Esmolol (hydrochloride)_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Esmolol (hydrochloride) perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Esmolol (hydrochloride)_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.208888
NRG1 neuregulin 1 0.183057
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.1283
HMGA2 high mobility group AT-hook 2 0.1202
EXT1 exostosin glycosyltransferase 1 0.0918038
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0870836
GLIS3 GLIS family zinc finger 3 0.0851767
EFNA5 ephrin-A5 0.0805208
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0750869
STC2 stanniocalcin 2 0.0746786
FTH1 ferritin, heavy polypeptide 1 0.0713837
VCL vinculin 0.0679266
ZSWIM6 zinc finger, SWIM-type containing 6 0.0632845
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0627244
TRIO trio Rho guanine nucleotide exchange factor 0.0600281
ASPH aspartate beta-hydroxylase 0.0591662
GRB10 growth factor receptor-bound protein 10 0.0542752
SYT1 synaptotagmin I 0.0534835
LIMCH1 LIM and calponin homology domains 1 0.0506729
SQSTM1 sequestosome 1 0.0499564
MYH9 myosin, heavy chain 9, non-muscle 0.0481026
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0480613
APLP2 amyloid beta (A4) precursor-like protein 2 0.0474101
SFTPA2 surfactant protein A2 0.0449459
RAI14 retinoic acid induced 14 0.0446906
AEBP2 AE binding protein 2 0.0439426
VEGFA vascular endothelial growth factor A 0.0438652
FNDC3B fibronectin type III domain containing 3B 0.0425962
ITGA1 integrin, alpha 1 0.0424419
LOXL2 lysyl oxidase-like 2 0.042305
DOCK5 dedicator of cytokinesis 5 0.0407686
PDLIM5 PDZ and LIM domain 5 0.0404559
MBD5 methyl-CpG binding domain protein 5 0.0402799
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0401352
MRPS6 mitochondrial ribosomal protein S6 0.0395746
HIPK2 homeodomain interacting protein kinase 2 0.0385053
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0380664
GPC6 glypican 6 0.0379121
SHB Src homology 2 domain containing adaptor protein B 0.0376512
TNS3 tensin 3 0.0371157
NRP1 neuropilin 1 0.0368783
FLNA filamin A, alpha 0.0367974
SMAD3 SMAD family member 3 0.0356741
PDE4D phosphodiesterase 4D, cAMP-specific 0.0341794
NTN4 netrin 4 0.0340048
MCL1 myeloid cell leukemia 1 0.033744
RASAL2 RAS protein activator like 2 0.0335161
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0334313
NPAS2 neuronal PAS domain protein 2 0.0333773
CTBP2 C-terminal binding protein 2 0.033265
MAML2 mastermind-like 2 (Drosophila) 0.0327203
PRKCA protein kinase C, alpha 0.0327123
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0323851
LOC112694756 uncharaterized LOC112694756 0.0321615
ERRFI1 ERBB receptor feedback inhibitor 1 0.0320804
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 0.0317016
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0311445
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0310657
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0310397
LRMDA leucine rich melanocyte differentiation associated 0.0305099
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0305065
PALLD palladin, cytoskeletal associated protein 0.0304579
ATXN1 ataxin 1 0.0304059
SRRM2 serine/arginine repetitive matrix 2 0.0303376
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0298783
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0296925
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0293532
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0288177
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0287487
ARHGAP35 Rho GTPase activating protein 35 0.0282589
INTS6 integrator complex subunit 6 0.0279843
ETV6 ets variant 6 0.0279251
TCIM transcriptional and immune response regulator 0.0275586
TGFB1 transforming growth factor, beta 1 0.0275529
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0274914
SEPTIN9 septin 9 0.0273279
NAV1 neuron navigator 1 0.0268395
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0265743
FHL2 four and a half LIM domains 2 0.0261435
EGFR epidermal growth factor receptor 0.0259908
RNF213 ring finger protein 213 0.0258032
OSMR oncostatin M receptor 0.0254408
DNAH5 dynein, axonemal, heavy chain 5 0.0253089
ZMIZ1 zinc finger, MIZ-type containing 1 0.0252826
ENO2 enolase 2 (gamma, neuronal) 0.0249777
DST dystonin 0.0248429
MACF1 microtubule-actin crosslinking factor 1 0.0245754
VEGFC vascular endothelial growth factor C 0.0245132
TBC1D22A TBC1 domain family, member 22A 0.0243352
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0243159
ERN1 endoplasmic reticulum to nucleus signaling 1 0.0241628
SLC35F3 solute carrier family 35, member F3 0.023947
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0235881
TUFT1 tuftelin 1 0.0234713
WNK1 WNK lysine deficient protein kinase 1 0.0233701
LOC102724023 ES1 protein homolog, mitochondrial 0.0233606
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0233327
RAD51B RAD51 paralog B 0.0232473
NRIP1 nuclear receptor interacting protein 1 0.0231971
CNIH3 cornichon family AMPA receptor auxiliary protein 3 0.0230253

decreased expression

Symbol Name Standardized Value
CXCL8 chemokine (C-X-C motif) ligand 8 -0.1433
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.142262
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0995608
NAMPT nicotinamide phosphoribosyltransferase -0.090313
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0669327
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0627003
PTMA prothymosin, alpha -0.0609238
FTL ferritin, light polypeptide -0.0601484
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0571983
TMSB10 thymosin beta 10 -0.0569948
RPL35A ribosomal protein L35a -0.0466215
RPS24 ribosomal protein S24 -0.0450232
IER3 immediate early response 3 -0.0401905
RPLP1 ribosomal protein, large, P1 -0.0337251
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0337186
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0332124
VIM vimentin -0.032342
MARCHF6 membrane associated ring-CH-type finger 6 -0.0309932
TPT1 tumor protein, translationally-controlled 1 -0.0308087
MT2A metallothionein 2A -0.0301011
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0300573
RNF145 ring finger protein 145 -0.0298358
RPL34 ribosomal protein L34 -0.0297916
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0292788
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 -0.0289465
RPL31 ribosomal protein L31 -0.028151
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0281189
ZNF292 zinc finger protein 292 -0.0276578
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.0276347
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0272898
TFPI2 tissue factor pathway inhibitor 2 -0.0268204
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 -0.0267722
SOD2 superoxide dismutase 2, mitochondrial -0.0264551
KDM3A lysine (K)-specific demethylase 3A -0.0264495
RPL12 ribosomal protein L12 -0.0249724
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) -0.0245815
RAD21 RAD21 homolog (S. pombe) -0.0243051
NIPBL Nipped-B homolog (Drosophila) -0.02363
CLINT1 clathrin interactor 1 -0.0235952
RHEB Ras homolog enriched in brain -0.0233584
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0233467
CANX calnexin -0.022676
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0220397
RPS27A ribosomal protein S27a -0.0214914
RBM39 RNA binding motif protein 39 -0.0212268
ZMYM2 zinc finger, MYM-type 2 -0.0210472
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme -0.0210073
NAP1L1 nucleosome assembly protein 1-like 1 -0.0209059
KPNB1 karyopherin (importin) beta 1 -0.0208534
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) -0.0206818
OGA O-GlcNAcase -0.0204976
RAP1B RAP1B, member of RAS oncogene family -0.0204577
TNPO1 transportin 1 -0.0204367
TFG TRK-fused gene -0.020414
ECT2 epithelial cell transforming 2 -0.0203315
ANLN anillin, actin binding protein -0.0201187
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0201172
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0201053
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0200207
MATR3 matrin 3 -0.0198518
RPS5 ribosomal protein S5 -0.0198114
QKI QKI, KH domain containing, RNA binding -0.0197643
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0195988
NPEPPS aminopeptidase puromycin sensitive -0.0195337
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -0.019127
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0189545
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0189307
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0189222
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0187141
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0186194
PGK1 phosphoglycerate kinase 1 -0.0185878
RPS8 ribosomal protein S8 -0.0181437
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0178997
RPLP0 ribosomal protein, large, P0 -0.0178593
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0178586
TXNRD1 thioredoxin reductase 1 -0.0178506
ARF1 ADP-ribosylation factor 1 -0.0178436
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0177913
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0177036
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0176707
RPS21 ribosomal protein S21 -0.0176483
INSIG2 insulin induced gene 2 -0.0176297
LCORL ligand dependent nuclear receptor corepressor-like -0.0176227
EREG epiregulin -0.0175874
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0175687
CENPF centromere protein F, 350/400kDa -0.0174365
MXI1 MAX interactor 1, dimerization protein -0.0172595
FAM162A family with sequence similarity 162, member A -0.0172078
USP3 ubiquitin specific peptidase 3 -0.0170407
TM9SF3 transmembrane 9 superfamily member 3 -0.0168825
S100A10 S100 calcium binding protein A10 -0.0168319
ELL2 elongation factor, RNA polymerase II, 2 -0.0167332
TMSB4X thymosin beta 4, X-linked -0.0167149
SGO2 shugoshin 2 -0.0164786
RPL36AL ribosomal protein L36a-like -0.0162639
RPL23 ribosomal protein L23 -0.0161916
RLF rearranged L-myc fusion -0.0161576
SMG7 SMG7 nonsense mediated mRNA decay factor -0.0160886
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0160558
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0159498