| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Esmolol (hydrochloride) perturbation in SW1417 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Esmolol (hydrochloride)_SW1417 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MAML2 | mastermind-like 2 (Drosophila) | 0.160697 |
| BCL2L1 | BCL2-like 1 | 0.145943 |
| MACC1 | metastasis associated in colon cancer 1 | 0.114097 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.105025 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0979546 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0976524 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.097308 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0972459 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0907267 |
| VCL | vinculin | 0.0874101 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0853397 |
| EHBP1 | EH domain binding protein 1 | 0.0837481 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | 0.081123 |
| EGR1 | early growth response 1 | 0.0809474 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0799594 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0797475 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0776676 |
| RPS6 | ribosomal protein S6 | 0.0713587 |
| FAT1 | FAT atypical cadherin 1 | 0.0691338 |
| NEBL | nebulette | 0.0683819 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0678027 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0676805 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0676403 |
| PRELID2 | PRELI domain containing 2 | 0.0663191 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0610063 |
| EZR | ezrin | 0.0584186 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0577791 |
| RUNX1 | runt-related transcription factor 1 | 0.057267 |
| MYO1E | myosin IE | 0.0565571 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0557251 |
| EPB41L1 | erythrocyte membrane protein band 4.1-like 1 | 0.0554122 |
| EXOC4 | exocyst complex component 4 | 0.0548883 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | 0.0543052 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0538508 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.053041 |
| CUX1 | cut-like homeobox 1 | 0.0527366 |
| RPL28 | ribosomal protein L28 | 0.0521225 |
| MYOF | myoferlin | 0.0518625 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | 0.0516984 |
| OSBPL10 | oxysterol binding protein-like 10 | 0.0513617 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | 0.0502893 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0495371 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | 0.0492501 |
| GMDS | GDP-mannose 4,6-dehydratase | 0.0488986 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0488929 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0486779 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | 0.0486671 |
| TGFA | transforming growth factor, alpha | 0.0480784 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0479976 |
| PATJ | PATJ crumbs cell polarity complex component | 0.0477883 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.0472738 |
| PCSK5 | proprotein convertase subtilisin/kexin type 5 | 0.0469385 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0467629 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0457738 |
| SLC20A2 | solute carrier family 20 (phosphate transporter), member 2 | 0.0430905 |
| KRT18 | keratin 18, type I | 0.0428023 |
| H1-0 | H1.0 linker histone | 0.0425758 |
| RAD51B | RAD51 paralog B | 0.0420297 |
| CLDN4 | claudin 4 | 0.0412067 |
| PKP4 | plakophilin 4 | 0.0409366 |
| ETV6 | ets variant 6 | 0.0399146 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0395777 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | 0.0391269 |
| PCLO | piccolo presynaptic cytomatrix protein | 0.0389004 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0386922 |
| FRMD5 | FERM domain containing 5 | 0.0386211 |
| RNF213 | ring finger protein 213 | 0.0385418 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0382457 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | 0.037157 |
| STC2 | stanniocalcin 2 | 0.0367773 |
| LDHA | lactate dehydrogenase A | 0.0366951 |
| CMIP | c-Maf inducing protein | 0.0365502 |
| MSI2 | musashi RNA-binding protein 2 | 0.0365415 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0364571 |
| TOP1 | topoisomerase (DNA) I | 0.0363606 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0356951 |
| CTDSPL | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like | 0.0356432 |
| CTNNA2 | catenin (cadherin-associated protein), alpha 2 | 0.0354082 |
| SEPTIN9 | septin 9 | 0.0351383 |
| GOLGB1 | golgin B1 | 0.034536 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0341596 |
| WWC1 | WW and C2 domain containing 1 | 0.0339456 |
| ARHGAP32 | Rho GTPase activating protein 32 | 0.0335482 |
| GPHN | gephyrin | 0.033326 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | 0.033308 |
| TMF1 | TATA element modulatory factor 1 | 0.0332392 |
| NFIA | nuclear factor I/A | 0.0331442 |
| SVIL | supervillin | 0.0330394 |
| NR6A1 | nuclear receptor subfamily 6, group A, member 1 | 0.0329325 |
| SEMA3B | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B | 0.0329263 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | 0.0327799 |
| RALY | RALY heterogeneous nuclear ribonucleoprotein | 0.0326478 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.032191 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0321638 |
| BBX | bobby sox homolog (Drosophila) | 0.0320162 |
| MYH14 | myosin, heavy chain 14, non-muscle | 0.0318393 |
| ZNRF3 | zinc and ring finger 3 | 0.0317068 |
| PARD3B | par-3 family cell polarity regulator beta | 0.0316223 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | 0.0316104 |
| HM13 | histocompatibility (minor) 13 | 0.0316024 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TMSB10 | thymosin beta 10 | -0.0921766 |
| PTMA | prothymosin, alpha | -0.0841817 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0840464 |
| UBC | ubiquitin C | -0.0662573 |
| MATR3 | matrin 3 | -0.05241 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0501286 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0447658 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0446685 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0443516 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0432614 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0424749 |
| RBM39 | RNA binding motif protein 39 | -0.0422741 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0399525 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0399029 |
| EPCAM | epithelial cell adhesion molecule | -0.0383377 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | -0.0383206 |
| RPS27A | ribosomal protein S27a | -0.0381278 |
| ZNF292 | zinc finger protein 292 | -0.0374875 |
| USP3 | ubiquitin specific peptidase 3 | -0.0359904 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | -0.0346444 |
| OGA | O-GlcNAcase | -0.0345237 |
| CAPZA2 | capping protein (actin filament) muscle Z-line, alpha 2 | -0.0338846 |
| RYBP | RING1 and YY1 binding protein | -0.0330485 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0328578 |
| RHEB | Ras homolog enriched in brain | -0.03281 |
| SLC20A1 | solute carrier family 20 (phosphate transporter), member 1 | -0.0327358 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | -0.0322428 |
| DDX3X | DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked | -0.0322188 |
| NDFIP1 | Nedd4 family interacting protein 1 | -0.0311709 |
| FMR1 | fragile X mental retardation 1 | -0.03077 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0302163 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0294635 |
| HBP1 | HMG-box transcription factor 1 | -0.0289771 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0287684 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0286354 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0281091 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.0272812 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0265318 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | -0.0254517 |
| AHNAK | AHNAK nucleoprotein | -0.0253478 |
| TOP2B | topoisomerase (DNA) II beta 180kDa | -0.0248059 |
| ABI1 | abl-interactor 1 | -0.0243035 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0228349 |
| HMGB2 | high mobility group box 2 | -0.0221086 |
| NCKAP1 | NCK-associated protein 1 | -0.0220941 |
| FNBP1L | formin binding protein 1-like | -0.0215422 |
| CANX | calnexin | -0.0215212 |
| TFG | TRK-fused gene | -0.0214266 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0213976 |
| VAPA | VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa | -0.0212052 |
| SERINC3 | serine incorporator 3 | -0.0210893 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.0204977 |
| TMSB4X | thymosin beta 4, X-linked | -0.0204571 |
| ZNF706 | zinc finger protein 706 | -0.0201659 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | -0.0200914 |
| PPP2CA | protein phosphatase 2, catalytic subunit, alpha isozyme | -0.0196497 |
| LMTK2 | lemur tyrosine kinase 2 | -0.0195765 |
| JAK1 | Janus kinase 1 | -0.0195019 |
| PERP | PERP, TP53 apoptosis effector | -0.0192582 |
| MEF2A | myocyte enhancer factor 2A | -0.0192526 |
| CMTM6 | CKLF-like MARVEL transmembrane domain containing 6 | -0.0188656 |
| OSER1 | oxidative stress responsive serine-rich 1 | -0.0188219 |
| MTF2 | metal response element binding transcription factor 2 | -0.0188087 |
| UBQLN1 | ubiquilin 1 | -0.0185385 |
| SLC3A2 | solute carrier family 3 (amino acid transporter heavy chain), member 2 | -0.0184016 |
| CHMP2B | charged multivesicular body protein 2B | -0.0183514 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0181613 |
| S100A10 | S100 calcium binding protein A10 | -0.0180999 |
| PDS5B | PDS5 cohesin associated factor B | -0.0179657 |
| GNA13 | guanine nucleotide binding protein (G protein), alpha 13 | -0.0179632 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | -0.0179477 |
| RPL4 | ribosomal protein L4 | -0.0176562 |
| H3-3B | H3.3 histone B | -0.0174384 |
| CCND1 | cyclin D1 | -0.0172928 |
| VPS26A | vacuolar protein sorting 26 homolog A (S. pombe) | -0.0169876 |
| RRAS2 | related RAS viral (r-ras) oncogene homolog 2 | -0.0167927 |
| FTL | ferritin, light polypeptide | -0.016532 |
| WAC | WW domain containing adaptor with coiled-coil | -0.016511 |
| ZNF207 | zinc finger protein 207 | -0.0163139 |
| RYK | receptor-like tyrosine kinase | -0.0161943 |
| HNRNPK | heterogeneous nuclear ribonucleoprotein K | -0.0161156 |
| PLEKHB2 | pleckstrin homology domain containing, family B (evectins) member 2 | -0.0158966 |
| SERINC1 | serine incorporator 1 | -0.0158197 |
| LRRFIP2 | leucine rich repeat (in FLII) interacting protein 2 | -0.0157842 |
| COPB2 | coatomer protein complex, subunit beta 2 (beta prime) | -0.0155979 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0155476 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0155061 |
| RPS24 | ribosomal protein S24 | -0.0154486 |
| AGFG1 | ArfGAP with FG repeats 1 | -0.0152486 |
| GADD45A | growth arrest and DNA-damage-inducible, alpha | -0.0152329 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0151065 |
| PAWR | PRKC, apoptosis, WT1, regulator | -0.0147367 |
| XPO1 | exportin 1 | -0.0147004 |
| RPL14 | ribosomal protein L14 | -0.0144543 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.014287 |
| PALS2 | protein associated with LIN7 2, MAGUK p55 family member | -0.0142853 |
| UBE2V1 | ubiquitin-conjugating enzyme E2 variant 1 | -0.014255 |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | -0.0141611 |
| PPP1CB | protein phosphatase 1, catalytic subunit, beta isozyme | -0.0140289 |
| RPL5 | ribosomal protein L5 | -0.0139498 |
