Esmolol (hydrochloride)_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Esmolol (hydrochloride) perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

141 genes differentially expressed following the Esmolol (hydrochloride)_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
RIOK3 RIO kinase 3 0.168592
RPL23 ribosomal protein L23 0.127793
ACTG1 actin gamma 1 0.125396
EXT1 exostosin glycosyltransferase 1 0.12056
RPS3 ribosomal protein S3 0.119479
MT2A metallothionein 2A 0.117444
RPS23 ribosomal protein S23 0.113839
EEF2 eukaryotic translation elongation factor 2 0.111219
MAML2 mastermind-like 2 (Drosophila) 0.0982674
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0959124
PSD3 pleckstrin and Sec7 domain containing 3 0.0957041
ZFAND3 zinc finger, AN1-type domain 3 0.0935579
EIF1 eukaryotic translation initiation factor 1 0.0923489
PTK2 protein tyrosine kinase 2 0.0919652
LIMCH1 LIM and calponin homology domains 1 0.0914499
ZNF292 zinc finger protein 292 0.0895661
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0881254
NKD1 naked cuticle homolog 1 (Drosophila) 0.0877083
ITSN1 intersectin 1 (SH3 domain protein) 0.0803262
MSI2 musashi RNA-binding protein 2 0.0775986
RPLP1 ribosomal protein, large, P1 0.0759131
IGF2 insulin-like growth factor 2 0.0744958
EPS8 epidermal growth factor receptor pathway substrate 8 0.0735831
ADM adrenomedullin 0.0684922
ENO1 enolase 1, (alpha) 0.0635588
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0615668
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0571783
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0523145
RBM39 RNA binding motif protein 39 0.0509114
FAM13A family with sequence similarity 13, member A 0.049521
PDE10A phosphodiesterase 10A 0.0450754
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0416622
SPAG9 sperm associated antigen 9 0.04131
TRA2A transformer 2 alpha homolog (Drosophila) 0.040855
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0401625
CALR calreticulin 0.037141
RPS6 ribosomal protein S6 0.036704
SRPK2 SRSF protein kinase 2 0.0360269
NBEAL1 neurobeachin-like 1 0.0353198
TCF12 transcription factor 12 0.0307119
VCL vinculin 0.0301598
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.0276966
NDRG1 N-myc downstream regulated 1 0.0256132
FNDC3B fibronectin type III domain containing 3B 0.0248539
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0223068
MARCHF7 membrane associated ring-CH-type finger 7 0.021407
FNDC3A fibronectin type III domain containing 3A 0.0207026
PARD3 par-3 family cell polarity regulator 0.0188844
PDLIM5 PDZ and LIM domain 5 0.0171813
DSCAM Down syndrome cell adhesion molecule 0.0170861
DOCK5 dedicator of cytokinesis 5 0.0162264
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0155196
PTMA prothymosin, alpha 0.0124601
SLTM SAFB-like, transcription modulator 0.0118624
FTH1 ferritin, heavy polypeptide 1 0.0113801
APP amyloid beta (A4) precursor protein 0.00884901
AOPEP aminopeptidase O (putative) 0.00883983
ZBTB20 zinc finger and BTB domain containing 20 0.00703349
TPT1 tumor protein, translationally-controlled 1 0.00701965
AKAP13 A kinase (PRKA) anchor protein 13 0.00634095
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0026278

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.209537
AKAP12 A kinase (PRKA) anchor protein 12 -0.205771
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.204002
PDE4D phosphodiesterase 4D, cAMP-specific -0.181644
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.163784
HMGA2 high mobility group AT-hook 2 -0.150689
TXNRD1 thioredoxin reductase 1 -0.132662
PKM pyruvate kinase, muscle -0.130509
TMSB10 thymosin beta 10 -0.129211
MAP4 microtubule-associated protein 4 -0.108845
AHNAK AHNAK nucleoprotein -0.108495
SETD5 SET domain containing 5 -0.101946
NF1 neurofibromin 1 -0.0972234
B2M beta-2-microglobulin -0.0961729
STC1 stanniocalcin 1 -0.0957098
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0882136
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0842062
FN1 fibronectin 1 -0.0831003
GRB10 growth factor receptor-bound protein 10 -0.0718841
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0649351
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.064924
ANKRD11 ankyrin repeat domain 11 -0.0642568
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0617187
LDHA lactate dehydrogenase A -0.0595422
EGFR epidermal growth factor receptor -0.0590349
RIGI RNA sensor RIG-I -0.0573168
RPL11 ribosomal protein L11 -0.0563182
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0556778
IGFBP3 insulin-like growth factor binding protein 3 -0.0538511
TAS2R14 taste receptor, type 2, member 14 -0.0537307
PRELID2 PRELI domain containing 2 -0.0531083
NAP1L1 nucleosome assembly protein 1-like 1 -0.0500367
CDH13 cadherin 13 -0.0489566
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0461048
ELOVL5 ELOVL fatty acid elongase 5 -0.0459306
MYO1E myosin IE -0.0408688
ALCAM activated leukocyte cell adhesion molecule -0.0386589
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0331374
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0328397
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0323835
MAP1B microtubule-associated protein 1B -0.0308193
DOCK4 dedicator of cytokinesis 4 -0.030004
OSMR oncostatin M receptor -0.0297185
FLNB filamin B, beta -0.0296756
KDM2A lysine (K)-specific demethylase 2A -0.0293709
PCCA propionyl CoA carboxylase, alpha polypeptide -0.0283051
PGK1 phosphoglycerate kinase 1 -0.0282679
ANXA2 annexin A2 -0.0278171
ASPH aspartate beta-hydroxylase -0.0268179
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0252706
KANSL1 KAT8 regulatory NSL complex subunit 1 -0.0252588
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.024618
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0216863
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0216527
CCNI cyclin I -0.0206999
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -0.0196291
ESYT2 extended synaptotagmin-like protein 2 -0.0188149
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0183242
RPS8 ribosomal protein S8 -0.0173312
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0170845
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 -0.0169664
PRRC2C proline-rich coiled-coil 2C -0.0164673
SMYD3 SET and MYND domain containing 3 -0.0155866
RORA RAR-related orphan receptor A -0.0150592
SMAD3 SMAD family member 3 -0.0136956
BBX bobby sox homolog (Drosophila) -0.0133192
THSD4 thrombospondin, type I, domain containing 4 -0.0132739
CTIF CBP80/20-dependent translation initiation factor -0.0132682
KMT2C lysine (K)-specific methyltransferase 2C -0.0108775
LPP LIM domain containing preferred translocation partner in lipoma -0.00721336
JMJD1C jumonji domain containing 1C -0.00626227
TRIO trio Rho guanine nucleotide exchange factor -0.00615067
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.00602516
GMDS GDP-mannose 4,6-dehydratase -0.00471378
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.00398368
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.00243593
RAP1B RAP1B, member of RAS oncogene family -0.00238
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) -0.0016214
SAMD4A sterile alpha motif domain containing 4A -7.02881E-4
NAMPT nicotinamide phosphoribosyltransferase -2.60549E-4