| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| Description | A carboxylic ester that is methyl 3-(4-hydroxyphenyl)propanoate in which the hydrogen attached to the phenoic hydroxy group is substituted by a 2-hydroxy-3-(isopropylamino)propyl group. A cardioselective and short-acting beta1 receptor blocker with rapid onset but lacking intrinsic sympathomimetic and membrane-stabilising properties, it is used as the hydrochloride salt in the management of supraventricular arrhythmias, and for the control of hypertension and tachycardia during surgery. (Chemical Entities of Biological Interest Ontology, CHEBI_4856) |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/59768 |
| Similar Terms | |
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198 proteins with high or low expression in Esmolol relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NPHP3 | nephronophthisis 3 (adolescent) | 1.17 |
| YAP1 | Yes-associated protein 1 | 0.78 |
| PPP2R3A | protein phosphatase 2, regulatory subunit B'', alpha | 0.76 |
| ANKRD26 | ankyrin repeat domain 26 | 0.71 |
| MYL3 | myosin, light chain 3, alkali; ventricular, skeletal, slow | 0.63 |
| MARK4 | MAP/microtubule affinity-regulating kinase 4 | 0.6 |
| CSTF2 | cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa | 0.59 |
| ZNF587 | zinc finger protein 587 | 0.51 |
| CRADD | CASP2 and RIPK1 domain containing adaptor with death domain | 0.51 |
| CCDC117 | coiled-coil domain containing 117 | 0.51 |
| ELOC | elongin C | 0.51 |
| PXDN | peroxidasin | 0.5 |
| TIMM10B | translocase of inner mitochondrial membrane 10 homolog B (yeast) | 0.49 |
| FBXL3 | F-box and leucine-rich repeat protein 3 | 0.49 |
| CENPP | centromere protein P | 0.48 |
| PXMP2 | peroxisomal membrane protein 2, 22kDa | 0.47 |
| WNK2 | WNK lysine deficient protein kinase 2 | 0.47 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.47 |
| DCTN2 | dynactin 2 (p50) | 0.46 |
| RPS25 | ribosomal protein S25 | 0.46 |
| WHAMM | WAS protein homolog associated with actin, golgi membranes and microtubules | 0.45 |
| SYDE1 | synapse defective 1, Rho GTPase, homolog 1 (C. elegans) | 0.45 |
| ZBTB47 | zinc finger and BTB domain containing 47 | 0.45 |
| TEPSIN | TEPSIN adaptor related protein complex 4 accessory protein | 0.44 |
| PIH1D1 | PIH1 domain containing 1 | 0.43 |
| FKBP1A | FK506 binding protein 1A, 12kDa | 0.42 |
| KCTD5 | potassium channel tetramerization domain containing 5 | 0.41 |
| STARD13 | StAR-related lipid transfer (START) domain containing 13 | 0.41 |
| HES1 | hes family bHLH transcription factor 1 | 0.4 |
| NUP62 | nucleoporin 62kDa | 0.4 |
| RPLP1 | ribosomal protein, large, P1 | 0.4 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.4 |
| BAG4 | BCL2-associated athanogene 4 | 0.39 |
| CLTA | clathrin, light chain A | 0.39 |
| CD320 | CD320 molecule | 0.39 |
| HAUS7 | HAUS augmin-like complex, subunit 7 | 0.38 |
| NAXE | NAD(P)HX epimerase | 0.38 |
| B2M | beta-2-microglobulin | 0.38 |
| SLC6A9 | solute carrier family 6 (neurotransmitter transporter, glycine), member 9 | 0.37 |
| POLR2I | polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa | 0.37 |
| BCAS2 | breast carcinoma amplified sequence 2 | 0.36 |
| RPE | ribulose-5-phosphate-3-epimerase | 0.35 |
| GNG5 | guanine nucleotide binding protein (G protein), gamma 5 | 0.35 |
| PDE3B | phosphodiesterase 3B, cGMP-inhibited | 0.35 |
| PEX5 | peroxisomal biogenesis factor 5 | 0.33 |
| CTSV | cathepsin V | 0.33 |
| SGTA | small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha | 0.33 |
| COPS4 | COP9 signalosome subunit 4 | 0.33 |
| HSP90AA4P | heat shock protein 90kDa alpha (cytosolic), class A member 4, pseudogene | 0.33 |
| CAPZB | capping protein (actin filament) muscle Z-line, beta | 0.33 |
| CENPL | centromere protein L | 0.33 |
| RABEP1 | rabaptin, RAB GTPase binding effector protein 1 | 0.32 |
| RPLP2 | ribosomal protein, large, P2 | 0.32 |
| TRMT112 | tRNA methyltransferase 11-2 homolog (S. cerevisiae) | 0.32 |
| ZNF407 | zinc finger protein 407 | 0.32 |
| SYAP1 | synapse associated protein 1 | 0.32 |
| CUTA | cutA divalent cation tolerance homolog (E. coli) | 0.32 |
| INPP5A | inositol polyphosphate-5-phosphatase, 40kDa | 0.32 |
| ZNF92 | zinc finger protein 92 | 0.32 |
| GINS3 | GINS complex subunit 3 (Psf3 homolog) | 0.32 |
| TET3 | tet methylcytosine dioxygenase 3 | 0.32 |
| SET | SET nuclear proto-oncogene | 0.32 |
| BMP4 | bone morphogenetic protein 4 | 0.31 |
| LGALSL | lectin, galactoside-binding-like | 0.31 |
| CD81 | CD81 molecule | 0.31 |
| MTX2 | metaxin 2 | 0.31 |
| YBX3 | Y box binding protein 3 | 0.3 |
| FAM102B | family with sequence similarity 102, member B | 0.3 |
| NLRX1 | NLR family member X1 | 0.3 |
| AGRN | agrin | 0.3 |
| DNAAF2 | dynein, axonemal, assembly factor 2 | 0.3 |
| RPL37 | ribosomal protein L37 | 0.29 |
| ATP6V0D1 | ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1 | 0.29 |
| MALSU1 | mitochondrial assembly of ribosomal large subunit 1 | 0.29 |
| MIEN1 | migration and invasion enhancer 1 | 0.29 |
| ZNF584 | zinc finger protein 584 | 0.29 |
| FAM241B | family with sequence similarity 241 member B | 0.29 |
| KLHL18 | kelch-like family member 18 | 0.29 |
| TRAPPC2 | trafficking protein particle complex 2 | 0.28 |
| MYLK | myosin light chain kinase | 0.28 |
| UBE2W | ubiquitin-conjugating enzyme E2W (putative) | 0.28 |
| F2R | coagulation factor II (thrombin) receptor | 0.28 |
| PSMB9 | proteasome (prosome, macropain) subunit, beta type, 9 | 0.28 |
| TBC1D32 | TBC1 domain family, member 32 | 0.28 |
| ATG3 | autophagy related 3 | 0.28 |
| RNASEH2C | ribonuclease H2, subunit C | 0.28 |
| C5ORF51 | chromosome 5 open reading frame 51 | 0.28 |
| UCHL3 | ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) | 0.27 |
| KLHL22 | kelch-like family member 22 | 0.27 |
| PEX19 | peroxisomal biogenesis factor 19 | 0.27 |
| ATP13A2 | ATPase type 13A2 | 0.27 |
| TBC1D13 | TBC1 domain family, member 13 | 0.27 |
| CHCHD4 | coiled-coil-helix-coiled-coil-helix domain containing 4 | 0.27 |
| UBE2A | ubiquitin-conjugating enzyme E2A | 0.27 |
| HPCAL4 | hippocalcin like 4 | 0.27 |
| ZSCAN21 | zinc finger and SCAN domain containing 21 | 0.27 |
| SMIM12 | small integral membrane protein 12 | 0.27 |
| MDP1 | magnesium-dependent phosphatase 1 | 0.27 |
| FGFRL1 | fibroblast growth factor receptor-like 1 | 0.27 |
| ATXN7L3B | ataxin 7-like 3B | 0.26 |
| Symbol | Name | Standardized Value |
|---|---|---|
| COBL | cordon-bleu WH2 repeat protein | -1.06 |
| KMT2B | lysine (K)-specific methyltransferase 2B | -0.99 |
| ZBTB38 | zinc finger and BTB domain containing 38 | -0.84 |
| ARHGAP42 | Rho GTPase activating protein 42 | -0.8 |
| NEK4 | NIMA-related kinase 4 | -0.68 |
| BLOC1S4 | biogenesis of lysosomal organelles complex-1, subunit 4, cappuccino | -0.61 |
| DES | desmin | -0.61 |
| ZNF557 | zinc finger protein 557 | -0.57 |
| SASH1 | SAM and SH3 domain containing 1 | -0.56 |
| PLEKHA3 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 3 | -0.56 |
| OTUB2 | OTU deubiquitinase, ubiquitin aldehyde binding 2 | -0.56 |
| HMOX1 | heme oxygenase 1 | -0.55 |
| GNPTG | N-acetylglucosamine-1-phosphate transferase, gamma subunit | -0.55 |
| TMEM246 | transmembrane protein 246 | -0.55 |
| TRIM62 | tripartite motif containing 62 | -0.54 |
| CCDC57 | coiled-coil domain containing 57 | -0.52 |
| OASL | 2'-5'-oligoadenylate synthetase-like | -0.51 |
| CTU1 | cytosolic thiouridylase subunit 1 | -0.51 |
| ARSB | arylsulfatase B | -0.5 |
| IGFN1 | immunoglobulin-like and fibronectin type III domain containing 1 | -0.5 |
| COMMD6 | COMM domain containing 6 | -0.49 |
| TPM4 | tropomyosin 4 | -0.48 |
| TMEM184A | transmembrane protein 184A | -0.47 |
| PCGF5 | polycomb group ring finger 5 | -0.47 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.46 |
| ZNF749 | zinc finger protein 749 | -0.45 |
| TNFRSF6B | tumor necrosis factor receptor superfamily, member 6b, decoy | -0.45 |
| CFAP410 | cilia and flagella associated protein 410 | -0.45 |
| ZNF354A | zinc finger protein 354A | -0.45 |
| KCTD1 | potassium channel tetramerization domain containing 1 | -0.45 |
| KIAA1107 | KIAA1107 | -0.44 |
| C18ORF32 | chromosome 18 open reading frame 32 | -0.44 |
| DOLPP1 | dolichyldiphosphatase 1 | -0.43 |
| RNF6 | ring finger protein (C3H2C3 type) 6 | -0.43 |
| ATP5PF | ATP synthase peripheral stalk subunit F6 | -0.43 |
| C2CD2L | C2CD2-like | -0.42 |
| POLR2L | polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa | -0.42 |
| RAB20 | RAB20, member RAS oncogene family | -0.41 |
| ATN1 | atrophin 1 | -0.41 |
| CD63 | CD63 molecule | -0.4 |
| IL13RA1 | interleukin 13 receptor, alpha 1 | -0.4 |
| RCOR2 | REST corepressor 2 | -0.4 |
| HAL | histidine ammonia-lyase | -0.4 |
| HSPA12B | heat shock 70kD protein 12B | -0.39 |
| SNAPC3 | small nuclear RNA activating complex, polypeptide 3, 50kDa | -0.39 |
| NDEL1 | nudE neurodevelopment protein 1-like 1 | -0.39 |
| CEP152 | centrosomal protein 152kDa | -0.38 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -0.38 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.38 |
| C1ORF52 | chromosome 1 open reading frame 52 | -0.37 |
| GPR180 | G protein-coupled receptor 180 | -0.37 |
| HOXA10 | homeobox A10 | -0.37 |
| SUCO | SUN domain containing ossification factor | -0.37 |
| ZNF689 | zinc finger protein 689 | -0.36 |
| TAOK2 | TAO kinase 2 | -0.36 |
| CPE | carboxypeptidase E | -0.36 |
| SLC5A6 | solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 | -0.36 |
| CLDN3 | claudin 3 | -0.36 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.35 |
| RPS29 | ribosomal protein S29 | -0.35 |
| ABCD1 | ATP-binding cassette, sub-family D (ALD), member 1 | -0.35 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.34 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.34 |
| PACSIN1 | protein kinase C and casein kinase substrate in neurons 1 | -0.34 |
| DENND4A | DENN/MADD domain containing 4A | -0.34 |
| SLC25A33 | solute carrier family 25 (pyrimidine nucleotide carrier), member 33 | -0.33 |
| GPAT2 | glycerol-3-phosphate acyltransferase 2, mitochondrial | -0.33 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.33 |
| ELL3 | elongation factor RNA polymerase II-like 3 | -0.33 |
| MSX1 | msh homeobox 1 | -0.33 |
| RIC1 | RAB6A GEF complex partner 1 | -0.32 |
| MANEA | mannosidase, endo-alpha | -0.32 |
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | -0.32 |
| TCOF1 | Treacher Collins-Franceschetti syndrome 1 | -0.32 |
| PHLDA3 | pleckstrin homology-like domain, family A, member 3 | -0.32 |
| CD2BP2 | CD2 (cytoplasmic tail) binding protein 2 | -0.32 |
| REL | v-rel avian reticuloendotheliosis viral oncogene homolog | -0.32 |
| SLC12A4 | solute carrier family 12 (potassium/chloride transporter), member 4 | -0.32 |
| THEMIS2 | thymocyte selection associated family member 2 | -0.32 |
| CHCHD6 | coiled-coil-helix-coiled-coil-helix domain containing 6 | -0.32 |
| DCAF5 | DDB1 and CUL4 associated factor 5 | -0.31 |
| CHST12 | carbohydrate (chondroitin 4) sulfotransferase 12 | -0.31 |
| MUC16 | mucin 16, cell surface associated | -0.31 |
| PTGES | prostaglandin E synthase | -0.31 |
| MANEAL | mannosidase, endo-alpha-like | -0.31 |
| SDHAF4 | succinate dehydrogenase complex assembly factor 4 | -0.31 |
| UBIAD1 | UbiA prenyltransferase domain containing 1 | -0.3 |
| KIRREL1 | kirre like nephrin family adhesion molecule 1 | -0.3 |
| NDST1 | N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 | -0.3 |
| ICAM5 | intercellular adhesion molecule 5, telencephalin | -0.3 |
| AHI1 | Abelson helper integration site 1 | -0.3 |
| ELF4 | E74-like factor 4 (ets domain transcription factor) | -0.3 |
| TMED4 | transmembrane emp24 protein transport domain containing 4 | -0.3 |
| NCKAP1L | NCK-associated protein 1-like | -0.3 |
| PCDH1 | protocadherin 1 | -0.3 |
| ST3GAL4 | ST3 beta-galactoside alpha-2,3-sialyltransferase 4 | -0.3 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.3 |
| ACTN4 | actinin, alpha 4 | -0.3 |
