Esmolol (hydrochloride)_Panc 03.27 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Esmolol (hydrochloride) perturbation in Panc 03.27 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Esmolol (hydrochloride)_Panc 03.27 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.145653
LAMA4 laminin, alpha 4 0.0941755
MUC16 mucin 16, cell surface associated 0.0823475
EGR1 early growth response 1 0.0776093
TGM2 transglutaminase 2 0.0750327
MUC4 mucin 4, cell surface associated 0.0745002
KRT19 keratin 19, type I 0.06803
MT2A metallothionein 2A 0.0630858
RPS6 ribosomal protein S6 0.0626989
C3 complement component 3 0.0565304
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0563967
HMGA1 high mobility group AT-hook 1 0.0539335
FTH1 ferritin, heavy polypeptide 1 0.0533825
H1-0 H1.0 linker histone 0.048481
LOC102724023 ES1 protein homolog, mitochondrial 0.0458154
NCEH1 neutral cholesterol ester hydrolase 1 0.0457708
BCAR3 breast cancer anti-estrogen resistance 3 0.0422016
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0414915
MAML2 mastermind-like 2 (Drosophila) 0.0406039
WWC1 WW and C2 domain containing 1 0.0371999
RPL28 ribosomal protein L28 0.0365686
PPDPF pancreatic progenitor cell differentiation and proliferation factor 0.0350093
SEPTIN9 septin 9 0.0342223
VCL vinculin 0.033496
OSMR oncostatin M receptor 0.0321467
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0315269
MKI67 marker of proliferation Ki-67 0.0303831
MYO1E myosin IE 0.0303698
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0300224
TJP1 tight junction protein 1 0.0299623
LAMA5 laminin, alpha 5 0.0293982
FNDC3B fibronectin type III domain containing 3B 0.0283524
AREG amphiregulin 0.0282451
RASAL2 RAS protein activator like 2 0.0272673
EGFR epidermal growth factor receptor 0.0270467
PDLIM5 PDZ and LIM domain 5 0.0268426
FN1 fibronectin 1 0.0264971
IL1RAP interleukin 1 receptor accessory protein 0.0263779
RAD51B RAD51 paralog B 0.026279
BCL2L1 BCL2-like 1 0.0258171
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0257536
LMO7 LIM domain 7 0.0250369
YBX3 Y box binding protein 3 0.0247452
MPRIP myosin phosphatase Rho interacting protein 0.0247339
LOC112694756 uncharaterized LOC112694756 0.0247105
RPL11 ribosomal protein L11 0.0240775
ZSWIM6 zinc finger, SWIM-type containing 6 0.0237335
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0236705
CD59 CD59 molecule, complement regulatory protein 0.0234628
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) 0.0234615
SVIL supervillin 0.0234378
TGFA transforming growth factor, alpha 0.0231343
HLA-A major histocompatibility complex, class I, A 0.0228246
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0220877
PPARD peroxisome proliferator-activated receptor delta 0.0220522
ERRFI1 ERBB receptor feedback inhibitor 1 0.0214746
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0211824
RPL35A ribosomal protein L35a 0.0210476
MELTF melanotransferrin 0.0208802
RPS19 ribosomal protein S19 0.0208518
EPS8 epidermal growth factor receptor pathway substrate 8 0.0208101
RPL13A ribosomal protein L13a 0.0205491
CLDN4 claudin 4 0.0203249
SGMS2 sphingomyelin synthase 2 0.0202308
SHB Src homology 2 domain containing adaptor protein B 0.0200071
EFHD2 EF-hand domain family, member D2 0.0200069
EFNA5 ephrin-A5 0.0198991
AFDN afadin, adherens junction formation factor 0.0198412
RPS8 ribosomal protein S8 0.0198194
SHROOM3 shroom family member 3 0.0197325
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.0197094
ETV6 ets variant 6 0.0193314
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0192851
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0190066
NCOR2 nuclear receptor corepressor 2 0.0189654
C6ORF132 chromosome 6 open reading frame 132 0.0189581
RPS2 ribosomal protein S2 0.0187115
LY6E lymphocyte antigen 6 complex, locus E 0.0185255
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0183474
IFITM3 interferon induced transmembrane protein 3 0.0183252
SLTM SAFB-like, transcription modulator 0.0182646
RUNX1 runt-related transcription factor 1 0.0182227
DLC1 DLC1 Rho GTPase activating protein 0.0177098
SIK3 SIK family kinase 3 0.0175988
ACTN1 actinin, alpha 1 0.0174653
ZMIZ2 zinc finger, MIZ-type containing 2 0.0173436
MX2 MX dynamin-like GTPase 2 0.0172902
RBMS2 RNA binding motif, single stranded interacting protein 2 0.0170665
RPL21 ribosomal protein L21 0.0169357
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0167397
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) 0.0166005
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0164749
CCNL1 cyclin L1 0.0164732
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough 0.0164443
MACC1 metastasis associated in colon cancer 1 0.0164361
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0164036
STC2 stanniocalcin 2 0.0164013
CAV1 caveolin 1, caveolae protein, 22kDa 0.0160741
ANKRD12 ankyrin repeat domain 12 0.0159957
AKAP9 A kinase (PRKA) anchor protein 9 0.0159526

decreased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.127102
AHNAK AHNAK nucleoprotein -0.125413
TMSB10 thymosin beta 10 -0.121097
UBC ubiquitin C -0.113931
KRT17 keratin 17, type I -0.104349
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.10103
CANX calnexin -0.0843572
PTMA prothymosin, alpha -0.0766582
RPS27A ribosomal protein S27a -0.0760843
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0713145
MYO6 myosin VI -0.0682689
CALR calreticulin -0.0628446
PCBP2 poly(rC) binding protein 2 -0.0583905
EIF4A2 eukaryotic translation initiation factor 4A2 -0.0538783
TMSB4X thymosin beta 4, X-linked -0.0528465
KRT8 keratin 8, type II -0.0514686
KRT7 keratin 7, type II -0.0506014
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0476251
OGA O-GlcNAcase -0.0446824
TPM4 tropomyosin 4 -0.0429062
KDM3A lysine (K)-specific demethylase 3A -0.0397004
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0381265
EEF2 eukaryotic translation elongation factor 2 -0.0374917
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0364576
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle -0.0357759
EMP1 epithelial membrane protein 1 -0.0355833
RPL23 ribosomal protein L23 -0.0346331
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 -0.0331601
HLA-E major histocompatibility complex, class I, E -0.0326684
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0311887
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0311511
HNRNPUL2 heterogeneous nuclear ribonucleoprotein U-like 2 -0.03021
RPS24 ribosomal protein S24 -0.0301238
XPO1 exportin 1 -0.0295641
THBS1 thrombospondin 1 -0.0295001
MATR3 matrin 3 -0.0278538
RIOK3 RIO kinase 3 -0.0277492
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0276659
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.027456
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0271077
PKM pyruvate kinase, muscle -0.026362
TPM3 tropomyosin 3 -0.0258281
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0257034
DSG2 desmoglein 2 -0.0255405
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -0.0255387
B2M beta-2-microglobulin -0.0250756
ZFAND3 zinc finger, AN1-type domain 3 -0.0249876
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0249407
FXR1 fragile X mental retardation, autosomal homolog 1 -0.0244085
ZNF148 zinc finger protein 148 -0.0241511
DSCAM Down syndrome cell adhesion molecule -0.0240448
ZMYM2 zinc finger, MYM-type 2 -0.0240275
EPCAM epithelial cell adhesion molecule -0.023912
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0236695
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.023295
RBM39 RNA binding motif protein 39 -0.0231387
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked -0.0229374
TAOK1 TAO kinase 1 -0.0226835
TXNRD1 thioredoxin reductase 1 -0.0225785
PDS5B PDS5 cohesin associated factor B -0.0225519
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0222108
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 -0.0220168
FBXL20 F-box and leucine-rich repeat protein 20 -0.0218736
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase -0.0217095
APP amyloid beta (A4) precursor protein -0.0213726
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0212245
CDK12 cyclin-dependent kinase 12 -0.0210906
RPLP1 ribosomal protein, large, P1 -0.0209523
MARCHF6 membrane associated ring-CH-type finger 6 -0.0208821
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.0208021
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0207726
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0204276
RBM25 RNA binding motif protein 25 -0.0202896
SDC4 syndecan 4 -0.0202023
ARRDC3 arrestin domain containing 3 -0.0200529
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0198579
NAMPT nicotinamide phosphoribosyltransferase -0.0197529
MYH9 myosin, heavy chain 9, non-muscle -0.019667
BIRC3 baculoviral IAP repeat containing 3 -0.0195631
RSF1 remodeling and spacing factor 1 -0.019345
AMOTL2 angiomotin like 2 -0.0192394
TRPM7 transient receptor potential cation channel, subfamily M, member 7 -0.0192261
PHC3 polyhomeotic homolog 3 (Drosophila) -0.019094
TNPO1 transportin 1 -0.018951
RPL4 ribosomal protein L4 -0.0187621
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0186947
SPDYA speedy/RINGO cell cycle regulator family member A -0.0186788
ZC3H11A zinc finger CCCH-type containing 11A -0.0186249
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0185941
PDIA3 protein disulfide isomerase family A, member 3 -0.0184083
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0183576
SRPK2 SRSF protein kinase 2 -0.0179434
FNBP1L formin binding protein 1-like -0.0179152
BIRC6 baculoviral IAP repeat containing 6 -0.0177548
PDIA4 protein disulfide isomerase family A, member 4 -0.0177501
ZNF207 zinc finger protein 207 -0.017626
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 -0.0176056
CLTC clathrin, heavy chain (Hc) -0.0175305
JUN jun proto-oncogene -0.017478
BBX bobby sox homolog (Drosophila) -0.0174673