Essential Tremor Gene Set

Dataset DisGeNET Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description A movement disorder that causes involuntary tremors, especially in the hands. It occurs alone without other neurological signs and symptoms. (Human Disease Ontology, DOID_4990)
External Link https://www.disgenet.org/browser/0/1/0/C0270736
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Genes

117 genes associated with the disease Essential Tremor in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

Symbol Name
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AKR1A1 aldo-keto reductase family 1, member A1 (aldehyde reductase)
ALAD aminolevulinate dehydratase
ANO3 anoctamin 3
APOB apolipoprotein B
ASXL1 additional sex combs like transcriptional regulator 1
ATXN1 ataxin 1
ATXN2 ataxin 2
ATXN3 ataxin 3
BDNF brain-derived neurotrophic factor
C9ORF72 chromosome 9 open reading frame 72
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
CACNA1G calcium channel, voltage-dependent, T type, alpha 1G subunit
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CALM2 calmodulin 2 (phosphorylase kinase, delta)
CALM3 calmodulin 3 (phosphorylase kinase, delta)
CAPG capping protein (actin filament), gelsolin-like
CAV3 caveolin 3
CCDC62 coiled-coil domain containing 62
CD46 CD46 molecule, complement regulatory protein
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2
CHM choroideremia (Rab escort protein 1)
CIT citron rho-interacting serine/threonine kinase
CNR1 cannabinoid receptor 1 (brain)
CTNNA3 catenin (cadherin-associated protein), alpha 3
CYP2C18 cytochrome P450, family 2, subfamily C, polypeptide 18
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
DNAJC13 DnaJ (Hsp40) homolog, subfamily C, member 13
DRD3 dopamine receptor D3
EPO erythropoietin
EWSR1 EWS RNA-binding protein 1
FGF20 fibroblast growth factor 20
FMR1 fragile X mental retardation 1
FUS FUS RNA binding protein
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1
GABRA4 gamma-aminobutyric acid (GABA) A receptor, alpha 4
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon
GABRQ gamma-aminobutyric acid (GABA) A receptor, theta
GABRR1 gamma-aminobutyric acid (GABA) A receptor, rho 1
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2
GABRR3 gamma-aminobutyric acid (GABA) A receptor, rho 3 (gene/pseudogene)
GBA glucosidase, beta, acid
GK5 glycerol kinase 5 (putative)
GSTP1 glutathione S-transferase pi 1
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1
HIP1R huntingtin interacting protein 1 related
HMOX1 heme oxygenase 1
HMOX2 heme oxygenase 2
HNMT histamine N-methyltransferase
HPGDS hematopoietic prostaglandin D synthase
HS1BP3 HCLS1 binding protein 3
HTRA2 HtrA serine peptidase 2
IGFALS insulin-like growth factor binding protein, acid labile subunit
IL1B interleukin 1, beta
KCNS2 potassium voltage-gated channel, modifier subfamily S, member 2
LINGO1 leucine rich repeat and Ig domain containing 1
LINGO2 leucine rich repeat and Ig domain containing 2
LINGO4 leucine rich repeat and Ig domain containing 4
LOC100996717 uncharacterized LOC100996717
LRP2 low density lipoprotein receptor-related protein 2
LRRK1 leucine-rich repeat kinase 1
LRRK2 leucine-rich repeat kinase 2
LRRTM3 leucine rich repeat transmembrane neuronal 3
LY6E lymphocyte antigen 6 complex, locus E
MAK16 MAK16 homolog (S. cerevisiae)
MAPT microtubule-associated protein tau
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
MCF2L MCF.2 cell line derived transforming sequence-like
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
NDUFS7 NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase)
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
PANK2 pantothenate kinase 2
PARK2 parkin RBR E3 ubiquitin protein ligase
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1
PICALM phosphatidylinositol binding clathrin assembly protein
PITX3 paired-like homeodomain 3
PNO1 partner of NOB1 homolog (S. cerevisiae)
PON1 paraoxonase 1
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PPP2R2B protein phosphatase 2, regulatory subunit B, beta
PTBP1 polypyrimidine tract binding protein 1
RBMS3 RNA binding motif, single stranded interacting protein 3
RPGRIP1L RPGRIP1-like
RTN4R reticulon 4 receptor
SCN11A sodium channel, voltage gated, type XI alpha subunit
SCN4A sodium channel, voltage gated, type IV alpha subunit
SCN8A sodium channel, voltage gated, type VIII alpha subunit
SEPHS1 selenophosphate synthetase 1
SF3B1 splicing factor 3b, subunit 1, 155kDa
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC38A7 solute carrier family 38, member 7
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3
SMS spermine synthase
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1
SNAP91 synaptosomal-associated protein, 91kDa
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SOD1 superoxide dismutase 1, soluble
SORT1 sortilin 1
SPCS3 signal peptidase complex subunit 3 homolog (S. cerevisiae)
SRRM2 serine/arginine repetitive matrix 2
STK32B serine/threonine kinase 32B
STS steroid sulfatase (microsomal), isozyme S
TBX4 T-box 4
TENM4 teneurin transmembrane protein 4
TET2 tet methylcytosine dioxygenase 2
TREM2 triggering receptor expressed on myeloid cells 2
TWNK twinkle mtDNA helicase
VIM vimentin
VPS35 vacuolar protein sorting 35 homolog (S. cerevisiae)
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon