| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Esmolol (hydrochloride) perturbation in hTERT-HPNE cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Esmolol (hydrochloride)_hTERT-HPNE drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| COL6A3 | collagen, type VI, alpha 3 | 0.156743 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0981295 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0856124 |
| CD44 | CD44 molecule (Indian blood group) | 0.0754552 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.075452 |
| RUNX1 | runt-related transcription factor 1 | 0.0666309 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0579848 |
| FAM13A | family with sequence similarity 13, member A | 0.0559647 |
| ARHGAP21 | Rho GTPase activating protein 21 | 0.0555968 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0532038 |
| SMAD3 | SMAD family member 3 | 0.0526604 |
| ANKRD28 | ankyrin repeat domain 28 | 0.050166 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0493718 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.047391 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.046827 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0463759 |
| ATP13A3 | ATPase type 13A3 | 0.0462193 |
| COL4A1 | collagen, type IV, alpha 1 | 0.0459462 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.04478 |
| VEGFA | vascular endothelial growth factor A | 0.0445526 |
| ADGRB3 | adhesion G protein-coupled receptor B3 | 0.0438914 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0438744 |
| COL6A1 | collagen, type VI, alpha 1 | 0.0429912 |
| SGIP1 | SH3-domain GRB2-like (endophilin) interacting protein 1 | 0.0424778 |
| COL5A3 | collagen, type V, alpha 3 | 0.0419686 |
| MYO10 | myosin X | 0.0408516 |
| MSN | moesin | 0.0407594 |
| SASH1 | SAM and SH3 domain containing 1 | 0.0404241 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | 0.0370025 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0345071 |
| NAV1 | neuron navigator 1 | 0.0337915 |
| NDRG1 | N-myc downstream regulated 1 | 0.032922 |
| PDE8A | phosphodiesterase 8A | 0.032543 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0320812 |
| SETD5 | SET domain containing 5 | 0.0315682 |
| PLPP3 | phospholipid phosphatase 3 | 0.0307667 |
| EGFR | epidermal growth factor receptor | 0.0304649 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0300951 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0298308 |
| LOX | lysyl oxidase | 0.0296344 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0294345 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.029389 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0292407 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0292368 |
| CDK17 | cyclin-dependent kinase 17 | 0.0282619 |
| VEGFC | vascular endothelial growth factor C | 0.0276552 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | 0.0267374 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | 0.0267188 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.025663 |
| RTN4 | reticulon 4 | 0.0255319 |
| SPRED1 | sprouty-related, EVH1 domain containing 1 | 0.0251029 |
| SEPTIN9 | septin 9 | 0.0247544 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0244799 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0243792 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.0234548 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0233773 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | 0.0225198 |
| PDGFRB | platelet-derived growth factor receptor, beta polypeptide | 0.0222641 |
| PHC2 | polyhomeotic homolog 2 (Drosophila) | 0.0221853 |
| NOTCH2 | notch 2 | 0.0216031 |
| EPAS1 | endothelial PAS domain protein 1 | 0.0214743 |
| COPA | coatomer protein complex, subunit alpha | 0.0207454 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0201742 |
| USP34 | ubiquitin specific peptidase 34 | 0.0200217 |
| AXL | AXL receptor tyrosine kinase | 0.0198507 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0196702 |
| SEPTIN11 | septin 11 | 0.0195754 |
| CDK19 | cyclin-dependent kinase 19 | 0.019481 |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 | 0.0194404 |
| SYAP1 | synapse associated protein 1 | 0.0193312 |
| TPM3 | tropomyosin 3 | 0.0185541 |
| COL5A2 | collagen, type V, alpha 2 | 0.0184127 |
| TLN1 | talin 1 | 0.0182991 |
| RPL3 | ribosomal protein L3 | 0.0182697 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0182347 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0181366 |
| SMOX | spermine oxidase | 0.0181155 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.017742 |
| WNT5A | wingless-type MMTV integration site family, member 5A | 0.0175335 |
| PCBP2 | poly(rC) binding protein 2 | 0.0173543 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | 0.0172901 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0172066 |
| DCAF6 | DDB1 and CUL4 associated factor 6 | 0.0170869 |
| COL4A2 | collagen, type IV, alpha 2 | 0.0170526 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | 0.0170254 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0169941 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0169799 |
| VMP1 | vacuole membrane protein 1 | 0.0169633 |
| ITGA11 | integrin, alpha 11 | 0.0169308 |
| PCM1 | pericentriolar material 1 | 0.0168714 |
| CALD1 | caldesmon 1 | 0.0168488 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0166437 |
| NAA16 | N(alpha)-acetyltransferase 16, NatA auxiliary subunit | 0.0165398 |
| C1D | C1D nuclear receptor corepressor | 0.0165386 |
| OSMR | oncostatin M receptor | 0.0165082 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0164434 |
| PRKAR1A | protein kinase, cAMP-dependent, regulatory, type I, alpha | 0.016394 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0163066 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.0162695 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0162307 |
| Symbol | Name | Standardized Value |
|---|---|---|
| INHBA | inhibin, beta A | -0.233433 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.14577 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.115642 |
| MMP1 | matrix metallopeptidase 1 | -0.109008 |
| PRKG1 | protein kinase, cGMP-dependent, type I | -0.105473 |
| TMSB10 | thymosin beta 10 | -0.0881681 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | -0.0776666 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0769368 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0721723 |
| CAVIN1 | caveolae associated protein 1 | -0.0720589 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0660722 |
| GREM1 | gremlin 1, DAN family BMP antagonist | -0.0656958 |
| EMP1 | epithelial membrane protein 1 | -0.0614667 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0613574 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.055515 |
| HLA-B | major histocompatibility complex, class I, B | -0.0550349 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0526288 |
| ACTG1 | actin gamma 1 | -0.0426861 |
| ASPH | aspartate beta-hydroxylase | -0.0421296 |
| COL3A1 | collagen, type III, alpha 1 | -0.0417978 |
| RPL34 | ribosomal protein L34 | -0.0412329 |
| AHNAK | AHNAK nucleoprotein | -0.0372024 |
| COL1A1 | collagen, type I, alpha 1 | -0.0362455 |
| RPS24 | ribosomal protein S24 | -0.035343 |
| CDH13 | cadherin 13 | -0.0343798 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0343768 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0341575 |
| IER3 | immediate early response 3 | -0.0328334 |
| FBN1 | fibrillin 1 | -0.0326781 |
| NCKAP5 | NCK-associated protein 5 | -0.0325311 |
| ADAMTS12 | ADAM metallopeptidase with thrombospondin type 1 motif, 12 | -0.03134 |
| CALR | calreticulin | -0.0304044 |
| EFCAB13 | EF-hand calcium binding domain 13 | -0.0303054 |
| TPM4 | tropomyosin 4 | -0.030215 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0294453 |
| VCL | vinculin | -0.02917 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0287891 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0285679 |
| RPL35A | ribosomal protein L35a | -0.0280488 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0274416 |
| CCND1 | cyclin D1 | -0.0273519 |
| SAMD3 | sterile alpha motif domain containing 3 | -0.0270695 |
| FTL | ferritin, light polypeptide | -0.027001 |
| PRRX1 | paired related homeobox 1 | -0.0262556 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0257795 |
| CANX | calnexin | -0.0254745 |
| IGF2 | insulin-like growth factor 2 | -0.024878 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0245918 |
| INTS6 | integrator complex subunit 6 | -0.0241659 |
| TCEAL9 | transcription elongation factor A like 9 | -0.0240563 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0238911 |
| RPS8 | ribosomal protein S8 | -0.0237957 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | -0.0230449 |
| GNAS | GNAS complex locus | -0.0223145 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0222436 |
| LAMB3 | laminin, beta 3 | -0.0221531 |
| RPL37A | ribosomal protein L37a | -0.0216982 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0216273 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | -0.0215669 |
| PRELID2 | PRELI domain containing 2 | -0.0214169 |
| MMP14 | matrix metallopeptidase 14 (membrane-inserted) | -0.0212396 |
| COL1A2 | collagen, type I, alpha 2 | -0.0211419 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0211271 |
| RPL23 | ribosomal protein L23 | -0.020965 |
| B2M | beta-2-microglobulin | -0.0208461 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | -0.0205513 |
| GLIS3 | GLIS family zinc finger 3 | -0.0202473 |
| TMSB4X | thymosin beta 4, X-linked | -0.020207 |
| PRSS23 | protease, serine, 23 | -0.0199892 |
| PTMA | prothymosin, alpha | -0.0199205 |
| DIAPH2 | diaphanous-related formin 2 | -0.0196467 |
| DGKI | diacylglycerol kinase, iota | -0.01951 |
| WNT2B | wingless-type MMTV integration site family, member 2B | -0.0193385 |
| TTC23L | tetratricopeptide repeat domain 23-like | -0.0193276 |
| RPL38 | ribosomal protein L38 | -0.0190361 |
| AEBP2 | AE binding protein 2 | -0.0184687 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0183547 |
| RPLP0 | ribosomal protein, large, P0 | -0.0182954 |
| VCAN | versican | -0.0182171 |
| RPLP1 | ribosomal protein, large, P1 | -0.0181403 |
| CD63 | CD63 molecule | -0.0180699 |
| HLA-E | major histocompatibility complex, class I, E | -0.0179119 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0176717 |
| RPL26 | ribosomal protein L26 | -0.0176129 |
| VIM | vimentin | -0.0175663 |
| RPS27A | ribosomal protein S27a | -0.0175097 |
| RPL9 | ribosomal protein L9 | -0.0174737 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0174101 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.017161 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0170578 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0169771 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0166123 |
| RPL19 | ribosomal protein L19 | -0.0165161 |
| FRMPD4 | FERM and PDZ domain containing 4 | -0.0163678 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0162849 |
| PGK1 | phosphoglycerate kinase 1 | -0.0162462 |
| RACK1 | receptor for activated C kinase 1 | -0.0161286 |
| IPO9 | importin 9 | -0.0161035 |
| ARHGAP22 | Rho GTPase activating protein 22 | -0.0158903 |
| RPL31 | ribosomal protein L31 | -0.0158531 |
