Esmolol (hydrochloride)_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Esmolol (hydrochloride) perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Esmolol (hydrochloride)_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific 0.186608
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.172643
PDE4B phosphodiesterase 4B, cAMP-specific 0.170297
EGFR epidermal growth factor receptor 0.153731
VCL vinculin 0.15241
RBMS3 RNA binding motif, single stranded interacting protein 3 0.136897
TJP1 tight junction protein 1 0.135181
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0992078
FOXP1 forkhead box P1 0.0969116
SOX6 SRY (sex determining region Y)-box 6 0.0924128
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0895982
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0849392
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0821787
NBEA neurobeachin 0.0772968
HDAC9 histone deacetylase 9 0.0771614
ADAM10 ADAM metallopeptidase domain 10 0.0743653
FLNB filamin B, beta 0.0733731
ENOX1 ecto-NOX disulfide-thiol exchanger 1 0.0725504
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 0.0710183
PDGFC platelet derived growth factor C 0.070822
SLC38A2 solute carrier family 38, member 2 0.0696907
CPED1 cadherin-like and PC-esterase domain containing 1 0.0692451
LPP LIM domain containing preferred translocation partner in lipoma 0.0684287
PABPC1 poly(A) binding protein, cytoplasmic 1 0.066667
NPAS2 neuronal PAS domain protein 2 0.0654059
PYGB phosphorylase, glycogen; brain 0.0633008
DLG1 discs, large homolog 1 (Drosophila) 0.0616378
EFNA5 ephrin-A5 0.0613931
TXNRD1 thioredoxin reductase 1 0.0603507
SSBP2 single-stranded DNA binding protein 2 0.0570884
CACNB4 calcium channel, voltage-dependent, beta 4 subunit 0.0562153
PRELID2 PRELI domain containing 2 0.0554845
GOLGA4 golgin A4 0.0553518
EZR ezrin 0.0543471
SMYD3 SET and MYND domain containing 3 0.0532876
LDHA lactate dehydrogenase A 0.0521183
GLI2 GLI family zinc finger 2 0.0519945
EML4 echinoderm microtubule associated protein like 4 0.0507595
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0503575
EVI5 ecotropic viral integration site 5 0.0501598
POTEF POTE ankyrin domain family, member F 0.0498346
PKM pyruvate kinase, muscle 0.0498264
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.0494401
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.0490806
CAMKMT calmodulin-lysine N-methyltransferase 0.0483395
JMJD1C jumonji domain containing 1C 0.0479515
TGFBR3 transforming growth factor, beta receptor III 0.0472406
EEF2 eukaryotic translation elongation factor 2 0.0468347
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0465692
ZEB1 zinc finger E-box binding homeobox 1 0.0464588
SRRM2 serine/arginine repetitive matrix 2 0.0457389
GLI3 GLI family zinc finger 3 0.0447679
TTC3 tetratricopeptide repeat domain 3 0.0440963
ANKRD17 ankyrin repeat domain 17 0.0435032
TRERF1 transcriptional regulating factor 1 0.0435013
MBNL1 muscleblind-like splicing regulator 1 0.0433454
NFIA nuclear factor I/A 0.0432381
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0426809
DSCAM Down syndrome cell adhesion molecule 0.0419681
GPHN gephyrin 0.0417515
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0407365
DPYD dihydropyrimidine dehydrogenase 0.0406823
PRPF38B pre-mRNA processing factor 38B 0.0394991
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2 0.0393731
FNDC3B fibronectin type III domain containing 3B 0.0390202
PTPRG protein tyrosine phosphatase, receptor type, G 0.0390096
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 0.0389414
ANKRD11 ankyrin repeat domain 11 0.0383699
NCEH1 neutral cholesterol ester hydrolase 1 0.0382758
TACC2 transforming, acidic coiled-coil containing protein 2 0.0373963
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0373052
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0370556
AHCYL2 adenosylhomocysteinase-like 2 0.0369311
SAMD4A sterile alpha motif domain containing 4A 0.0367695
HEG1 heart development protein with EGF-like domains 1 0.0366234
HDLBP high density lipoprotein binding protein 0.03644
ZCCHC7 zinc finger, CCHC domain containing 7 0.035906
ZNF608 zinc finger protein 608 0.0354733
NF1 neurofibromin 1 0.0352459
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0351221
MAP3K14 mitogen-activated protein kinase kinase kinase 14 0.0343086
NBAS neuroblastoma amplified sequence 0.034264
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0341408
SBF2 SET binding factor 2 0.0340919
CYB5B cytochrome b5 type B (outer mitochondrial membrane) 0.0339132
SETD5 SET domain containing 5 0.033794
EXOC6B exocyst complex component 6B 0.0337112
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.033706
ZBTB20 zinc finger and BTB domain containing 20 0.0333578
ZMYND8 zinc finger, MYND-type containing 8 0.0332951
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0332908
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0321172
TBC1D5 TBC1 domain family, member 5 0.0319359
PICALM phosphatidylinositol binding clathrin assembly protein 0.0317726
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0317176
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0314185
DOCK3 dedicator of cytokinesis 3 0.0313293
CAMTA1 calmodulin binding transcription activator 1 0.0312781
TMEM65 transmembrane protein 65 0.031241
ZFAND3 zinc finger, AN1-type domain 3 0.0308111

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.15973
TPT1 tumor protein, translationally-controlled 1 -0.0801632
RPL35A ribosomal protein L35a -0.072522
RPLP1 ribosomal protein, large, P1 -0.0477033
RPS8 ribosomal protein S8 -0.0450834
BMP10 bone morphogenetic protein 10 -0.0417929
RPL31 ribosomal protein L31 -0.0406618
RPL34 ribosomal protein L34 -0.0387192
RPLP2 ribosomal protein, large, P2 -0.0358018
RPS19 ribosomal protein S19 -0.0307692
RPS13 ribosomal protein S13 -0.0273089
RPS24 ribosomal protein S24 -0.0268994
RPS23 ribosomal protein S23 -0.0260758
RPS27A ribosomal protein S27a -0.0259554
RPL37A ribosomal protein L37a -0.0259265
RPL9 ribosomal protein L9 -0.0257102
TMSB10 thymosin beta 10 -0.0255219
RPL12 ribosomal protein L12 -0.0251844
MYL12B myosin, light chain 12B, regulatory -0.0250284
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0248979
RPL23 ribosomal protein L23 -0.0221562
MKI67 marker of proliferation Ki-67 -0.0221175
EIF1 eukaryotic translation initiation factor 1 -0.0220662
RPS21 ribosomal protein S21 -0.021932
RPL38 ribosomal protein L38 -0.0211745
RPL19 ribosomal protein L19 -0.0203374
RPL32 ribosomal protein L32 -0.0193926
RPS29 ribosomal protein S29 -0.0189852
RPS27 ribosomal protein S27 -0.0189701
S100A9 S100 calcium binding protein A9 -0.0187628
DIAPH3 diaphanous-related formin 3 -0.0179368
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0177879
RPL7A ribosomal protein L7a -0.0176439
RPS17 ribosomal protein S17 -0.01717
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0164301
RPL36 ribosomal protein L36 -0.0164249
ARL4C ADP-ribosylation factor-like 4C -0.0163707
ALDH1A2 aldehyde dehydrogenase 1 family, member A2 -0.0163144
RPS11 ribosomal protein S11 -0.0161169
RPS25 ribosomal protein S25 -0.0160609
RPL26 ribosomal protein L26 -0.0159129
RPL36A ribosomal protein L36a -0.0158801
RPS5 ribosomal protein S5 -0.0158503
RPS3 ribosomal protein S3 -0.0157023
FTL ferritin, light polypeptide -0.0153166
RACK1 receptor for activated C kinase 1 -0.0148002
HJURP Holliday junction recognition protein -0.0147343
S100A4 S100 calcium binding protein A4 -0.0146438
RPS6 ribosomal protein S6 -0.0146303
RPS10 ribosomal protein S10 -0.0142986
RPL30 ribosomal protein L30 -0.0140253
RPS16 ribosomal protein S16 -0.0140003
RPLP0 ribosomal protein, large, P0 -0.0138333
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.0135989
RPS15 ribosomal protein S15 -0.0135706
RPS12 ribosomal protein S12 -0.0134426
RPL8 ribosomal protein L8 -0.0134393
RPS4X ribosomal protein S4, X-linked -0.0131571
RPL5 ribosomal protein L5 -0.0129337
S100A10 S100 calcium binding protein A10 -0.0125165
TUBB4B tubulin, beta 4B class IVb -0.0122016
HSPH1 heat shock 105kDa/110kDa protein 1 -0.0117532
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) -0.0115967
RPL37 ribosomal protein L37 -0.011452
TUBA1B tubulin, alpha 1b -0.0114233
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0113663
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0112478
MT2A metallothionein 2A -0.0110088
AKAP12 A kinase (PRKA) anchor protein 12 -0.0109988
RPL4 ribosomal protein L4 -0.0109718
H3-3B H3.3 histone B -0.0109679
VIM vimentin -0.0107282
RPS28 ribosomal protein S28 -0.0107168
RSL1D1 ribosomal L1 domain containing 1 -0.0105487
NAV2 neuron navigator 2 -0.0104456
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0103363
CD63 CD63 molecule -0.0102749
THBD thrombomodulin -0.010109
TYMS thymidylate synthetase -0.00996009
GSTP1 glutathione S-transferase pi 1 -0.00994906
ANLN anillin, actin binding protein -0.00993515
FN1 fibronectin 1 -0.00990286
GADD45A growth arrest and DNA-damage-inducible, alpha -0.00981568
CCND1 cyclin D1 -0.00977011
RPL18 ribosomal protein L18 -0.00975392
YBX3 Y box binding protein 3 -0.00972205
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 -0.00965573
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.00964103
KPNB1 karyopherin (importin) beta 1 -0.00961374
RAN RAN, member RAS oncogene family -0.00954578
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.00948537
PARK7 parkinson protein 7 -0.00937219
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.00934332
RPS14 ribosomal protein S14 -0.00931909
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 -0.0092481
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.00923195
UQCRB ubiquinol-cytochrome c reductase binding protein -0.00912645
SELENOK selenoprotein K -0.00908261
HLA-E major histocompatibility complex, class I, E -0.00900047
SERF2 small EDRK-rich factor 2 -0.00891053