| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Esmolol (hydrochloride) perturbation in RPMI-7951 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Esmolol (hydrochloride)_RPMI-7951 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | 0.39702 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.219335 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.175708 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.162362 |
| NDRG1 | N-myc downstream regulated 1 | 0.126723 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.112048 |
| COL1A2 | collagen, type I, alpha 2 | 0.109047 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | 0.099098 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.0932674 |
| POTEF | POTE ankyrin domain family, member F | 0.0887271 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0884652 |
| ENO1 | enolase 1, (alpha) | 0.0881735 |
| COL6A1 | collagen, type VI, alpha 1 | 0.0875627 |
| VEGFA | vascular endothelial growth factor A | 0.085236 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0847299 |
| COL1A1 | collagen, type I, alpha 1 | 0.0829363 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0821005 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.081932 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0815236 |
| TGM2 | transglutaminase 2 | 0.0792085 |
| FRMD4A | FERM domain containing 4A | 0.0755821 |
| COL6A2 | collagen, type VI, alpha 2 | 0.0749046 |
| NRP1 | neuropilin 1 | 0.0709651 |
| MSN | moesin | 0.0698982 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0658965 |
| TPM1 | tropomyosin 1 (alpha) | 0.0657829 |
| TMEM178B | transmembrane protein 178B | 0.0654571 |
| COL5A1 | collagen, type V, alpha 1 | 0.0646525 |
| NAV1 | neuron navigator 1 | 0.0637108 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0589839 |
| PKM | pyruvate kinase, muscle | 0.0588174 |
| B2M | beta-2-microglobulin | 0.0580496 |
| RAD51B | RAD51 paralog B | 0.0570862 |
| MT2A | metallothionein 2A | 0.0555653 |
| ANGPTL4 | angiopoietin-like 4 | 0.0553635 |
| ASPH | aspartate beta-hydroxylase | 0.0548655 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | 0.054418 |
| FLNB | filamin B, beta | 0.0543911 |
| MEF2A | myocyte enhancer factor 2A | 0.0528447 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0525417 |
| LOXL2 | lysyl oxidase-like 2 | 0.0516374 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.048524 |
| CD109 | CD109 molecule | 0.0482564 |
| VIM | vimentin | 0.0466131 |
| FAM13A | family with sequence similarity 13, member A | 0.0458991 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.0437503 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0436186 |
| H1-0 | H1.0 linker histone | 0.0435888 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | 0.0435338 |
| ATXN1 | ataxin 1 | 0.041725 |
| CLIC4 | chloride intracellular channel 4 | 0.0415294 |
| APCDD1L | adenomatosis polyposis coli down-regulated 1-like | 0.0413796 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0404652 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0400165 |
| MYO1B | myosin IB | 0.0394212 |
| PLOD1 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 | 0.039132 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0389087 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0384315 |
| COL7A1 | collagen, type VII, alpha 1 | 0.0383279 |
| YEATS2 | YEATS domain containing 2 | 0.0383052 |
| FHIT | fragile histidine triad | 0.0382134 |
| SETBP1 | SET binding protein 1 | 0.0379808 |
| ANXA2 | annexin A2 | 0.0377965 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | 0.0376371 |
| PFKP | phosphofructokinase, platelet | 0.0376278 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | 0.0376252 |
| CALD1 | caldesmon 1 | 0.0371908 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0369441 |
| RUNX1 | runt-related transcription factor 1 | 0.0366018 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | 0.0365687 |
| MTSS1 | metastasis suppressor 1 | 0.0365146 |
| TGFB1 | transforming growth factor, beta 1 | 0.0364545 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0361651 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0357035 |
| LDHA | lactate dehydrogenase A | 0.0355124 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0354337 |
| C1D | C1D nuclear receptor corepressor | 0.0353181 |
| CDCP1 | CUB domain containing protein 1 | 0.0350706 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0350651 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0346593 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0344747 |
| MMP2 | matrix metallopeptidase 2 | 0.0341257 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.0340849 |
| HLA-B | major histocompatibility complex, class I, B | 0.0337118 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0336232 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0335143 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | 0.0335037 |
| FOSL1 | FOS-like antigen 1 | 0.0330948 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0328367 |
| ACTN1 | actinin, alpha 1 | 0.0328363 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | 0.0324084 |
| TMF1 | TATA element modulatory factor 1 | 0.03221 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0319615 |
| CCDC88A | coiled-coil domain containing 88A | 0.0313248 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0312796 |
| ITGA11 | integrin, alpha 11 | 0.0310009 |
| AGRN | agrin | 0.0308726 |
| EGR1 | early growth response 1 | 0.0308395 |
| SMAD3 | SMAD family member 3 | 0.0305498 |
| ECE1 | endothelin converting enzyme 1 | 0.0304592 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.141172 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0784357 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0572082 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0505505 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0359184 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0344149 |
| TMSB10 | thymosin beta 10 | -0.0312841 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0306501 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0295637 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0280841 |
| STC1 | stanniocalcin 1 | -0.0255914 |
| FBXO11 | F-box protein 11 | -0.0252933 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0251937 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.022767 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0225866 |
| IER3 | immediate early response 3 | -0.0211696 |
| RAB2A | RAB2A, member RAS oncogene family | -0.0211615 |
| LCORL | ligand dependent nuclear receptor corepressor-like | -0.0207031 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0205843 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0203266 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | -0.0202248 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0199903 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0198728 |
| ARF1 | ADP-ribosylation factor 1 | -0.019216 |
| COPB2 | coatomer protein complex, subunit beta 2 (beta prime) | -0.0189307 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0188989 |
| SCLT1 | sodium channel and clathrin linker 1 | -0.0187761 |
| TRPC4AP | transient receptor potential cation channel, subfamily C, member 4 associated protein | -0.0185084 |
| PTMA | prothymosin, alpha | -0.0180371 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0179957 |
| EXT1 | exostosin glycosyltransferase 1 | -0.017876 |
| TEX10 | testis expressed 10 | -0.0178429 |
| KYNU | kynureninase | -0.0178268 |
| STK4 | serine/threonine kinase 4 | -0.0177552 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0176826 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0174305 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0172255 |
| SENP5 | SUMO1/sentrin specific peptidase 5 | -0.0171824 |
| MORF4L2 | mortality factor 4 like 2 | -0.0171719 |
| NCOA3 | nuclear receptor coactivator 3 | -0.0169971 |
| EIF3H | eukaryotic translation initiation factor 3, subunit H | -0.0168962 |
| TXNRD1 | thioredoxin reductase 1 | -0.0168679 |
| IL1B | interleukin 1, beta | -0.0168431 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0168076 |
| SPAG9 | sperm associated antigen 9 | -0.0167371 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0165624 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0165126 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0161703 |
| SELENOK | selenoprotein K | -0.016063 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0160158 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0157463 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0157024 |
| USP15 | ubiquitin specific peptidase 15 | -0.0153218 |
| CLINT1 | clathrin interactor 1 | -0.015266 |
| GLG1 | golgi glycoprotein 1 | -0.0152193 |
| SP100 | SP100 nuclear antigen | -0.0149732 |
| EREG | epiregulin | -0.0147907 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.0142873 |
| LTN1 | listerin E3 ubiquitin protein ligase 1 | -0.0141982 |
| RLF | rearranged L-myc fusion | -0.0138209 |
| UGGT2 | UDP-glucose glycoprotein glucosyltransferase 2 | -0.0137504 |
| RBM25 | RNA binding motif protein 25 | -0.0137001 |
| KRTAP11-1 | keratin associated protein 11-1 | -0.0136651 |
| RBM39 | RNA binding motif protein 39 | -0.0135988 |
| GOLT1B | golgi transport 1B | -0.0135699 |
| OSER1 | oxidative stress responsive serine-rich 1 | -0.0134806 |
| RHEB | Ras homolog enriched in brain | -0.0134697 |
| GOLGA3 | golgin A3 | -0.0131702 |
| TPST1 | tyrosylprotein sulfotransferase 1 | -0.0130599 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0130489 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0129989 |
| TARS1 | threonyl-tRNA synthetase 1 | -0.0127097 |
| MAMLD1 | mastermind-like domain containing 1 | -0.0125877 |
| PRRC1 | proline-rich coiled-coil 1 | -0.0125633 |
| RHOQ | ras homolog family member Q | -0.0125345 |
| PARK7 | parkinson protein 7 | -0.0124907 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0124709 |
| HBP1 | HMG-box transcription factor 1 | -0.0123333 |
| DDX3X | DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked | -0.0123098 |
| TOP2B | topoisomerase (DNA) II beta 180kDa | -0.0122977 |
| FBXW11 | F-box and WD repeat domain containing 11 | -0.0121196 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0119879 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | -0.0119603 |
| GNL2 | guanine nucleotide binding protein-like 2 (nucleolar) | -0.0119485 |
| TTK | TTK protein kinase | -0.0119428 |
| LRRFIP2 | leucine rich repeat (in FLII) interacting protein 2 | -0.0119164 |
| CD63 | CD63 molecule | -0.0118429 |
| CLTC | clathrin, heavy chain (Hc) | -0.0118376 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0118195 |
| NUMB | numb homolog (Drosophila) | -0.0118147 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.011756 |
| FAM168B | family with sequence similarity 168, member B | -0.0117076 |
| WDR43 | WD repeat domain 43 | -0.0116467 |
| TFRC | transferrin receptor | -0.0115879 |
| ECT2 | epithelial cell transforming 2 | -0.0115629 |
| KLHL24 | kelch-like family member 24 | -0.0115154 |
| RPL4 | ribosomal protein L4 | -0.0113606 |
| UBE2G1 | ubiquitin-conjugating enzyme E2G 1 | -0.0112476 |
| UBR1 | ubiquitin protein ligase E3 component n-recognin 1 | -0.0112167 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | -0.0111904 |
