| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Esmolol (hydrochloride) perturbation in PANC-1 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Esmolol (hydrochloride)_PANC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| VCL | vinculin | 0.258911 |
| PLEKHG2 | pleckstrin homology domain containing, family G (with RhoGef domain) member 2 | 0.120288 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.107616 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0927709 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0886547 |
| AKT2 | v-akt murine thymoma viral oncogene homolog 2 | 0.0879627 |
| ACTN4 | actinin, alpha 4 | 0.084946 |
| ZFP36 | ZFP36 ring finger protein | 0.0820115 |
| SMAD3 | SMAD family member 3 | 0.0797454 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0777845 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0770637 |
| JMJD1C | jumonji domain containing 1C | 0.0725452 |
| EGR1 | early growth response 1 | 0.0695293 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0636635 |
| SEPTIN9 | septin 9 | 0.0622903 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0577653 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0574302 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0563363 |
| SAMD4B | sterile alpha motif domain containing 4B | 0.0533458 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | 0.0519101 |
| VMP1 | vacuole membrane protein 1 | 0.051552 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.0513644 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0513222 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0505406 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0495163 |
| RPL28 | ribosomal protein L28 | 0.0494892 |
| GCNT2 | glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) | 0.0479795 |
| MCL1 | myeloid cell leukemia 1 | 0.0474841 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0471782 |
| CENPF | centromere protein F, 350/400kDa | 0.0460586 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0460064 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | 0.0451766 |
| FHL2 | four and a half LIM domains 2 | 0.0450428 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0440073 |
| ITGAV | integrin, alpha V | 0.0429723 |
| NUP98 | nucleoporin 98kDa | 0.0428307 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.042056 |
| CD44 | CD44 molecule (Indian blood group) | 0.0410585 |
| ANO6 | anoctamin 6 | 0.0406706 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0402921 |
| PRRC2A | proline-rich coiled-coil 2A | 0.040201 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0387998 |
| CCDC88A | coiled-coil domain containing 88A | 0.038141 |
| BRD2 | bromodomain containing 2 | 0.0381319 |
| YBX1 | Y box binding protein 1 | 0.0380822 |
| DSTN | destrin (actin depolymerizing factor) | 0.03791 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0378836 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0374935 |
| MED13L | mediator complex subunit 13-like | 0.0374288 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0372202 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0361612 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0356232 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0356104 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0355129 |
| ATXN1 | ataxin 1 | 0.0349144 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.034895 |
| ASPH | aspartate beta-hydroxylase | 0.0345495 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 0.0344997 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0342495 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0332086 |
| L1CAM | L1 cell adhesion molecule | 0.0326827 |
| TM9SF4 | transmembrane 9 superfamily protein member 4 | 0.0324358 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0324041 |
| PCBP2 | poly(rC) binding protein 2 | 0.0321872 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.03207 |
| DGKD | diacylglycerol kinase, delta 130kDa | 0.0316054 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | 0.0313908 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | 0.0310666 |
| ITGB5 | integrin, beta 5 | 0.0310076 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0307195 |
| TMEM41B | transmembrane protein 41B | 0.0306856 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0305248 |
| FOSL1 | FOS-like antigen 1 | 0.0305171 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | 0.0302691 |
| PXDN | peroxidasin | 0.0298052 |
| EPAS1 | endothelial PAS domain protein 1 | 0.029556 |
| SETD5 | SET domain containing 5 | 0.0290428 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | 0.0288804 |
| EPB41L2 | erythrocyte membrane protein band 4.1-like 2 | 0.0288223 |
| INTS6 | integrator complex subunit 6 | 0.0287958 |
| LENG8 | leukocyte receptor cluster (LRC) member 8 | 0.0287794 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.0286367 |
| PDE10A | phosphodiesterase 10A | 0.0283982 |
| MYO1E | myosin IE | 0.0278981 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0278856 |
| MSN | moesin | 0.0278597 |
| RAD51B | RAD51 paralog B | 0.0276939 |
| TOP1 | topoisomerase (DNA) I | 0.0276717 |
| MORF4L2 | mortality factor 4 like 2 | 0.0272148 |
| RPS2 | ribosomal protein S2 | 0.0271775 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0271236 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0269642 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0268413 |
| CD59 | CD59 molecule, complement regulatory protein | 0.0267499 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.026454 |
| CCNL1 | cyclin L1 | 0.0262577 |
| RPL21 | ribosomal protein L21 | 0.026088 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.0260076 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0257634 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.0256678 |
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.401249 |
| VIM | vimentin | -0.256465 |
| AHNAK | AHNAK nucleoprotein | -0.158555 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.102188 |
| TMSB10 | thymosin beta 10 | -0.0910532 |
| PTMA | prothymosin, alpha | -0.0892913 |
| FBL | fibrillarin | -0.0804035 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0537965 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0475234 |
| RPL35A | ribosomal protein L35a | -0.0465348 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0449971 |
| RPS24 | ribosomal protein S24 | -0.0439985 |
| CTSD | cathepsin D | -0.0424969 |
| AFAP1 | actin filament associated protein 1 | -0.0379056 |
| SLC35F3 | solute carrier family 35, member F3 | -0.0340319 |
| FTL | ferritin, light polypeptide | -0.0324851 |
| CAVIN1 | caveolae associated protein 1 | -0.030785 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0296646 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0290526 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0274735 |
| RSL1D1 | ribosomal L1 domain containing 1 | -0.0260679 |
| RPL4 | ribosomal protein L4 | -0.024528 |
| RIGI | RNA sensor RIG-I | -0.0239588 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0236394 |
| FBXO27 | F-box protein 27 | -0.0230374 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.0220472 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0215147 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0209761 |
| RPLP1 | ribosomal protein, large, P1 | -0.0203861 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0200063 |
| LMNA | lamin A/C | -0.019829 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0195503 |
| S100A6 | S100 calcium binding protein A6 | -0.019393 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0192031 |
| FBXO17 | F-box protein 17 | -0.0190679 |
| RPL38 | ribosomal protein L38 | -0.0189978 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0188694 |
| TXNRD1 | thioredoxin reductase 1 | -0.018843 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | -0.0181393 |
| PARK7 | parkinson protein 7 | -0.0178779 |
| CBL | Cbl proto-oncogene, E3 ubiquitin protein ligase | -0.0173941 |
| PDGFB | platelet-derived growth factor beta polypeptide | -0.0172042 |
| RPLP0 | ribosomal protein, large, P0 | -0.0163132 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0162943 |
| CCND1 | cyclin D1 | -0.0160437 |
| RRBP1 | ribosome binding protein 1 | -0.0152738 |
| ZNF780B | zinc finger protein 780B | -0.0151342 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0150657 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0148027 |
| HMGA2 | high mobility group AT-hook 2 | -0.0146534 |
| AHNAK2 | AHNAK nucleoprotein 2 | -0.0145413 |
| CANX | calnexin | -0.0145151 |
| PGK1 | phosphoglycerate kinase 1 | -0.0144955 |
| RBM3 | RNA binding motif (RNP1, RRM) protein 3 | -0.0142427 |
| CCT4 | chaperonin containing TCP1, subunit 4 (delta) | -0.0139997 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0139592 |
| RPL31 | ribosomal protein L31 | -0.0138861 |
| ATG7 | autophagy related 7 | -0.0138645 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0138478 |
| KHSRP | KH-type splicing regulatory protein | -0.0138422 |
| HNRNPK | heterogeneous nuclear ribonucleoprotein K | -0.0135926 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | -0.0132453 |
| HNRNPD | heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) | -0.0132434 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0131919 |
| CCT8 | chaperonin containing TCP1, subunit 8 (theta) | -0.0125208 |
| GNAS | GNAS complex locus | -0.0124606 |
| NHSL1 | NHS-like 1 | -0.0123268 |
| ODF2L | outer dense fiber of sperm tails 2-like | -0.0121638 |
| NPR2 | natriuretic peptide receptor 2 | -0.0121272 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0120793 |
| PKM | pyruvate kinase, muscle | -0.0120664 |
| CEP170 | centrosomal protein 170kDa | -0.011883 |
| MATR3 | matrin 3 | -0.0117867 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0117765 |
| DIAPH2 | diaphanous-related formin 2 | -0.0117197 |
| CDCP1 | CUB domain containing protein 1 | -0.0116174 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0116033 |
| TMEM123 | transmembrane protein 123 | -0.0115019 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0114316 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0113396 |
| ANP32A | acidic (leucine-rich) nuclear phosphoprotein 32 family, member A | -0.0113373 |
| CTBS | chitobiase, di-N-acetyl- | -0.0112502 |
| PPARG | peroxisome proliferator-activated receptor gamma | -0.0111943 |
| ARMC9 | armadillo repeat containing 9 | -0.0111812 |
| REEP3 | receptor accessory protein 3 | -0.0111687 |
| TRIM56 | tripartite motif containing 56 | -0.0111247 |
| ARL4C | ADP-ribosylation factor-like 4C | -0.011029 |
| ITPRIPL2 | inositol 1,4,5-trisphosphate receptor interacting protein-like 2 | -0.0109856 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0109724 |
| TMSB4X | thymosin beta 4, X-linked | -0.0109537 |
| SCAMP1 | secretory carrier membrane protein 1 | -0.0107052 |
| CRYBG1 | crystallin beta-gamma domain containing 1 | -0.0105924 |
| KRT18 | keratin 18, type I | -0.0103424 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0102703 |
| C15ORF48 | chromosome 15 open reading frame 48 | -0.0102417 |
| ICAM1 | intercellular adhesion molecule 1 | -0.010226 |
| TCF12 | transcription factor 12 | -0.0101453 |
| TARS1 | threonyl-tRNA synthetase 1 | -0.0100934 |
| MXI1 | MAX interactor 1, dimerization protein | -0.0100893 |
| HDAC2 | histone deacetylase 2 | -0.0100062 |
