Esmolol (hydrochloride)_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Esmolol (hydrochloride) perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Esmolol (hydrochloride)_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.170425
COL6A3 collagen, type VI, alpha 3 0.15775
FTH1 ferritin, heavy polypeptide 1 0.129412
MT2A metallothionein 2A 0.0609181
LOC112694756 uncharaterized LOC112694756 0.0568059
MAP1B microtubule-associated protein 1B 0.0557934
SDC4 syndecan 4 0.051631
TTC3 tetratricopeptide repeat domain 3 0.0505859
PDIA3 protein disulfide isomerase family A, member 3 0.0493013
ECE1 endothelin converting enzyme 1 0.0464714
HLA-A major histocompatibility complex, class I, A 0.0447809
GOLGB1 golgin B1 0.0443857
COL6A2 collagen, type VI, alpha 2 0.0427519
TOP1 topoisomerase (DNA) I 0.0421522
MSN moesin 0.0405016
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0402425
ZBTB20 zinc finger and BTB domain containing 20 0.0399804
MYH9 myosin, heavy chain 9, non-muscle 0.0392044
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0377131
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.03731
PDE4D phosphodiesterase 4D, cAMP-specific 0.0355277
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.0348669
HILPDA hypoxia inducible lipid droplet-associated 0.0336512
CLIP2 CAP-GLY domain containing linker protein 2 0.032895
GPBP1 GC-rich promoter binding protein 1 0.0327201
ACTN1 actinin, alpha 1 0.0326859
PTGES2 prostaglandin E synthase 2 0.0325065
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0320624
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 0.0316096
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0312905
HDAC9 histone deacetylase 9 0.0311841
PKM pyruvate kinase, muscle 0.0310949
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0309347
RND3 Rho family GTPase 3 0.0308282
CDK6 cyclin-dependent kinase 6 0.0301813
PMM2 phosphomannomutase 2 0.0300133
SMTN smoothelin 0.0296147
PCBP2 poly(rC) binding protein 2 0.0294194
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0293794
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0292225
RPS8 ribosomal protein S8 0.0287874
RAB1A RAB1A, member RAS oncogene family 0.028719
ANLN anillin, actin binding protein 0.0286331
HLA-B major histocompatibility complex, class I, B 0.0283067
SEPTIN9 septin 9 0.0280806
RAB22A RAB22A, member RAS oncogene family 0.0278298
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0276069
ASXL1 additional sex combs like transcriptional regulator 1 0.0275525
TGFB1 transforming growth factor, beta 1 0.027401
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0272627
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0268233
PDIA4 protein disulfide isomerase family A, member 4 0.0265174
UBA6 ubiquitin-like modifier activating enzyme 6 0.0264622
CKAP5 cytoskeleton associated protein 5 0.0264199
NKD1 naked cuticle homolog 1 (Drosophila) 0.0261859
ANKRD17 ankyrin repeat domain 17 0.0261812
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0256319
FNDC3B fibronectin type III domain containing 3B 0.0256255
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0254331
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 0.0253686
FN1 fibronectin 1 0.0253455
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0252679
DPYSL2 dihydropyrimidinase-like 2 0.0251839
SETD5 SET domain containing 5 0.0251373
PHF14 PHD finger protein 14 0.0249493
ITFG1 integrin alpha FG-GAP repeat containing 1 0.0245562
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0242908
COG5 component of oligomeric golgi complex 5 0.0239883
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0239403
ADM adrenomedullin 0.0235394
ACTR2 ARP2 actin-related protein 2 homolog (yeast) 0.0234194
COL4A1 collagen, type IV, alpha 1 0.0232854
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0229761
CDH13 cadherin 13 0.0228017
ENO1 enolase 1, (alpha) 0.0226083
TLN1 talin 1 0.022444
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0223444
SEC31A SEC31 homolog A (S. cerevisiae) 0.0221481
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0221201
SH3GLB1 SH3-domain GRB2-like endophilin B1 0.0219666
TPI1 triosephosphate isomerase 1 0.0219617
ATXN1 ataxin 1 0.0218779
SMAD4 SMAD family member 4 0.0218386
FLNB filamin B, beta 0.0217812
DNAAF9 dynein axonemal assembly factor 9 0.0217574
COL6A1 collagen, type VI, alpha 1 0.0216555
NCOR2 nuclear receptor corepressor 2 0.0216372
PDLIM5 PDZ and LIM domain 5 0.0215975
SCFD2 sec1 family domain containing 2 0.0215505
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0214164
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0213841
MYADM myeloid-associated differentiation marker 0.0212429
NUMB numb homolog (Drosophila) 0.0211705
USP34 ubiquitin specific peptidase 34 0.0211622
SLC25A51 solute carrier family 25, member 51 0.0209826
N4BP2L2 NEDD4 binding protein 2-like 2 0.0209298
ASPH aspartate beta-hydroxylase 0.0208938
WAC WW domain containing adaptor with coiled-coil 0.0208368
ANXA2 annexin A2 0.0207178
COG6 component of oligomeric golgi complex 6 0.0206835

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.234822
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0844381
TMSB10 thymosin beta 10 -0.0695943
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0682874
ATP13A3 ATPase type 13A3 -0.0648969
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0645618
PRELID2 PRELI domain containing 2 -0.0552431
COL1A2 collagen, type I, alpha 2 -0.0490886
IGFBP3 insulin-like growth factor binding protein 3 -0.0484158
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0480061
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0476431
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0458158
AUTS2 autism susceptibility candidate 2 -0.0455009
CALD1 caldesmon 1 -0.0454305
UBE2H ubiquitin-conjugating enzyme E2H -0.044999
NAMPT nicotinamide phosphoribosyltransferase -0.0441471
TENT5A terminal nucleotidyltransferase 5A -0.0433086
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0426322
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0397573
RAI14 retinoic acid induced 14 -0.0377652
HIBADH 3-hydroxyisobutyrate dehydrogenase -0.0374338
FAM13A family with sequence similarity 13, member A -0.0354902
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1 -0.0354562
CALU calumenin -0.0348271
SSBP2 single-stranded DNA binding protein 2 -0.034627
PGK1 phosphoglycerate kinase 1 -0.0342892
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0342273
DPYD dihydropyrimidine dehydrogenase -0.0337621
MORF4L2 mortality factor 4 like 2 -0.0327553
ELF2 E74-like factor 2 (ets domain transcription factor) -0.0325659
TRIO trio Rho guanine nucleotide exchange factor -0.0315015
ZNF395 zinc finger protein 395 -0.0313906
FAM20C family with sequence similarity 20, member C -0.031268
GLIS3 GLIS family zinc finger 3 -0.030435
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0303507
TPT1 tumor protein, translationally-controlled 1 -0.0298576
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0298124
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0296904
NIPBL Nipped-B homolog (Drosophila) -0.0296514
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 -0.0294807
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -0.0292511
HOOK2 hook microtubule-tethering protein 2 -0.0286466
IFRD1 interferon-related developmental regulator 1 -0.0284217
MARCHF6 membrane associated ring-CH-type finger 6 -0.0283128
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.02816
DENND4C DENN/MADD domain containing 4C -0.0281321
ELL2 elongation factor, RNA polymerase II, 2 -0.0280577
GLIPR1 GLI pathogenesis-related 1 -0.027823
ZNF292 zinc finger protein 292 -0.0278126
THBS1 thrombospondin 1 -0.0272204
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 -0.0271292
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0270552
MEF2A myocyte enhancer factor 2A -0.0270287
DLG1 discs, large homolog 1 (Drosophila) -0.0266786
RYK receptor-like tyrosine kinase -0.0265653
PHF21A PHD finger protein 21A -0.0262488
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 -0.0260652
LUC7L2 LUC7-like 2 (S. cerevisiae) -0.0256706
RPS12 ribosomal protein S12 -0.0254516
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0251454
FTL ferritin, light polypeptide -0.0245396
ANKRD12 ankyrin repeat domain 12 -0.0244965
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0244438
LCOR ligand dependent nuclear receptor corepressor -0.0243421
GOLGA4 golgin A4 -0.0243344
KANSL1 KAT8 regulatory NSL complex subunit 1 -0.0242324
CTNNBL1 catenin, beta like 1 -0.0238452
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0238385
DYNC1I2 dynein, cytoplasmic 1, intermediate chain 2 -0.0237361
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0236493
KAZN kazrin, periplakin interacting protein -0.023411
WTAP Wilms tumor 1 associated protein -0.0231874
MATR3 matrin 3 -0.0230704
RPL34 ribosomal protein L34 -0.0229598
KMT2C lysine (K)-specific methyltransferase 2C -0.0229037
DHX34 DEAH (Asp-Glu-Ala-His) box polypeptide 34 -0.0225983
DYM dymeclin -0.0221888
BBX bobby sox homolog (Drosophila) -0.0220185
CDC73 cell division cycle 73 -0.0219774
COL5A1 collagen, type V, alpha 1 -0.0218213
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0218202
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 -0.0216937
TMEM41B transmembrane protein 41B -0.0216402
DKK3 dickkopf WNT signaling pathway inhibitor 3 -0.0216245
PEG10 paternally expressed 10 -0.0214834
TFPI2 tissue factor pathway inhibitor 2 -0.021114
RPS24 ribosomal protein S24 -0.0210269
DNAH11 dynein, axonemal, heavy chain 11 -0.0209383
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0208612
NDFIP1 Nedd4 family interacting protein 1 -0.0207601
SH3RF3 SH3 domain containing ring finger 3 -0.0207589
ZMYND8 zinc finger, MYND-type containing 8 -0.0207348
GORASP2 golgi reassembly stacking protein 2, 55kDa -0.0207329
CSNK1A1 casein kinase 1, alpha 1 -0.0206479
TPM1 tropomyosin 1 (alpha) -0.0201951
SOD2 superoxide dismutase 2, mitochondrial -0.0200666
RPL36 ribosomal protein L36 -0.0200445
MED13L mediator complex subunit 13-like -0.0198253
COL3A1 collagen, type III, alpha 1 -0.0196984
PDPK1 3-phosphoinositide dependent protein kinase 1 -0.0194345