| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Esmolol (hydrochloride) perturbation in NCI-H460 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Esmolol (hydrochloride)_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | 0.192801 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | 0.121554 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.117769 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | 0.0952536 |
| GDA | guanine deaminase | 0.0910218 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0745565 |
| COL5A2 | collagen, type V, alpha 2 | 0.0691826 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.0684626 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0671423 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0560807 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.055852 |
| RPS6 | ribosomal protein S6 | 0.0542409 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0533284 |
| CD109 | CD109 molecule | 0.0462508 |
| SMYD3 | SET and MYND domain containing 3 | 0.0427357 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.0416272 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.040589 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0389348 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0388498 |
| PCBP3 | poly(rC) binding protein 3 | 0.038193 |
| COL8A1 | collagen, type VIII, alpha 1 | 0.0378071 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | 0.0369968 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.0367222 |
| EPB41L3 | erythrocyte membrane protein band 4.1-like 3 | 0.0365432 |
| STC1 | stanniocalcin 1 | 0.0364461 |
| RPS2 | ribosomal protein S2 | 0.0364153 |
| DGKD | diacylglycerol kinase, delta 130kDa | 0.0361508 |
| PYGL | phosphorylase, glycogen, liver | 0.0361384 |
| DST | dystonin | 0.0360308 |
| NEK7 | NIMA-related kinase 7 | 0.0352407 |
| SPAG9 | sperm associated antigen 9 | 0.0345221 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0339819 |
| KYNU | kynureninase | 0.0335663 |
| PM20D1 | peptidase M20 domain containing 1 | 0.033466 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0331245 |
| PDGFA | platelet-derived growth factor alpha polypeptide | 0.0329648 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0327478 |
| FAM13A | family with sequence similarity 13, member A | 0.0322272 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0312433 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.031103 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0306539 |
| YBX3 | Y box binding protein 3 | 0.0305551 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0302912 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.029742 |
| P3H2 | prolyl 3-hydroxylase 2 | 0.0297235 |
| HLA-B | major histocompatibility complex, class I, B | 0.0294362 |
| JMJD1C | jumonji domain containing 1C | 0.0288146 |
| RPL11 | ribosomal protein L11 | 0.0287088 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0285824 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.028263 |
| RPL13A | ribosomal protein L13a | 0.0280493 |
| HLA-A | major histocompatibility complex, class I, A | 0.0278154 |
| SLC25A6 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6 | 0.0276029 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0274306 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0274202 |
| SLC39A8 | solute carrier family 39 (zinc transporter), member 8 | 0.0270899 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0270477 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0268505 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0263846 |
| TNFRSF19 | tumor necrosis factor receptor superfamily, member 19 | 0.0258402 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0257978 |
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | 0.0252015 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0247432 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0245139 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0244393 |
| ANXA1 | annexin A1 | 0.0243996 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | 0.0241357 |
| RPL28 | ribosomal protein L28 | 0.0238238 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 0.0234146 |
| ZEB2 | zinc finger E-box binding homeobox 2 | 0.0232255 |
| S100A6 | S100 calcium binding protein A6 | 0.0232013 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0231423 |
| TBXT | T-box transcription factor T | 0.0228722 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0228273 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0225862 |
| RPL36 | ribosomal protein L36 | 0.0225629 |
| OASL | 2'-5'-oligoadenylate synthetase-like | 0.0224967 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0220697 |
| GPRIN3 | GPRIN family member 3 | 0.0219161 |
| RTN1 | reticulon 1 | 0.0217819 |
| SLC25A5 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 | 0.0217012 |
| GOLGA4 | golgin A4 | 0.02159 |
| TENT5A | terminal nucleotidyltransferase 5A | 0.0212136 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0211253 |
| OSMR | oncostatin M receptor | 0.0208329 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0208184 |
| CRLF2 | cytokine receptor-like factor 2 | 0.0207309 |
| HP1BP3 | heterochromatin protein 1, binding protein 3 | 0.020663 |
| ADGRD1 | adhesion G protein-coupled receptor D1 | 0.020503 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0201531 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0201417 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0201171 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.0200304 |
| MKI67 | marker of proliferation Ki-67 | 0.019933 |
| RPL37 | ribosomal protein L37 | 0.0198781 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0196681 |
| MCL1 | myeloid cell leukemia 1 | 0.0196605 |
| CTSC | cathepsin C | 0.0195304 |
| TMX4 | thioredoxin-related transmembrane protein 4 | 0.0194484 |
| BMERB1 | bMERB domain containing 1 | 0.0194421 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.113586 |
| TMSB10 | thymosin beta 10 | -0.090123 |
| UBC | ubiquitin C | -0.0820222 |
| RPS27A | ribosomal protein S27a | -0.0666766 |
| PKM | pyruvate kinase, muscle | -0.0613656 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.059525 |
| TXNRD1 | thioredoxin reductase 1 | -0.0594349 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0580057 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.056802 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0560816 |
| ASPH | aspartate beta-hydroxylase | -0.0468855 |
| RPS24 | ribosomal protein S24 | -0.0461757 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.045359 |
| AHNAK | AHNAK nucleoprotein | -0.0416494 |
| RPL31 | ribosomal protein L31 | -0.0413603 |
| ENO1 | enolase 1, (alpha) | -0.0380285 |
| PCBP2 | poly(rC) binding protein 2 | -0.0360169 |
| RPL4 | ribosomal protein L4 | -0.0339099 |
| PRKN | parkin RBR E3 ubiquitin protein ligase | -0.0325812 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0305844 |
| LDHA | lactate dehydrogenase A | -0.0294995 |
| RPLP1 | ribosomal protein, large, P1 | -0.029324 |
| TKT | transketolase | -0.0272206 |
| GRAMD1B | GRAM domain containing 1B | -0.0264403 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0258044 |
| TPM3 | tropomyosin 3 | -0.0255156 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0246347 |
| DPP10 | dipeptidyl-peptidase 10 (non-functional) | -0.0237583 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | -0.0232592 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0221784 |
| LSAMP | limbic system-associated membrane protein | -0.0219964 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.0210379 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0206348 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0202171 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0199994 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0195401 |
| RPL23 | ribosomal protein L23 | -0.0194922 |
| CADM2 | cell adhesion molecule 2 | -0.0192905 |
| CDH13 | cadherin 13 | -0.0191332 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | -0.0190402 |
| RPS23 | ribosomal protein S23 | -0.0189343 |
| RPS5 | ribosomal protein S5 | -0.0188232 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | -0.0187725 |
| RPS17 | ribosomal protein S17 | -0.0183355 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0181479 |
| RPL5 | ribosomal protein L5 | -0.0180979 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | -0.017597 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | -0.0175302 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0174381 |
| RAD51B | RAD51 paralog B | -0.0169827 |
| SQSTM1 | sequestosome 1 | -0.0167301 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0165982 |
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -0.0165432 |
| NRXN3 | neurexin 3 | -0.016542 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | -0.0159733 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | -0.0158383 |
| MATR3 | matrin 3 | -0.0158193 |
| RGS2 | regulator of G-protein signaling 2 | -0.0157028 |
| DDX3X | DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked | -0.0154729 |
| POTEF | POTE ankyrin domain family, member F | -0.0152747 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.015213 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.014856 |
| FTL | ferritin, light polypeptide | -0.0147918 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0147378 |
| INTS6 | integrator complex subunit 6 | -0.0146878 |
| PRELID2 | PRELI domain containing 2 | -0.014478 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | -0.014072 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.0140074 |
| NBEAL1 | neurobeachin-like 1 | -0.0137101 |
| CCT4 | chaperonin containing TCP1, subunit 4 (delta) | -0.013709 |
| AUTS2 | autism susceptibility candidate 2 | -0.0135448 |
| SFPQ | splicing factor proline/glutamine-rich | -0.0135416 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0134109 |
| CCT5 | chaperonin containing TCP1, subunit 5 (epsilon) | -0.0132548 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | -0.013136 |
| CTSL | cathepsin L | -0.0130513 |
| DDX1 | DEAD (Asp-Glu-Ala-Asp) box helicase 1 | -0.0130141 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0128334 |
| MARCHF1 | membrane associated ring-CH-type finger 1 | -0.0126958 |
| PLK2 | polo-like kinase 2 | -0.0125174 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | -0.0124966 |
| ARHGEF7 | Rho guanine nucleotide exchange factor (GEF) 7 | -0.0124918 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.012409 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0123205 |
| GPC6 | glypican 6 | -0.0122542 |
| IPO7 | importin 7 | -0.0121686 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | -0.0121415 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | -0.0120853 |
| LINGO2 | leucine rich repeat and Ig domain containing 2 | -0.012031 |
| CALR | calreticulin | -0.0119779 |
| FUS | FUS RNA binding protein | -0.0118953 |
| CHD4 | chromodomain helicase DNA binding protein 4 | -0.0117136 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 | -0.0116074 |
| USP34 | ubiquitin specific peptidase 34 | -0.0115557 |
| EDEM3 | ER degradation enhancer, mannosidase alpha-like 3 | -0.0115477 |
| ANTXR1 | anthrax toxin receptor 1 | -0.0115188 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0114928 |
| ADARB2 | adenosine deaminase, RNA-specific, B2 (non-functional) | -0.0113301 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | -0.0111778 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | -0.011177 |
