| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Esmolol (hydrochloride) perturbation in SK-MEL-2 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Esmolol (hydrochloride)_SK-MEL-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | 0.250853 |
| FNDC3B | fibronectin type III domain containing 3B | 0.131868 |
| FMN1 | formin 1 | 0.122619 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0961507 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0873201 |
| MSN | moesin | 0.0716133 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0710337 |
| ICAM1 | intercellular adhesion molecule 1 | 0.0643779 |
| FMNL2 | formin-like 2 | 0.0626084 |
| FRMD5 | FERM domain containing 5 | 0.0618347 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | 0.0605635 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0549379 |
| FLNA | filamin A, alpha | 0.0544237 |
| TENM1 | teneurin transmembrane protein 1 | 0.0534546 |
| NOTCH2 | notch 2 | 0.0511086 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0495429 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0485286 |
| SMAD3 | SMAD family member 3 | 0.046435 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0444696 |
| EP300 | E1A binding protein p300 | 0.0444558 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0429415 |
| CLIP4 | CAP-GLY domain containing linker protein family, member 4 | 0.042718 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.041176 |
| MT1X | metallothionein 1X | 0.0402644 |
| RPL3 | ribosomal protein L3 | 0.0393732 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0381474 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | 0.0371814 |
| CD59 | CD59 molecule, complement regulatory protein | 0.0355978 |
| RUNX1 | runt-related transcription factor 1 | 0.0344907 |
| MCL1 | myeloid cell leukemia 1 | 0.0336919 |
| VMP1 | vacuole membrane protein 1 | 0.0334963 |
| NF1 | neurofibromin 1 | 0.0328935 |
| ARB2A | ARB2 cotranscriptional regulator A | 0.0325705 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0325372 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0315898 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0307665 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0304901 |
| MT2A | metallothionein 2A | 0.0304158 |
| PRELID2 | PRELI domain containing 2 | 0.0303977 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0299583 |
| NAV2 | neuron navigator 2 | 0.0296775 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.0294352 |
| NDRG1 | N-myc downstream regulated 1 | 0.0291558 |
| PRKCSH | protein kinase C substrate 80K-H | 0.0289195 |
| RTN4 | reticulon 4 | 0.0288176 |
| HDAC9 | histone deacetylase 9 | 0.0284324 |
| YEATS2 | YEATS domain containing 2 | 0.0277574 |
| CDK19 | cyclin-dependent kinase 19 | 0.0274752 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0273681 |
| XRCC6 | X-ray repair complementing defective repair in Chinese hamster cells 6 | 0.0272261 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0266331 |
| UBE2E1 | ubiquitin-conjugating enzyme E2E 1 | 0.0265784 |
| CD44 | CD44 molecule (Indian blood group) | 0.025777 |
| RBM25 | RNA binding motif protein 25 | 0.0256974 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0256422 |
| ACBD3 | acyl-CoA binding domain containing 3 | 0.025398 |
| RNF145 | ring finger protein 145 | 0.0252479 |
| ITGB5 | integrin, beta 5 | 0.0248267 |
| CLINT1 | clathrin interactor 1 | 0.0246978 |
| POTEF | POTE ankyrin domain family, member F | 0.0244854 |
| PCBP2 | poly(rC) binding protein 2 | 0.024411 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | 0.0242669 |
| TCERG1 | transcription elongation regulator 1 | 0.0241703 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0241332 |
| ATP2C1 | ATPase, Ca++ transporting, type 2C, member 1 | 0.0239953 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0234501 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0233558 |
| FAM219A | family with sequence similarity 219, member A | 0.0233116 |
| SETD5 | SET domain containing 5 | 0.0230209 |
| ABI1 | abl-interactor 1 | 0.0229571 |
| NEK7 | NIMA-related kinase 7 | 0.0227526 |
| NKTR | natural killer cell triggering receptor | 0.0227266 |
| ANKRD1 | ankyrin repeat domain 1 (cardiac muscle) | 0.0227124 |
| SLC39A11 | solute carrier family 39, member 11 | 0.0227006 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.0223512 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0222913 |
| SOX6 | SRY (sex determining region Y)-box 6 | 0.0222381 |
| PUM1 | pumilio RNA-binding family member 1 | 0.0221184 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.0220244 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0219703 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0217717 |
| ACTN1 | actinin, alpha 1 | 0.0217465 |
| OSBPL10 | oxysterol binding protein-like 10 | 0.0217355 |
| ERBIN | erbb2 interacting protein | 0.0214976 |
| ZNF654 | zinc finger protein 654 | 0.0214234 |
| HELZ | helicase with zinc finger | 0.0213346 |
| OGA | O-GlcNAcase | 0.0212527 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0211463 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0210625 |
| NPC1 | Niemann-Pick disease, type C1 | 0.0209724 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0206852 |
| ATP13A3 | ATPase type 13A3 | 0.0205201 |
| NDUFA10 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa | 0.0204122 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0202777 |
| TUSC3 | tumor suppressor candidate 3 | 0.0202596 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | 0.0201386 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0200475 |
| UBE2D2 | ubiquitin-conjugating enzyme E2D 2 | 0.0200345 |
| SUCO | SUN domain containing ossification factor | 0.0200078 |
| YTHDC1 | YTH domain containing 1 | 0.0199065 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.192094 |
| NLGN1 | neuroligin 1 | -0.16022 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.142537 |
| VIM | vimentin | -0.141305 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0878174 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0779433 |
| PTMA | prothymosin, alpha | -0.0696672 |
| FRMD4A | FERM domain containing 4A | -0.0695977 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0654848 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0632737 |
| CCND1 | cyclin D1 | -0.0580599 |
| RPL23 | ribosomal protein L23 | -0.0558799 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0549076 |
| RPLP1 | ribosomal protein, large, P1 | -0.0497507 |
| RPS6 | ribosomal protein S6 | -0.0491158 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0490428 |
| RPL35A | ribosomal protein L35a | -0.0486655 |
| RPS8 | ribosomal protein S8 | -0.0477522 |
| CFAP20DC | CFAP20 domain containing | -0.0466616 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0417886 |
| LSAMP | limbic system-associated membrane protein | -0.0414081 |
| PKM | pyruvate kinase, muscle | -0.0408011 |
| RPL38 | ribosomal protein L38 | -0.0405639 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0400003 |
| SP100 | SP100 nuclear antigen | -0.0385378 |
| RPS3 | ribosomal protein S3 | -0.0370092 |
| TMSB10 | thymosin beta 10 | -0.0368004 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0367285 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0365425 |
| B2M | beta-2-microglobulin | -0.0355746 |
| CENPF | centromere protein F, 350/400kDa | -0.0335991 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0326728 |
| RPL34 | ribosomal protein L34 | -0.0322159 |
| RACK1 | receptor for activated C kinase 1 | -0.0314502 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0313712 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0309882 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0307157 |
| RPL31 | ribosomal protein L31 | -0.0295937 |
| ASPH | aspartate beta-hydroxylase | -0.0295587 |
| AHNAK | AHNAK nucleoprotein | -0.0295294 |
| ENO1 | enolase 1, (alpha) | -0.0293081 |
| TPM4 | tropomyosin 4 | -0.0291014 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0290529 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.0289411 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0284673 |
| NRG3 | neuregulin 3 | -0.02816 |
| BBX | bobby sox homolog (Drosophila) | -0.0277244 |
| PIK3R3 | phosphoinositide-3-kinase, regulatory subunit 3 (gamma) | -0.0275694 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.027526 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | -0.0274326 |
| MSI2 | musashi RNA-binding protein 2 | -0.0274284 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0273925 |
| INTS6 | integrator complex subunit 6 | -0.0273136 |
| RPS29 | ribosomal protein S29 | -0.0272956 |
| TKT | transketolase | -0.027014 |
| MAP4 | microtubule-associated protein 4 | -0.026682 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0266118 |
| LITAF | lipopolysaccharide-induced TNF factor | -0.0262682 |
| RPS27A | ribosomal protein S27a | -0.0260213 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | -0.0257769 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | -0.0257578 |
| RRBP1 | ribosome binding protein 1 | -0.0255125 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0251931 |
| DIAPH2 | diaphanous-related formin 2 | -0.0251912 |
| PRAME | preferentially expressed antigen in melanoma | -0.0250679 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0250545 |
| RPL37A | ribosomal protein L37a | -0.0249386 |
| MAGI3 | membrane associated guanylate kinase, WW and PDZ domain containing 3 | -0.0248457 |
| RPS24 | ribosomal protein S24 | -0.0247167 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0244547 |
| RPS13 | ribosomal protein S13 | -0.0242778 |
| DST | dystonin | -0.0240464 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0240396 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0239278 |
| IER3 | immediate early response 3 | -0.0238385 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0236159 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0234216 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0232248 |
| IFI44L | interferon-induced protein 44-like | -0.0231216 |
| AUTS2 | autism susceptibility candidate 2 | -0.0230683 |
| S100A10 | S100 calcium binding protein A10 | -0.0229823 |
| CANX | calnexin | -0.0229536 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0229399 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0229381 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.0229324 |
| RPL10A | ribosomal protein L10a | -0.0228352 |
| HMGA2 | high mobility group AT-hook 2 | -0.022826 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0226483 |
| HLA-E | major histocompatibility complex, class I, E | -0.0225571 |
| DPP6 | dipeptidyl-peptidase 6 | -0.0223713 |
| RPLP2 | ribosomal protein, large, P2 | -0.0222567 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0218895 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0216676 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0215829 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | -0.0215472 |
| FTL | ferritin, light polypeptide | -0.0214318 |
| ATXN1 | ataxin 1 | -0.0213174 |
| RPS17 | ribosomal protein S17 | -0.0206993 |
| ST13 | suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) | -0.0205855 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.0205687 |
