Estrogen signaling pathway Gene Set

Dataset KEGG Pathways 2026
Category structural or functional annotations
Type pathway
Description Estrogens are steroid hormones that regulate a plethora of physiological processes in mammals, including reproduction, cardiovascular protection, bone integrity, cellular homeostasis, and behavior. Estrogen mediates its cellular actions through two signaling pathways classified as "nuclear-initiated steroid signaling" and "membrane-initiated steroid signaling". In the "nuclear" pathway, estrogen binds either ERalpha or ERbeta, which in turn translocates to the nucleus, binds DNA at ERE elements and activates the expression of ERE-dependent genes. In "membrane" pathway, Estrogen can exert its actions through a subpopulation of ER at the plasma membrane (mER) or novel G-protein coupled E2 receptors (GPER). Upon activation of these receptors various signaling pathways (i.e. Ca2+, cAMP, protein kinase cascades) are rapidly activated and ultimately influence downstream transcription factors. (Kyoto Encyclopedia of Genes and Genomes, hsa04915)
External Link https://www.kegg.jp/entry/hsa04915
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135 proteins participating in the Estrogen signaling pathway pathway from the KEGG Pathways 2026 dataset.

Symbol Name
ADCY1 adenylate cyclase 1 (brain)
ADCY2 adenylate cyclase 2 (brain)
ADCY4 adenylate cyclase 4
ADCY5 adenylate cyclase 5
ADCY6 adenylate cyclase 6
ADCY7 adenylate cyclase 7
ADCY8 adenylate cyclase 8 (brain)
ADCY9 adenylate cyclase 9
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT2 v-akt murine thymoma viral oncogene homolog 2
AKT3 v-akt murine thymoma viral oncogene homolog 3
ATF4 activating transcription factor 4
ATF6B activating transcription factor 6 beta
BCL2 B-cell CLL/lymphoma 2
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CALM2 calmodulin 2 (phosphorylase kinase, delta)
CALM3 calmodulin 3 (phosphorylase kinase, delta)
CALML3 calmodulin-like 3
CALML4 calmodulin-like 4
CALML5 calmodulin-like 5
CALML6 calmodulin-like 6
CLSTN1 calsyntenin 1
CREB1 cAMP responsive element binding protein 1
CREB3L1 cAMP responsive element binding protein 3-like 1
CREB3L2 cAMP responsive element binding protein 3-like 2
CREB3L3 cAMP responsive element binding protein 3-like 3
CREB3L4 cAMP responsive element binding protein 3-like 4
CREB5 cAMP responsive element binding protein 5
CTSD cathepsin D
DAND5 DAN domain family member 5, BMP antagonist
EBAG9 estrogen receptor binding site associated, antigen, 9
EGFR epidermal growth factor receptor
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
FKBP4 FK506 binding protein 4, 59kDa
FKBP5 FK506 binding protein 5
FOS FBJ murine osteosarcoma viral oncogene homolog
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GDNF glial cell derived neurotrophic factor
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3
GNAO1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
GNAQ guanine nucleotide binding protein (G protein), q polypeptide
GNAS GNAS complex locus
GPER1 G protein-coupled estrogen receptor 1
GRB2 growth factor receptor-bound protein 2
GREB1 growth regulation by estrogen in breast cancer 1
GRM1 glutamate receptor, metabotropic 1
HBEGF heparin-binding EGF-like growth factor
HRAS Harvey rat sarcoma viral oncogene homolog
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA1A heat shock 70kDa protein 1A
HSPA1B heat shock 70kDa protein 1B
HSPA1L heat shock 70kDa protein 1-like
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
JUN jun proto-oncogene
KCNJ3 potassium channel, inwardly rectifying subfamily J, member 3
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5
KCNJ6 potassium channel, inwardly rectifying subfamily J, member 6
KCNJ9 potassium channel, inwardly rectifying subfamily J, member 9
KRT10 keratin 10, type I
KRT12 keratin 12, type I
KRT13 keratin 13, type I
KRT14 keratin 14, type I
KRT15 keratin 15, type I
KRT16 keratin 16, type I
KRT17 keratin 17, type I
KRT18 keratin 18, type I
KRT19 keratin 19, type I
KRT20 keratin 20, type I
KRT23 keratin 23, type I
KRT24 keratin 24, type I
KRT25 keratin 25, type I
KRT26 keratin 26, type I
KRT27 keratin 27, type I
KRT28 keratin 28, type I
KRT31 keratin 31, type I
KRT32 keratin 32, type I
KRT33A keratin 33A, type I
KRT33B keratin 33B, type I
KRT34 keratin 34, type I
KRT35 keratin 35, type I
KRT36 keratin 36, type I
KRT37 keratin 37, type I
KRT38 keratin 38, type I
KRT39 keratin 39, type I
KRT40 keratin 40, type I
KRT9 keratin 9, type I
LNCEGFL7OS lncRNA EGFL7 opposite strand
MAP2K1 mitogen-activated protein kinase kinase 1
MAP2K2 mitogen-activated protein kinase kinase 2
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MMP2 matrix metallopeptidase 2
MMP9 matrix metallopeptidase 9
NANOS3 nanos homolog 3 (Drosophila)
NCOA1 nuclear receptor coactivator 1
NCOA2 nuclear receptor coactivator 2
NCOA3 nuclear receptor coactivator 3
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
OPRM1 opioid receptor, mu 1
PGR progesterone receptor
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLCB2 phospholipase C, beta 2
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLCB4 phospholipase C, beta 4
POMC proopiomelanocortin
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRKACG protein kinase, cAMP-dependent, catalytic, gamma
PRKCA protein kinase C, alpha
PRKCD protein kinase C, delta
RARA retinoic acid receptor, alpha
RNASE3 ribonuclease, RNase A family, 3
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SHC2 SHC (Src homology 2 domain containing) transforming protein 2
SHC3 SHC (Src homology 2 domain containing) transforming protein 3
SHC4 SHC (Src homology 2 domain containing) family, member 4
SOS1 son of sevenless homolog 1 (Drosophila)
SOS2 son of sevenless homolog 2 (Drosophila)
SRC SRC proto-oncogene, non-receptor tyrosine kinase
TFF1 trefoil factor 1
TGFA transforming growth factor, alpha