Estrogen Receptor-Negative Breast Cancer Gene Set

Dataset DisGeNET Gene-Disease Associations
Category disease or phenotype associations
Type disease
External Link https://www.disgenet.org/browser/0/1/0/C4733092
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Genes

328 genes associated with the disease Estrogen Receptor-Negative Breast Cancer in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

Symbol Name
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ACSL5 acyl-CoA synthetase long-chain family member 5
ACTB actin, beta
ADAMTS2 ADAM metallopeptidase with thrombospondin type 1 motif, 2
ADRM1 adhesion regulating molecule 1
AGFG1 ArfGAP with FG repeats 1
AGO2 argonaute RISC catalytic component 2
AGR2 anterior gradient 2
AHR aryl hydrocarbon receptor
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)
AIMP2 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2
AKR1C1 aldo-keto reductase family 1, member C1
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALCAM activated leukocyte cell adhesion molecule
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ANGPT2 angiopoietin 2
ANKLE2 ankyrin repeat and LEM domain containing 2
AR androgen receptor
AREG amphiregulin
ARNT aryl hydrocarbon receptor nuclear translocator
ARSA arylsulfatase A
ATF4 activating transcription factor 4
ATM ATM serine/threonine kinase
BCL2 B-cell CLL/lymphoma 2
BMP6 bone morphogenetic protein 6
BMP7 bone morphogenetic protein 7
BRCA1 breast cancer 1, early onset
BRCA2 breast cancer 2, early onset
CALM2 calmodulin 2 (phosphorylase kinase, delta)
CCDC170 coiled-coil domain containing 170
CCL2 chemokine (C-C motif) ligand 2
CCN1 cellular communication network factor 1
CCND1 cyclin D1
CCR7 chemokine (C-C motif) receptor 7
CD24 CD24 molecule
CD274 CD274 molecule
CD44 CD44 molecule (Indian blood group)
CD82 CD82 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDK4 cyclin-dependent kinase 4
CDKN2A cyclin-dependent kinase inhibitor 2A
CDT1 chromatin licensing and DNA replication factor 1
CDX2 caudal type homeobox 2
CENPI centromere protein I
CETP cholesteryl ester transfer protein, plasma
CHP1 calcineurin-like EF-hand protein 1
CIP2A cellular inhibitor of PP2A
CLIC3 chloride intracellular channel 3
CLPTM1L CLPTM1-like
COL1A1 collagen, type I, alpha 1
COMT catechol-O-methyltransferase
COX2
CRB3 crumbs family member 3
CREBBP CREB binding protein
CRH corticotropin releasing hormone
CRHR1 corticotropin releasing hormone receptor 1
CRHR2 corticotropin releasing hormone receptor 2
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CRY2 cryptochrome circadian clock 2
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTSD cathepsin D
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR4 chemokine (C-X-C motif) receptor 4
CXXC5 CXXC finger protein 5
CYB5R3 cytochrome b5 reductase 3
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DCAF1 DDB1 and CUL4 associated factor 1
DCTN3 dynactin 3 (p22)
DDB2 damage-specific DNA binding protein 2, 48kDa
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DEK DEK proto-oncogene
DLC1 DLC1 Rho GTPase activating protein
DUSP4 dual specificity phosphatase 4
DUSP7 dual specificity phosphatase 7
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1
E2F1 E2F transcription factor 1
E2F4 E2F transcription factor 4, p107/p130-binding
E2F8 E2F transcription factor 8
ECT2 epithelial cell transforming 2
EGF epidermal growth factor
EGFR epidermal growth factor receptor
ELAVL2 ELAV like neuron-specific RNA binding protein 2
EMSY EMSY transcriptional repressor, BRCA2 interacting
EP300 E1A binding protein p300
EPAS1 endothelial PAS domain protein 1
EPCAM epithelial cell adhesion molecule
EPHB2 EPH receptor B2
EPRS1 glutamyl-prolyl-tRNA synthetase 1
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
ESR1 estrogen receptor 1
ESRP1 epithelial splicing regulatory protein 1
ESRRG estrogen-related receptor gamma
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FAM102A family with sequence similarity 102, member A
FBXL22 F-box and leucine-rich repeat protein 22
FGF1 fibroblast growth factor 1 (acidic)
FGF2 fibroblast growth factor 2 (basic)
FGFR1 fibroblast growth factor receptor 1
FGFR2 fibroblast growth factor receptor 2
FKBP4 FK506 binding protein 4, 59kDa
FKBPL FK506 binding protein like
FLOT2 flotillin 2
FLT1 fms-related tyrosine kinase 1
FOSL1 FOS-like antigen 1
FOXA1 forkhead box A1
FOXC1 forkhead box C1
FOXM1 forkhead box M1
FXYD5 FXYD domain containing ion transport regulator 5
FYN FYN proto-oncogene, Src family tyrosine kinase
G0S2 G0/G1 switch 2
GATA3 GATA binding protein 3
GHR growth hormone receptor
GHRH growth hormone releasing hormone
GJB2 gap junction protein, beta 2, 26kDa
GLB1 galactosidase, beta 1
GLI1 GLI family zinc finger 1
GLS glutaminase
GPER1 G protein-coupled estrogen receptor 1
GRAP2 GRB2-related adaptor protein 2
GRB2 growth factor receptor-bound protein 2
GREM1 gremlin 1, DAN family BMP antagonist
GRN granulin
GSK3B glycogen synthase kinase 3 beta
GSTK1 glutathione S-transferase kappa 1
GSTP1 glutathione S-transferase pi 1
HDAC6 histone deacetylase 6
HDAC9 histone deacetylase 9
HOXB13 homeobox B13
HOXC10 homeobox C10
HSD17B1 hydroxysteroid (17-beta) dehydrogenase 1
HSF1 heat shock transcription factor 1
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
IDO1 indoleamine 2,3-dioxygenase 1
IFNA1 interferon, alpha 1
IFNA13 interferon, alpha 13
IFNB1 interferon, beta 1, fibroblast
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF1R insulin-like growth factor 1 receptor
IGF2R insulin-like growth factor 2 receptor
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
IL17A interleukin 17A
IL6 interleukin 6
INCENP inner centromere protein antigens 135/155kDa
INHBB inhibin, beta B
IRS1 insulin receptor substrate 1
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
JAG1 jagged 1
JMJD6 jumonji domain containing 6
KDM5B lysine (K)-specific demethylase 5B
KDR kinase insert domain receptor
KIF18A kinesin family member 18A
KIF2C kinesin family member 2C
KLF5 Kruppel-like factor 5 (intestinal)
LAMTOR5 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5
LEP leptin
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LHCGR luteinizing hormone/choriogonadotropin receptor
LOX lysyl oxidase
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast)
MAP2K1 mitogen-activated protein kinase kinase 1
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MAP3K11 mitogen-activated protein kinase kinase kinase 11
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAPT microtubule-associated protein tau
MASTL microtubule associated serine/threonine kinase-like
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MDM4 MDM4, p53 regulator
MECOM MDS1 and EVI1 complex locus
MGC57346-CRHR1 MGC57346-CRHR1 readthrough
MGMT O-6-methylguanine-DNA methyltransferase
MGP matrix Gla protein
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MSN moesin
MT1E metallothionein 1E
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MUC1 mucin 1, cell surface associated
MXD1 MAX dimerization protein 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NCOA3 nuclear receptor coactivator 3
NEUROD1 neuronal differentiation 1
NF2 neurofibromin 2 (merlin)
NFIB nuclear factor I/B
NNAT neuronatin
NOS2 nitric oxide synthase 2, inducible
NR0B1 nuclear receptor subfamily 0, group B, member 1
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NR5A2 nuclear receptor subfamily 5, group A, member 2
OCA2 oculocutaneous albinism II
OSM oncostatin M
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PADI2 peptidyl arginine deiminase, type II
PARVA parvin, alpha
PBX1 pre-B-cell leukemia homeobox 1
PCNA proliferating cell nuclear antigen
PDE4D phosphodiesterase 4D, cAMP-specific
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PELP1 proline, glutamate and leucine rich protein 1
PGR progesterone receptor
PHB2 prohibitin 2
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PIP prolactin-induced protein
PKM pyruvate kinase, muscle
PLAT plasminogen activator, tissue
PLCD1 phospholipase C, delta 1
POLDIP2 polymerase (DNA-directed), delta interacting protein 2
PON1 paraoxonase 1
POU5F1 POU class 5 homeobox 1
PPARG peroxisome proliferator-activated receptor gamma
PPIF peptidylprolyl isomerase F
PPIL3 peptidylprolyl isomerase (cyclophilin)-like 3
PRB2 proline-rich protein BstNI subfamily 2
PRDX1 peroxiredoxin 1
PRKAG3 protein kinase, AMP-activated, gamma 3 non-catalytic subunit
PRL prolactin
PRNP prion protein
PSAT1 phosphoserine aminotransferase 1
PSCA prostate stem cell antigen
PSG1 pregnancy specific beta-1-glycoprotein 1
PTEN phosphatase and tensin homolog
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTHLH parathyroid hormone-like hormone
PTK6 protein tyrosine kinase 6
PTPRA protein tyrosine phosphatase, receptor type, A
PTPRU protein tyrosine phosphatase, receptor type, U
PVR poliovirus receptor
PXN paxillin
RAB27B RAB27B, member RAS oncogene family
RAB31 RAB31, member RAS oncogene family
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RASAL2 RAS protein activator like 2
RBBP8 retinoblastoma binding protein 8
REG1A regenerating islet-derived 1 alpha
RET ret proto-oncogene
RGCC regulator of cell cycle
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RIPK3 receptor-interacting serine-threonine kinase 3
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
ROBO3 roundabout, axon guidance receptor, homolog 3 (Drosophila)
RPAIN RPA interacting protein
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3
RPS6KA6 ribosomal protein S6 kinase, 90kDa, polypeptide 6
RRAS2 related RAS viral (r-ras) oncogene homolog 2
RRM2 ribonucleotide reductase M2
RUNX1 runt-related transcription factor 1
S100A7 S100 calcium binding protein A7
S100B S100 calcium binding protein B
S1PR2 sphingosine-1-phosphate receptor 2
S1PR4 sphingosine-1-phosphate receptor 4
SCO2 SCO2 cytochrome c oxidase assembly protein
SDC2 syndecan 2
SEPT4 septin 4
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SIPA1 signal-induced proliferation-associated 1
SIRT1 sirtuin 1
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5
SLCO6A1 solute carrier organic anion transporter family, member 6A1
SOCS7 suppressor of cytokine signaling 7
SOX2 SRY (sex determining region Y)-box 2
SP1 Sp1 transcription factor
SPDEF SAM pointed domain containing ETS transcription factor
SPHK1 sphingosine kinase 1
SPHK2 sphingosine kinase 2
SPP1 secreted phosphoprotein 1
SRSF6 serine/arginine-rich splicing factor 6
ST14 suppression of tumorigenicity 14 (colon carcinoma)
ST8SIA1 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT5A signal transducer and activator of transcription 5A
STAT5B signal transducer and activator of transcription 5B
STMN1 stathmin 1
TADA3 transcriptional adaptor 3
TARBP2 TAR (HIV-1) RNA binding protein 2
TCF4 transcription factor 4
TERT telomerase reverse transcriptase
TFF3 trefoil factor 3 (intestinal)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TK1 thymidine kinase 1, soluble
TLR4 toll-like receptor 4
TLR9 toll-like receptor 9
TNF tumor necrosis factor
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11
TOX3 TOX high mobility group box family member 3
TP53 tumor protein p53
TP53BP1 tumor protein p53 binding protein 1
TP53INP2 tumor protein p53 inducible nuclear protein 2
TPT1 tumor protein, translationally-controlled 1
TRIM29 tripartite motif containing 29
TRIP10 thyroid hormone receptor interactor 10
TRMT61B tRNA methyltransferase 61B
TRPV6 transient receptor potential cation channel, subfamily V, member 6
TSC1 tuberous sclerosis 1
TWIST1 twist family bHLH transcription factor 1
TXNRD1 thioredoxin reductase 1
TYMP thymidine phosphorylase
UBASH3B ubiquitin associated and SH3 domain containing B
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1
USP9X ubiquitin specific peptidase 9, X-linked
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA vascular endothelial growth factor A
VIM vimentin
WBP2 WW domain binding protein 2
WDR43 WD repeat domain 43
WDR7 WD repeat domain 7
WISP2 WNT1 inducible signaling pathway protein 2
WWC1 WW and C2 domain containing 1
YAP1 Yes-associated protein 1
ZNF217 zinc finger protein 217