Essential Hypertension Gene Set

Dataset DisGeNET Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description A hypertension with no known cause. It is the most common type of hypertension. (Human Disease Ontology, DOID_10825)
External Link https://www.disgenet.org/browser/0/1/0/C0085580
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Genes

416 genes associated with the disease Essential Hypertension in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABO ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
ACACA acetyl-CoA carboxylase alpha
ACADSB acyl-CoA dehydrogenase, short/branched chain
ACE angiotensin I converting enzyme
ACE2 angiotensin I converting enzyme 2
ACKR3 atypical chemokine receptor 3
ACSM1 acyl-CoA synthetase medium-chain family member 1
ACSM3 acyl-CoA synthetase medium-chain family member 3
ACVRL1 activin A receptor type II-like 1
ADA adenosine deaminase
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary)
ADD1 adducin 1 (alpha)
ADD2 adducin 2 (beta)
ADIPOQ adiponectin, C1Q and collagen domain containing
ADM adrenomedullin
ADORA1 adenosine A1 receptor
ADORA2A adenosine A2a receptor
ADRA1A adrenoceptor alpha 1A
ADRA1B adrenoceptor alpha 1B
ADRA2B adrenoceptor alpha 2B
ADRB1 adrenoceptor beta 1
ADRB2 adrenoceptor beta 2, surface
ADRB3 adrenoceptor beta 3
AGER advanced glycosylation end product-specific receptor
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AGTR1 angiotensin II receptor, type 1
AGTR2 angiotensin II receptor, type 2
AHR aryl hydrocarbon receptor
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ALB albumin
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALOX12 arachidonate 12-lipoxygenase
AMPD1 adenosine monophosphate deaminase 1
ANGPT2 angiopoietin 2
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
APLN apelin
APLNR apelin receptor
APOA1 apolipoprotein A-I
APOB apolipoprotein B
APOE apolipoprotein E
APOL1 apolipoprotein L, 1
ARG1 arginase 1
ARNT aryl hydrocarbon receptor nuclear translocator
ARNTL aryl hydrocarbon receptor nuclear translocator-like
ASIC5 acid sensing (proton gated) ion channel family member 5
ATF1 activating transcription factor 1
ATM ATM serine/threonine kinase
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
ATP2B2 ATPase, Ca++ transporting, plasma membrane 2
ATP2B3 ATPase, Ca++ transporting, plasma membrane 3
AVPR1A arginine vasopressin receptor 1A
BCAR1 breast cancer anti-estrogen resistance 1
BCL10 B-cell CLL/lymphoma 10
BDKRB1 bradykinin receptor B1
BDKRB2 bradykinin receptor B2
BGN biglycan
BLVRA biliverdin reductase A
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase)
BMS1 BMS1 ribosome biogenesis factor
BRD4 bromodomain containing 4
BRS3 bombesin-like receptor 3
BSND barttin CLCNK-type chloride channel accessory beta subunit
C4BPA complement component 4 binding protein, alpha
C4BPB complement component 4 binding protein, beta
CALCA calcitonin-related polypeptide alpha
CALCRL calcitonin receptor-like
CALY calcyon neuron-specific vesicular protein
CAMK1D calcium/calmodulin-dependent protein kinase ID
CAPN10 calpain 10
CARD8 caspase recruitment domain family, member 8
CASZ1 castor zinc finger 1
CAT catalase
CCHCR1 coiled-coil alpha-helical rod protein 1
CCL2 chemokine (C-C motif) ligand 2
CCL21 chemokine (C-C motif) ligand 21
CCL23 chemokine (C-C motif) ligand 23
CCR2 chemokine (C-C motif) receptor 2
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CD164L2 CD164 sialomucin-like 2
CD36 CD36 molecule (thrombospondin receptor)
CD44 CD44 molecule (Indian blood group)
CHGA chromogranin A
CHPT1 choline phosphotransferase 1
CHST3 carbohydrate (chondroitin 6) sulfotransferase 3
CLCNKA chloride channel, voltage-sensitive Ka
CLCNKB chloride channel, voltage-sensitive Kb
CLU clusterin
CMA1 chymase 1, mast cell
CNR1 cannabinoid receptor 1 (brain)
CRAT carnitine O-acetyltransferase
CRP C-reactive protein, pentraxin-related
CSE1L CSE1 chromosome segregation 1-like (yeast)
CTF1 cardiotrophin 1
CTH cystathionine gamma-lyase
CTNND1 catenin (cadherin-associated protein), delta 1
CUL3 cullin 3
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL13 chemokine (C-X-C motif) ligand 13
CXCR6 chemokine (C-X-C motif) receptor 6
CYBA cytochrome b-245, alpha polypeptide
CYP11B1 cytochrome P450, family 11, subfamily B, polypeptide 1
CYP11B2 cytochrome P450, family 11, subfamily B, polypeptide 2
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1
CYP2C18 cytochrome P450, family 2, subfamily C, polypeptide 18
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
CYP4A11 cytochrome P450, family 4, subfamily A, polypeptide 11
CYP4F2 cytochrome P450, family 4, subfamily F, polypeptide 2
CYP4F3 cytochrome P450, family 4, subfamily F, polypeptide 3
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase)
DBP D site of albumin promoter (albumin D-box) binding protein
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial
DHDDS dehydrodolichyl diphosphate synthase
DNMT1 DNA (cytosine-5-)-methyltransferase 1
DRD1 dopamine receptor D1
DRD2 dopamine receptor D2
DRD3 dopamine receptor D3
DROSHA drosha, ribonuclease type III
EBP emopamil binding protein (sterol isomerase)
ECE1 endothelin converting enzyme 1
ECE2 endothelin converting enzyme 2
EDN1 endothelin 1
EDN2 endothelin 2
EDNRA endothelin receptor type A
EDNRB endothelin receptor type B
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EMILIN1 elastin microfibril interfacer 1
ENO1 enolase 1, (alpha)
ENPEP glutamyl aminopeptidase (aminopeptidase A)
EPHB1 EPH receptor B1
EPHX2 epoxide hydrolase 2, cytoplasmic
EPO erythropoietin
ERAP1 endoplasmic reticulum aminopeptidase 1
ERAP2 endoplasmic reticulum aminopeptidase 2
F11R F11 receptor
FABP2 fatty acid binding protein 2, intestinal
FABP3 fatty acid binding protein 3, muscle and heart
FBN1 fibrillin 1
FBN2 fibrillin 2
FCN3 ficolin (collagen/fibrinogen domain containing) 3
FGF23 fibroblast growth factor 23
FGF5 fibroblast growth factor 5
FKBP1B FK506 binding protein 1B, 12.6 kDa
FMO3 flavin containing monooxygenase 3
FOXO3 forkhead box O3
FSHR follicle stimulating hormone receptor
FTO fat mass and obesity associated
FURIN furin (paired basic amino acid cleaving enzyme)
FZD4 frizzled class receptor 4
GAL3ST1 galactose-3-O-sulfotransferase 1
GATA5 GATA binding protein 5
GCA grancalcin, EF-hand calcium binding protein
GCG glucagon
GCGR glucagon receptor
GCK glucokinase (hexokinase 4)
GDF15 growth differentiation factor 15
GDF2 growth differentiation factor 2
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GJA1 gap junction protein, alpha 1, 43kDa
GJA4 gap junction protein, alpha 4, 37kDa
GJA5 gap junction protein, alpha 5, 40kDa
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GNAS GNAS complex locus
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3
GNG5 guanine nucleotide binding protein (G protein), gamma 5
GOSR2 golgi SNAP receptor complex member 2
GPR151 G protein-coupled receptor 151
GPR42 G protein-coupled receptor 42 (gene/pseudogene)
GPRC6A G protein-coupled receptor, class C, group 6, member A
GPT glutamic-pyruvate transaminase (alanine aminotransferase)
GPX1 glutathione peroxidase 1
GPX3 glutathione peroxidase 3
GPX4 glutathione peroxidase 4
GRHL1 grainyhead-like 1 (Drosophila)
GRK4 G protein-coupled receptor kinase 4
GSTK1 glutathione S-transferase kappa 1
GSTM1 glutathione S-transferase mu 1
GSTM2 glutathione S-transferase mu 2 (muscle)
GSTO1 glutathione S-transferase omega 1
GSTT1 glutathione S-transferase theta 1
GSTT2B glutathione S-transferase theta 2B (gene/pseudogene)
GUCA2B guanylate cyclase activator 2B (uroguanylin)
HAP1 huntingtin-associated protein 1
HCRT hypocretin (orexin) neuropeptide precursor
HFE hemochromatosis
HFE2 hemochromatosis type 2 (juvenile)
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HLA-A major histocompatibility complex, class I, A
HLA-B major histocompatibility complex, class I, B
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HLA-DRB3 major histocompatibility complex, class II, DR beta 3
HMGB1 high mobility group box 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMOX1 heme oxygenase 1
HMOX2 heme oxygenase 2
HP haptoglobin
HPGDS hematopoietic prostaglandin D synthase
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2
HSD3B1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
HSD3B2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
HSPA4 heat shock 70kDa protein 4
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
IAPP islet amyloid polypeptide
IFNG interferon, gamma
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF1R insulin-like growth factor 1 receptor
IGF2 insulin-like growth factor 2
IL10 interleukin 10
IL33R interleukin 33 receptor
IL6 interleukin 6
INPPL1 inositol polyphosphate phosphatase-like 1
INS insulin
INSR insulin receptor
ISYNA1 inositol-3-phosphate synthase 1
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KCNJ11 potassium channel, inwardly rectifying subfamily J, member 11
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KCNMB1 potassium channel subfamily M regulatory beta subunit 1
KIAA1755 KIAA1755
KIR2DS5 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 5
KL klotho
KLHL3 kelch-like family member 3
KLK1 kallikrein 1
KLKB1 kallikrein B, plasma (Fletcher factor) 1
KNG1 kininogen 1
KYNU kynureninase
LCN1 lipocalin 1
LDLR low density lipoprotein receptor
LEP leptin
LEPR leptin receptor
LGALS3 lectin, galactoside-binding, soluble, 3
LGR6 leucine-rich repeat containing G protein-coupled receptor 6
LPA lipoprotein, Lp(a)
LPAR1 lysophosphatidic acid receptor 1
LPAR2 lysophosphatidic acid receptor 2
LPAR3 lysophosphatidic acid receptor 3
LPCAT3 lysophosphatidylcholine acyltransferase 3
LPL lipoprotein lipase
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
LTA lymphotoxin alpha
MEX3C mex-3 RNA binding family member C
MFN2 mitofusin 2
MME membrane metallo-endopeptidase
MMP9 matrix metallopeptidase 9
MOK MOK protein kinase
MPO myeloperoxidase
MRGPRX1 MAS-related GPR, member X1
MRGPRX3 MAS-related GPR, member X3
MRGPRX4 MAS-related GPR, member X4
MT-ATP6 ATP synthase F0 subunit 6
MT-ND2 MTND2
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MTPN myotrophin
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase
MYLK myosin light chain kinase
NAMPT nicotinamide phosphoribosyltransferase
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NEFH neurofilament, heavy polypeptide
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFYA nuclear transcription factor Y, alpha
NFYB nuclear transcription factor Y, beta
NLRP3 NLR family, pyrin domain containing 3
NLRP6 NLR family, pyrin domain containing 6
NOS1 nitric oxide synthase 1 (neuronal)
NOS2 nitric oxide synthase 2, inducible
NOS3 nitric oxide synthase 3 (endothelial cell)
NOX1 NADPH oxidase 1
NOX5 NADPH oxidase, EF-hand calcium binding domain 5
NPPA natriuretic peptide A
NPPB natriuretic peptide B
NPPC natriuretic peptide C
NPR1 natriuretic peptide receptor 1
NPR2 natriuretic peptide receptor 2
NPR3 natriuretic peptide receptor 3
NPY neuropeptide Y
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NR3C2 nuclear receptor subfamily 3, group C, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
OGN osteoglycin
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1
OR10A4 olfactory receptor, family 10, subfamily A, member 4
OXER1 oxoeicosanoid (OXE) receptor 1
OXSR1 oxidative stress responsive 1
P2RY2 purinergic receptor P2Y, G-protein coupled, 2
PCSK1 proprotein convertase subtilisin/kexin type 1
PDE5A phosphodiesterase 5A, cGMP-specific
PECAM1 platelet/endothelial cell adhesion molecule 1
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
PLG plasminogen
PNMT phenylethanolamine N-methyltransferase
POMC proopiomelanocortin
PON1 paraoxonase 1
POU2F2 POU class 2 homeobox 2
PPARD peroxisome proliferator-activated receptor delta
PPARG peroxisome proliferator-activated receptor gamma
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PRCP prolylcarboxypeptidase (angiotensinase C)
PRKCH protein kinase C, eta
PRSS8 protease, serine, 8
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa
PTGFR prostaglandin F receptor (FP)
PTGIS prostaglandin I2 (prostacyclin) synthase
PTH parathyroid hormone
PTK2B protein tyrosine kinase 2 beta
PTPN1 protein tyrosine phosphatase, non-receptor type 1
PTX3 pentraxin 3, long
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
REN renin
RENBP renin binding protein
RETN resistin
RGS2 regulator of G-protein signaling 2
RGS5 regulator of G-protein signaling 5
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
RNLS renalase, FAD-dependent amine oxidase
ROCK2 Rho-associated, coiled-coil containing protein kinase 2
RRAS related RAS viral (r-ras) oncogene homolog
S100A12 S100 calcium binding protein A12
S100A6 S100 calcium binding protein A6
SCN10A sodium channel, voltage gated, type X alpha subunit
SCN7A sodium channel, voltage gated, type VII alpha subunit
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SCNN1B sodium channel, non voltage gated 1 beta subunit
SELE selectin E
SELENBP1 selenium binding protein 1
SELP selectin P (granule membrane protein 140kDa, antigen CD62)
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SGK1 serum/glucocorticoid regulated kinase 1
SHBG sex hormone-binding globulin
SHMT1 serine hydroxymethyltransferase 1 (soluble)
SLC12A1 solute carrier family 12 (sodium/potassium/chloride transporter), member 1
SLC12A3 solute carrier family 12 (sodium/chloride transporter), member 3
SLC22A12 solute carrier family 22 (organic anion/urate transporter), member 12
SLC22A2 solute carrier family 22 (organic cation transporter), member 2
SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1
SLC35A1 solute carrier family 35 (CMP-sialic acid transporter), member A1
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SLC6A18 solute carrier family 6 (neutral amino acid transporter), member 18
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2
SLC6A9 solute carrier family 6 (neurotransmitter transporter, glycine), member 9
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SLC9C1 solute carrier family 9, subfamily C (Na+-transporting carboxylic acid decarboxylase), member 1
SLCO1B1 solute carrier organic anion transporter family, member 1B1
SLCO6A1 solute carrier organic anion transporter family, member 6A1
SMAD4 SMAD family member 4
SMAD9 SMAD family member 9
SMTN smoothelin
SNX1 sorting nexin 1
SOD1 superoxide dismutase 1, soluble
SOD2 superoxide dismutase 2, mitochondrial
SOD3 superoxide dismutase 3, extracellular
SPP1 secreted phosphoprotein 1
SPRR2A small proline-rich protein 2A
SSTR4 somatostatin receptor 4
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STK24 serine/threonine kinase 24
STK39 serine threonine kinase 39
SYNE1 spectrin repeat containing, nuclear envelope 1
TAT tyrosine aminotransferase
TBX1 T-box 1
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor)
TESC tescalcin
TFPI2 tissue factor pathway inhibitor 2
TGFB1 transforming growth factor, beta 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGFBRAP1 transforming growth factor, beta receptor associated protein 1
TH tyrosine hydroxylase
TLR2 toll-like receptor 2
TMEM38A transmembrane protein 38A
TNF tumor necrosis factor
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TNFRSF4 tumor necrosis factor receptor superfamily, member 4
TOR2A torsin family 2, member A
TRPC3 transient receptor potential cation channel, subfamily C, member 3
TRPC6 transient receptor potential cation channel, subfamily C, member 6
TRPV6 transient receptor potential cation channel, subfamily V, member 6
TSC1 tuberous sclerosis 1
TXN thioredoxin
UCP1 uncoupling protein 1 (mitochondrial, proton carrier)
UMOD uromodulin
UTS2 urotensin 2
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA vascular endothelial growth factor A
VEGFC vascular endothelial growth factor C
VIP vasoactive intestinal peptide
VKORC1 vitamin K epoxide reductase complex, subunit 1
VPS51 vacuolar protein sorting 51 homolog (S. cerevisiae)
WNK1 WNK lysine deficient protein kinase 1
WNK4 WNK lysine deficient protein kinase 4
XDH xanthine dehydrogenase
XYLT2 xylosyltransferase II
ZC3HC1 zinc finger, C3HC-type containing 1
ZNF148 zinc finger protein 148
ZNF410 zinc finger protein 410