | growth factor receptor-bound protein 10 | 0.122188 |
| FN1 | fibronectin 1 | 0.117474 |
| LAMB3 | laminin, beta 3 | 0.116873 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.112011 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | 0.097606 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0862526 |
| LMO7 | LIM domain 7 | 0.0842214 |
| SDC4 | syndecan 4 | 0.0822139 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.080638 |
| ASPH | aspartate beta-hydroxylase | 0.0778184 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0774104 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0755591 |
| EFNA5 | ephrin-A5 | 0.0746775 |
| NPEPPS | aminopeptidase puromycin sensitive | 0.0746651 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0711506 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | 0.0708452 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0706235 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0705496 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0702871 |
| TOP1 | topoisomerase (DNA) I | 0.0702417 |
| CTSB | cathepsin B | 0.0676312 |
| ERBIN | erbb2 interacting protein | 0.0667875 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0639117 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0631885 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0621859 |
| NDRG1 | N-myc downstream regulated 1 | 0.0620119 |
| HLA-A | major histocompatibility complex, class I, A | 0.0604455 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0598735 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0591491 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.057483 |
| SACK1A | scaffolding CK1 anchoring protein A | 0.0571832 |
| RALGPS2 | Ral GEF with PH domain and SH3 binding motif 2 | 0.0557652 |
| PGK1 | phosphoglycerate kinase 1 | 0.0550571 |
| PTK2 | protein tyrosine kinase 2 | 0.0539023 |
| CD2AP | CD2-associated protein | 0.0520668 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0520642 |
| CDCP1 | CUB domain containing protein 1 | 0.0516186 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0515224 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0513003 |
| MICAL3 | microtubule associated monooxygenase, calponin and LIM domain containing 3 | 0.0510114 |
| UBE2E1 | ubiquitin-conjugating enzyme E2E 1 | 0.0507174 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.0503838 |
| SEMA3B | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B | 0.0493555 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0473322 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0468291 |
| BCL2L1 | BCL2-like 1 | 0.0467007 |
| MCTP2 | multiple C2 domains, transmembrane 2 | 0.0466431 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.0457453 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0455168 |
| DUSP10 | dual specificity phosphatase 10 | 0.0452858 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0450596 |
| TXNIP | thioredoxin interacting protein | 0.045057 |
| TMEM165 | transmembrane protein 165 | 0.0447909 |
| ENO1 | enolase 1, (alpha) | 0.0447314 |
| FLNB | filamin B, beta | 0.0441663 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.0439328 |
| CD109 | CD109 molecule | 0.0437896 |
| OSMR | oncostatin M receptor | 0.0436303 |
| NR3C2 | nuclear receptor subfamily 3, group C, member 2 | 0.0434281 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0433066 |
| MAP3K9 | mitogen-activated protein kinase kinase kinase 9 | 0.0432252 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | 0.0426152 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 0.0426138 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0425501 |
| COPA | coatomer protein complex, subunit alpha | 0.042525 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0425158 |
| RASAL2 | RAS protein activator like 2 | 0.0422293 |
| MYO1E | myosin IE | 0.0421983 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0420611 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0417679 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0411499 |
| H1-0 | H1.0 linker histone | 0.0411284 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | 0.0411246 |
| CLDN4 | claudin 4 | 0.0408817 |
| ARHGAP29 | Rho GTPase activating protein 29 | 0.0402626 |
| STRN3 | striatin, calmodulin binding protein 3 | 0.0400342 |
| SOX4 | SRY (sex determining region Y)-box 4 | 0.0400227 |
| JUP | junction plakoglobin | 0.0389371 |
| PRAG1 | PEAK1 related, kinase-activating pseudokinase 1 | 0.0386597 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | 0.038207 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0381725 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0373365 |
| OCLN | occludin | 0.0373155 |
| EGFR | epidermal growth factor receptor | 0.0370987 |
| RCOR1 | REST corepressor 1 | 0.0369507 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0369343 |
| VGLL3 | vestigial-like family member 3 | 0.0364544 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0364375 |
| EZR | ezrin | 0.0364159 |
| RUNX1 | runt-related transcription factor 1 | 0.0363192 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0362493 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.0362113 |
| FAM3C | family with sequence similarity 3, member C | 0.0361717 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 0.0360851 |
| TMF1 | TATA element modulatory factor 1 | 0.0358212 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.15924 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0986596 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0783415 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0509175 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0501506 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0444389 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0442487 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0427951 |
| CANX | calnexin | -0.0404237 |
| RPLP1 | ribosomal protein, large, P1 | -0.0398088 |
| SQSTM1 | sequestosome 1 | -0.0391065 |
| CCND1 | cyclin D1 | -0.0383196 |
| PTMA | prothymosin, alpha | -0.0376692 |
| TXNRD1 | thioredoxin reductase 1 | -0.0362659 |
| RPS3 | ribosomal protein S3 | -0.0357651 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0355494 |
| RPS23 | ribosomal protein S23 | -0.0326853 |
| RPL7 | ribosomal protein L7 | -0.0323528 |
| RPS27A | ribosomal protein S27a | -0.0315207 |
| TMSB4X | thymosin beta 4, X-linked | -0.0311258 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0310316 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0308689 |
| RPL32 | ribosomal protein L32 | -0.0308165 |
| RPS6 | ribosomal protein S6 | -0.0304423 |
| RPL9 | ribosomal protein L9 | -0.0300018 |
| TKT | transketolase | -0.0290503 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0286427 |
| RPL37A | ribosomal protein L37a | -0.0282028 |
| RPL35A | ribosomal protein L35a | -0.028009 |
| RPS8 | ribosomal protein S8 | -0.02799 |
| RPL5 | ribosomal protein L5 | -0.02733 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0271131 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | -0.0267996 |
| RPLP2 | ribosomal protein, large, P2 | -0.0265521 |
| RPS29 | ribosomal protein S29 | -0.0264043 |
| CALR | calreticulin | -0.0262855 |
| RPL34 | ribosomal protein L34 | -0.0261227 |
| UPP1 | uridine phosphorylase 1 | -0.0257872 |
| AHNAK | AHNAK nucleoprotein | -0.0257793 |
| PEG10 | paternally expressed 10 | -0.0251011 |
| TARS1 | threonyl-tRNA synthetase 1 | -0.0250936 |
| RPS24 | ribosomal protein S24 | -0.0243791 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | -0.0242287 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | -0.0238722 |
| RPLP0 | ribosomal protein, large, P0 | -0.0235406 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0233863 |
| RPL8 | ribosomal protein L8 | -0.0232082 |
| DDX3X | DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked | -0.0227814 |
| TFRC | transferrin receptor | -0.0227063 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.022439 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | -0.0223756 |
| MATR3 | matrin 3 | -0.0222795 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0221961 |
| PAPOLA | poly(A) polymerase alpha | -0.0219895 |
| RPL38 | ribosomal protein L38 | -0.0216043 |
| EEF1D | eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) | -0.0214814 |
| RBM3 | RNA binding motif (RNP1, RRM) protein 3 | -0.0210128 |
| RYBP | RING1 and YY1 binding protein | -0.0207429 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0204921 |
| RPL14 | ribosomal protein L14 | -0.0204346 |
| RIGI | RNA sensor RIG-I | -0.0204298 |
| INTS6 | integrator complex subunit 6 | -0.0202191 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0201165 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | -0.0200803 |
| HNRNPK | heterogeneous nuclear ribonucleoprotein K | -0.020066 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | -0.0198821 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0189463 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0188949 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0188877 |
| CCT5 | chaperonin containing TCP1, subunit 5 (epsilon) | -0.0187488 |
| RACK1 | receptor for activated C kinase 1 | -0.0186995 |
| LDHB | lactate dehydrogenase B | -0.0185874 |
| FHIT | fragile histidine triad | -0.0185038 |
| RPL12 | ribosomal protein L12 | -0.0181917 |
| RPS17 | ribosomal protein S17 | -0.0178956 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0177932 |
| SET | SET nuclear proto-oncogene | -0.0176711 |
| RPL4 | ribosomal protein L4 | -0.017398 |
| RPS19 | ribosomal protein S19 | -0.0170558 |
| RPS10 | ribosomal protein S10 | -0.0169383 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0169272 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | -0.0167573 |
| RPS14 | ribosomal protein S14 | -0.0166164 |
| RPS13 | ribosomal protein S13 | -0.0165028 |
| RPS12 | ribosomal protein S12 | -0.0164558 |
| DEK | DEK proto-oncogene | -0.016366 |
| OTUD4 | OTU deubiquitinase 4 | -0.0163616 |
| RPS20 | ribosomal protein S20 | -0.0160675 |
| RPL6 | ribosomal protein L6 | -0.015711 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | -0.0157066 |
| RPL15 | ribosomal protein L15 | -0.0157029 |
| EIF3E | eukaryotic translation initiation factor 3, subunit E | -0.0154243 |
| YBX1 | Y box binding protein 1 | -0.0153332 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.014931 |
| EPCAM | epithelial cell adhesion molecule | -0.0148549 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | -0.0146888 |
| RSL24D1 | ribosomal L24 domain containing 1 | -0.0146777 |
| RPS21 | ribosomal protein S21 | -0.0146693 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | -0.0146214 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0146071 |
