Esmolol (hydrochloride)_SHP-77 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Esmolol (hydrochloride) perturbation in SHP-77 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Esmolol (hydrochloride)_SHP-77 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE10A phosphodiesterase 10A 0.36348
SNAP25 synaptosomal-associated protein, 25kDa 0.089725
PEG10 paternally expressed 10 0.0706602
SMOC1 SPARC related modular calcium binding 1 0.0654514
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 0.0574826
TENT5A terminal nucleotidyltransferase 5A 0.0573775
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0489012
PDE4B phosphodiesterase 4B, cAMP-specific 0.046394
FAT1 FAT atypical cadherin 1 0.0418731
PDE4D phosphodiesterase 4D, cAMP-specific 0.0369727
CENPF centromere protein F, 350/400kDa 0.0356377
SASH1 SAM and SH3 domain containing 1 0.0355241
RIT2 Ras-like without CAAX 2 0.0338438
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 0.033453
PCSK1 proprotein convertase subtilisin/kexin type 1 0.0333531
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.0325522
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.032339
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0321281
ARHGAP26 Rho GTPase activating protein 26 0.0303985
PCM1 pericentriolar material 1 0.0300564
MYH9 myosin, heavy chain 9, non-muscle 0.0299616
TOX thymocyte selection-associated high mobility group box 0.0296471
SYT1 synaptotagmin I 0.0289775
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 0.0288358
FNDC3A fibronectin type III domain containing 3A 0.0281346
NALF1 NALCN channel auxiliary factor 1 0.0280277
CDH12 cadherin 12, type 2 (N-cadherin 2) 0.0277127
VGF VGF nerve growth factor inducible 0.0270026
FGF14 fibroblast growth factor 14 0.0269001
PCBP3 poly(rC) binding protein 3 0.0264902
RAD51B RAD51 paralog B 0.0260873
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.025027
PRKD1 protein kinase D1 0.0230601
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0229292
GRAMD4 GRAM domain containing 4 0.0228445
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.0227974
NCKAP5 NCK-associated protein 5 0.0227409
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0226003
PEX5L peroxisomal biogenesis factor 5-like 0.0225337
LIFR leukemia inhibitory factor receptor alpha 0.0225019
UBE2QL1 ubiquitin-conjugating enzyme E2Q family-like 1 0.0223797
ARB2A ARB2 cotranscriptional regulator A 0.0223796
AOPEP aminopeptidase O (putative) 0.0222856
PCCA propionyl CoA carboxylase, alpha polypeptide 0.0222083
PBX3 pre-B-cell leukemia homeobox 3 0.0219863
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) 0.0219395
AGBL4 ATP/GTP binding protein-like 4 0.0216709
SIK2 salt-inducible kinase 2 0.021668
DST dystonin 0.0212655
TOP2A topoisomerase (DNA) II alpha 170kDa 0.021221
AUTS2 autism susceptibility candidate 2 0.0210079
IGF1R insulin-like growth factor 1 receptor 0.0207867
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0201694
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0201171
CNKSR3 CNKSR family member 3 0.02001
ADGRL3 adhesion G protein-coupled receptor L3 0.0198481
NRXN1 neurexin 1 0.0196283
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8 0.0196067
MTMR7 myotubularin related protein 7 0.0195124
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0192325
AP1S3 adaptor-related protein complex 1, sigma 3 subunit 0.0191246
ZC3H12B zinc finger CCCH-type containing 12B 0.0188647
SLF1 SMC5-SMC6 complex localization factor 1 0.0186958
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0184471
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related) 0.0184438
SPIDR scaffolding protein involved in DNA repair 0.0183128
TRIM9 tripartite motif containing 9 0.018261
RIMS2 regulating synaptic membrane exocytosis 2 0.0181274
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0180982
KCND2 potassium channel, voltage gated Shal related subfamily D, member 2 0.0180279
GPRIN3 GPRIN family member 3 0.0178323
TPR translocated promoter region, nuclear basket protein 0.017791
NLGN1 neuroligin 1 0.0176121
DPYSL3 dihydropyrimidinase-like 3 0.0174156
KIAA0825 KIAA0825 0.0172718
DTNA dystrobrevin, alpha 0.0171094
AFF1 AF4/FMR2 family, member 1 0.0169272
CADM1 cell adhesion molecule 1 0.016906
MKI67 marker of proliferation Ki-67 0.0165465
PSD3 pleckstrin and Sec7 domain containing 3 0.0165402
PDK4 pyruvate dehydrogenase kinase, isozyme 4 0.0164363
MBNL2 muscleblind-like splicing regulator 2 0.0164336
ZNF407 zinc finger protein 407 0.0162255
ADAR adenosine deaminase, RNA-specific 0.016206
FARS2 phenylalanyl-tRNA synthetase 2, mitochondrial 0.0161566
TBC1D5 TBC1 domain family, member 5 0.0160835
CAMTA1 calmodulin binding transcription activator 1 0.0158546
BCAS3 breast carcinoma amplified sequence 3 0.0158525
MPRIP myosin phosphatase Rho interacting protein 0.0152627
LIMCH1 LIM and calponin homology domains 1 0.0150707
FANCL Fanconi anemia, complementation group L 0.0149637
RNF144A ring finger protein 144A 0.0149524
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0149455
PCLO piccolo presynaptic cytomatrix protein 0.0149024
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0148407
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0147518
WWOX WW domain containing oxidoreductase 0.0146934
DACH1 dachshund family transcription factor 1 0.0145414
G2E3 G2/M-phase specific E3 ubiquitin protein ligase 0.0145384
COA1 cytochrome c oxidase assembly factor 1 homolog (S. cerevisiae) 0.0144723

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.137999
CALCA calcitonin-related polypeptide alpha -0.0776929
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0697159
IGFBP2 insulin-like growth factor binding protein 2, 36kDa -0.057097
RPS21 ribosomal protein S21 -0.0548025
RPL37A ribosomal protein L37a -0.0542471
NDRG1 N-myc downstream regulated 1 -0.0498839
RPS6 ribosomal protein S6 -0.0489999
RPS3 ribosomal protein S3 -0.0436926
CHGA chromogranin A -0.0415285
RPL37 ribosomal protein L37 -0.0413873
RPS8 ribosomal protein S8 -0.0401599
RPL31 ribosomal protein L31 -0.0396147
RPS25 ribosomal protein S25 -0.0395527
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0391899
FTL ferritin, light polypeptide -0.0384053
ACTG1 actin gamma 1 -0.0376461
RPL26 ribosomal protein L26 -0.0371034
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0356957
RPLP1 ribosomal protein, large, P1 -0.0347082
RPL8 ribosomal protein L8 -0.0344753
ISG15 ISG15 ubiquitin-like modifier -0.033253
S100A9 S100 calcium binding protein A9 -0.0332483
RPL38 ribosomal protein L38 -0.0328253
RPS27 ribosomal protein S27 -0.0327002
RPS27A ribosomal protein S27a -0.0325527
ATP5F1E ATP synthase F1 subunit epsilon -0.0318074
RPS29 ribosomal protein S29 -0.0316205
SCG2 secretogranin II -0.0314943
TPT1 tumor protein, translationally-controlled 1 -0.0298301
RPS19 ribosomal protein S19 -0.0290136
RPS17 ribosomal protein S17 -0.0287489
RPL23 ribosomal protein L23 -0.0280476
RPL34 ribosomal protein L34 -0.0272612
IFI6 interferon, alpha-inducible protein 6 -0.0270402
RPS16 ribosomal protein S16 -0.02673
RPL11 ribosomal protein L11 -0.0263871
PPIB peptidylprolyl isomerase B (cyclophilin B) -0.0263148
RPS23 ribosomal protein S23 -0.0257305
RPL36AL ribosomal protein L36a-like -0.0250735
RPL36 ribosomal protein L36 -0.0245506
EGR1 early growth response 1 -0.0241979
RPL35A ribosomal protein L35a -0.0239886
MCL1 myeloid cell leukemia 1 -0.0239605
EIF1 eukaryotic translation initiation factor 1 -0.0232223
PTCHD4 patched domain containing 4 -0.023177
IGFBP5 insulin-like growth factor binding protein 5 -0.0230617
TMSB4X thymosin beta 4, X-linked -0.0227175
TMSB10 thymosin beta 10 -0.0226384
PKM pyruvate kinase, muscle -0.0225964
STC1 stanniocalcin 1 -0.022379
GNAS GNAS complex locus -0.0222042
RPS5 ribosomal protein S5 -0.0221315
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0219887
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0217523
RPL30 ribosomal protein L30 -0.0217404
RPL35 ribosomal protein L35 -0.0216606
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0215569
TSHZ2 teashirt zinc finger homeobox 2 -0.0214607
RPS13 ribosomal protein S13 -0.02134
RPL7 ribosomal protein L7 -0.0213395
SEC11C SEC11 homolog C (S. cerevisiae) -0.0209355
TFF3 trefoil factor 3 (intestinal) -0.0208759
SSR2 signal sequence receptor, beta (translocon-associated protein beta) -0.0208509
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0205845
UBB ubiquitin B -0.0205342
RPS12 ribosomal protein S12 -0.0205014
RPL7A ribosomal protein L7a -0.0204085
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0202689
RACK1 receptor for activated C kinase 1 -0.0198775
RPS15 ribosomal protein S15 -0.0196697
CALR calreticulin -0.0196359
COX6C cytochrome c oxidase subunit VIc -0.0195146
RPL36A ribosomal protein L36a -0.019465
RPS24 ribosomal protein S24 -0.0193803
EIF5B eukaryotic translation initiation factor 5B -0.0192995
KCNB2 potassium channel, voltage gated Shab related subfamily B, member 2 -0.0190032
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0185246
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0183971
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.0182421
RPL19 ribosomal protein L19 -0.0180353
GPC5 glypican 5 -0.0179944
SOX4 SRY (sex determining region Y)-box 4 -0.0177194
RPL5 ribosomal protein L5 -0.0176125
RPS11 ribosomal protein S11 -0.0175495
KPNB1 karyopherin (importin) beta 1 -0.017489
RPLP2 ribosomal protein, large, P2 -0.0173856
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0173006
RPL32 ribosomal protein L32 -0.0172467
JUN jun proto-oncogene -0.0167676
CPE carboxypeptidase E -0.0167566
RORA RAR-related orphan receptor A -0.0167298
FOXC1 forkhead box C1 -0.0164742
HSPH1 heat shock 105kDa/110kDa protein 1 -0.0160776
RAN RAN, member RAS oncogene family -0.0159599
RPS14 ribosomal protein S14 -0.0157794
KIF26B kinesin family member 26B -0.0156186
RPL12 ribosomal protein L12 -0.0149796
RPL15 ribosomal protein L15 -0.0149784
COX6A1 cytochrome c oxidase subunit VIa polypeptide 1 -0.0149616