| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| Description | 1,3-Benzothiazole substituted a sulfonamide and an ethoxy group at positions 2 and 6, respectively. A carbonic anhydrase inhibitor, it has been used in the treatment of glaucoma, and as a diuretic. (Chemical Entities of Biological Interest Ontology, CHEBI_101096) |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/3295 |
| Similar Terms | |
| Downloads & Tools |
199 proteins with high or low expression in Ethoxzolamide relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| OSGIN1 | oxidative stress induced growth inhibitor 1 | 2.77 |
| CYP4F11 | cytochrome P450, family 4, subfamily F, polypeptide 11 | 1.56 |
| FTL | ferritin, light polypeptide | 1.34 |
| HMOX1 | heme oxygenase 1 | 1.32 |
| SRXN1 | sulfiredoxin 1 | 1.29 |
| DSCAM | Down syndrome cell adhesion molecule | 1.27 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 1.12 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | 1.02 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 1.0 |
| GCLM | glutamate-cysteine ligase, modifier subunit | 0.94 |
| CHAC1 | ChaC glutathione-specific gamma-glutamylcyclotransferase 1 | 0.9 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | 0.83 |
| ABCB6 | ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) | 0.8 |
| RMDN2 | regulator of microtubule dynamics 2 | 0.74 |
| GPC1 | glypican 1 | 0.74 |
| TXNRD1 | thioredoxin reductase 1 | 0.72 |
| AKR1C2 | aldo-keto reductase family 1, member C2 | 0.69 |
| TRIM16 | tripartite motif containing 16 | 0.68 |
| RAP1GAP | RAP1 GTPase activating protein | 0.64 |
| ABHD4 | abhydrolase domain containing 4 | 0.63 |
| HKDC1 | hexokinase domain containing 1 | 0.63 |
| ZNF543 | zinc finger protein 543 | 0.6 |
| CTSV | cathepsin V | 0.6 |
| UGDH | UDP-glucose 6-dehydrogenase | 0.56 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | 0.56 |
| PIR | pirin (iron-binding nuclear protein) | 0.54 |
| GSR | glutathione reductase | 0.53 |
| ABCC2 | ATP-binding cassette, sub-family C (CFTR/MRP), member 2 | 0.48 |
| ALAS1 | 5'-aminolevulinate synthase 1 | 0.48 |
| DCAF12 | DDB1 and CUL4 associated factor 12 | 0.47 |
| NDEL1 | nudE neurodevelopment protein 1-like 1 | 0.47 |
| RPL26 | ribosomal protein L26 | 0.45 |
| FLNB | filamin B, beta | 0.44 |
| SQSTM1 | sequestosome 1 | 0.44 |
| B2M | beta-2-microglobulin | 0.44 |
| DNAJB4 | DnaJ (Hsp40) homolog, subfamily B, member 4 | 0.42 |
| PREX1 | phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 | 0.42 |
| G6PD | glucose-6-phosphate dehydrogenase | 0.41 |
| ME1 | malic enzyme 1, NADP(+)-dependent, cytosolic | 0.41 |
| DUSP5 | dual specificity phosphatase 5 | 0.4 |
| ASF1A | anti-silencing function 1A histone chaperone | 0.39 |
| CA8 | carbonic anhydrase VIII | 0.39 |
| ALDH3A2 | aldehyde dehydrogenase 3 family, member A2 | 0.39 |
| MAP2 | microtubule-associated protein 2 | 0.38 |
| HECW1 | HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 | 0.37 |
| CCDC138 | coiled-coil domain containing 138 | 0.37 |
| HTATIP2 | HIV-1 Tat interactive protein 2, 30kDa | 0.37 |
| IFRD1 | interferon-related developmental regulator 1 | 0.36 |
| FBXO30 | F-box protein 30 | 0.35 |
| NUMBL | numb homolog (Drosophila)-like | 0.35 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.35 |
| CBR3 | carbonyl reductase 3 | 0.35 |
| USP43 | ubiquitin specific peptidase 43 | 0.34 |
| RNF216 | ring finger protein 216 | 0.34 |
| DBNL | drebrin-like | 0.34 |
| LRP8 | low density lipoprotein receptor-related protein 8, apolipoprotein e receptor | 0.33 |
| ZNF304 | zinc finger protein 304 | 0.33 |
| GPRC5B | G protein-coupled receptor, class C, group 5, member B | 0.33 |
| SELENOI | selenoprotein I | 0.32 |
| PACC1 | proton activated chloride channel 1 | 0.32 |
| ZNF724 | zinc finger protein 724 | 0.32 |
| NAV3 | neuron navigator 3 | 0.32 |
| CBR1 | carbonyl reductase 1 | 0.32 |
| METRNL | meteorin, glial cell differentiation regulator-like | 0.31 |
| RND3 | Rho family GTPase 3 | 0.31 |
| MAFG | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G | 0.31 |
| NAV2 | neuron navigator 2 | 0.3 |
| DNLZ | DNL-type zinc finger | 0.3 |
| B9D1 | B9 protein domain 1 | 0.3 |
| EPHX1 | epoxide hydrolase 1, microsomal (xenobiotic) | 0.3 |
| TUBE1 | tubulin, epsilon 1 | 0.29 |
| ADM | adrenomedullin | 0.29 |
| PSAT1 | phosphoserine aminotransferase 1 | 0.29 |
| GPAT3 | glycerol-3-phosphate acyltransferase 3 | 0.29 |
| CLU | clusterin | 0.28 |
| GRB10 | growth factor receptor-bound protein 10 | 0.28 |
| PIP5K1A | phosphatidylinositol-4-phosphate 5-kinase, type I, alpha | 0.28 |
| GPT2 | glutamic pyruvate transaminase (alanine aminotransferase) 2 | 0.28 |
| UCK1 | uridine-cytidine kinase 1 | 0.28 |
| CEBPB | CCAAT/enhancer binding protein (C/EBP), beta | 0.27 |
| SLC39A3 | solute carrier family 39 (zinc transporter), member 3 | 0.27 |
| ACTN2 | actinin, alpha 2 | 0.27 |
| COX16 | COX16 cytochrome c oxidase assembly homolog (S. cerevisiae) | 0.27 |
| FECH | ferrochelatase | 0.27 |
| HDAC4 | histone deacetylase 4 | 0.27 |
| RUBCN | rubicon autophagy regulator | 0.26 |
| AIFM2 | apoptosis-inducing factor, mitochondrion-associated, 2 | 0.26 |
| OIP5 | Opa interacting protein 5 | 0.26 |
| SDCCAG8 | serologically defined colon cancer antigen 8 | 0.26 |
| SEL1L3 | sel-1 suppressor of lin-12-like 3 (C. elegans) | 0.26 |
| ZNF114 | zinc finger protein 114 | 0.26 |
| ZNF652 | zinc finger protein 652 | 0.26 |
| CREBZF | CREB/ATF bZIP transcription factor | 0.26 |
| IVNS1ABP | influenza virus NS1A binding protein | 0.26 |
| EVA1C | eva-1 homolog C (C. elegans) | 0.26 |
| ABCC3 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | 0.26 |
| C12ORF60 | chromosome 12 open reading frame 60 | 0.25 |
| ASNSD1 | asparagine synthetase domain containing 1 | 0.25 |
| CEBPA | CCAAT/enhancer binding protein (C/EBP), alpha | 0.25 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ATP6V1F | ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F | -1.64 |
| ADPRH | ADP-ribosylarginine hydrolase | -1.5 |
| FGG | fibrinogen gamma chain | -1.1 |
| CNTLN | centlein, centrosomal protein | -1.07 |
| TDRD9 | tudor domain containing 9 | -1.05 |
| TRIM29 | tripartite motif containing 29 | -0.96 |
| PIK3C2B | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta | -0.87 |
| FAM219A | family with sequence similarity 219, member A | -0.84 |
| NTN1 | netrin 1 | -0.76 |
| MISP3 | MISP family member 3 | -0.71 |
| TNFRSF10D | tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain | -0.68 |
| LRP1 | low density lipoprotein receptor-related protein 1 | -0.67 |
| KMT2B | lysine (K)-specific methyltransferase 2B | -0.67 |
| ADCY9 | adenylate cyclase 9 | -0.66 |
| GJB3 | gap junction protein, beta 3, 31kDa | -0.65 |
| CNNM1 | cyclin and CBS domain divalent metal cation transport mediator 1 | -0.62 |
| S100A2 | S100 calcium binding protein A2 | -0.61 |
| PTPRB | protein tyrosine phosphatase, receptor type, B | -0.61 |
| ETV5 | ets variant 5 | -0.59 |
| HAS3 | hyaluronan synthase 3 | -0.58 |
| SET | SET nuclear proto-oncogene | -0.57 |
| KPTN | kaptin (actin binding protein) | -0.56 |
| KDF1 | keratinocyte differentiation factor 1 | -0.56 |
| PYGM | phosphorylase, glycogen, muscle | -0.54 |
| UQCRH | ubiquinol-cytochrome c reductase hinge protein | -0.54 |
| SLC9A1 | solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 | -0.53 |
| LRP12 | low density lipoprotein receptor-related protein 12 | -0.53 |
| TRIAP1 | TP53 regulated inhibitor of apoptosis 1 | -0.52 |
| LAMC2 | laminin, gamma 2 | -0.52 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.51 |
| TMSB10 | thymosin beta 10 | -0.51 |
| LRIG3 | leucine-rich repeats and immunoglobulin-like domains 3 | -0.5 |
| ZNF160 | zinc finger protein 160 | -0.5 |
| NGFR | nerve growth factor receptor | -0.5 |
| MT1F | metallothionein 1F | -0.49 |
| DCHS1 | dachsous cadherin-related 1 | -0.49 |
| KITLG | KIT ligand | -0.49 |
| HBA1 | hemoglobin, alpha 1 | -0.49 |
| KSR2 | kinase suppressor of ras 2 | -0.49 |
| NAA80 | N-alpha-acetyltransferase 80, NatH catalytic subunit | -0.48 |
| WIPI1 | WD repeat domain, phosphoinositide interacting 1 | -0.48 |
| PCMTD1 | protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 | -0.47 |
| SLC26A11 | solute carrier family 26 (anion exchanger), member 11 | -0.47 |
| DCAF16 | DDB1 and CUL4 associated factor 16 | -0.47 |
| MBP | myelin basic protein | -0.47 |
| MCL1 | myeloid cell leukemia 1 | -0.46 |
| OGG1 | 8-oxoguanine DNA glycosylase | -0.46 |
| PCSK9 | proprotein convertase subtilisin/kexin type 9 | -0.46 |
| GRAMD2B | GRAM domain containing 2B | -0.45 |
| TANK | TRAF family member-associated NFKB activator | -0.45 |
| GNPTG | N-acetylglucosamine-1-phosphate transferase, gamma subunit | -0.44 |
| SGSM1 | small G protein signaling modulator 1 | -0.44 |
| MT2A | metallothionein 2A | -0.43 |
| C6ORF132 | chromosome 6 open reading frame 132 | -0.43 |
| DNAH1 | dynein, axonemal, heavy chain 1 | -0.43 |
| BANF1 | barrier to autointegration factor 1 | -0.43 |
| TMEM200A | transmembrane protein 200A | -0.42 |
| HIST1H1T | histone cluster 1, H1t | -0.42 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.42 |
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | -0.42 |
| DOHH | deoxyhypusine hydroxylase/monooxygenase | -0.41 |
| METTL7A | methyltransferase like 7A | -0.41 |
| CELSR1 | cadherin, EGF LAG seven-pass G-type receptor 1 | -0.41 |
| CTHRC1 | collagen triple helix repeat containing 1 | -0.41 |
| FBXL2 | F-box and leucine-rich repeat protein 2 | -0.4 |
| WNT16 | wingless-type MMTV integration site family, member 16 | -0.4 |
| RNF181 | ring finger protein 181 | -0.4 |
| MSANTD4 | Myb/SANT-like DNA-binding domain containing 4 with coiled-coils | -0.4 |
| GFOD1 | glucose-fructose oxidoreductase domain containing 1 | -0.4 |
| COA4 | cytochrome c oxidase assembly factor 4 homolog (S. cerevisiae) | -0.4 |
| ETV6 | ets variant 6 | -0.4 |
| ANKRD10 | ankyrin repeat domain 10 | -0.4 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.4 |
| PCDH1 | protocadherin 1 | -0.4 |
| MPV17 | MpV17 mitochondrial inner membrane protein | -0.4 |
| TMEM59 | transmembrane protein 59 | -0.39 |
| S100A6 | S100 calcium binding protein A6 | -0.39 |
| ANTXR1 | anthrax toxin receptor 1 | -0.39 |
| LTBP3 | latent transforming growth factor beta binding protein 3 | -0.38 |
| STARD3NL | STARD3 N-terminal like | -0.38 |
| RNF115 | ring finger protein 115 | -0.38 |
| MFGE8 | milk fat globule-EGF factor 8 protein | -0.38 |
| CYP1A1 | cytochrome P450, family 1, subfamily A, polypeptide 1 | -0.38 |
| ATXN7L2 | ataxin 7-like 2 | -0.38 |
| ZNF14 | zinc finger protein 14 | -0.37 |
| NAA38 | N(alpha)-acetyltransferase 38, NatC auxiliary subunit | -0.37 |
| MT1X | metallothionein 1X | -0.37 |
| TTN | titin | -0.37 |
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | -0.37 |
| UBAP1 | ubiquitin associated protein 1 | -0.37 |
| ATP5PF | ATP synthase peripheral stalk subunit F6 | -0.37 |
| GEM | GTP binding protein overexpressed in skeletal muscle | -0.36 |
| ACSM3 | acyl-CoA synthetase medium-chain family member 3 | -0.36 |
| MAN2A2 | mannosidase, alpha, class 2A, member 2 | -0.36 |
| FHIT | fragile histidine triad | -0.35 |
| WWC3 | WWC family member 3 | -0.35 |
| CYP51A1 | cytochrome P450, family 51, subfamily A, polypeptide 1 | -0.35 |
| FAT3 | FAT atypical cadherin 3 | -0.35 |
| CST6 | cystatin E/M | -0.35 |
| CCDC66 | coiled-coil domain containing 66 | -0.35 |
