Ethynyl Estradiol Gene Set

Dataset DeepCoverMOA Drug Mechanisms of Action
Category proteomics
Type drug perturbation
External Link https://pubchem.ncbi.nlm.nih.gov/compound/5991
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Genes

200 proteins with high or low expression in Ethynyl Estradiol relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.

high expression

Symbol Name Standardized Value
GVINP1 GTPase, very large interferon inducible pseudogene 1 1.45
KMT2B lysine (K)-specific methyltransferase 2B 1.35
DES desmin 1.22
MDM1 Mdm1 nuclear protein homolog (mouse) 1.15
DIPK1B divergent protein kinase domain 1B 1.11
TP53 tumor protein p53 1.07
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.97
PTBP1 polypyrimidine tract binding protein 1 0.89
KLHL15 kelch-like family member 15 0.79
PRKD3 protein kinase D3 0.75
DOLK dolichol kinase 0.73
ZMYM5 zinc finger, MYM-type 5 0.71
MARCHF7 membrane associated ring-CH-type finger 7 0.64
ZNF226 zinc finger protein 226 0.57
RCAN3 RCAN family member 3 0.56
UBE2A ubiquitin-conjugating enzyme E2A 0.55
PHLDA3 pleckstrin homology-like domain, family A, member 3 0.55
MT-ATP6 ATP synthase F0 subunit 6 0.52
TRAF3 TNF receptor-associated factor 3 0.51
DGKE diacylglycerol kinase, epsilon 64kDa 0.5
MT1L metallothionein 1L (gene/pseudogene) 0.48
POLH polymerase (DNA directed), eta 0.47
TTLL4 tubulin tyrosine ligase-like family member 4 0.47
MT2A metallothionein 2A 0.46
LDHD lactate dehydrogenase D 0.45
COQ4 coenzyme Q4 0.45
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.44
TINAGL1 tubulointerstitial nephritis antigen-like 1 0.43
DHRS2 dehydrogenase/reductase (SDR family) member 2 0.43
TSPAN31 tetraspanin 31 0.42
CYBA cytochrome b-245, alpha polypeptide 0.42
MRAS muscle RAS oncogene homolog 0.41
CCDC85B coiled-coil domain containing 85B 0.4
TMEM106C transmembrane protein 106C 0.4
TCP11L1 t-complex 11, testis-specific-like 1 0.4
PPCDC phosphopantothenoylcysteine decarboxylase 0.38
UBQLN4 ubiquilin 4 0.38
PLEKHG1 pleckstrin homology domain containing, family G (with RhoGef domain) member 1 0.38
KCTD12 potassium channel tetramerization domain containing 12 0.38
YIF1B Yip1 interacting factor homolog B (S. cerevisiae) 0.38
ZNF444 zinc finger protein 444 0.37
ZNF564 zinc finger protein 564 0.37
LASP1 LIM and SH3 protein 1 0.36
RPL3L ribosomal protein L3-like 0.35
MT1E metallothionein 1E 0.35
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1 0.35
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1 0.35
ZNF729 zinc finger protein 729 0.35
RABEP2 rabaptin, RAB GTPase binding effector protein 2 0.35
RAP1B RAP1B, member of RAS oncogene family 0.34
TDG thymine-DNA glycosylase 0.34
PMF1 polyamine-modulated factor 1 0.34
FKBP7 FK506 binding protein 7 0.34
CCND1 cyclin D1 0.34
TMEM173 transmembrane protein 173 0.33
AURKA aurora kinase A 0.33
SOX12 SRY (sex determining region Y)-box 12 0.33
ZNF428 zinc finger protein 428 0.33
TMUB2 transmembrane and ubiquitin-like domain containing 2 0.33
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like 0.33
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.32
SLC38A9 solute carrier family 38, member 9 0.32
RNF111 ring finger protein 111 0.32
NAIF1 nuclear apoptosis inducing factor 1 0.32
KAT6B K(lysine) acetyltransferase 6B 0.32
SMTN smoothelin 0.32
ZNF551 zinc finger protein 551 0.32
MT1F metallothionein 1F 0.31
PDIA4 protein disulfide isomerase family A, member 4 0.3
ZNF91 zinc finger protein 91 0.3
CCNQ cyclin Q 0.3
RPL36AL ribosomal protein L36a-like 0.3
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.3
MT1X metallothionein 1X 0.29
JMJD4 jumonji domain containing 4 0.29
CYBRD1 cytochrome b reductase 1 0.29
NOS3 nitric oxide synthase 3 (endothelial cell) 0.29
FBXL16 F-box and leucine-rich repeat protein 16 0.29
PKM pyruvate kinase, muscle 0.29
ALKBH7 alkB, alkylation repair homolog 7 (E. coli) 0.28
ARL4A ADP-ribosylation factor-like 4A 0.28
SELENOT selenoprotein T 0.28
MRPL42 mitochondrial ribosomal protein L42 0.28
C1ORF109 chromosome 1 open reading frame 109 0.28
VMP1 vacuole membrane protein 1 0.28
HYKK hydroxylysine kinase 0.28
TVP23C trans-golgi network vesicle protein 23 homolog C (S. cerevisiae) 0.28
EIF4A1 eukaryotic translation initiation factor 4A1 0.28
UBE2S ubiquitin-conjugating enzyme E2S 0.28
PTGES prostaglandin E synthase 0.28
SEC24D SEC24 family member D 0.28
DOP1A DOP1 leucine zipper like protein A 0.27
KIF20A kinesin family member 20A 0.27
PRDM16 PR domain containing 16 0.27
KDM8 lysine (K)-specific demethylase 8 0.27
FUT10 fucosyltransferase 10 (alpha (1,3) fucosyltransferase) 0.27
ISL2 ISL LIM homeobox 2 0.27
FOXD2 forkhead box D2 0.27
HMGB2 high mobility group box 2 0.27
HPCAL4 hippocalcin like 4 0.27

low expression

Symbol Name Standardized Value
RGN regucalcin -0.97
PCLO piccolo presynaptic cytomatrix protein -0.95
ESYT2 extended synaptotagmin-like protein 2 -0.76
BCAM basal cell adhesion molecule (Lutheran blood group) -0.63
TPM4 tropomyosin 4 -0.6
UPF3A UPF3 regulator of nonsense transcripts homolog A (yeast) -0.59
HOXB4 homeobox B4 -0.57
MCFD2 multiple coagulation factor deficiency 2 -0.54
VEZT vezatin, adherens junctions transmembrane protein -0.54
FAM135B family with sequence similarity 135, member B -0.53
CALU calumenin -0.51
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -0.51
TMEM63A transmembrane protein 63A -0.5
TSPAN3 tetraspanin 3 -0.5
FAM102B family with sequence similarity 102, member B -0.49
ZNF282 zinc finger protein 282 -0.49
KCTD18 potassium channel tetramerization domain containing 18 -0.48
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2 -0.46
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.46
ZSCAN5A zinc finger and SCAN domain containing 5A -0.46
SGMS2 sphingomyelin synthase 2 -0.46
FGFR1 fibroblast growth factor receptor 1 -0.44
PPP1R15B protein phosphatase 1, regulatory subunit 15B -0.44
ARSG arylsulfatase G -0.44
DIPK1A divergent protein kinase domain 1A -0.42
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4 -0.42
NDRG2 NDRG family member 2 -0.42
GABRQ gamma-aminobutyric acid (GABA) A receptor, theta -0.41
RITA1 RBPJ interacting and tubulin associated 1 -0.41
EPG5 ectopic P-granules autophagy protein 5 homolog (C. elegans) -0.41
ANKRD22 ankyrin repeat domain 22 -0.4
ITGA7 integrin, alpha 7 -0.4
SIPA1L2 signal-induced proliferation-associated 1 like 2 -0.4
TBRG1 transforming growth factor beta regulator 1 -0.4
SPTB spectrin, beta, erythrocytic -0.38
ELK4 ELK4, ETS-domain protein (SRF accessory protein 1) -0.38
FAM171A1 family with sequence similarity 171, member A1 -0.38
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A -0.38
ZC3H12A zinc finger CCCH-type containing 12A -0.37
UQCRFS1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 -0.36
LIMCH1 LIM and calponin homology domains 1 -0.36
KIAA0232 KIAA0232 -0.35
ZBED8L ZBED8 like -0.35
WDR60 WD repeat domain 60 -0.35
FGD6 FYVE, RhoGEF and PH domain containing 6 -0.35
USP43 ubiquitin specific peptidase 43 -0.35
NEK2 NIMA-related kinase 2 -0.35
ARHGAP23 Rho GTPase activating protein 23 -0.35
CREG1 cellular repressor of E1A-stimulated genes 1 -0.35
C15ORF61 chromosome 15 open reading frame 61 -0.35
PLEK pleckstrin -0.34
ZNF697 zinc finger protein 697 -0.34
TYRO3 TYRO3 protein tyrosine kinase -0.34
FRMD6 FERM domain containing 6 -0.33
IRF9 interferon regulatory factor 9 -0.33
RBPJL recombination signal binding protein for immunoglobulin kappa J region-like -0.33
LRP4 low density lipoprotein receptor-related protein 4 -0.33
AFG1L AFG1 like ATPase -0.32
FRS2 fibroblast growth factor receptor substrate 2 -0.32
ABCA13 ATP-binding cassette, sub-family A (ABC1), member 13 -0.32
BAIAP2 BAI1-associated protein 2 -0.32
TOR2A torsin family 2, member A -0.32
POMT2 protein-O-mannosyltransferase 2 -0.32
E4F1 E4F transcription factor 1 -0.32
ZC4H2 zinc finger, C4H2 domain containing -0.32
AKAP2 A kinase (PRKA) anchor protein 2 -0.31
RNF130 ring finger protein 130 -0.31
SP110 SP110 nuclear body protein -0.31
ADIPOR1 adiponectin receptor 1 -0.31
SEC14L1 SEC14-like 1 (S. cerevisiae) -0.31
SLC6A9 solute carrier family 6 (neurotransmitter transporter, glycine), member 9 -0.31
POLQ polymerase (DNA directed), theta -0.31
AGFG2 ArfGAP with FG repeats 2 -0.31
TMEM200A transmembrane protein 200A -0.3
EVPL envoplakin -0.3
TMCC1 transmembrane and coiled-coil domain family 1 -0.3
ERBB3 erb-b2 receptor tyrosine kinase 3 -0.3
ATXN2 ataxin 2 -0.29
PLEC plectin -0.29
GRK3 G protein-coupled receptor kinase 3 -0.29
IL6ST interleukin 6 signal transducer -0.29
MIER2 mesoderm induction early response 1, family member 2 -0.29
FAM20C family with sequence similarity 20, member C -0.29
ALKBH5 AlkB family member 5, RNA demethylase -0.28
SPICE1 spindle and centriole associated protein 1 -0.28
SLC26A11 solute carrier family 26 (anion exchanger), member 11 -0.28
CBWD1 COBW domain containing 1 -0.27
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 -0.27
RAD51 RAD51 recombinase -0.27
PLPP3 phospholipid phosphatase 3 -0.27
CD274 CD274 molecule -0.27
PDLIM2 PDZ and LIM domain 2 (mystique) -0.27
ZSCAN20 zinc finger and SCAN domain containing 20 -0.27
NFE2L3 nuclear factor, erythroid 2-like 3 -0.26
EGFL7 EGF-like-domain, multiple 7 -0.26
FAM241B family with sequence similarity 241 member B -0.26
CEP55 centrosomal protein 55kDa -0.26
MEGF8 multiple EGF-like-domains 8 -0.26
SIMC1 SUMO-interacting motifs containing 1 -0.26
CNNM1 cyclin and CBS domain divalent metal cation transport mediator 1 -0.26